Results 1 to 10 of about 3,960 (214)

Structural basis of heterotetrameric assembly and disease mutations in the human cis-prenyltransferase complex

Nature Communications, 2020
The human cis-prenyltransferase (hcis-PT) complex synthesizes the precursor of the glycosyl carrier dolichol-phosphate and as such it is essential for protein N-glycosylation.
Michal Lisnyansky Bar-El, Pavla Vaňková, Adva Yeheskel, Luba Simhaev, Hamutal Engel, Petr Man, Yoni Haitin, Moshe Giladi   +7 more
doaj   +2 more sources

Cloning and Characterization of Protein Prenyltransferase Alpha Subunit in Rice

Rice Science, 2021
Protein prenylation plays a crucial role in plant development and stress response. We report the function of prenyltransferase α-subunit in rice. Protein-protein interactions showed that the farnesyl- transferase (OsPFT)/geranylgeranyltransferase-I ...
Wang Tao, Lou Lijuan, Li Zeyu, Shang Lianguang, Wang Quan   +4 more
doaj   +1 more source

Thematic review series: Lipid Posttranslational Modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I

Journal of Lipid Research, 2006
More than 100 proteins necessary for eukaryotic cell growth, differentiation, and morphology require posttranslational modification by the covalent attachment of an isoprenoid lipid (prenylation).
Kimberly T. Lane, Lorena S. Beese
doaj   +1 more source

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

The FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu, Maximilian J. L. J. Fürst, Oscar P. Kuipers   +2 more
wiley   +1 more source

Cloning and Characterization of Naringenin 8-Prenyltransferase, a Flavonoid-Specific Prenyltransferase of Sophora flavescens     [PDF]

Plant Physiology, 2008
Abstract Prenylated flavonoids are natural compounds that often represent the active components in various medicinal plants and exhibit beneficial effects on human health. Prenylated flavonoids are hybrid products composed of a flavonoid core mainly attached to either 5-carbon (dimethylallyl) or 10-carbon (geranyl) prenyl groups ...
Kanako, Sasaki, Kouji, Mito, Kazuaki, Ohara, Hirobumi, Yamamoto, Kazufumi, Yazaki   +4 more
openaire   +2 more sources

Structural and mutational analysis of Methanosarcina mazei prenylated FMN synthase reveals the basis of its unique prenyl donor substrate specificity

The FEBS Journal, EarlyView.
Some prenylated flavin mononucleotide (prFMN) synthases exceptionally prefer dimethylallyl phosphate (DMAP) over dimethylallyl diphosphate (DMAPP), which is a common prenyl donor substrate for many prenyltransferases. Structural and mutagenic analyses of Methanosarcina mazei prFMN synthase, which prefers DMAP but can also accept DMAPP, elucidated its ...
Sou Fukuhara, Hideaki Unno, Soma Ishimine, Ryuhei Nagata, Tomokazu Ito, Hisashi Hemmi   +5 more
wiley   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, Volume 13, Issue 50, 7 September 2026.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Microbiome‐mediated chemical communication in insects: Implications for pest management

Pest Management Science, Volume 82, Issue 9, Page 8132-8151, September 2026.
Microbiome–semiochemical interactions involve the following processes: direct microbial synthesis, host gene regulation, precursor biotransformation, microbiome modulation and indirect ecological signaling. Abstract Insects rely on semiochemicals to regulate aggregation, mating, foraging, and host selection. This review synthesizes evidence that insect‐
Ioannis Eleftherianos, Wei Zhang, Amr Mohamed, Rasha K. Al‐Akeel, Abeer M. Alkhaibari, Nemat Keyhani, Guy Smagghe   +6 more
wiley   +1 more source

GmERF109 Positively Enhances Soybean Resistance to Phytophthora sojae by Transcriptionally Activating GmG4DT‐Like to Promote Glyceollin I Accumulation

Molecular Plant Pathology, Volume 27, Issue 9, September 2026.
GmERF109 is strongly induced in P. sojae‐resistant but not susceptible soybeans. GmERF109 functions as a nuclear AP2/ERF transcription factor, P. sojae directly binding the GCC‐box to activate GmG4DT‐like expression. The GmERF109–GmG4DT‐like module enhances glyceollin I accumulation for soybean resistance to P. sojae.
Xin Fang, Rui Liang, Yiling Cheng, Hong Gao, Chuanzhong Zhang, Jingcan Sun, Junjun Song, Gengpu Zhang, Meng Liu, Yuxin Zhao, Yan Sun, Xiran Wang, Xiaoyu Chen, Kexin Ma, Shuo Wang, Kexin Li, Jiapeng Tong, Junjiang Wu, Pengfei Xu, Shuzhen Zhang   +19 more
wiley   +1 more source

CloQ, a prenyltransferase involved in clorobiocin biosynthesis [PDF]

Proceedings of the National Academy of Sciences, 2003
Ring A (3-dimethylallyl-4-hydroxybenzoic acid) is a structural moiety of the aminocoumarin antibiotics novobiocin and clorobiocin. In the present study, the prenyltransferase involved in the biosynthesis of this moiety was identified from the clorobiocin producer ( Streptomyces roseochromogenes
Florence, Pojer, Emmanuel, Wemakor, Bernd, Kammerer, Huawei, Chen, Christopher T, Walsh, Shu-Ming, Li, Lutz, Heide   +6 more
openaire   +2 more sources