Results 41 to 50 of about 3,663 (218)
Journal of Lipid Research, 2010 Over a hundred proteins in eukaryotic cells carry a C-terminal CaaX box sequence, which targets them for posttranslational isoprenylation of the cysteine residue.
Julia M. Fres +2 more
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Metabolic Engineering Communications, 2021 Reconstitution of prenylflavonoids using the flavonoid biosynthetic pathway and prenyltransferases (PTs) in microbes can be a promising attractive alternative to plant-based production or chemical synthesis.
Shota Isogai +7 more
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Structure, catalysis, and inhibition mechanism of prenyltransferase [PDF]
IUBMB Life, 2020 AbstractIsoprenoids, also known as terpenes or terpenoids, represent a large family of natural products composed of five‐carbon isopentenyl diphosphate or its isomer dimethylallyl diphosphate as the building blocks. Isoprenoids are structurally and functionally diverse and include dolichols, steroid hormones, carotenoids, retinoids, aromatic ...
Hsin‐Yang Chang +2 more
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Frontiers in Plant Science, 2019 Polyprenyl diphosphate synthase (PPS) plays important roles in the biosynthesis of functionally important plastoquinone (PQ) and ubiquinone (UQ). However, only few plant PPS genes have been functionally characterized.
Miaomiao Liu +6 more
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Characterization of Coumarin-Specific Prenyltransferase Activities in Citrus limon Peel [PDF]
, 2012 Coumarins, a large group of polyphenols, play important roles in the defense mechanisms of plants, and they also exhibit various biological activities beneficial to human health, often enhanced by prenylation.
KOEDUKA, Takao +9 more
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Structure of a membrane-embedded prenyltransferase homologous to UBIAD1. [PDF]
PLoS Biology, 2014 Membrane-embedded prenyltransferases from the UbiA family catalyze the Mg2+-dependent transfer of a hydrophobic polyprenyl chain onto a variety of acceptor molecules and are involved in the synthesis of molecules that mediate electron transport ...
Hua Huang +5 more
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Cloning and Characterization of Naringenin 8-Prenyltransferase, a Flavonoid-Specific Prenyltransferase of Sophora flavescens [PDF]
Plant Physiology, 2008 Abstract Prenylated flavonoids are natural compounds that often represent the active components in various medicinal plants and exhibit beneficial effects on human health. Prenylated flavonoids are hybrid products composed of a flavonoid core mainly attached to either 5-carbon (dimethylallyl) or 10-carbon (geranyl) prenyl groups ...
Kanako, Sasaki +4 more
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Evolutionary Developments in Plant Specialized Metabolism, Exemplified by Two Transferase Families
Frontiers in Plant Science, 2019 Plant specialized metabolism emerged from the land colonization by ancient plants, becoming diversified along with plant evolution. To date, more than 1 million metabolites have been predicted to exist in the plant kingdom, and their metabolic processes ...
Hiroaki Kusano +5 more
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Microbial soluble aromatic prenyltransferases for engineered biosynthesis
Synthetic and Systems Biotechnology, 2021 Prenyltransferase (PTase) enzymes play crucial roles in natural product biosynthesis by transferring isoprene unit(s) to target substrates, thereby generating prenylated compounds.
He-Ping Chen, Ikuro Abe
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CloQ, a prenyltransferase involved in clorobiocin biosynthesis [PDF]
Proceedings of the National Academy of Sciences, 2003 Ring A (3-dimethylallyl-4-hydroxybenzoic acid) is a structural moiety of the aminocoumarin antibiotics novobiocin and clorobiocin. In the present study, the prenyltransferase involved in the biosynthesis of this moiety was identified from the clorobiocin producer (Streptomyces roseochromogenes), overexpressed, and purified.
Florence, Pojer +6 more
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