Results 11 to 20 of about 38,918 (216)

Uncovering protein prenylation in Th1 cells: novel prenylation sites and insights into statin and farnesyltransferase inhibition

BMC Biology
Background T helper 1 (Th1) cell activation is an essential process for immune responses and is tightly regulated, including the prenylation of proteins critical for T cell function.
Jana Koch, Alessandra Ruggia, Carina Beha, Irina Wipf, Damir Zhakparov, Patrick Westermann, Svenja Schmelzer, Anja Heider, Klemens Fröhlich, Katja Baerenfaller   +9 more
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Protein Prenylation in Plant Stress Responses

Molecules, 2019
Protein prenylation is one of the most important posttranslational modifications of proteins. Prenylated proteins play important roles in different developmental processes as well as stress responses in plants as the addition of hydrophobic prenyl chains
Michal Hála, Viktor Žárský
doaj   +2 more sources

Protein Prenylation in Plants: Mechanisms and Functional Implications

Plants
Protein prenylation is a crucial post-translational modification that involves the formation of a covalent bond between isoprenoid lipids and the cysteine residues of specific proteins.
Chang Tian, Quan Wang
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Protein Prenylation in the moss Physcomitrium patens [PDF]

, 2021
Protein prenylation is the addition of a 15 or 20 carbon lipid to a cysteine near carboxyl terminus of target proteins. Prenylation increases hydrophobicity, which facilitates membrane associations and protein-protein interaction.
Running, Mark P., Ahmed, Anam F., Qaissi, Zayna H., Running, Mark P, Qaissi, Zayna, Brown, Katherine Vo., Brown, Katherine V   +6 more
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Characterization, sub-cellular localization and expression profiling of the isoprenylcysteine methylesterase gene family in Arabidopsis thaliana [PDF]

, 2010
Background: Isoprenylcysteine methylesterases (ICME) demethylate prenylated protein in eukaryotic cell. Until now, knowledge about their molecular information, localization and expression pattern is largely unavailable in plant species.
Wang, H.Z., Huizhong Wang, Ping Lan, Li, W.F., Lan, P., Wujun Ma, Wenfeng Li, Ma, W.   +7 more
core   +1 more source

SmgGDS: An Emerging Master Regulator of Prenylation and Trafficking by Small GTPases in the Ras and Rho Families

Frontiers in Molecular Biosciences, 2021
Newly synthesized small GTPases in the Ras and Rho families are prenylated by cytosolic prenyltransferases and then escorted by chaperones to membranes, the nucleus, and other sites where the GTPases participate in a variety of signaling cascades ...
Anthony C. Brandt, Olivia J. Koehn, Carol L. Williams   +2 more
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Chloroplastic prenylated proteins [PDF]

FEBS Letters, 1997
By in vivo [3H]mevalonate labelling of spinach combined with biochemical analysis, evidence is provided for the existence of protein prenylation in chloroplasts. Approximately 20 prenylated polypeptides were resolved by SDS‐PAGE followed by autoradiography.
Parmryd, Ingela, Shipton, Catherine Ann, Swiezewska, Ewa, Dallner, Gustav, Andersson, Bertil   +4 more
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The Biological Activity of AAV Vectors for Choroideremia Gene Therapy Can Be Measured by In Vitro Prenylation of RAB6A

Molecular Therapy: Methods & Clinical Development, 2018
Choroideremia (CHM) is a rare, X-linked recessive retinal dystrophy caused by mutations in the CHM gene. CHM is ubiquitously expressed in human cells and encodes Rab escort protein 1 (REP1).
Maria I. Patrício, Alun R. Barnard, Christopher I. Cox, Clare Blue, Robert E. MacLaren   +4 more
doaj   +1 more source

Lipidation of small GTPase Cdc42 as regulator of its physiological and pathophysiological functions

Frontiers in Physiology, 2023
The protein cell division cycle 42 (Cdc42) is a small GTPase of the Rho family regulating a plethora of physiological functions in a tissue, cell and subcellular-specific manner via participating in multiple signaling pathways.
Alexander Wirth, Evgeni Ponimaskin
doaj   +1 more source

Prenylated Rab Acceptor Protein Is a Receptor for Prenylated Small GTPases [PDF]

Journal of Biological Chemistry, 2001
Localization of Ras and Ras-like proteins to the correct subcellular compartment is essential for these proteins to mediate their biological effects. Many members of the Ras superfamily (Ha-Ras, N-Ras, TC21, and RhoA) are prenylated in the cytoplasm and then transit through the endomembrane system on their way to the plasma membrane.
C, Figueroa, J, Taylor, A B, Vojtek
openaire   +2 more sources