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Chloroplastic protein prenylation: an internal or external affair? Reconciling biochemical data through a new hypothesis [PDF]
Frontiers in Plant ScienceProtein prenylation facilitates membrane association, protein interactions, and trafficking by attaching isoprenoid groups to C-terminal cysteine residues in the cytosol, with subsequent proteolysis and carboxymethylation occurring in the endoplasmic ...
Manfei Luo, Wei Chi
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The prenylated pUS2 protein of pseudorabies virus contributes to phosphorylation of connexin 43 and suppression of gap junctional intercellular communication [PDF]
Journal of VirologyGap junctional intercellular communication (GJIC) enables the direct transfer of signaling molecules between neighboring cells and plays an important role in innate antiviral immunity by facilitating bystander defense responses. We previously showed that
Alexander Tishchenko +9 more
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Regulation of protein prenylation
Biomedicine and Pharmacotherapy, 2023 Prenyltransferases (PTases) are known to play a role in embryonic development, normal tissue homeostasis and cancer by posttranslationally modifying proteins involved in these processes. They are being discussed as potential drug targets in an increasing number of diseases, ranging from Alzheimer's disease to malaria.
Hagen Sjard Bachmann, Dominik Jung
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Discovery of unprecedented prenylated indole piperazines and pyrazines through cryptic biosynthetic gene cluster heterologous expression [PDF]
Natural Products and BioprospectingPrenylation modifications of natural products typically introduce greater structural complexity and enhance their biological activities. Yet, the modification of piperazine alkaloids by dimethylallyl tryptophan synthases (DMATS) remains unreported.
Ziou Zha +12 more
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Plants, 2023 Heavy metal-associated isoprenylated plant proteins (HIPPs) are a metallochaperone-like protein family comprising a combination of structural features unique to vascular plants.
Zoe Kathleen Barr +2 more
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PLoS ONE, 2022 Protein prenylation by farnesyltransferase (FTase) is often described as the targeting of a cysteine-containing motif (CaaX) that is enriched for aliphatic amino acids at the a1 and a2 positions, while quite flexible at the X position.
Brittany M Berger +6 more
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Specific Disruption of Ras2 CAAX Proteolysis Alters Its Localization and Function
Microbiology Spectrum, 2023 Many CAAX proteins, such as Ras GTPase, undergo a series of posttranslational modifications at their carboxyl terminus (i.e., cysteine prenylation, endoproteolysis of AAX, and carboxylmethylation).
Rajani Ravishankar +6 more
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Single prenyl-binding site on protein prenyl transferases [PDF]
Proceedings of the National Academy of Sciences, 1998 Three distinct protein prenyl transferases, one protein farnesyl transferase (FTase) and two protein geranylgeranyl transferases (GGTase), catalyze prenylation of many cellular proteins. One group of protein substrates contains a C-terminal C AAX motif (C is Cys, A
L, Desnoyers, M C, Seabra
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PDE6D Mediates Trafficking of Prenylated Proteins NIM1K and UBL3 to Primary Cilia
Cells, 2023 Mutations in PDE6D impair the function of its cognate protein, phosphodiesterase 6D (PDE6D), in prenylated protein trafficking towards the ciliary membrane, causing the human ciliopathy Joubert Syndrome (JBTS22) and retinal degeneration in mice.
Siebren Faber +10 more
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Haematologica, 2007 Statins are used to treat hypercholesterolemia and seem to have a preventive effect against cancer through pleiotropic effects including prenylation-inhibition. So far nothing is known about the activity of statins or more specific prenylation-inhibitors
Bastian von Tresckow +5 more
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