Results 71 to 80 of about 44,008 (221)

Beyond the Mevalonate Pathway: Control of Post-Prenylation Processing by Mutant p53

Frontiers in Oncology, 2020
Missense mutations in the TP53 gene are among the most frequent alterations in human cancer. Consequently, many tumors show high expression of p53 point mutants, which may acquire novel activities that contribute to develop aggressive tumors.
Carla M Borini Etichetti, Evelyn Arel Zalazar, Nabila Cocordano, Javier Girardini   +3 more
doaj   +1 more source

G protein beta gamma subunits synthesized in Sf9 cells. Functional characterization and the significance of prenylation of gamma [PDF]

, 1992
Heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) consist of a nucleotide-binding alpha subunit and a high- affinity complex of beta and gamma subunits.
Gilman, Alfred G., Iñiguez-Lluhi, Jorge A., Robishaw, Janet D., Simon, Melvin I.   +3 more
core  

Comparative analysis of Drosophila and mammalian complexins as fusion clamps and facilitators of neurotransmitter release [PDF]

, 2010
The SNARE-binding protein complexin (Cpx) has been demonstrated to regulate synaptic vesicle fusion. Previous studies are consistent with Cpx functioning either as a synaptic vesicle fusion clamp to prevent premature exocytosis, or as a facilitator to ...
Cho, Richard W., Littleton, J. Troy, Song, Yun   +2 more
core   +1 more source

Shigella Effector VirA Suppresses Plant Immunity by Compromising PRA1.F3‐Dependent Accumulation of FLS2 at the Plasma Membrane

Plant, Cell &Environment, EarlyView.
ABSTRACT Surface immune receptors such as flagellin‐sensitive 2 (FLS2) are critical for plant defence, and their accumulation at the plasma membrane is tightly controlled by the endomembrane system. Here, we identify the Arabidopsis thaliana prenylated Rab acceptor PRA1.F3 as a positive regulator required for efficient accumulation of FLS2 at the ...
Sung Hee Jo, Sukyoung Jung, Myoung Hui Lee, Inhwan Hwang, Jeong Mee Park   +4 more
wiley   +1 more source

Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. [PDF]

, 2006
3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is a critical enzyme in the mevalonate pathway that regulates the biosynthesis of cholesterol as well as isoprenoids that mediate the membrane association of certain GTPases.
Dunn, Shannon E, Goldstein, Matthew J, Prod'homme, Thomas, Steinman, Lawrence, Weber, Martin S, Youssef, Sawsan, Zamvil, Scott S   +6 more
core   +1 more source

Targeting Protein Prenylation in Progeria [PDF]

Science Translational Medicine, 2013
Results of a recent clinical trial in children with Hutchinson-Gilford progeria spur scientists to consider new therapeutic strategies.
Stephen G, Young, Shao H, Yang, Brandon S J, Davies, Hea-Jin, Jung, Loren G, Fong   +4 more
openaire   +2 more sources

Umbelliprenin in Food and Medicinal Plants: Phytochemical Occurrence, Biosynthesis, Analytical Approaches, and Biological Activities

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
This review provides an extensive and critical synthesis of current knowledge on umbelliprenin, integrating phytochemical, analytical, biological, ecological, and food science perspectives, and identifies priorities for future research. ABSTRACT Umbelliprenin (7‐farnesyloxycoumarin) is an oxyprenylated coumarin that has gained increasing attention in ...
Chiara Collevecchio, Lorenzo Marchetti, Francesco Epifano, Salvatore Genovese, Serena Fiorito   +4 more
wiley   +1 more source

Antitumor Activity of Some Prenylated Xanthones

Pharmaceuticals, 2009
Pyranoxanthones 6-8 were obtained by dehydrogenation of the respective dihydropyranoxanthones 3-5 with DDQ in dry dioxane. Two prenylated xanthones 10,11 were obtained from the reaction of 1-hydroxyxanthone (9) with prenyl bromide in alkaline medium, or ...
Raquel A.P. Castanheiro, Artur M.S. Silva, Naïr A.N. Campos, Maria S.J. Nascimento, Madalena M.M. Pinto   +4 more
doaj   +1 more source

Prenylation inhibitors stimulate both estrogen receptor α transcriptional activity through AF-1 and AF-2 and estrogen receptor β transcriptional activity [PDF]

, 2005
INTRODUCTION: We showed in a previous study that prenylated proteins play a role in estradiol stimulation of proliferation. However, these proteins antagonize the ability of estrogen receptor (ER) alpha to stimulate estrogen response element (ERE ...
Z Weihua, P Webb, SM Cowley, S Ogawa, K Pettersson, R Reiter, Y Shang, CK Osborne, G Castoria, EK Lobenhofer, CW Wong, M Razandi, F Barletta, A Migliaccio, A Migliaccio, FL Zhang, SF Doisneau-Sixou, D Robyr, P Balaguer, V Kumar, ST Dillon, D Gagne, SF Doisneau-Sixou, LF Su, LF Su, MP Gaub, Y Umayahara, K Paech, MM Liu, J Adnane, CS Hill, PF Lebowitz, C Allal, G Fritz, M Razandi, PA Michaely, M Yamaga, C Giamarchi, P Maruvada, Z Nawaz, ME Engel, M Wherlock, P De Cremoux, W Du, D Rubino, A Avots, AS Alberts, SRD Johnston, SR Johnston, SM Sebti   +49 more
core   +2 more sources

GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling

British Journal of Pharmacology, Volume 183, Issue 11, Page 2619-2633, June 2026.
G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins.
Vsevolod V. Gurevich
wiley   +1 more source