Results 1 to 10 of about 18,433 (200)

A redundant isoprenoid biosynthetic pathway supports Staphylococcus aureus metabolic versatility [PDF]

mBio
Isoprenoids are ubiquitous molecules that serve as fundamental building blocks for life. In bacteria, isoprenoids are precursors for carotenoid pigments, respiratory cofactors, and essential sugar carrier lipids, such as lipid II.
Troy A. Burtchett, Elizabeth N. Ottosen, Tomotaka Jitsukawa, Momoko Kaneko, Miu Yasui, Jessica A. Lysne, Paige J. Kies, Jessica A. Bailey, Sean M. Thomas, Shingo Fujisaki, Neal D. Hammer   +10 more
doaj   +2 more sources

Antibacterial effect of some eukaryotic sterol biosynthesis inhibitors

Advanced Biomedical Research, 2022
Background: Isoprenoids and their derivatives are building blocks for the synthesis of biomolecules with important biological functions such as cholesterol in eukaryotes and lipid carrier undecaprenol, which is involved in cell wall biosynthesis in ...
Ghasem Arjmand, Mohammad Reza Haeri
doaj   +1 more source

Inhibition of Phytosterol Biosynthesis by Azasterols

Molecules, 2020
Inhibitors of enzymes in essential cellular pathways are potent probes to decipher intricate physiological functions of biomolecules. The analysis of Arabidopsis thaliana sterol profiles upon treatment with a series of azasterols reveals a specific in ...
Sylvain Darnet, Laetitia B B Martin, Pierre Mercier, Franz Bracher, Philippe Geoffroy, Hubert Schaller   +5 more
doaj   +1 more source

Biological effects of trans, trans-farnesol in Leishmania amazonensis

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionFarnesol, derived from farnesyl pyrophosphate in the sterols biosynthetic pathway, is a molecule with three unsaturations and four possible isomers.
Liliane Sena Pinheiro, Liliane Sena Pinheiro, Valter Viana Andrade-Neto, Marcio Mantuano-Barradas, Elisa Cavalcante Pereira, Rodrigo Cesar Fernandes Barbosa, Marcia Cristina Campos de Oliveira, Rubem Figueiredo Sadok Menna-Barreto, Edézio Ferreira Cunha-Júnior, Eduardo Caio Torres-Santos   +9 more
doaj   +1 more source

Genetic Manipulation of Biosynthetic Pathways in Mint

Frontiers in Plant Science, 2022
In recent years, the study of aromatic plants has seen an increase, with great interest from industrial, academic, and pharmaceutical industries. Among plants attracting increased attention are the Mentha spp.
Lorenz K. Fuchs, Alistair H. Holland, Richard A. Ludlow, Ryan J. Coates, Harvey Armstrong, John A. Pickett, John L. Harwood, Simon Scofield   +7 more
doaj   +1 more source

Exploring the Deoxy-D-xylulose-5-phosphate Synthase Gene Family in Tomato (Solanum lycopersicum)

Plants, 2023
Isoprenoids are a wide family of metabolites including high-value chemicals, flavors, pigments, and drugs. Isoprenoids are particularly abundant and diverse in plants.
Xueni Di, Manuel Rodriguez-Concepcion
doaj   +1 more source

Crystal Structure of Geranylgeranyl Pyrophosphate Synthase (CrtE) Involved in Cyanobacterial Terpenoid Biosynthesis

Frontiers in Plant Science, 2020
Cyanobacteria are photosynthetic prokaryotes that perform oxygenic photosynthesis. Due to their ability to use the photon energy of sunlight to fix carbon dioxide into biomass, cyanobacteria are promising hosts for the sustainable production of ...
Yuchi Feng, R. Marc L. Morgan, Paul D. Fraser, Klaus Hellgardt, Peter J. Nixon   +4 more
doaj   +1 more source

Presence of Phylloquinone in the Intraerythrocytic Stages of Plasmodium falciparum

Frontiers in Cellular and Infection Microbiology, 2022
Malaria is one of the most widespread parasitic diseases, especially in Africa, Southeast Asia and South America. One of the greatest problems for control of the disease is the emergence of drug resistance, which leads to a need for the development of ...
Rodrigo A. C. Sussmann, Rodrigo A. C. Sussmann, Heloisa B. Gabriel, Alejandro García Ríos, Alejandro García Ríos, Danielle S. Menchaca Vega, Lydia F. Yamaguchi, Antonio Doménech-Carbó, Gerardo Cebrián-Torrejón, Emilia A. Kimura, Massuo J. Kato, Ignasi Bofill Verdaguer, Marcell Crispim, Alejandro M. Katzin   +13 more
doaj   +1 more source

Arginine in the FARM and SARM: A Role in Chain-Length Determination for Arginine in the Aspartate-Rich Motifs of Isoprenyl Diphosphate Synthases from Mycobacterium tuberculosis

Molecules, 2018
Isoprenyl chains are found in many important metabolites. These are derived from precursors of the appropriate length produced by isoprenyl diphosphate synthases (IDSs).
Raimund Nagel, Jill A. Thomas, Faith A. Adekunle, Francis M. Mann, Reuben J. Peters   +4 more
doaj   +1 more source

Germacrene A Synthases for Sesquiterpene Lactone Biosynthesis Are Expressed in Vascular Parenchyma Cells Neighboring Laticifers in Lettuce

Plants, 2022
Sesquiterpene lactone (STL) and natural rubber (NR) are characteristic isoprenoids in lettuce (Lactuca sativa). Both STL and NR co-accumulate in laticifers, pipe-like structures located along the vasculature.
Moonhyuk Kwon, Connor L. Hodgins, Tegan M. Haslam, Susan A. Roth, Trinh-Don Nguyen, Edward C. Yeung, Dae-Kyun Ro   +6 more
doaj   +1 more source