Results 91 to 100 of about 38,918 (216)
High-content assay to study protein prenylation.
, 2008 The mevalonate pathway leads to synthesis of cholesterol and isoprenoid lipids. Prenyltransferases attach the isoprenoid lipids to the C-terminus of several small guanosine triphosphate-binding proteins. The prenyl groups are essential for the biological
Zimmermann, Johann +7 more
core +1 more source
Investigating the Regulation of Ras Protein Prenylation [PDF]
, 2019 Ras family small GTPases undergo prenylation for proper localization to the plasma membrane, where they carry out their signaling function. Prevalent mutations in these proteins that render them persistently active have attracted a lot of attention due ...
Garcia-Torres, Desiree
core +4 more sources
Cancer Medicine, Volume 15, Issue 9, September 2026.Metabolic reprogramming in cancer stem cells: lipid flux, mitochondrial plasticity, and therapeutic resistance. Lipid metabolism in CSCs: de novo lipogenesis, CD36 uptake, FAO, lipid droplets, and membrane remodeling. Mitochondrial dynamics in CSC survival: fusion, fission, mitophagy, OXPHOS switching, and ROS regulation.
Daniel Ejim Uti +5 more
wiley +1 more source
Regiospecific Prenylation of Hydroxyxanthones by a Plant Flavonoid Prenyltransferase
, 2016 C-Prenylated xanthones are pharmacologically attractive specialized metabolites that are distributed in plants and microorganisms. The prenylation of xanthones often contributes to the structural diversity and biological activities of these compounds ...
Jianhua Li (36075) +7 more
core +1 more source
A chemical proteomic approach to investigate Rab prenylation in living systems [PDF]
, 2013 Protein prenylation is an important post-translational modification that occurs in all eukaryotes; defects in the prenylation machinery can lead to toxicity or pathogenesis.
Berry, Alexandra Fay Helen
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Veterinary ResearchLawsonia intracellularis, a Gram-negative obligate intracellular bacterium causing porcine proliferative enteropathy, possesses a type III secretion system (T3SS), yet only a handful of its substrates have been experimentally characterized. In this study,
Yuanxiu Zhong +4 more
doaj +1 more source
Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.A medicinal plant Eriosema glomeratum has potentially lead compounds, erioschalcones A and B, and their semisynthetic derivatives for drug discovery. ABSTRACT Plants are sources of compounds with benefits in human health and animal well‐being. Plant‐based foods may contain huge numbers of different phytochemicals.
Gaétan Tchangou Tabakam +1 more
wiley +1 more source
Biotechnologie, Agronomie, Société et Environnement, 2014 Protein prenylation in insects: a potential target for the development of bio-rational insecticides targeting the Lepidoptera?. Short-chain prenyltransferases (farnesyl diphosphate synthase [FPPS] and geranylgeranyl diphosphate synthase [GGPPS]) and ...
Barbar, A., Cusson, M.
doaj
Structural Basis of Tryptophan Reverse N‑Prenylation Catalyzed by CymD
, 2019 Indole prenyltransferases catalyze the prenylation of l-tryptophan (l-Trp) and other indoles to produce a diverse set of natural products in bacteria, fungi, and plants, many of which possess useful biological properties.
Benjamin W. Roose (6953287) +1 more
core +1 more source
Molecules, 2016 Arahypin-16 (1), a new prenylated resveratrol with a unique dihydrobenzofuran ring, has been isolated as a microbial metabolite of resveratrol (2) from whole-cell fermentation of Aspergillus sp. SCSIOW2.
Liyan Wang +4 more
doaj +1 more source