Results 71 to 80 of about 38,918 (216)
Advances in Cytosolic dsRNA Sensing of Viral Infections
Immunology &Cell Biology, EarlyView.Activation of cytosolic dsRNA sensors by viral infection generates multiple outcomes. dsRNA generated during viral infection, either of viral origin or from endogenous sources, can activate multiple cytosolic dsRNA sensors. Activation of PKR critically induces protein translation shutdown via phosphorylation of eukaryotic translation initiation factor ...
Sofia Maceratessi, Natalia G. Sampaio
wiley +1 more source
, 2021 Protein prenylation is an important post-translational modification that regulates protein interactions, localizations, and signaling pathways in normal functioning of eukaryotic cells.
Saiful M. Chowdhury (1654066) +1 more
core +1 more source
Beyond the Mevalonate Pathway: Control of Post-Prenylation Processing by Mutant p53
Frontiers in Oncology, 2020 Missense mutations in the TP53 gene are among the most frequent alterations in human cancer. Consequently, many tumors show high expression of p53 point mutants, which may acquire novel activities that contribute to develop aggressive tumors.
Carla M Borini Etichetti +3 more
doaj +1 more source
Oral Surgery, EarlyView.ABSTRACT Background Osteonecrosis of the jaws is associated with various drugs, including antiresorptives such as bisphosphonates and denosumab, as well as antiangiogenics. These drugs are used for the treatment of multiple diseases, notably osteoporosis, bone metastases, Paget's disease, osteogenesis imperfecta, malignant hypocalcaemia, among others ...
Rodríguez Naranjo Julia Alexandra +3 more
wiley +1 more source
Role for protein prenylation and CAAX processing in photoreceptor neurons [PDF]
, 2016 The efficient folding, assembly and trafficking of phototransduction proteins from site of synthesis in the inner segment (IS) to the site of action in the outer segment (OS) is crucial for photoreceptor cell survival and function.
Pendse, Nachiket D.
core +1 more source
Antitumor Activity of Some Prenylated Xanthones
Pharmaceuticals, 2009 Pyranoxanthones 6-8 were obtained by dehydrogenation of the respective dihydropyranoxanthones 3-5 with DDQ in dry dioxane. Two prenylated xanthones 10,11 were obtained from the reaction of 1-hydroxyxanthone (9) with prenyl bromide in alkaline medium, or ...
Raquel A.P. Castanheiro +4 more
doaj +1 more source
Multiple Factors Contribute to Inefficient Prenylation of Rab27a in Rab Prenylation Diseases [PDF]
Journal of Biological Chemistry, 2003 Post-translational geranylgeranylation of Rab GT-Pases is essential for their membrane association and function as regulators of intracellular vesicular transport. The reaction is catalyzed by Rab geranylgeranyltransferase (RGGT) and is assisted by the Rab escort proteins (REP), which form stable complexes with newly synthesized GDP-bound Rabs.
Banafshé, Larijani +3 more
openaire +2 more sources
Periodontology 2000, EarlyView.Abstract Background/Aim Antiresorptive therapy represents a cornerstone in the management of osteoporosis and cancer‐related bone disease through suppression of osteoclast‐mediated bone resorption. As implant therapy becomes more common in aging populations, clinicians increasingly encounter patients receiving these medications, thus making their ...
Emilio A. Cafferata +2 more
wiley +1 more source
The Underexplored Mechanobiology of Lamin A Biogenesis and Homeostasis
Biology of the Cell, Volume 118, Issue 10, October 2026.We highlight current evidence, unresolved questions, and future directions, proposing that mechanical regulation of lamin A biogenesis represents an underexplored dimension of lamin mechanobiology with broad implications for development, aging, laminopathies, and mechanically driven diseases. ABSTRACT Lamin A is a major contributor to nuclear mechanics
Sandrine Fraboulet +2 more
wiley +1 more source
Defective Protein Prenylation in a Spectrum of Patients With Mevalonate Kinase Deficiency
Frontiers in Immunology, 2019 The rare autoinflammatory disease mevalonate kinase deficiency (MKD, which includes HIDS and mevalonic aciduria) is caused by recessive, pathogenic variants in the MVK gene encoding mevalonate kinase.
Marcia A. Munoz +10 more
doaj +1 more source