Results 91 to 100 of about 36,883 (221)
Amyloid-beta Causes Autophagy Dysfunction by Inhibiting Protein Prenylation
, 2016 There is ample evidence that autophagy is affected in Alzheimer’s disease (AD) but the causes, the nature of the dysfunction and the mechanisms of autophagy impairment are unclear.
Smith, Kevan Thomas
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The FEBS Journal, Volume 293, Issue 11, Page 3303-3319, June 2026.Characterization of anhydromevalonate phosphate decarboxylase, the UbiD‐family decarboxylase involved in the archaeal mevalonate pathway, was conducted. The enzyme is responsible for the biosynthesis of isoprenoids, such as archaeal membrane lipids, respiratory quinones, and dolichols.
Rino Ishikawa +9 more
wiley +1 more source
Biotechnologie, Agronomie, Société et Environnement, 2014 Protein prenylation in insects: a potential target for the development of bio-rational insecticides targeting the Lepidoptera?. Short-chain prenyltransferases (farnesyl diphosphate synthase [FPPS] and geranylgeranyl diphosphate synthase [GGPPS]) and ...
Barbar, A., Cusson, M.
doaj
Structural Basis of Tryptophan Reverse N‑Prenylation Catalyzed by CymD
, 2019 Indole prenyltransferases catalyze the prenylation of l-tryptophan (l-Trp) and other indoles to produce a diverse set of natural products in bacteria, fungi, and plants, many of which possess useful biological properties.
Benjamin W. Roose (6953287) +1 more
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Asymmetric Reduction of Unactivated Alkenes
Chemistry – A European Journal, Volume 32, Issue 18, 14 May 2026.Unactivated alkenes rank among the most inert functional groups in synthesis and their selective reduction remains challenging. This Review charts the evolution from classical metal‐catalyzed hydrogenation to radical hydrogen atom transfer (HAT) and emerging biocatalytic concepts, highlighting how complementary mechanistic strategies, including the ...
Nico D. Fessner +3 more
wiley +1 more source
Role for protein prenylation and CAAX processing in photoreceptor neurons
, 2016 The efficient folding, assembly and trafficking of phototransduction proteins from site of synthesis in the inner segment (IS) to the site of action in the outer segment (OS) is crucial for photoreceptor cell survival and function.
Pendse, Nachiket D.
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The chemical logic associated with assembly of many bacterial terpenoids remains poorly understood. We focused our efforts on the early-stage biosynthesis of the phenalinolactone diterpenoids, demonstrating that the anti/anti/syn-perhydrophenanthrene ...
Liao-Bin, Dong +8 more
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Inhibition of Protein Prenylation of GTPases Alters Endothelial Barrier Function
, 2019 The members of Rho family of GTPases, RhoA and Rac1 regulate endothelial cytoskeleton dynamics and hence barrier integrity. The spatial activities of these GTPases are regulated by post-translational prenylation. In the present study, we investigated the
Christian Troidl +5 more
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Probability distributions for prenylation and cleavage predictions made by SVM-ESM-1b.
, 2022 Probability distributions for both prenylation (A) and cleavage (B) determined for the training sets (top) and for all 8000 Cxxx motifs (bottom). A) For prenylation, the training set distribution is represented as a stacked bar plot where prenylated ...
Arnav Goyal (12936633) +6 more
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, 2022 The cholesterol biosynthesis represents a crucial metabolic pathway for cellular homeostasis. The end products of this pathway are sterols, such as cholesterol, which are essential components of cell membranes, precursors of steroid hormones, bile acids,
Elisabetta Melloni +15 more
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