Results 41 to 50 of about 35,022 (176)
CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems
The FEBS Journal, EarlyView.Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén +11 more
wiley +1 more source
Frontiers in Neuroscience, 2019 Thirty years after the first description and modeling of G protein coupled receptors (GPCRs), information about their mode of action is still limited. One of the questions that is hard to answer is: how do the allosteric changes in the GPCR induced by, e.
Arnold De Loof, Liliane Schoofs
doaj +1 more source
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.The primary function of statins is to inhibit cholesterol synthesis, which contributes to their antidiabetic effects. However, the majority of the diabetic effects of statins are due to inhibition of isoprenoid synthesis. Atorvastatin, simvastatin and rosuvastatin possess the most pronounced diabetogenic properties. In contrast, lovastatin, fluvastatin,
Ali Nosrati Andevari, Mohsen Koolivand
wiley +1 more source
A basidomycetous hydroxynaphthalene-prenylating enzyme exhibits promiscuity toward prenyl donors
Applied Microbiology and Biotechnology, 2023 Abstract The fungal prenyltransferase ShPT from Stereum hirsutum was believed to prenylate 4-hydroxybenzyl alcohol and thereby be involved in the vibralactone biosynthesis. In this study, we demonstrate that hydroxynaphthalenes instead of benzyl alcohol or aldehyde were accepted by ShPT for regular C-prenylation in the ...
Andreas Martin +3 more
openaire +2 more sources
Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions
Nature Communications, 2019 Macrophage specific deletion of GGTase-I, a prenylation enzyme, in mice induces inflammatory response and rheumatoid arthritis. Here the authors show that GGTase-I deficiency and the resulting reduction of RAC1 prenylation increase RAC1 interaction with ...
Murali K. Akula +13 more
doaj +1 more source
Pharmacology Research & Perspectives, 2022 While there is a growing interest in the use of statins, HMG‐CoA reductase inhibitors, to treat neurodegenerative diseases, statins are associated with conflicting effects within the central nervous system (CNS) without clear evidence of the underlying ...
Hui Wang +7 more
doaj +1 more source
eLife, 2021 Bisphosphonates drugs target the skeleton and are used globally for the treatment of common bone disorders. Nitrogen-containing bisphosphonates act by inhibiting the mevalonate pathway in bone-resorbing osteoclasts but, surprisingly, also appear to ...
Marcia A Munoz +11 more
doaj +1 more source
Oxysterols in Cancer: From Biosynthesis and Pathophysiology to Targeted Therapeutics
MedComm – Oncology, Volume 5, Issue 3, September 2026.Mechanisms by which oxysterol targeting may enhance immunotherapy efficacy. This figure illustrates potential metabolic interventions that may improve antitumor immunity by modulating oxysterol related pathways. CH25H modulation may reduce 25‐HC accumulation, promote the conversion of cold tumors into hot tumors, and increase T cell infiltration and PD‐
Haili Shang, Yongsheng Li
wiley +1 more source
Analyzing the postulated inhibitory effect of Manumycin A on farnesyltransferase
Frontiers in Chemistry, 2022 Manumycin A is postulated to be a specific inhibitor against the farnesyltransferase (FTase) since this effect has been shown in 1993 for yeast FTase.
Anna Hagemann +6 more
doaj +1 more source
Archiv der Pharmazie, Volume 359, Issue 8, August 2026.A series of 25 functionalized indeno[1,2‐b]indoles was selected from in‐house compound library and additional synthesis work. Capillary electrophoresis‐based and thermal shift assays, X‐ray analysis of small molecules, and co‐crystallization studies highlighted a key molecular template for the inhibitory potential of protein kinase CK2.
Matheus M. Guimarães +18 more
wiley +1 more source