Results 61 to 70 of about 38,918 (216)
Differential requirements of protein geranylgeranylation for the virulence of human pathogenic fungi
Virulence, 2019 Protein prenylation is a crucial post-translational modification largely mediated by two heterodimeric enzyme complexes, farnesyltransferase and geranylgeranyltransferase type-I (GGTase-I), each composed of a shared α-subunit and a unique β-subunit ...
Ana Camila Oliveira Souza +9 more
doaj +1 more source
Frontiers in Neuroscience, 2019 Thirty years after the first description and modeling of G protein coupled receptors (GPCRs), information about their mode of action is still limited. One of the questions that is hard to answer is: how do the allosteric changes in the GPCR induced by, e.
Arnold De Loof, Liliane Schoofs
doaj +1 more source
CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems
The FEBS Journal, EarlyView.Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén +11 more
wiley +1 more source
Pharmacology Research & Perspectives, 2022 While there is a growing interest in the use of statins, HMG‐CoA reductase inhibitors, to treat neurodegenerative diseases, statins are associated with conflicting effects within the central nervous system (CNS) without clear evidence of the underlying ...
Hui Wang +7 more
doaj +1 more source
eLife, 2021 Bisphosphonates drugs target the skeleton and are used globally for the treatment of common bone disorders. Nitrogen-containing bisphosphonates act by inhibiting the mevalonate pathway in bone-resorbing osteoclasts but, surprisingly, also appear to ...
Marcia A Munoz +11 more
doaj +1 more source
UbiB proteins mediate an ATP‐dependent decarboxylation step in bacterial ubiquinone biosynthesis
The FEBS Journal, EarlyView.UbiB proteins are atypical protein kinase‐like enzymes essential for ubiquinone biosynthesis. Here, we demonstrate that bacterial UbiB proteins catalyze the O2‐dependent decarboxylation of ubiquinone precursors, a process linked to their ATPase activity.
Katayoun Kazemzadeh +12 more
wiley +1 more source
SmgGDS-607 Regulation of RhoA GTPase Prenylation Is Nucleotide-Dependent
, 2018 Protein prenylation involves the attachment of a hydrophobic isoprenoid moiety to the C-terminus of proteins. Several small GTPases, including members of the Ras and Rho subfamilies, require prenylation for their normal and pathological functions. Recent
Benjamin C. Jennings (1931434) +7 more
core +1 more source
Amyloid-beta Causes Autophagy Dysfunction by Inhibiting Protein Prenylation [PDF]
, 2016 There is ample evidence that autophagy is affected in Alzheimer’s disease (AD) but the causes, the nature of the dysfunction and the mechanisms of autophagy impairment are unclear.
Smith, Kevan Thomas
core +1 more source
Comparison of prenylation and cleavage prediction models with empirical observations.
, 2022 Comparison of prenylation and cleavage prediction models with empirical observations.
Arnav Goyal (12936633) +6 more
core +1 more source
Analyzing the postulated inhibitory effect of Manumycin A on farnesyltransferase
Frontiers in Chemistry, 2022 Manumycin A is postulated to be a specific inhibitor against the farnesyltransferase (FTase) since this effect has been shown in 1993 for yeast FTase.
Anna Hagemann +6 more
doaj +1 more source