Results 41 to 50 of about 3,960 (214)

Molecular basis for the plasticity of aromatic prenyltransferases in hapalindole biosynthesis

Beilstein Journal of Organic Chemistry, 2019
Aromatic prenyltransferases (PTases) are enzymes that catalyze Friedel–Crafts reactions between aromatic compounds and isoprenoid diphosphates. In hapalindole biosynthesis, the aromatic PTases AmbP1 and AmbP3 exhibit surprisingly plastic selectivities ...
Takayoshi Awakawa, Ikuro Abe
doaj   +1 more source

Purification of the CaaX-modified, dynamin-related large GTPase hGBP1 by coexpression with farnesyltransferase[S]

Journal of Lipid Research, 2010
Over a hundred proteins in eukaryotic cells carry a C-terminal CaaX box sequence, which targets them for posttranslational isoprenylation of the cysteine residue.
Julia M. Fres, Stefan Müller, Gerrit J.K. Praefcke   +2 more
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Enhancing flavonoid production by promiscuous activity of prenyltransferase, BrPT2 from Boesenbergia rotunda [PDF]

PeerJ, 2020
Flavonoids and prenylated flavonoids are active components in medicinal plant extracts which exhibit beneficial effects on human health. Prenylated flavonoids consist of a flavonoid core with a prenyl group attached to it.
Yvonne Jing Mei Liew, Yean Kee Lee, Norzulaani Khalid, Noorsaadah Abd Rahman, Boon Chin Tan   +4 more
doaj   +2 more sources

Substrate and catalytic promiscuity of secondary metabolite enzymes: O-prenylation of hydroxyxanthones with different prenyl donors by a bisindolyl benzoquinone C- and N-prenyltransferase† [PDF]

RSC Advances, 2014
Prenylated xanthones are secondary metabolites with a broad spectrum of biological activities including antimicrobial and antitumor activities. One xanthone O-prenyltransferase XptB has been identified in Aspergillus nidulans.
Sylwia Tarcz, Xiulan Xie, Shu-Ming Li
doaj   +1 more source

Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression

Journal of Lipid Research, 1998
We report the nucleotide sequence of human geranylgeranyl diphosphate (GGPP) synthase cDNA isolated from a fetal heart library. The 2.5 kb cDNA encodes a protein of 34 kDa.
Johan Ericsson, John M. Greene, Kenneth C. Carter, Brenda K. Shell, D. Roxanne Duan, Charles Florence, Peter A. Edwards   +6 more
doaj   +1 more source

Characterization of Coumarin-Specific Prenyltransferase Activities in Citrus limon Peel [PDF]

, 2012
Coumarins, a large group of polyphenols, play important roles in the defense mechanisms of plants, and they also exhibit various biological activities beneficial to human health, often enhanced by prenylation.
KOEDUKA, Takao, MUNAKATA, Ryosuke, INOUE, Tsuyoshi, TSURUMARU, Yusuke, UTO, Yoshihiro, YAZAKI, Kazufumi, SASAKI, Kanako, AZUMA, Jun-ichi, SUGIYAMA, Akifumi, HORI, Hitoshi   +9 more
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Functional Analysis of Polyprenyl Diphosphate Synthase Genes Involved in Plastoquinone and Ubiquinone Biosynthesis in Salvia miltiorrhiza

Frontiers in Plant Science, 2019
Polyprenyl diphosphate synthase (PPS) plays important roles in the biosynthesis of functionally important plastoquinone (PQ) and ubiquinone (UQ). However, only few plant PPS genes have been functionally characterized.
Miaomiao Liu, Yimian Ma, Qing Du, Qing Du, Xuemin Hou, Meizhen Wang, Shanfa Lu   +6 more
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Synthetic production of prenylated naringenins in yeast using promiscuous microbial prenyltransferases

Metabolic Engineering Communications, 2021
Reconstitution of prenylflavonoids using the flavonoid biosynthetic pathway and prenyltransferases (PTs) in microbes can be a promising attractive alternative to plant-based production or chemical synthesis.
Shota Isogai, Nobuyuki Okahashi, Ririka Asama, Tomomi Nakamura, Tomohisa Hasunuma, Fumio Matsuda, Jun Ishii, Akihiko Kondo   +7 more
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Enzymatic formation of prenyl β-carbolines by a fungal indole prenyltransferase [PDF]

, 2022
富山大学博士（薬科学）Article富山大学・富医薬博甲第401号・Sherif Ahmed Muhammed Ahmed Hamdy・2022/08/31 公表論文 1.Hamdy, S.A., Kodama, T., Nakashima, Y. et al. Enzymatic formation of a prenyl β-carboline by a fungal indole prenyltransferase. J Nat Med 76, 873–879 (2022).
HAMDY, Sherif Ahmed Muhammed Ahmed
core   +1 more source

Enzymatic studies on aromatic prenyltransferases [PDF]

Journal of Natural Medicines, 2020
AbstractAromatic prenyltransferases (PTases), including ABBA-type and dimethylallyl tryptophan synthase (DMATS)-type enzymes from bacteria and fungi, play important role for diversification of the natural products and improvement of the biological activities.
openaire   +2 more sources