Results 51 to 60 of about 38,918 (216)
Catalytic Mechanism of Aromatic Prenylation by NphB
, 2016 NphB is an aromatic prenyltransferase that catalyzes the attachment of a 10-carbon geranyl group to aromatic substrates. Importantly, NphB exhibits a rich substrate selectivity and product regioselectivity.
Yue Yang (52715) +4 more
core +1 more source
eLife, 2021 UbiA prenyltransferase domain-containing protein-1 (UBIAD1) utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize the vitamin K2 subtype menaquinone-4. The prenyltransferase has emerged as a key regulator of sterol-accelerated, endoplasmic reticulum
Rania Elsabrouty +4 more
doaj +1 more source
A basidomycetous hydroxynaphthalene-prenylating enzyme exhibits promiscuity toward prenyl donors
Applied Microbiology and Biotechnology, 2023 Abstract The fungal prenyltransferase ShPT from Stereum hirsutum was believed to prenylate 4-hydroxybenzyl alcohol and thereby be involved in the vibralactone biosynthesis. In this study, we demonstrate that hydroxynaphthalenes instead of benzyl alcohol or aldehyde were accepted by ShPT for regular C-prenylation in the ...
Andreas Martin +3 more
openaire +2 more sources
European Journal of Organic Chemistry, EarlyView.A simple, modular, and unified strategy for the synthesis of reverse‐prenylated hexahydropyrrolo indole alkaloids has been developed. An unusual retrosynthetic disconnection allows for the late introduction of a side chain, which distinguishes many members of this class of natural products.
Daniel Schmelzer +2 more
wiley +1 more source
Multisite Prenylation of 4‑Substituted Tryptophans by Dimethylallyltryptophan Synthase
, 2016 The aromatic prenyltransferase dimethylallyltryptophan synthase in Claviceps purpurea catalyzes the normal prenylation of tryptophan at C4 of the indole nucleus in the first committed step of ergot alkaloid biosynthesis.
Jeffrey D. Rudolf (1328910) +2 more
core +1 more source
Communicative & Integrative Biology, 2017 Cells are powerful miniature electrophoresis chambers, at least during part of their life cycle. They die at the moment the voltage gradient over their plasma membrane, and their ability to drive a self-generated electric current carried by inorganic ...
Arnold De Loof
doaj +1 more source
Group IVC cytosolic phospholipase A2γ is farnesylated and palmitoylated in mammalian cells
Journal of Lipid Research, 2005 Cytosolic phospholipase A2γ (cPLA2γ) is a member of the group IV family of intracellular phospholipase A2 enzymes, but unlike the well-studied cPLA2α, it is constitutively bound to membrane and is calcium independent.
Dawn E. Tucker +6 more
doaj +1 more source
Increased RhoA prenylation in the loechrig (loe) mutant leads to progressive neurodegeneration. [PDF]
PLoS ONE, 2012 The Drosophila mutant loechrig (loe) shows age-dependent degeneration of the nervous system and is caused by the loss of a neuronal isoform of the AMP-activated protein kinase (AMPK) γ-subunit (also known as SNF4Aγ).
Mandy Cook +3 more
doaj +1 more source
The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1
The FEBS Journal, EarlyView.ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu +2 more
wiley +1 more source
RhoGDI facilitates geranylgeranyltransferase-I-mediated RhoA prenylation
, 2014 Protein prenylation is a post-translational modification where farnesyl or geranylgeranyl groups are enzymatically attached to a C-terminal cysteine residue.
Abankwa, Daniel +2 more
core +1 more source