Results 61 to 70 of about 44,008 (221)

A Comprehensive Analysis of Choroideremia: From Genetic Characterization to Clinical Practice. [PDF]

, 2016
Choroideremia (CHM) is a rare X-linked disease leading to progressive retinal degeneration resulting in blindness. The disorder is caused by mutations in the CHM gene encoding REP-1 protein, an essential component of the Rab geranylgeranyltransferase ...
Avila-Fernandez, A., Ayuso, C., Blanco-Kelly, F., Corton, M., Garcia-Hoyos, M., Garcia-Sandoval, B., Gimenez, A., Kalatzis, V., Lopez-Martinez, M.A., Lopez-Molina, M.I., Lorda, I., Perez-Carro, R., Riveiro-Alvarez, R., Rivolta, C., Rodrigues-Jacy da Silva, L., Sanchez-Alcudia, R., Sanchez-Bolivar, N., Torriano, S., Trujillo-Tiebas, M.J., Villaverde, C., Zurita, O.   +20 more
core   +7 more sources

Flip-Flopping Retinal in Microbial Rhodopsins as a Template for a Farnesyl/Prenyl Flip-Flop Model in Eukaryote GPCRs

Frontiers in Neuroscience, 2019
Thirty years after the first description and modeling of G protein coupled receptors (GPCRs), information about their mode of action is still limited. One of the questions that is hard to answer is: how do the allosteric changes in the GPCR induced by, e.
Arnold De Loof, Liliane Schoofs
doaj   +1 more source

Biphasic effects of statins on neuron cell functions under oxygen–glucose deprivation and normal culturing conditions via different mechanisms

Pharmacology Research & Perspectives, 2022
While there is a growing interest in the use of statins, HMG‐CoA reductase inhibitors, to treat neurodegenerative diseases, statins are associated with conflicting effects within the central nervous system (CNS) without clear evidence of the underlying ...
Hui Wang, Yun Chen, Ping Li, Yan Chen, Danfang Yu, Qian Tan, Xiaoli Liu, Zhenli Guo   +7 more
doaj   +1 more source

Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages

eLife, 2021
Bisphosphonates drugs target the skeleton and are used globally for the treatment of common bone disorders. Nitrogen-containing bisphosphonates act by inhibiting the mevalonate pathway in bone-resorbing osteoclasts but, surprisingly, also appear to ...
Marcia A Munoz, Emma K Fletcher, Oliver P Skinner, Julie Jurczyluk, Esther Kristianto, Mark P Hodson, Shuting Sun, Frank H Ebetino, David R Croucher, Philip M Hansbro, Jacqueline R Center, Michael J Rogers   +11 more
doaj   +1 more source

Incidence and Risk Factors of Bisphosphonate-Related Osteonecrosis of the Jaw in Multiple Myeloma Patients Having Undergone Autologous Stem Cell Transplantation [PDF]

, 2012
Background: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe complication of bisphosphonate therapy. Due to their long survival and subsequently high cumulative doses of bisphosphonates, multiple myeloma patients have the highest risk ...
Baumann, Philipp, Bumeder, Irmgard, Hörauf, Natalie, Oduncu, Fuat S., Otto, Sven, Pautke, Christoph, Röhnisch, Tim, Schmidmaier, Ralf, Then, Cornelia, Tresckow, Emmo von   +9 more
core   +1 more source

Deciphering the properties and reaction mechanism of anhydromevalonate phosphate decarboxylase, a prenylated flavin mononucleotide‐dependent enzyme in the archaeal mevalonate pathway

The FEBS Journal, EarlyView.
Characterization of anhydromevalonate phosphate decarboxylase, the UbiD‐family decarboxylase involved in the archaeal mevalonate pathway, was conducted. The enzyme is responsible for the biosynthesis of isoprenoids, such as archaeal membrane lipids, respiratory quinones, and dolichols.
Rino Ishikawa, Natsumi Matsushima, Soma Ishimine, Honoka Nakamoto, Hajime Hayakawa, Yoko Yasuno, Tetsuro Shinada, Hiroshi Kawaide, Tomokazu Ito, Hisashi Hemmi   +9 more
wiley   +1 more source

Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions

Nature Communications, 2019
Macrophage specific deletion of GGTase-I, a prenylation enzyme, in mice induces inflammatory response and rheumatoid arthritis. Here the authors show that GGTase-I deficiency and the resulting reduction of RAC1 prenylation increase RAC1 interaction with ...
Murali K. Akula, Mohamed X. Ibrahim, Emil G. Ivarsson, Omar M. Khan, Israiel T. Kumar, Malin Erlandsson, Christin Karlsson, Xiufeng Xu, Mikael Brisslert, Cord Brakebusch, Donghai Wang, Maria Bokarewa, Volkan I. Sayin, Martin O. Bergo   +13 more
doaj   +1 more source

Analyzing the postulated inhibitory effect of Manumycin A on farnesyltransferase

Frontiers in Chemistry, 2022
Manumycin A is postulated to be a specific inhibitor against the farnesyltransferase (FTase) since this effect has been shown in 1993 for yeast FTase.
Anna Hagemann, Philipp Klemens Altrogge, Miriam Caroline Alice Kehrenberg, Daniel Diehl, Dominik Jung, Lea Weber, Hagen Sjard Bachmann   +6 more
doaj   +1 more source

Statins and protein prenylation in cancer cell biology and therapy [PDF]

, 2012
El pdf del artículo es la versión post-print.The use of statins has scaled up to become one of the most prescribed medicines in the world and have been very useful in the manegement of cardiovascular diseases and related mortality.
Fernández-Checa, José C., García-Ruiz, Carmen, Morales, Albert   +2 more
core   +2 more sources

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

The FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu, Maximilian J. L. J. Fürst, Oscar P. Kuipers   +2 more
wiley   +1 more source