Results 101 to 110 of about 38,918 (216)

A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro[S]

Journal of Lipid Research, 2011
Statins and nitrogenous bisphosphonates (NBP) inhibit 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (HMGCR) and farnesyl diphosphate synthase (FDPS), respectively, leading to depletion of farnesyl diphosphate (FPP) and disruption of protein prenylation.
Brian M. Wasko, Jacqueline P. Smits, Larry W. Shull, David F. Wiemer, Raymond J. Hohl   +4 more
doaj   +1 more source

Inhibition of Protein Prenylation of GTPases Alters Endothelial Barrier Function

, 2019
The members of Rho family of GTPases, RhoA and Rac1 regulate endothelial cytoskeleton dynamics and hence barrier integrity. The spatial activities of these GTPases are regulated by post-translational prenylation. In the present study, we investigated the
Christian Troidl, Muhammad Aslam, Dursun Gündüz, Christian W. Hamm, Christian Tanislav, Susanne Rohrbach   +5 more
core   +1 more source

Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats

Physiological Reports
Fast‐twitch muscles are less susceptible to disuse atrophy, activate the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway, and increase protein synthesis under prolonged muscle disuse conditions.
Munehiro Uda, Toshinori Yoshihara, Noriko Ichinoseki‐Sekine, Takeshi Baba   +3 more
doaj   +1 more source

Structure Prediction and Genome Mining‐Aided Discovery of the Bacterial C‐Terminal Tryptophan Prenyltransferase PalQ

Advanced Science
Post‐translational prenylations, found in eukaryotic primary metabolites and bacterial secondary metabolites, play crucial roles in biomolecular interactions.
Azusa Miyata, Sohei Ito, Daisuke Fujinami   +2 more
doaj   +1 more source

Characterization Of Protein Prenyltransferases And Protein Prenylation In Plasmodium Falciparum [PDF]

, 2004
Malaria kills at least one million people each year, mostly children - a death every 30 seconds. Almost one half of the world population is at risk from malaria.
DaSilva, Thiago Gaspar
core  

Antibodies and Unnatural Substrates of Prenylation Enzymes for Use in Detecting and Isolating Prenylated Proteins [PDF]

, 2010
Unnatural substrates of prenylation enzymens and antibodies that recognize unique moieties of prenylated proteins, which unique moieties are transferred from the unnatural substrates are used for detecting and isolating prenylated proteins, and for ...
Spielmann, H. Peter, Andres, Douglas A.
core   +1 more source

Dual‐Ligand Strategy in Rh‐Catalyzed Sequential Hydrofunctionalization of Valylene

Advanced Science
Controlling regio‐ and chemo‐selectivity in transition‐metal‐catalyzed reactions involving coupling reagents with multiple reactive sites remains a significant challenge.
Yong‐Kang Mei, Su‐Yang Xu, Zhi‐Hui Wang, Ding‐Wei Ji, Qing‐An Chen   +4 more
doaj   +1 more source

Use of a prenylation inhibitor as a novel antiviral agent

, 1998
No specific therapy exists for hepatitis delta virus (HDV), which can cause severe liver disease. Molecular genetic studies have implicated the prenylation site of large delta antigen as a critical determinant of HDV particle assembly.
James C. Marsters, Harry B. Greenberg, Jeffrey S. Glenn   +2 more
core  

Prenylation of aromatic amino acids and plant phenolics by an aromatic prenyltransferase from Rasamsonia emersonii [PDF]

Dimethylallyl tryptophan synthases (DMATSs) are aromatic prenyltransferases that catalyze the transfer of a prenyl moiety from a donor to an aromatic acceptor during the biosynthesis of microbial secondary metabolites. Due to their broad substrate scope,
Gran-Scheuch, Alejandro A, van Berkel, Willem J H, Vincken, Jean-Paul, de Bruijn, Wouter J C, Vreeke, Gijs J C, Kabel, Mirjam A, Fraaije, Marco W, Chunkrua, Pimvisuth, Leschonski, Kai P   +8 more
core   +1 more source

Prenylation in the Moss Physcomitrella patens

, 2018
Protein prenylation is a post-translational modification that involves the addition of lipid groups to the end of a target protein and is necessary for protein activity.
Perez-Martinez, Susana, Singh, Parul, Bao, Liang, Botaka, Noela, Running, Mark   +4 more
core   +1 more source