Structure of bifunctional variediene synthase yields unique insight on biosynthetic diterpene assembly and cyclization [PDF]
Nature CommunicationsAn unusual family of bifunctional terpene synthases has been identified in which a prenyltransferase assembles 5-carbon precursors to form C20 geranylgeranyl diphosphate (GGPP), which is then converted into a polycyclic product by a cyclase.
Eliott S. Wenger, David W. Christianson
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Enzymatic Prenylation of Proteins and Peptides: From Cysteine S-Prenylation to Tryptophan-Selective Biocatalysis. [PDF]
ChemistryThis review highlights biocatalytic prenylation as a versatile strategy for tailoring the functional properties of peptides and proteins. By comparing branched isoprenoids with linear lipids, we illustrate how specific prenyl architectures modulate the behaviors of lipidated proteins within membrane environments.
Fujinami D, Ozawa H, Ito S.
europepmc +2 more sources
Frontiers in Plant Science, 2022 Epimedium pubescens is a species of the family Berberidaceae in the basal eudicot lineage, and a main plant source for the traditional Chinese medicine “Herba Epimedii”. The current study achieved a chromosome-level genome assembly of E.
Yongzhen Pang, Xu Chaoqun, Guo Baolin
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Frontiers in Plant Science, 2021 Rehmannia glutinosa has important medicinal value; terpenoid is one of the main active components in R. glutinosa. In this study, iTRAQ technique was used to analyze the relative abundance of proteins in roots of R. glutinosa, and 6,752 reliable proteins
Mingwei Zhao +2 more
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LaPT2 Gene Encodes a Flavonoid Prenyltransferase in White Lupin
Frontiers in Plant Science, 2021 Legume plants are rich in prenylated flavonoid compounds, which play an important role in plant defense and human health. In the present study, we identified a prenyltransferase (PT) gene, named LaPT2, in white lupin (Lupinus albus), which shows a high ...
Wenbo Jiang +2 more
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Acta Pharmaceutica Sinica B, 2018 Prenylflavonoids are valuable natural products that have diverse biological properties, and are usually generated biologically by multiple metabolic enzymes in nature.
Dawei Chen, Jungui Dai, Ridao Chen
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Active Site Loop Dynamics of PriB, a C-prenyltransferase [PDF]
Structural DynamicsNumerous biological functions are demonstrated by prenylated natural compounds, such as prenylated indole analogs. Natural product biosynthesis and modification of structures are significantly influenced by prenyltransferases.
Omowumi Oreoluwa Fagbohun +1 more
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Genome mining reveals the unique function of UbiA-type prenyltransferase in Laetiporus sulphureus [PDF]
Natural Products and BioprospectingEight UbiA-type prenyltransferases were mined in Laetiporus sulphureus by bioinformatic analysis, and phylogenetic analysis showed that they have unique functions.
Yue Wang +7 more
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Genome-Wide Analysis of the Cis-Prenyltransferase (CPT) Gene Family in Taraxacum kok-saghyz Provides Insights into Its Expression Patterns in Response to Hormonal Treatments [PDF]
PlantsTaraxacum kok-saghyz (TKS) is a natural rubber (NR)-producing plant with great development prospects. Accurately understanding the molecular mechanism of natural rubber biosynthesis is of great significance.
Liyu Zhang +10 more
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Biosynthesis of novel cannabigerolic acid derivatives by engineering the substrate specificity of aromatic prenyltransferase [PDF]
Frontiers in Bioengineering and BiotechnologyIntroductionCannabinoids possess significant therapeutic potential, but their natural chemical diversity derived from plant biosynthesis is limited. Efficient biotransformation processes are required to expand the range of accessible cannabinoids.
Hoe-Suk Lee +14 more
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