Results 31 to 40 of about 38,918 (216)

K-Ras prenylation as a potential anticancer target [PDF]

, 2020
KRAS is one of the most commonly mutated oncogene and a negative predictive factor for a number of targeted therapies. Therefore, the development of targeting strategies against mutant KRAS is urgently needed.
Baranyi, Marcell, Hegedűs, Balázs, Buday, László   +2 more
core   +1 more source

Prenylation inhibitors in renal disease

, 2000
Members of the superfamily of Ras GTPase signalling proteins (monomeric G proteins) require post-translational carboxy-terminal prenylation to function.
John O Connolly, Arif Khwaja, Hendry, B M, Bruce M Hendry, Connolly, J O, Khwaja, A   +5 more
core   +1 more source

Inhibition of protein prenylation by patulin [PDF]

, 1993
The antibiotic patulin was found to inhibit protein prenylation in mouse FM3A cells. Thus, the agent reduced incorporation of [3H]mevalonate into proteins by 50% at a concentration of 7 μM.
Hasumi, Keiji, Keiji Hasumi, Endo, Akira, Miura, Shinji, Shinji Miura, Akira Endo   +5 more
core   +1 more source

Profiling protein prenylation using a quantitative chemical proteomics approach [PDF]

, 2017
Prenylation, the attachment of a farnesyl or geranylgeranyl isoprenoid to a C-terminal cysteine, is a post-translational modification which modulates localisation and function of key proteins such as members of the RAS superfamily, nuclear lamins and ...
Storck Saha, Elisabeth
core   +1 more source

Updates on protein-prenylation and associated inherited retinopathies

Frontiers in Ophthalmology
Membrane-anchored proteins play critical roles in cell signaling, cellular architecture, and membrane biology. Hydrophilic proteins are post-translationally modified by a diverse range of lipid molecules such as phospholipids ...
Sudhat Ashok, Sriganesh Ramachandra Rao, Sriganesh Ramachandra Rao, Sriganesh Ramachandra Rao   +3 more
doaj   +1 more source

Atorvastatin-mediated inhibition of prenylation of Rab27b and Rap1a in platelets attenuates their prothrombotic capacity and modulates clot structure

Platelets, 2023
Statins inhibit the mevalonate pathway by impairing protein prenylation via depletion of lipid geranylgeranyl diphosphate (GGPP). Rab27b and Rap1a are small GTPase proteins involved in dense granule secretion, platelet activation, and regulation.
Mohammed M Jalal, Claire S Whyte, Fraser P Coxon, Nicola J Mutch   +3 more
doaj   +1 more source

Thematic review series: Lipid Posttranslational Modifications. Lysosomal metabolism of lipid-modified proteins

Journal of Lipid Research, 2006
Much is now understood concerning the synthesis of prenylated and palmitoylated proteins, but what is known of their metabolic fate? This review details metabolic pathways for the lysosomal degradation of S-fatty acylated and prenylated proteins. Central
Jui-Yun Lu, Sandra L. Hofmann
doaj   +1 more source

Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation. [PDF]

PLoS ONE, 2012
Statins such as simvastatin are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors and standard therapy for the prevention and treatment of cardiovascular diseases in mammals.
Stephen R Spindler, Rui Li, Joseph M Dhahbi, Amy Yamakawa, Patricia Mote, Rolf Bodmer, Karen Ocorr, Renee T Williams, Yinsheng Wang, Kenneth P Ablao   +9 more
doaj   +1 more source

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

Advanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen, Zhiquan Liu, Wenmin Wang, Qing Wang, Tia J. Kowal, Fan Zhang, Grzegorz Walkiewicz, Faruk Hossen, Herbert M. Lachman, Jinqiong Zhou, Yiting Wang, Yang Sun   +11 more
wiley   +1 more source

Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases [PDF]

, 2016
Mevalonate kinase deficiency (MKD) is caused by mutations in a key enzyme of the mevalonate-cholesterol biosynthesis pathway, leading to recurrent autoinflammatory disease characterised by enhanced release of interleukin-1β (IL-1β).
Rogers, MJ ; https://orcid.org/, Quinn, JMW ; https://orcid.org/, Brown, AJ ; https://orcid.org/, Ali, N, Skinner, OP ; https://orcid.org/, Jurczyluk, J, Argent, E, Tangye, SG ; https://orcid.org/, Mehr, S, Chai, RC ; https://orcid.org/, Preston, A, Munoz, MA ; https://orcid.org/, Palendira, U, Ziegler, JB ; https://orcid.org/   +13 more
core   +2 more sources