Results 1 to 10 of about 36,883 (221)
Pharmacology Research & Perspectives, 2022 While there is a growing interest in the use of statins, HMG‐CoA reductase inhibitors, to treat neurodegenerative diseases, statins are associated with conflicting effects within the central nervous system (CNS) without clear evidence of the underlying ...
Hui Wang +7 more
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eLife, 2021 Bisphosphonates drugs target the skeleton and are used globally for the treatment of common bone disorders. Nitrogen-containing bisphosphonates act by inhibiting the mevalonate pathway in bone-resorbing osteoclasts but, surprisingly, also appear to ...
Marcia A Munoz +11 more
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Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions
Nature Communications, 2019 Macrophage specific deletion of GGTase-I, a prenylation enzyme, in mice induces inflammatory response and rheumatoid arthritis. Here the authors show that GGTase-I deficiency and the resulting reduction of RAC1 prenylation increase RAC1 interaction with ...
Murali K. Akula +13 more
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Analyzing the postulated inhibitory effect of Manumycin A on farnesyltransferase
Frontiers in Chemistry, 2022 Manumycin A is postulated to be a specific inhibitor against the farnesyltransferase (FTase) since this effect has been shown in 1993 for yeast FTase.
Anna Hagemann +6 more
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Beyond the Mevalonate Pathway: Control of Post-Prenylation Processing by Mutant p53
Frontiers in Oncology, 2020 Missense mutations in the TP53 gene are among the most frequent alterations in human cancer. Consequently, many tumors show high expression of p53 point mutants, which may acquire novel activities that contribute to develop aggressive tumors.
Carla M Borini Etichetti +3 more
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Antitumor Activity of Some Prenylated Xanthones
Pharmaceuticals, 2009 Pyranoxanthones 6-8 were obtained by dehydrogenation of the respective dihydropyranoxanthones 3-5 with DDQ in dry dioxane. Two prenylated xanthones 10,11 were obtained from the reaction of 1-hydroxyxanthone (9) with prenyl bromide in alkaline medium, or ...
Raquel A.P. Castanheiro +4 more
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Double Prenylation by RabGGTase Can Proceed without Dissociation of the Mono-prenylated Intermediate [PDF]
Journal of Biological Chemistry, 2001 Rab geranylgeranyltransferase (RabGGTase) catalyzes the prenylation of Rab proteins. Despite possessing a single active site, RabGGTase is able to add geranylgeranyl moieties onto each of the two C-terminal cysteine residues of Rab. We have studied the kinetics of Rab double prenylation employing a combination of a novel high pressure liquid ...
Thoma, N. H. +3 more
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Defective Protein Prenylation in a Spectrum of Patients With Mevalonate Kinase Deficiency
Frontiers in Immunology, 2019 The rare autoinflammatory disease mevalonate kinase deficiency (MKD, which includes HIDS and mevalonic aciduria) is caused by recessive, pathogenic variants in the MVK gene encoding mevalonate kinase.
Marcia A. Munoz +10 more
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Molecular Therapy: Methods & Clinical Development, 2020 Recent advances in recombinant adeno-associated virus (rAAV) gene therapy for choroideremia show gene replacement to be a promising approach. It is, however, well known that contact of vector solution with plastic materials in the surgical device may ...
Maria I. Patrício +5 more
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Veterinary ResearchLawsonia intracellularis, a Gram-negative obligate intracellular bacterium causing porcine proliferative enteropathy, possesses a type III secretion system (T3SS), yet only a handful of its substrates have been experimentally characterized. In this study,
Yuanxiu Zhong +4 more
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