Results 1 to 10 of about 23,928 (250)

Engineering Isoprenoid Quinone Production in Yeast [PDF]

ACS Synthetic Biology, 2020
Isoprenoid quinones are bioactive molecules that include an isoprenoid chain and a quinone head. They are traditionally found to be involved in primary metabolism, where they act as electron transporters, but specialized isoprenoid quinones are also ...
Divjot Kaur, Christophe Corre, Fabrizio Alberti   +2 more
exaly   +2 more sources

Adaptation of hydroxymethylbutenyl diphosphate reductase enables volatile isoprenoid production [PDF]

eLife, 2020
Volatile isoprenoids produced by plants are emitted in vast quantities into the atmosphere, with substantial effects on global carbon cycling. Yet, the molecular mechanisms regulating the balance between volatile and non-volatile isoprenoid production ...
Mareike Bongers, Jordi Perez-Gil, Mark P Hodson, Lars Schrübbers, Tune Wulff, Morten OA Sommer, Lars K Nielsen, Claudia E Vickers   +7 more
doaj   +2 more sources

A redundant isoprenoid biosynthetic pathway supports Staphylococcus aureus metabolic versatility [PDF]

mBio
Isoprenoids are ubiquitous molecules that serve as fundamental building blocks for life. In bacteria, isoprenoids are precursors for carotenoid pigments, respiratory cofactors, and essential sugar carrier lipids, such as lipid II.
Troy A. Burtchett, Elizabeth N. Ottosen, Tomotaka Jitsukawa, Momoko Kaneko, Miu Yasui, Jessica A. Lysne, Paige J. Kies, Jessica A. Bailey, Sean M. Thomas, Shingo Fujisaki, Neal D. Hammer   +10 more
doaj   +2 more sources

Downregulation of Squalene Synthase Broadly Impacts Isoprenoid Biosynthesis in Guayule [PDF]

Metabolites, 2022
Production of natural rubber by Parthenium argentaum (guayule) requires increased yield for economic sustainability. An RNAi gene silencing strategy was used to engineer isoprenoid biosynthesis by downregulation of squalene synthase (SQS), such that the ...
Dante Placido, Niu Dong, Bashar Amer, Chen Dong, Grisel Ponciano, Talwinder Kahlon, Maureen Whalen, Edward E. K. Baidoo, Colleen McMahan   +8 more
doaj   +2 more sources

Diversifying Isoprenoid Platforms via Atypical Carbon Substrates and Non-model Microorganisms [PDF]

Frontiers in Microbiology, 2021
Isoprenoid compounds are biologically ubiquitous, and their characteristic modularity has afforded products ranging from pharmaceuticals to biofuels. Isoprenoid production has been largely successful in Escherichia coli and Saccharomyces cerevisiae with ...
David N. Carruthers, David N. Carruthers, Taek Soon Lee, Taek Soon Lee   +3 more
doaj   +2 more sources

Growth-uncoupled isoprenoid synthesis in Rhodobacter sphaeroides

Biotechnology for Biofuels, 2020
Background Microbial cell factories are usually engineered and employed for cultivations that combine product synthesis with growth. Such a strategy inevitably invests part of the substrate pool towards the generation of biomass and cellular maintenance.
Enrico Orsi, Ioannis Mougiakos, Wilbert Post, Jules Beekwilder, Marco Dompè, Gerrit Eggink, John van der Oost, Servé W. M. Kengen, Ruud A. Weusthuis   +8 more
doaj   +2 more sources

Antibacterial effect of some eukaryotic sterol biosynthesis inhibitors

Advanced Biomedical Research, 2022
Background: Isoprenoids and their derivatives are building blocks for the synthesis of biomolecules with important biological functions such as cholesterol in eukaryotes and lipid carrier undecaprenol, which is involved in cell wall biosynthesis in ...
Ghasem Arjmand, Mohammad Reza Haeri
doaj   +1 more source

Inhibition of Phytosterol Biosynthesis by Azasterols

Molecules, 2020
Inhibitors of enzymes in essential cellular pathways are potent probes to decipher intricate physiological functions of biomolecules. The analysis of Arabidopsis thaliana sterol profiles upon treatment with a series of azasterols reveals a specific in ...
Sylvain Darnet, Laetitia B B Martin, Pierre Mercier, Franz Bracher, Philippe Geoffroy, Hubert Schaller   +5 more
doaj   +1 more source

Biological effects of trans, trans-farnesol in Leishmania amazonensis

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionFarnesol, derived from farnesyl pyrophosphate in the sterols biosynthetic pathway, is a molecule with three unsaturations and four possible isomers.
Liliane Sena Pinheiro, Liliane Sena Pinheiro, Valter Viana Andrade-Neto, Marcio Mantuano-Barradas, Elisa Cavalcante Pereira, Rodrigo Cesar Fernandes Barbosa, Marcia Cristina Campos de Oliveira, Rubem Figueiredo Sadok Menna-Barreto, Edézio Ferreira Cunha-Júnior, Eduardo Caio Torres-Santos   +9 more
doaj   +1 more source

Genetic Manipulation of Biosynthetic Pathways in Mint

Frontiers in Plant Science, 2022
In recent years, the study of aromatic plants has seen an increase, with great interest from industrial, academic, and pharmaceutical industries. Among plants attracting increased attention are the Mentha spp.
Lorenz K. Fuchs, Alistair H. Holland, Richard A. Ludlow, Ryan J. Coates, Harvey Armstrong, John A. Pickett, John L. Harwood, Simon Scofield   +7 more
doaj   +1 more source