Results 71 to 80 of about 2,966 (173)

Regulation of protein prenyltransferase in central neurons

Communicative & Integrative Biology, 2009
Geranylgeranyltransferase I (GGT) is a protein prenyltransferase that mediates lipid modification of some proteins such as Rho family small GTPases. Since the activation of Rho GTPases mediates tumorgenesis and metastasis, GGT has become an attractive target for anti-tumor drug design. Although GGT is extensively expressed in the brain, the function of
Xiu-Ping, Zhou, Zhen-Ge, Luo
openaire   +2 more sources

Chromosome‐Scale Haplotype Genome Assemblies for the Australian Mango ‘Kensington Pride’ and a Wild Relative, Mangifera laurina, Provide Insights Into Anthracnose‐Resistance and Volatile Compound Biosynthesis Genes

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3172-3188, May 2026.
ABSTRACT Mango (Mangifera indica) is one of the most popular fruits cultivated in tropical and subtropical regions of the world. The availability of reference genomes helps to identify the genetic basis of important traits. Here, we report assembled high‐quality chromosome‐level genomes for the Australian mango cultivar ‘Kensington Pride’ and M ...
Upendra Kumari Wijesundara, Agnelo Furtado, Ardashir Kharabian Masouleh, Natalie L. Dillon, Heather E. Smyth, Robert J. Henry   +5 more
wiley   +1 more source

Marine-Derived Prenyltransferases

MarineMedicine
The biochemical characteristics and structural features of prenyltransferases (PTs) continue to be elucidated, revealing their significant potential as biocatalysts for the enzymatic synthesis of novel drug lead compounds. This paper comprehensively reviews marine-derived PTs, outlining the current research progress and status for each enzyme type, and
Fuhao Liu, Wenxue Wang, Changfei Li, Yue Zhang, Chuanteng Ma, Qian Che, Tianjiao Zhu, Dehai Li   +7 more
openaire   +1 more source

UBIAD1 mutation alters a mitochondrial prenyltransferase to cause Schnyder corneal dystrophy.

PLoS ONE, 2010
BackgroundMutations in a novel gene, UBIAD1, were recently found to cause the autosomal dominant eye disease Schnyder corneal dystrophy (SCD). SCD is characterized by an abnormal deposition of cholesterol and phospholipids in the cornea resulting in ...
Michael L Nickerson, Brittany N Kostiha, Wolfgang Brandt, William Fredericks, Ke-Ping Xu, Fu-Shin Yu, Bert Gold, James Chodosh, Marc Goldberg, Da Wen Lu, Masakazu Yamada, Timo M Tervo, Richard Grutzmacher, Chris Croasdale, Maria Hoeltzenbein, John Sutphin, S Bruce Malkowicz, Ludger Wessjohann, Howard S Kruth, Michael Dean, Jayne S Weiss   +20 more
doaj   +1 more source

Protein Prenyltransferases [PDF]

Journal of Biological Chemistry, 1996
P J, Casey, M C, Seabra
openaire   +2 more sources

Genome-based discovery of a novel membrane-bound 1,6-dihydroxyphenazine prenyltransferase from a marine actinomycete.

PLoS ONE, 2014
Recently, novel prenylated derivatives of 1,6-dihydroxyphenazine have been isolated from the marine sponge-associated Streptomyces sp. SpC080624SC-11.
Philipp Zeyhle, Judith S Bauer, Jörn Kalinowski, Kazuo Shin-ya, Harald Gross, Lutz Heide   +5 more
doaj   +1 more source

Usefulness of Prenyltransferase for Organic Synthesis: Carbon—Carbon Bond Forming Reactions by Prenyltransferases and Their Mutated Enzymes

ChemInform, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Maki, Yuji, Nagaki, Masahiko, Nishino, Tokuzo, Koyama, Tanetoshi   +3 more
openaire   +2 more sources

The UbiX flavin prenyltransferase reaction mechanism resembles class I terpene cyclase chemistry

Nature Communications, 2019
The UbiD-UbiX decarboxylase system is required for the biosynthesis of quinone cofactors. Here, the authors combine structural and biochemical analyses to elucidate the UbiX reaction mechanism, showing that it resembles the mode of action of class I ...
Stephen A. Marshall, Karl A. P. Payne, Karl Fisher, Mark D. White, Aisling Ní Cheallaigh, Arune Balaikaite, Stephen E. J. Rigby, David Leys   +7 more
doaj   +1 more source

Identification and Reconstitution of the First Two Enzymatic Steps for the Biosynthesis of Bioactive Meroterpenoids from Hericium erinaceus (Lion’s Mane Mushroom)

Molecules
Hericium erinaceus (Lion’s Mane mushroom) is widely consumed for its numerous reported benefits for brain health. A growing body of evidence suggests that these benefits are likely attributable to aromatic compounds contained in its fruiting bodies ...
Riccardo Iacovelli, Fons Poon, Kristina Haslinger   +2 more
doaj   +1 more source

Uncovering protein prenylation in Th1 cells: novel prenylation sites and insights into statin and farnesyltransferase inhibition

BMC Biology
Background T helper 1 (Th1) cell activation is an essential process for immune responses and is tightly regulated, including the prenylation of proteins critical for T cell function.
Jana Koch, Alessandra Ruggia, Carina Beha, Irina Wipf, Damir Zhakparov, Patrick Westermann, Svenja Schmelzer, Anja Heider, Klemens Fröhlich, Katja Baerenfaller   +9 more
doaj   +1 more source