Results 11 to 20 of about 36,883 (221)
Protein Prenylation in Plants: Mechanisms and Functional Implications [PDF]
PlantsProtein prenylation is a crucial post-translational modification that involves the formation of a covalent bond between isoprenoid lipids and the cysteine residues of specific proteins.
Chang Tian, Quan Wang
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Protein Prenylation in Plant Stress Responses
Molecules, 2019 Protein prenylation is one of the most important posttranslational modifications of proteins. Prenylated proteins play important roles in different developmental processes as well as stress responses in plants as the addition of hydrophobic prenyl chains
Michal Hála, Viktor Žárský
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Regulation of protein prenylation
Biomedicine and Pharmacotherapy, 2023 Prenyltransferases (PTases) are known to play a role in embryonic development, normal tissue homeostasis and cancer by posttranslationally modifying proteins involved in these processes. They are being discussed as potential drug targets in an increasing number of diseases, ranging from Alzheimer's disease to malaria.
Dominik Jung, Hagen S Bachmann
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Uncovering protein prenylation in Th1 cells: novel prenylation sites and insights into statin and farnesyltransferase inhibition [PDF]
BMC BiologyBackground T helper 1 (Th1) cell activation is an essential process for immune responses and is tightly regulated, including the prenylation of proteins critical for T cell function.
Jana Koch +9 more
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Impact of protein prenylation inhibition on Mycobacterium leprae viability and IL-1β production in infected macrophages [PDF]
Journal of BacteriologyLeprosy is a chronic infectious disease caused by Mycobacterium leprae and M. lepromatosis. Brazil consistently ranks among the countries with the highest number of leprosy cases. Data from our group showed that M.
Matheus da Silva Rocha +11 more
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Discovery of unprecedented prenylated indole piperazines and pyrazines through cryptic biosynthetic gene cluster heterologous expression [PDF]
Natural Products and BioprospectingPrenylation modifications of natural products typically introduce greater structural complexity and enhance their biological activities. Yet, the modification of piperazine alkaloids by dimethylallyl tryptophan synthases (DMATS) remains unreported.
Ziou Zha +12 more
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Multiple domain insertions and losses in the evolution of the Rab prenylation complex [PDF]
BMC Evolutionary Biology, 2007 Background Rab proteins are regulators of vesicular trafficking, requiring a lipid modification for proper function, prenylation of C-terminal cysteines.
Pereira-Leal Jose B, Rasteiro Rita
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Probes for protein prenylation [PDF]
Nature Methods, 2019 Allison Doerr, Doerr Allison
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Plants, 2023 Heavy metal-associated isoprenylated plant proteins (HIPPs) are a metallochaperone-like protein family comprising a combination of structural features unique to vascular plants.
Zoe Kathleen Barr +2 more
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Prenylated flavins: structures and mechanisms [PDF]
The FEBS Journal, 2022 The UbiX/UbiD system is widespread in microbes and responsible for the reversible decarboxylation of unsaturated carboxylic acids. The UbiD enzyme catalyzes this unusual reaction using a prenylated flavin (prFMN) as cofactor, the latter formed by the flavin prenyltransferase UbiX.
Bloor, Samuel +3 more
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