Results 81 to 90 of about 36,883 (221)
High-content assay to study protein prenylation.
, 2008 The mevalonate pathway leads to synthesis of cholesterol and isoprenoid lipids. Prenyltransferases attach the isoprenoid lipids to the C-terminus of several small guanosine triphosphate-binding proteins. The prenyl groups are essential for the biological
Zimmermann, Johann +7 more
core +1 more source
Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.Abstract INTRODUCTION The apolipoprotein E4 (APOE4) allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD). ApoE4 has reduced lipidation capacity and impaired lipid transport, disrupting neuronal maintenance. The high‐density lipoprotein (HDL)‐mimetic peptide 4F offers a potential therapeutic strategy.
Allison Chang +5 more
wiley +1 more source
Prenylation defects in inherited retinal diseases
, 2014 Contains fulltext : 136580.pdf (Publisher’s version ) (Open Access)Many proteins depend on post-translational prenylation for a correct subcellular localisation and membrane anchoring.
Siemiatkowska, A.M. +4 more
core +1 more source
Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.This review provides an extensive and critical synthesis of current knowledge on umbelliprenin, integrating phytochemical, analytical, biological, ecological, and food science perspectives, and identifies priorities for future research. ABSTRACT Umbelliprenin (7‐farnesyloxycoumarin) is an oxyprenylated coumarin that has gained increasing attention in ...
Chiara Collevecchio +4 more
wiley +1 more source
Prenylation enhances the biological activity of dietary flavonoids by altering their bioavailability [PDF]
, 2018 Flavonoids are distributed across the plant kingdom and have attracted substantial attention owing to their potential benefits for human health. Several studies have demonstrated that flavonoids prenylation enhances various biological activities ...
向井, 理恵 +5 more
core +2 more sources
Phytochemicals in Asthma Management: Mechanism, Translational Gap and Clinical Integration
Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.The phytochemicals including flavonoids, alkaloids, terpenoids, and saponins modulate inflammatory, oxidative, and immune pathways in asthma. It highlights their mechanisms of action, translational challenges, advanced formulation strategies, and emerging clinical potential as adjunct therapies for precision‐based asthma management.
Pulak Majumder, Trisita Majumder
wiley +1 more source
Regiospecific Prenylation of Hydroxyxanthones by a Plant Flavonoid Prenyltransferase
, 2016 C-Prenylated xanthones are pharmacologically attractive specialized metabolites that are distributed in plants and microorganisms. The prenylation of xanthones often contributes to the structural diversity and biological activities of these compounds ...
Jianhua Li (36075) +7 more
core +1 more source
Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.ABSTRACT Statins, widely prescribed for cardiovascular prevention, have emerged as potential disease‐modifying agents in neurodegenerative disorders due to their pleiotropic effects on cholesterol metabolism, neuroinflammation, oxidative stress, and protein aggregation.
Luigi Maria Chiatto +7 more
wiley +1 more source
GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling
British Journal of Pharmacology, Volume 183, Issue 11, Page 2619-2633, June 2026.G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins.
Vsevolod V. Gurevich
wiley +1 more source
7-Isopentenyloxycoumarin: What Is New across the Last Decade
Molecules, 2020 7-Isopentenyloxycoumarin is among the most widespread naturally occurring prenyloxy umbelliferone derivatives. This secondary metabolite of mixed biosynthetic origin has been typically isolated from plants belonging to several genera of the Rutaceae and ...
Francesca Preziuso +6 more
doaj +1 more source