Results 81 to 90 of about 38,918 (216)
ChemMedChem, Volume 21, Issue 17, 14 September 2026.Computational studies allowed the identification of a PDE9A inhibitor. A novel HPLC‐based assay was developed and optimized to measure enzyme function to assess PDE9A inhibition. Furthermore, in vitro tests supported the activity of the compound against neuroinflammation. Oxidative stress and inflammation are key players in central nervous system (CNS)
Giovanni Ribaudo +10 more
wiley +1 more source
Molecular Therapy: Methods & Clinical Development, 2020 Recent advances in recombinant adeno-associated virus (rAAV) gene therapy for choroideremia show gene replacement to be a promising approach. It is, however, well known that contact of vector solution with plastic materials in the surgical device may ...
Maria I. Patrício +5 more
doaj +1 more source
Double Prenylation by RabGGTase Can Proceed without Dissociation of the Mono-prenylated Intermediate [PDF]
Journal of Biological Chemistry, 2001 Rab geranylgeranyltransferase (RabGGTase) catalyzes the prenylation of Rab proteins. Despite possessing a single active site, RabGGTase is able to add geranylgeranyl moieties onto each of the two C-terminal cysteine residues of Rab. We have studied the kinetics of Rab double prenylation employing a combination of a novel high pressure liquid ...
Thoma, N. H. +3 more
openaire +6 more sources
FEBS Letters, Volume 600, Issue 17, Page 2564-2578, September 2026.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Early-Stage Biosynthesis of Phenalinolactone Diterpenoids Involves Sequential Prenylation, Epoxidation, and Cyclization [PDF]
The chemical logic associated with assembly of many bacterial terpenoids remains poorly understood. We focused our efforts on the early-stage biosynthesis of the phenalinolactone diterpenoids, demonstrating that the anti/anti/syn-perhydrophenanthrene ...
Liao-Bin, Dong +8 more
core +2 more sources
Advanced Science, Volume 13, Issue 51, 14 September 2026.Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang +8 more
wiley +1 more source
Protein prenylation comprises a class of post-translational modifications that regulates the localization and function of over 100 proteins, including RAS oncogenes.
Hassan, Sarah
core +1 more source
Prenylation defects in inherited retinal diseases
, 2014 Contains fulltext : 136580.pdf (Publisher’s version ) (Open Access)Many proteins depend on post-translational prenylation for a correct subcellular localisation and membrane anchoring.
Siemiatkowska, A.M. +4 more
core +1 more source
Structure, regulation and cellular functions of Rab geranylgeranyl transferase and its cellular partner Rab Escort Protein [PDF]
, 2012 Rab geranylgeranyl transferase is an enzyme responsible for double geranylgeranylation of Rab proteins in all eukaryotic cells. In the present article we would like to focus on new findings concerning the holoenzyme structure and mechanism of catalytic ...
Swiezewska, Ewa, Gutkowska, Malgorzata
core +1 more source
Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.Abstract INTRODUCTION Limbic‐predominant age‐related transactive response DNA binding protein 43 kDa encephalopathy neuropathological change (LATE‐NC) frequently co‐occurs with Alzheimer's disease neuropathologic change (ADNC), complicating classification.
Qi Qiao +9 more
wiley +1 more source