Results 61 to 70 of about 3,663 (218)

Elucidation of the Streptoazine Biosynthetic Pathway in Streptomyces aurantiacus Reveals the Presence of a Promiscuous Prenyltransferase/Cyclase

, 2021
Heterologous expression of a three-gene cluster from Streptomyces aurantiacus coding for a cyclodipeptide synthase, a prenyltransferase, and a methyltransferase led to the elucidation of the biosynthetic steps of streptoazine C (2).
Yiling Yang, Jing Liu, Yiling Yang (761552), Lauritz Harken, Shu-Ming Li, Jing Liu (38537), Lauritz Harken (11772258), Shu-Ming Li (1523233)   +7 more
core   +1 more source

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

The FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu, Maximilian J. L. J. Fürst, Oscar P. Kuipers   +2 more
wiley   +1 more source

Enzymatic formation of prenyl β-carbolines by a fungal indole prenyltransferase

, 2022
富山大学博士（薬科学）Article富山大学・富医薬博甲第401号・Sherif Ahmed Muhammed Ahmed Hamdy・2022/08/31 公表論文 1.Hamdy, S.A., Kodama, T., Nakashima, Y. et al. Enzymatic formation of a prenyl β-carboline by a fungal indole prenyltransferase. J Nat Med 76, 873–879 (2022).
HAMDY, Sherif Ahmed Muhammed Ahmed
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, Volume 600, Issue 11, Page 1621-1637, June 2026.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Exosomal miR‐4644 Targets SPRY3 to Promote Proliferation and Invasion of Pancreatic Cancer

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Tumor‐derived exosomes (TDEs) can carry diverse genetic material that modulates pancreatic cancer (PC) proliferation and invasion. Despite this, the involvement of microRNAs (miRNAs) in TDE‐mediated tumor progression in PC remains inadequately explored. Methods Ultracentrifugation was used to isolate exosomes derived from AsPC‐1 and
Xiangyu Chu, Dongqi Li, Fusheng Zhang, Yongsu Ma, Yongqi Deng, Chen Wang, Xiaodong Tian, Yanlian Yang, Yinmo Yang   +8 more
wiley   +1 more source

Evolutionary Relationships of Microbial Aromatic Prenyltransferases

PLoS ONE, 2011
The linkage of isoprenoid and aromatic moieties, catalyzed by aromatic prenyltransferases (PTases), leads to an impressive diversity of primary and secondary metabolites, including important pharmaceuticals and toxins. A few years ago, a hydroxynaphthalene PTase, NphB, featuring a novel ten-stranded β-barrel fold was identified in Streptomyces sp ...
Bonitz, T., Alva, V., Saleh, O., Lupas, A., Heide, L.   +4 more
openaire   +5 more sources

Diversity of ABBA Prenyltransferases in Marine Streptomyces sp. CNQ-509: Promiscuous Enzymes for the Biosynthesis of Mixed Terpenoid Compounds.

PLoS ONE, 2015
Terpenoids are arguably the largest and most diverse family of natural products, featuring prominently in e.g. signalling, self-defence, UV-protection and electron transfer.
Franziska Leipoldt, Philipp Zeyhle, Andreas Kulik, Jörn Kalinowski, Lutz Heide, Leonard Kaysser   +5 more
doaj   +1 more source

Biosynthesis of the diterpenoid lycosantalonol via nerylneryl diphosphate in Solanum lycopersicum. [PDF]

PLoS ONE, 2015
We recently reported that three genes involved in the biosynthesis of monoterpenes in trichomes, a cis-prenyltransferase named neryl diphosphate synthase 1 (NDPS1) and two terpene synthases (TPS19 and TPS20), are present in close proximity to each other ...
Yuki Matsuba, Jiachen Zi, A Daniel Jones, Reuben J Peters, Eran Pichersky   +4 more
doaj   +1 more source

Umbelliprenin in Food and Medicinal Plants: Phytochemical Occurrence, Biosynthesis, Analytical Approaches, and Biological Activities

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
This review provides an extensive and critical synthesis of current knowledge on umbelliprenin, integrating phytochemical, analytical, biological, ecological, and food science perspectives, and identifies priorities for future research. ABSTRACT Umbelliprenin (7‐farnesyloxycoumarin) is an oxyprenylated coumarin that has gained increasing attention in ...
Chiara Collevecchio, Lorenzo Marchetti, Francesco Epifano, Salvatore Genovese, Serena Fiorito   +4 more
wiley   +1 more source

Research Progress on Fungal Sesterterpenoids Biosynthesis

Journal of Fungi, 2022
Sesterterpenes are 25-carbon terpenoids formed by the cyclization of dimethyl allyl diphosphate (DMAPP) and isopentenyl diphosphate (IPP) as structural units by sesterterpenes synthases.
Ping Zhang, Jianzhao Qi, Yingce Duan, Jin-ming Gao, Chengwei Liu   +4 more
doaj   +1 more source