Results 61 to 70 of about 3,960 (214)

Candida albicans cis-prenyltransferase Rer2 is required for protein glycosylation, cell wall integrity and hypha formation [PDF]

, 2014
Cis-prenyltransferase is the first enzyme of the mevalonate pathway committed to the biosynthesis of dolichol in eukaryotes. The RER2 gene encoding cis-prenyltransferase (Rer2p) in the human fungal pathogen Candida albicans was characterized. In addition,
Swiezewska, Ewa, Palamarczyk, Grazyna, Ernst, J.F., Juchimiuk, Mateusz, Orłowski, Jacek, Gawarecka, Katarzyna   +5 more
core   +1 more source

Evolutionary Relationships of Microbial Aromatic Prenyltransferases

PLoS ONE, 2011
The linkage of isoprenoid and aromatic moieties, catalyzed by aromatic prenyltransferases (PTases), leads to an impressive diversity of primary and secondary metabolites, including important pharmaceuticals and toxins. A few years ago, a hydroxynaphthalene PTase, NphB, featuring a novel ten-stranded β-barrel fold was identified in Streptomyces sp ...
Bonitz, T., Alva, V., Saleh, O., Lupas, A., Heide, L.   +4 more
openaire   +5 more sources

Elucidation of the Streptoazine Biosynthetic Pathway in Streptomyces aurantiacus Reveals the Presence of a Promiscuous Prenyltransferase/Cyclase

, 2021
Heterologous expression of a three-gene cluster from Streptomyces aurantiacus coding for a cyclodipeptide synthase, a prenyltransferase, and a methyltransferase led to the elucidation of the biosynthetic steps of streptoazine C (2).
Yiling Yang, Jing Liu, Yiling Yang (761552), Lauritz Harken, Shu-Ming Li, Jing Liu (38537), Lauritz Harken (11772258), Shu-Ming Li (1523233)   +7 more
core   +1 more source

Diversity of ABBA Prenyltransferases in Marine Streptomyces sp. CNQ-509: Promiscuous Enzymes for the Biosynthesis of Mixed Terpenoid Compounds.

PLoS ONE, 2015
Terpenoids are arguably the largest and most diverse family of natural products, featuring prominently in e.g. signalling, self-defence, UV-protection and electron transfer.
Franziska Leipoldt, Philipp Zeyhle, Andreas Kulik, Jörn Kalinowski, Lutz Heide, Leonard Kaysser   +5 more
doaj   +1 more source

Biosynthesis of the diterpenoid lycosantalonol via nerylneryl diphosphate in Solanum lycopersicum. [PDF]

PLoS ONE, 2015
We recently reported that three genes involved in the biosynthesis of monoterpenes in trichomes, a cis-prenyltransferase named neryl diphosphate synthase 1 (NDPS1) and two terpene synthases (TPS19 and TPS20), are present in close proximity to each other ...
Yuki Matsuba, Jiachen Zi, A Daniel Jones, Reuben J Peters, Eran Pichersky   +4 more
doaj   +1 more source

Regiospecific Prenylation of Hydroxyxanthones by a Plant Flavonoid Prenyltransferase

, 2016
C-Prenylated xanthones are pharmacologically attractive specialized metabolites that are distributed in plants and microorganisms. The prenylation of xanthones often contributes to the structural diversity and biological activities of these compounds ...
Jianhua Li (36075), Xiao Liu (65413), Ruishan Wang (1748581), Ridao Chen (1662145), Ying Peng (26452), Jungui Dai (610572), Dawei Chen (169831), Kebo Xie (603041)   +7 more
core   +1 more source

Research Progress on Fungal Sesterterpenoids Biosynthesis

Journal of Fungi, 2022
Sesterterpenes are 25-carbon terpenoids formed by the cyclization of dimethyl allyl diphosphate (DMAPP) and isopentenyl diphosphate (IPP) as structural units by sesterterpenes synthases.
Ping Zhang, Jianzhao Qi, Yingce Duan, Jin-ming Gao, Chengwei Liu   +4 more
doaj   +1 more source

Stress‐Induced Switch in Small Extracellular Vesicle Secretion: From Constitutive ‘Torn Bag Mechanism’ to Exocytosis

Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.
Stress‐induced switch. Under stress conditions, small extracellular vesicle release shifts from the constitutive ‘torn bag mechanism’ to exocytosis of multivesicular endosomes. https://BioRender.com/xn1pa1e. ABSTRACT The biogenesis of small extracellular vesicles (sEVs) is only partially understood.
Dorina Lenzinger, Lilla Lankovics, István Dudás, Tünde Bárkai, Zsófia Szász, Mirjam Balbisi, Anthony Yan‐Tang Wu, Krisztina V. Vukman, Kelsey Fletcher, Attila Csomos, Zoltán Mucsi, Edina Bugyik, Csaba Cserép, Ádám Dénes, Szilvia Bősze, Lilla Turiák, Charles Pin‐Kuang Lai, Edit I. Buzás, Tamás Visnovitz   +18 more
wiley   +1 more source

Analogues of geranyl pyrophosphate as inhibitors of prenyltransferase [PDF]

Biochemical Journal, 1969
Six analogues of geranyl pyrophosphate (the monophosphates of geraniol and tetrahydrogeraniol, and the pyrophosphates of nerol, octan-1-ol, tetrahydrogeraniol and citronellol) were synthesized, and were found to be inhibitors of pig liver prenyl- (geranyl-)transferase.
G, Popják, P W, Holloway, R P, Bond, M, Roberts   +3 more
openaire   +2 more sources

Genome mining of cyclodipeptide synthases unravels unusual tRNA-dependent diketopiperazine-terpene biosynthetic machinery

Nature Communications, 2018
Diketopiperazine derivatives are bioactive molecules with scaffold formed by the condensation of two amino acids. Here, Yao et al. mine the genomes of Streptomyces strains and identify new biosynthetic machinery for drimentines biosynthesis, which ...
Tingting Yao, Jing Liu, Zengzhi Liu, Tong Li, Huayue Li, Qian Che, Tianjiao Zhu, Dehai Li, Qianqun Gu, Wenli Li   +9 more
doaj   +1 more source