Results 11 to 20 of about 35,022 (176)
Single prenyl-binding site on protein prenyl transferases [PDF]
Proceedings of the National Academy of Sciences, 1998 Three distinct protein prenyl transferases, one protein farnesyl transferase (FTase) and two protein geranylgeranyl transferases (GGTase), catalyze prenylation of many cellular proteins. One group of protein substrates contains a C-terminal C AAX motif (C is Cys, A
L, Desnoyers, M C, Seabra
openaire +2 more sources
Chloroplastic prenylated proteins [PDF]
FEBS Letters, 1997 By in vivo [3H]mevalonate labelling of spinach combined with biochemical analysis, evidence is provided for the existence of protein prenylation in chloroplasts. Approximately 20 prenylated polypeptides were resolved by SDS‐PAGE followed by autoradiography.
Parmryd, Ingela +4 more
openaire +2 more sources
Lipidation of small GTPase Cdc42 as regulator of its physiological and pathophysiological functions
Frontiers in Physiology, 2023 The protein cell division cycle 42 (Cdc42) is a small GTPase of the Rho family regulating a plethora of physiological functions in a tissue, cell and subcellular-specific manner via participating in multiple signaling pathways.
Alexander Wirth, Evgeni Ponimaskin
doaj +1 more source
Molecular Therapy: Methods & Clinical Development, 2018 Choroideremia (CHM) is a rare, X-linked recessive retinal dystrophy caused by mutations in the CHM gene. CHM is ubiquitously expressed in human cells and encodes Rab escort protein 1 (REP1).
Maria I. Patrício +4 more
doaj +1 more source
Cells, 2020 Nuclear shape modulates cell behavior and function, while aberrant nuclear morphologies correlate with pathological phenotype severity. Nevertheless, functions of specific nuclear morphological features and underlying molecular mechanisms remain poorly ...
Sebastian Martewicz +9 more
doaj +1 more source
Prenylated Rab Acceptor Protein Is a Receptor for Prenylated Small GTPases [PDF]
Journal of Biological Chemistry, 2001 Localization of Ras and Ras-like proteins to the correct subcellular compartment is essential for these proteins to mediate their biological effects. Many members of the Ras superfamily (Ha-Ras, N-Ras, TC21, and RhoA) are prenylated in the cytoplasm and then transit through the endomembrane system on their way to the plasma membrane.
C, Figueroa, J, Taylor, A B, Vojtek
openaire +2 more sources
Angewandte Chemie, EarlyView.Fluorescence‐based visualization and targeted mass–spectrometric enrichment of membrane‐embedded isoprenoids in Bacillus subtilis via cell‐permeant, alkynylated DMAPP analogs. ABSTRACT Isoprenoids are a chemically and functionally diverse class of metabolites that underlie essential bacterial physiology including respiration and cell envelope ...
Zackary N. Hulsey +7 more
wiley +2 more sources
Multiple domain insertions and losses in the evolution of the Rab prenylation complex
BMC Evolutionary Biology, 2007 Background Rab proteins are regulators of vesicular trafficking, requiring a lipid modification for proper function, prenylation of C-terminal cysteines.
Pereira-Leal Jose B, Rasteiro Rita
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2010 The Dot/Icm type IV translocated Ankyrin B (AnkB) effector of Legionella pneumophila is modified by the host prenylation machinery that anchors it into the outer leaflet of the Legionella-containing vacuole (LCV), which is essential for biological ...
Christopher T Price +3 more
doaj +1 more source
Molecules, 2022 Herein, we report the use of the Suzuki–Miyaura cross-coupling reaction for the preparation of a library of synthetic derivatives of flavonoids for biological activity assays.
Martina Hurtová +5 more
doaj +1 more source