Results 1 to 10 of about 44,008 (221)

Uncovering protein prenylation in Th1 cells: novel prenylation sites and insights into statin and farnesyltransferase inhibition [PDF]

BMC Biology
Background T helper 1 (Th1) cell activation is an essential process for immune responses and is tightly regulated, including the prenylation of proteins critical for T cell function.
Jana Koch, Alessandra Ruggia, Carina Beha, Irina Wipf, Damir Zhakparov, Patrick Westermann, Svenja Schmelzer, Anja Heider, Klemens Fröhlich, Katja Baerenfaller   +9 more
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Protein Prenylation in Plants: Mechanisms and Functional Implications [PDF]

Plants
Protein prenylation is a crucial post-translational modification that involves the formation of a covalent bond between isoprenoid lipids and the cysteine residues of specific proteins.
Chang Tian, Quan Wang
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Impact of protein prenylation inhibition on Mycobacterium leprae viability and IL-1β production in infected macrophages [PDF]

Journal of Bacteriology
Leprosy is a chronic infectious disease caused by Mycobacterium leprae and M. lepromatosis. Brazil consistently ranks among the countries with the highest number of leprosy cases. Data from our group showed that M.
Matheus da Silva Rocha, Antônio Marcos Rodrigues Pereira, Plínio Marcos Freire dos Santos, André Alves Dias, Melissa Pontes Pereira, Patrícia Sammarco Rosa, Daniele F. F. Bertoluci, John T. Belisle, Fabricio da Mota Ramalho Costa, Cristiana Santos de Macedo, Maria Cristina Vidal Pessolani, Marcia Berrêdo-Pinho   +11 more
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Discovery of unprecedented prenylated indole piperazines and pyrazines through cryptic biosynthetic gene cluster heterologous expression [PDF]

Natural Products and Bioprospecting
Prenylation modifications of natural products typically introduce greater structural complexity and enhance their biological activities. Yet, the modification of piperazine alkaloids by dimethylallyl tryptophan synthases (DMATS) remains unreported.
Ziou Zha, Dan He, Jianguo Song, Zhenhua Guan, Jiapei Han, Chang Liu, Xinyu Wang, Yongchun Zhu, Hucheng Zhu, Wencai Ye, Qin Li, Yonghui Zhang, Yuan Zhou   +12 more
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Dual‐Ligand Strategy in Rh‐Catalyzed Sequential Hydrofunctionalization of Valylene [PDF]

Advanced Science
Controlling regio‐ and chemo‐selectivity in transition‐metal‐catalyzed reactions involving coupling reagents with multiple reactive sites remains a significant challenge.
Yong‐Kang Mei, Su‐Yang Xu, Zhi‐Hui Wang, Ding‐Wei Ji, Qing‐An Chen   +4 more
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Heavy Metal-Associated Isoprenylated Plant Proteins (HIPPs) at Plasmodesmata: Exploring the Link between Localization and Function

Plants, 2023
Heavy metal-associated isoprenylated plant proteins (HIPPs) are a metallochaperone-like protein family comprising a combination of structural features unique to vascular plants.
Zoe Kathleen Barr, Tomáš Werner, Jens Tilsner   +2 more
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Functional classification and validation of yeast prenylation motifs using machine learning and genetic reporters.

PLoS ONE, 2022
Protein prenylation by farnesyltransferase (FTase) is often described as the targeting of a cysteine-containing motif (CaaX) that is enriched for aliphatic amino acids at the a1 and a2 positions, while quite flexible at the X position.
Brittany M Berger, Wayland Yeung, Arnav Goyal, Zhongliang Zhou, Emily R Hildebrandt, Natarajan Kannan, Walter K Schmidt   +6 more
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Specific Disruption of Ras2 CAAX Proteolysis Alters Its Localization and Function

Microbiology Spectrum, 2023
Many CAAX proteins, such as Ras GTPase, undergo a series of posttranslational modifications at their carboxyl terminus (i.e., cysteine prenylation, endoproteolysis of AAX, and carboxylmethylation).
Rajani Ravishankar, Emily R. Hildebrandt, Grace Greenway, Nadeem Asad, Sangram Gore, Timothy M. Dore, Walter K. Schmidt   +6 more
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Chloroplastic prenylated proteins [PDF]

FEBS Letters, 1997
By in vivo [3H]mevalonate labelling of spinach combined with biochemical analysis, evidence is provided for the existence of protein prenylation in chloroplasts. Approximately 20 prenylated polypeptides were resolved by SDS‐PAGE followed by autoradiography.
Parmryd, Ingela, Shipton, Catherine Ann, Swiezewska, Ewa, Dallner, Gustav, Andersson, Bertil   +4 more
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Single prenyl-binding site on protein prenyl transferases [PDF]

Proceedings of the National Academy of Sciences, 1998
Three distinct protein prenyl transferases, one protein farnesyl transferase (FTase) and two protein geranylgeranyl transferases (GGTase), catalyze prenylation of many cellular proteins. One group of protein substrates contains a C-terminal C AAX motif (C is Cys, A is aliphatic, and
L, Desnoyers, M C, Seabra
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