Results 1 to 10 of about 35,022 (176)

Uncovering protein prenylation in Th1 cells: novel prenylation sites and insights into statin and farnesyltransferase inhibition [PDF]

BMC Biology
Background T helper 1 (Th1) cell activation is an essential process for immune responses and is tightly regulated, including the prenylation of proteins critical for T cell function.
Jana Koch, Alessandra Ruggia, Carina Beha, Irina Wipf, Damir Zhakparov, Patrick Westermann, Svenja Schmelzer, Anja Heider, Klemens Fröhlich, Katja Baerenfaller   +9 more
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Protein Prenylation in Plants: Mechanisms and Functional Implications [PDF]

Plants
Protein prenylation is a crucial post-translational modification that involves the formation of a covalent bond between isoprenoid lipids and the cysteine residues of specific proteins.
Chang Tian, Quan Wang
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Impact of protein prenylation inhibition on Mycobacterium leprae viability and IL-1β production in infected macrophages [PDF]

Journal of Bacteriology
Leprosy is a chronic infectious disease caused by Mycobacterium leprae and M. lepromatosis. Brazil consistently ranks among the countries with the highest number of leprosy cases. Data from our group showed that M.
Matheus da Silva Rocha, Antônio Marcos Rodrigues Pereira, Plínio Marcos Freire dos Santos, André Alves Dias, Melissa Pontes Pereira, Patrícia Sammarco Rosa, Daniele F. F. Bertoluci, John T. Belisle, Fabricio da Mota Ramalho Costa, Cristiana Santos de Macedo, Maria Cristina Vidal Pessolani, Marcia Berrêdo-Pinho   +11 more
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Discovery of unprecedented prenylated indole piperazines and pyrazines through cryptic biosynthetic gene cluster heterologous expression [PDF]

Natural Products and Bioprospecting
Prenylation modifications of natural products typically introduce greater structural complexity and enhance their biological activities. Yet, the modification of piperazine alkaloids by dimethylallyl tryptophan synthases (DMATS) remains unreported.
Ziou Zha, Dan He, Jianguo Song, Zhenhua Guan, Jiapei Han, Chang Liu, Xinyu Wang, Yongchun Zhu, Hucheng Zhu, Wencai Ye, Qin Li, Yonghui Zhang, Yuan Zhou   +12 more
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Heavy Metal-Associated Isoprenylated Plant Proteins (HIPPs) at Plasmodesmata: Exploring the Link between Localization and Function

Plants, 2023
Heavy metal-associated isoprenylated plant proteins (HIPPs) are a metallochaperone-like protein family comprising a combination of structural features unique to vascular plants.
Zoe Kathleen Barr, Tomáš Werner, Jens Tilsner   +2 more
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Functional classification and validation of yeast prenylation motifs using machine learning and genetic reporters.

PLoS ONE, 2022
Protein prenylation by farnesyltransferase (FTase) is often described as the targeting of a cysteine-containing motif (CaaX) that is enriched for aliphatic amino acids at the a1 and a2 positions, while quite flexible at the X position.
Brittany M Berger, Wayland Yeung, Arnav Goyal, Zhongliang Zhou, Emily R Hildebrandt, Natarajan Kannan, Walter K Schmidt   +6 more
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Specific Disruption of Ras2 CAAX Proteolysis Alters Its Localization and Function

Microbiology Spectrum, 2023
Many CAAX proteins, such as Ras GTPase, undergo a series of posttranslational modifications at their carboxyl terminus (i.e., cysteine prenylation, endoproteolysis of AAX, and carboxylmethylation).
Rajani Ravishankar, Emily R. Hildebrandt, Grace Greenway, Nadeem Asad, Sangram Gore, Timothy M. Dore, Walter K. Schmidt   +6 more
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PDE6D Mediates Trafficking of Prenylated Proteins NIM1K and UBL3 to Primary Cilia

Cells, 2023
Mutations in PDE6D impair the function of its cognate protein, phosphodiesterase 6D (PDE6D), in prenylated protein trafficking towards the ciliary membrane, causing the human ciliopathy Joubert Syndrome (JBTS22) and retinal degeneration in mice.
Siebren Faber, Stef J. F. Letteboer, Katrin Junger, Rossano Butcher, Trinadh V. Satish Tammana, Sylvia E. C. van Beersum, Marius Ueffing, Rob W. J. Collin, Qin Liu, Karsten Boldt, Ronald Roepman   +10 more
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Simvastatin-dependent apoptosis in Hodgkin’s lymphoma cells and growth impairment of human Hodgkin’s tumors in vivo

Haematologica, 2007
Statins are used to treat hypercholesterolemia and seem to have a preventive effect against cancer through pleiotropic effects including prenylation-inhibition. So far nothing is known about the activity of statins or more specific prenylation-inhibitors
Bastian von Tresckow, Elke Pogge von Strandmann, Stephanie Sasse, Samir Tawadros, Andreas Engert, Hinrich P. Hansen   +5 more
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SmgGDS: An Emerging Master Regulator of Prenylation and Trafficking by Small GTPases in the Ras and Rho Families

Frontiers in Molecular Biosciences, 2021
Newly synthesized small GTPases in the Ras and Rho families are prenylated by cytosolic prenyltransferases and then escorted by chaperones to membranes, the nucleus, and other sites where the GTPases participate in a variety of signaling cascades ...
Anthony C. Brandt, Olivia J. Koehn, Carol L. Williams   +2 more
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