Results 41 to 50 of about 36,883 (221)
Profiling protein prenylation using a quantitative chemical proteomics approach [PDF]
, 2017 Prenylation, the attachment of a farnesyl or geranylgeranyl isoprenoid to a C-terminal cysteine, is a post-translational modification which modulates localisation and function of key proteins such as members of the RAS superfamily, nuclear lamins and ...
Storck Saha, Elisabeth
core +1 more source
Journal of Lipid Research, 2006 Much is now understood concerning the synthesis of prenylated and palmitoylated proteins, but what is known of their metabolic fate? This review details metabolic pathways for the lysosomal degradation of S-fatty acylated and prenylated proteins. Central
Jui-Yun Lu, Sandra L. Hofmann
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Platelets, 2023 Statins inhibit the mevalonate pathway by impairing protein prenylation via depletion of lipid geranylgeranyl diphosphate (GGPP). Rab27b and Rap1a are small GTPase proteins involved in dense granule secretion, platelet activation, and regulation.
Mohammed M Jalal +3 more
doaj +1 more source
Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation. [PDF]
PLoS ONE, 2012 Statins such as simvastatin are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors and standard therapy for the prevention and treatment of cardiovascular diseases in mammals.
Stephen R Spindler +9 more
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, 2010 Background: Isoprenylcysteine methylesterases (ICME) demethylate prenylated protein in eukaryotic cell. Until now, knowledge about their molecular information, localization and expression pattern is largely unavailable in plant species.
Wang, H.Z. +7 more
core +1 more source
Updates on protein-prenylation and associated inherited retinopathies
Frontiers in OphthalmologyMembrane-anchored proteins play critical roles in cell signaling, cellular architecture, and membrane biology. Hydrophilic proteins are post-translationally modified by a diverse range of lipid molecules such as phospholipids ...
Sudhat Ashok +3 more
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Marine Drugs, 2023 A new prenylated indole diketopiperazine alkaloid, rubrumline P (1), was isolated along with six more analogues and characterized from the fermentation culture of a marine sediment-derived fungus, Aspergillus chevalieri, collected at a depth of 15 m near
Dina H. El-Kashef +12 more
doaj +1 more source
A basidomycetous hydroxynaphthalene-prenylating enzyme exhibits promiscuity toward prenyl donors
Applied Microbiology and Biotechnology, 2023 Abstract The fungal prenyltransferase ShPT from Stereum hirsutum was believed to prenylate 4-hydroxybenzyl alcohol and thereby be involved in the vibralactone biosynthesis. In this study, we demonstrate that hydroxynaphthalenes instead of benzyl alcohol or aldehyde were accepted by ShPT for regular C-prenylation in the ...
Andreas Martin +3 more
openaire +2 more sources
Protein prenylation in spinach chloroplasts
, 1999 Protein prenylation in plants was studied by in vivo metabolic (3)H-mevalonate labeling in combination with a range of protein synthesis inhibitors.
Andersson, B, +2 more
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Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function
Advanced Science, EarlyView.This review explains how Extracellular vesiclesâproducing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang +10 more
wiley +1 more source