Results 111 to 120 of about 36,883 (221)

Mechanisms of negative regulation of protein prenylation: investigation of murine guanylate-binding protein 1

, 2000
Covalent attachment of isoprenoid lipids to proteins is a post-translational modification that occurs on approximately 2% of all cellular proteins. Proteins that contain a CaaX motif as their final four amino acids are presumed to be targets for the ...
Stickney, John
core   +1 more source

Investigating the Regulation of Ras Protein Prenylation [PDF]

, 2019
Ras family small GTPases undergo prenylation for proper localization to the plasma membrane, where they carry out their signaling function. Prevalent mutations in these proteins that render them persistently active have attracted a lot of attention due ...
Garcia-Torres, Desiree
core  

Ir-Catalyzed Reverse Prenylation of 3‑Substituted Indoles: Total Synthesis of (+)-Aszonalenin and (−)-Brevicompanine B

, 2016
The selective reverse prenylation of 3-substituted-1H-indoles at C3 is described. The iridium-catalyzed reaction proceeds with high branched to linear selectivity (>20:1) for a variety of indoles.
Erick M. Carreira (1330920), Jonathan Ruchti (1711801)   +1 more
core   +1 more source

Prenylation of Aromatic Secondary Metabolites: A New Frontier for Development of Novel Drugs

, 2014
Prenylation of aromatic secondary metabolites is an important process involved in the biosynthesis of many biologically active compounds in plants and animals.
Uba, A, Alhassan, AM, Umar, A, Abdullahi, MI   +3 more
core   +1 more source

Characterization Of Protein Prenyltransferases And Protein Prenylation In Plasmodium Falciparum

, 2004
Malaria kills at least one million people each year, mostly children - a death every 30 seconds. Almost one half of the world population is at risk from malaria.
DaSilva, Thiago Gaspar
core  

Enzymology and Biology of CaaX Protein Prenylation

, 2014
[[abstract]]Protein prenylation refers to a type of lipid modification in which tither a 15-carbon farnesyl or 20-carbon geranylgeranyl isoprenoid is linked via a thioether bond to specific cysteine residues of proteins.
Fu, HW;Casey, PJ
core  

Role of inhibition of protein prenylation in the cholesterol-dependent and cholesterol-independent effects of simvastatin

, 2006
Statins are widely used to treat hypercholesterolemia. Statins inhibit cholesterol biosynthesis, thereby activating genes involved in cholesterol homeostasis, which are under the control of the Sterol Regulatory Element (SRE).
Volk, Catherine B.
core  

Studies of protein prenylation in living systems: implications toward the better understanding of diseases

, 2012
University of Minnesota Ph.D. dissertation. August 2012. Major: Chemistry. Advisor: Dr. Mark D. Distefano. 1 computer file (PDF); xv, 199 pages, appendices A-B.Protein prenylation is a post-translational modification that is present in a large number of ...
Ochocki, Joshua Daniel
core  

Prenylation in the Moss Physcomitrella patens

, 2018
Protein prenylation is a post-translational modification that involves the addition of lipid groups to the end of a target protein and is necessary for protein activity.
Perez-Martinez, Susana, Singh, Parul, Bao, Liang, Botaka, Noela, Running, Mark   +4 more
core  

Structural and functional consequences of PDE6 prenylation in rod and cone photoreceptors

Phosphodiesterase-6 (PDE6) serves as a pivotal component in the phototransduction pathways of both cone and rod photoreceptors. In cones, PDE6 consists of tetrameric subunits: inhibitory (γ\u27) and catalytic (α\u27).
Moakedi, Faezeh
core   +1 more source