Results 31 to 40 of about 35,022 (176)

C-terminus Proteolysis and Palmitoylation Cooperate for Optimal Plasma Membrane Localization of RasA in Aspergillus fumigatus

Frontiers in Microbiology, 2018
RasA is a major regulator of fungal morphogenesis and virulence in Aspergillus fumigatus. The proper localization of RasA to the plasma membrane is essential for the formation of invasive hyphae during infection.
Qusai Al Abdallah, Adela Martin-Vicente, Ana Camila Oliveira Souza, Wenbo Ge, Jarrod R. Fortwendel   +4 more
doaj   +1 more source

Photoredox-catalyzed diastereoselective dearomative prenylation and reverse-prenylation of electron-deficient indole derivatives

Nature Communications, 2023
Prenylated and reverse-prenylated indolines are privileged scaffolds in numerous naturally occurring indole alkaloids with a broad spectrum of important biological properties.
Xuexue Chang, Fangqing Zhang, Shibo Zhu, Zhuang Yang, Xiaoming Feng, Yangbin Liu   +5 more
doaj   +1 more source

Advances in protein–polyphenol complexation: Unraveling mechanisms, modulation, and functional outcomes

Food Biomacromolecules, EarlyView.
Abstract Polyphenolic compounds have attracted increasing market demand and extensive attention due to their potential health benefits and bioactivities. Meanwhile, proteins are widely used in the food industry for their nutritional and functional properties. However, the application of proteins in the food industry is often limited by challenges, such
Fang Li, Ziming Xu, Tian Zhao, Gongshuai Song, Danli Wang, Tinglan Yuan, Ling Li, Jinyan Gong   +7 more
wiley   +1 more source

The prenylated pUS2 protein of pseudorabies virus contributes to phosphorylation of connexin 43 and suppression of gap junctional intercellular communication

Journal of Virology
Gap junctional intercellular communication (GJIC) enables the direct transfer of signaling molecules between neighboring cells and plays an important role in innate antiviral immunity by facilitating bystander defense responses. We previously showed that
Alexander Tishchenko, Benjamin De Boeck, Cliff Van Waesberghe, Fien van Raemdonck, Walter Fuchs, Barbara G. Klupp, Thomas C. Mettenleiter, Oliver Vickman, Gregory A. Smith, Herman W. Favoreel   +9 more
doaj   +1 more source

Calcitox-aging counterbalanced by endogenous farnesol-like sesquiterpenoids: An undervalued evolutionarily ancient key signaling pathway

Communicative & Integrative Biology, 2017
Cells are powerful miniature electrophoresis chambers, at least during part of their life cycle. They die at the moment the voltage gradient over their plasma membrane, and their ability to drive a self-generated electric current carried by inorganic ...
Arnold De Loof
doaj   +1 more source

Type 1 polyisoprenoid diphosphate phosphatase modulates geranylgeranyl-mediated control of HMG CoA reductase and UBIAD1

eLife, 2021
UbiA prenyltransferase domain-containing protein-1 (UBIAD1) utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize the vitamin K2 subtype menaquinone-4. The prenyltransferase has emerged as a key regulator of sterol-accelerated, endoplasmic reticulum
Rania Elsabrouty, Youngah Jo, Seonghwan Hwang, Dong-Jae Jun, Russell A DeBose-Boyd   +4 more
doaj   +1 more source

The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1

The FEBS Journal, EarlyView.
ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu, Maximilian J. L. J. Fürst, Oscar P. Kuipers   +2 more
wiley   +1 more source

Differential requirements of protein geranylgeranylation for the virulence of human pathogenic fungi

Virulence, 2019
Protein prenylation is a crucial post-translational modification largely mediated by two heterodimeric enzyme complexes, farnesyltransferase and geranylgeranyltransferase type-I (GGTase-I), each composed of a shared α-subunit and a unique β-subunit ...
Ana Camila Oliveira Souza, Qusai Al Abdallah, Kaci DeJarnette, Adela Martin-Vicente, Ashley V. Nywening, Christian DeJarnette, Emily A. Sansevere, Wenbo Ge, Glen E. Palmer, Jarrod R Fortwendel   +9 more
doaj   +1 more source

Group IVC cytosolic phospholipase A2γ is farnesylated and palmitoylated in mammalian cells

Journal of Lipid Research, 2005
Cytosolic phospholipase A2γ (cPLA2γ) is a member of the group IV family of intracellular phospholipase A2 enzymes, but unlike the well-studied cPLA2α, it is constitutively bound to membrane and is calcium independent.
Dawn E. Tucker, Allison Stewart, Laxman Nallan, Pravine Bendale, Farideh Ghomashchi, Michael H. Gelb, Christina C. Leslie   +6 more
doaj   +1 more source

Increased RhoA prenylation in the loechrig (loe) mutant leads to progressive neurodegeneration. [PDF]

PLoS ONE, 2012
The Drosophila mutant loechrig (loe) shows age-dependent degeneration of the nervous system and is caused by the loss of a neuronal isoform of the AMP-activated protein kinase (AMPK) γ-subunit (also known as SNF4Aγ).
Mandy Cook, Priya Mani, Jill S Wentzell, Doris Kretzschmar   +3 more
doaj   +1 more source