Results 101 to 110 of about 36,883 (221)

Biotransformation of Resveratrol: New Prenylated trans-Resveratrol Synthesized by Aspergillus sp. SCSIOW2

Molecules, 2016
Arahypin-16 (1), a new prenylated resveratrol with a unique dihydrobenzofuran ring, has been isolated as a microbial metabolite of resveratrol (2) from whole-cell fermentation of Aspergillus sp. SCSIOW2.
Liyan Wang, Yanhua Wu, Yongtao Chen, Jiaxin Zou, Xiaofan Li   +4 more
doaj   +1 more source

A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro[S]

Journal of Lipid Research, 2011
Statins and nitrogenous bisphosphonates (NBP) inhibit 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (HMGCR) and farnesyl diphosphate synthase (FDPS), respectively, leading to depletion of farnesyl diphosphate (FPP) and disruption of protein prenylation.
Brian M. Wasko, Jacqueline P. Smits, Larry W. Shull, David F. Wiemer, Raymond J. Hohl   +4 more
doaj   +1 more source

Prelamin A prenylation and the treatment of progeria [PDF]

Journal of Lipid Research, 2010
Hutchinson-Gilford progeria syndrome (HGPS) is a rare, sporadic, autosomal dominant disease with phenotypic features of premature aging (1). It is caused by de novo mutations in LMNA that encodes the A-type nuclear lamins, intermediate filament proteins that are components of the nuclear lamina (2, 3).
openaire   +2 more sources

Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats

Physiological Reports
Fast‐twitch muscles are less susceptible to disuse atrophy, activate the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway, and increase protein synthesis under prolonged muscle disuse conditions.
Munehiro Uda, Toshinori Yoshihara, Noriko Ichinoseki‐Sekine, Takeshi Baba   +3 more
doaj   +1 more source

Structure Prediction and Genome Mining‐Aided Discovery of the Bacterial C‐Terminal Tryptophan Prenyltransferase PalQ

Advanced Science
Post‐translational prenylations, found in eukaryotic primary metabolites and bacterial secondary metabolites, play crucial roles in biomolecular interactions.
Azusa Miyata, Sohei Ito, Daisuke Fujinami   +2 more
doaj   +1 more source

Deletion and Gene Expression Analyses Define the Paxilline Biosynthetic Gene Cluster in Penicillium paxilli

Toxins, 2013
The indole-diterpene paxilline is an abundant secondary metabolite synthesized by Penicillium paxilli. In total, 21 genes have been identified at the PAX locus of which six have been previously confirmed to have a functional role in paxilline ...
Emily J. Parker, Brian A. Tapper, Sarah C. Finch, Ruth E. Wrenn, Andrea Bryant, Carla J. Eaton, Albert Koulman, Jonathan Astin, Brendon J. Monahan, Sanjay Saikia, Lisa K. McMillan, Carolyn A. Young, Geoffrey B. Jameson, Barry Scott   +13 more
doaj   +1 more source

Structure, regulation and cellular functions of Rab geranylgeranyl transferase and its cellular partner Rab Escort Protein [PDF]

, 2012
Rab geranylgeranyl transferase is an enzyme responsible for double geranylgeranylation of Rab proteins in all eukaryotic cells. In the present article we would like to focus on new findings concerning the holoenzyme structure and mechanism of catalytic ...
Swiezewska, Ewa, Gutkowska, Malgorzata
core  

Prenylation of aromatic amino acids and plant phenolics by an aromatic prenyltransferase from Rasamsonia emersonii [PDF]

Dimethylallyl tryptophan synthases (DMATSs) are aromatic prenyltransferases that catalyze the transfer of a prenyl moiety from a donor to an aromatic acceptor during the biosynthesis of microbial secondary metabolites. Due to their broad substrate scope,
Gran-Scheuch, Alejandro A, van Berkel, Willem J H, Vincken, Jean-Paul, de Bruijn, Wouter J C, Vreeke, Gijs J C, Kabel, Mirjam A, Fraaije, Marco W, Chunkrua, Pimvisuth, Leschonski, Kai P   +8 more
core   +1 more source

Use of a prenylation inhibitor as a novel antiviral agent

, 1998
No specific therapy exists for hepatitis delta virus (HDV), which can cause severe liver disease. Molecular genetic studies have implicated the prenylation site of large delta antigen as a critical determinant of HDV particle assembly.
James C. Marsters, Harry B. Greenberg, Jeffrey S. Glenn   +2 more
core  

Dual‐Ligand Strategy in Rh‐Catalyzed Sequential Hydrofunctionalization of Valylene

Advanced Science
Controlling regio‐ and chemo‐selectivity in transition‐metal‐catalyzed reactions involving coupling reagents with multiple reactive sites remains a significant challenge.
Yong‐Kang Mei, Su‐Yang Xu, Zhi‐Hui Wang, Ding‐Wei Ji, Qing‐An Chen   +4 more
doaj   +1 more source