Results 101 to 110 of about 44,008 (221)

Investigation of LKB1 Ser⁴³¹ phosphorylation and Cys⁴³³ farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity [PDF]

, 2014
The LKB1 tumour suppressor protein kinase functions to activate two isoforms of AMPK (AMP-activated protein kinase) and 12 members of the AMPK-related family of protein kinases. The highly conserved C-terminal residues of LKB1 are phosphorylated (Ser(431)
Alessi, Alessi, Alessi, Andrade-Vieira, Baas, Barnes, Bayascas, Boudeau, Boudeau, Boutin, Carling, Carling, Chen, Clark, Collins, Corton, Dario R. Alessi, Davisson, Denison, Denison, Farnsworth, Fogarty, Fogarty, Foretz, Gwinn, Hardie, Hardie, Hawley, Hayashi, Hemminki, Henriksson, Hunter, Jansen, Jeppesen, Ji, Joby Varghese, Kei Sakamoto, Kishi, Koh, Komander, Liu, Lizcano, Maria Stella Ritorto, Martin, McLaughlin, Mitchelhill, Moores, Mora, Najafov, Nakada, Natalia Shpiro, Oakhill, Paul Davies, Robert Gourlay, Sakamoto, Sakamoto, Sakamoto, Sanchez-Cespedes, Sanchez-Cespedes, Sanders, Sapkota, Sapkota, Screaton, Shaw, Shelly, Su, Towler, Vanessa P. Houde, Vavvas, Viollet, Wiggin, Woods, Wullschleger, Zagorska, Zeqiraj, Zeqiraj, Zhang   +76 more
core   +2 more sources

Resurrected Ancestral Cannabis Enzymes Unveil the Origin and Functional Evolution of Cannabinoid Synthases

Plant Biotechnology Journal, Volume 24, Issue 4, Page 2685-2697, April 2026.
ABSTRACT Cannabinoids, such as tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA) and cannabichromenic acid (CBCA), are bioactive and medicinally relevant compounds found in the cannabis plant (Cannabis sativa L.). These three compounds are synthesised from a single precursor, cannabigerolic acid (CBGA), through regioselective reactions ...
Cloé Villard, Idil Baser, Arjen C. van de Peppel, Katarina Cankar, M. Eric Schranz, Robin van Velzen   +5 more
wiley   +1 more source

Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells [PDF]

, 2006
BACKGROUND: Nitrogen-containing bisphosphonates (N-BPs) have been designed to inhibit osteoclast-mediated bone resorption. However, it is now accepted that part of their anti-tumor activities is related to interference with the mevalonate pathway ...
M Goffinet, M Thoulouzan, A Pradines, I Lajoie-Mazenc, Carolyn Weinbaum, JC Faye, S Séronie-Vivien, MJ Rogers, JR Green, D Amin, JD Bergstrom, K Thompson, E van Beek, HL Benford, SP Luckman, T Iguchi, JE Fisher, K Sawada, C Denoyelle, FP Coxon, ER Van Beek, GM Oades, SG Senaratne, SS Virtanen, F Saad, MR Smith, S Boissier, MV Lee, EC Lerner, TF McGuire, O Cussenot, P Skehan, AB Awad, E Corey, DC Crick, RB Lobell, SA Holstein, SE Ownby, C Allal, JE Dunford, JE Fisher   +40 more
core   +2 more sources

Catalytic enantioselective synthesis of quaternary carbon stereocentres. [PDF]

, 2014
Quaternary carbon stereocentres-carbon atoms to which four distinct carbon substituents are attached-are common features of molecules found in nature. However, before recent advances in chemical catalysis, there were few methods of constructing single ...
Overman, Larry E, Quasdorf, Kyle W
core  

The effector domain of Rab6, plus a highly hydrophobic C terminus, is required for Golgi apparatus localization [PDF]

, 1994
C-terminal lipid modifications are essential for the interaction of Ras-related proteins with membranes. While all Ras proteins are farnesylated and some palmitoylated, the majority of other Ras-related proteins are geranylgeranylated.
Beranger, F., Paterson, H., Powers, S., de Gunzburg, J., Hancock, J. F.   +4 more
core   +1 more source

GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis [PDF]

, 2014
Background: Hepatocellular carcinoma (HCC) has been associated with diabetes and obesity, but a possible connection with the metabolic syndrome (MetS) and its potential interaction with hepatitis and cirrhosis are open to discussion.
Chen, Jun, Ding, Yi-tao, Li, Chao-jun, Liu, Jia, Shao, Jiao-jiao, Shen, Xiao, Xia, Hong-guang, Xue, Bin, Yu, De-cai   +8 more
core   +1 more source

The ubiquitin system and jasmonate signaling [PDF]

, 2016
The ubiquitin (Ub) system is involved in most, if not all, biological processes in eukaryotes. The major specificity determinants of this system are the E3 ligases, which bind and ubiquitinate specific sets of proteins and are thereby responsible for ...
Goossens, Alain, Nagels Durand, Astrid, Pauwels, Laurens   +2 more
core   +3 more sources

Biotransformation of Resveratrol: New Prenylated trans-Resveratrol Synthesized by Aspergillus sp. SCSIOW2

Molecules, 2016
Arahypin-16 (1), a new prenylated resveratrol with a unique dihydrobenzofuran ring, has been isolated as a microbial metabolite of resveratrol (2) from whole-cell fermentation of Aspergillus sp. SCSIOW2.
Liyan Wang, Yanhua Wu, Yongtao Chen, Jiaxin Zou, Xiaofan Li   +4 more
doaj   +1 more source

Geranylgeranyltransferase I is essential for dendritic development of cerebellar Purkinje cells [PDF]

, 2010
Background During cerebellar development, Purkinje cells (PCs) form the most elaborate dendritic trees among neurons in the brain, but the mechanism regulating PC arborization remains largely unknown.
Kong-Yan Wu, Xiu-Ping Zhou, Zhen-Ge Luo
core   +2 more sources

A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro[S]

Journal of Lipid Research, 2011
Statins and nitrogenous bisphosphonates (NBP) inhibit 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (HMGCR) and farnesyl diphosphate synthase (FDPS), respectively, leading to depletion of farnesyl diphosphate (FPP) and disruption of protein prenylation.
Brian M. Wasko, Jacqueline P. Smits, Larry W. Shull, David F. Wiemer, Raymond J. Hohl   +4 more
doaj   +1 more source