Results 1 to 10 of about 3,663 (218)
Active Site Loop Dynamics of PriB, a C-prenyltransferase [PDF]
Structural DynamicsNumerous biological functions are demonstrated by prenylated natural compounds, such as prenylated indole analogs. Natural product biosynthesis and modification of structures are significantly influenced by prenyltransferases.
Omowumi Oreoluwa Fagbohun +1 more
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Structure of bifunctional variediene synthase yields unique insight on biosynthetic diterpene assembly and cyclization [PDF]
Nature CommunicationsAn unusual family of bifunctional terpene synthases has been identified in which a prenyltransferase assembles 5-carbon precursors to form C20 geranylgeranyl diphosphate (GGPP), which is then converted into a polycyclic product by a cyclase.
Eliott S. Wenger, David W. Christianson
doaj +2 more sources
Creation of bioactive non-natural flavonoids via combinatorial prenylation-glycosylation cascades. [PDF]
mLifemLife, Volume 5, Issue 2, Page 254-258, April 2026.
Zhang H, Zhang A, Ji J, Yin WB.
europepmc +2 more sources
Characterization of a Cis-Prenyltransferase from Lilium longiflorum Anther
Molecules, 2019 A group of prenyltransferases catalyze chain elongation of farnesyl diphosphate (FPP) to designated lengths via consecutive condensation reactions with specific numbers of isopentenyl diphosphate (IPP).
Jyun-Yu Yao +4 more
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Acta Pharmaceutica Sinica B, 2018 Prenylflavonoids are valuable natural products that have diverse biological properties, and are usually generated biologically by multiple metabolic enzymes in nature.
Ridao Chen, Ruishan Wang, Kebo Xie
exaly +3 more sources
Nature Communications, 2020 The human cis-prenyltransferase (hcis-PT) complex synthesizes the precursor of the glycosyl carrier dolichol-phosphate and as such it is essential for protein N-glycosylation.
Michal Lisnyansky Bar-El +7 more
doaj +2 more sources
Structural elucidation of the cis -prenyltransferase NgBR/DHDDS complex reveals insights in regulation of protein glycosylation [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2020 Cis- prenyltransferase ( cis- PTase) catalyzes the rate-limiting step in the synthesis of glycosyl carrier lipids required for protein glycosylation in the lumen of endoplasmic reticulum.
Kariona A Grabińska +2 more
exaly +2 more sources
Genome mining reveals the unique function of UbiA-type prenyltransferase in Laetiporus sulphureus [PDF]
Natural Products and BioprospectingEight UbiA-type prenyltransferases were mined in Laetiporus sulphureus by bioinformatic analysis, and phylogenetic analysis showed that they have unique functions.
Yue Wang +7 more
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ChemBioChem, 2014 Zeyhle P, Bauer JS, Steimle M, et al. A Membrane-Bound Prenyltransferase Catalyzes the O-Prenylation of 1,6-Dihydroxyphenazine in the Marine Bacterium Streptomyces sp CNQ-509. ChemBioChem. 2014;15(16):2385-2392.Streptomyces sp.
Jorn Kalinowski +2 more
exaly +2 more sources
Structure and Mechanism of PhdC, a Prenylated-Flavin Maturase. [PDF]
ProteinsABSTRACT Prenylated flavin mononucleotide (prFMN) is a modified flavin cofactor required by the UbiD family of (de)carboxylase enzymes. While the reduced prFMNH2 form is produced by the flavin prenyltransferase UbiX, the corresponding two‐electron oxidized prFMNiminium form is required to support UbiD catalysis. Thus, oxidative maturation of prFMNH2 is
Whittall DR +4 more
europepmc +2 more sources