Results 31 to 40 of about 36,883 (221)
Summary of prenylation and cleavage predictions.
, 2022 Summary of prenylation and cleavage predictions.
Arnav Goyal (12936633) +6 more
core +1 more source
Molecular Therapy: Methods & Clinical Development, 2018 Choroideremia (CHM) is a rare, X-linked recessive retinal dystrophy caused by mutations in the CHM gene. CHM is ubiquitously expressed in human cells and encodes Rab escort protein 1 (REP1).
Maria I. Patrício +4 more
doaj +1 more source
Prenylated Rab Acceptor Protein Is a Receptor for Prenylated Small GTPases [PDF]
Journal of Biological Chemistry, 2001 Localization of Ras and Ras-like proteins to the correct subcellular compartment is essential for these proteins to mediate their biological effects. Many members of the Ras superfamily (Ha-Ras, N-Ras, TC21, and RhoA) are prenylated in the cytoplasm and then transit through the endomembrane system on their way to the plasma membrane.
C, Figueroa, J, Taylor, A B, Vojtek
openaire +2 more sources
Frontiers in Cellular and Infection Microbiology, 2010 The Dot/Icm type IV translocated Ankyrin B (AnkB) effector of Legionella pneumophila is modified by the host prenylation machinery that anchors it into the outer leaflet of the Legionella-containing vacuole (LCV), which is essential for biological ...
Christopher T Price +3 more
doaj +1 more source
Performance of various models for prenylation prediction.
, 2022 Performance of various models for prenylation prediction.
Arnav Goyal (12936633) +6 more
core +1 more source
Molecules, 2022 Herein, we report the use of the Suzuki–Miyaura cross-coupling reaction for the preparation of a library of synthetic derivatives of flavonoids for biological activity assays.
Martina Hurtová +5 more
doaj +1 more source
K-Ras prenylation as a potential anticancer target [PDF]
, 2020 KRAS is one of the most commonly mutated oncogene and a negative predictive factor for a number of targeted therapies. Therefore, the development of targeting strategies against mutant KRAS is urgently needed.
Baranyi, Marcell +2 more
core +1 more source
Beilstein Journal of Organic Chemistry, 2015 The hemisynthesis of the naturally occurring bioactive flavonoid glycoside icariin (1) has been accomplished in eleven steps with 7% overall yield from kaempferol.
Qinggang Mei +4 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2022 Aromatic prenylated metabolites have important biological roles and activities in all living organisms. Compared to their importance in all domains of life, we know relatively little about their substrate scopes and metabolic functions. Here, we describe
Jamshid Amiri Moghaddam +4 more
doaj +1 more source
Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics [PDF]
, 2019 Post-translational farnesylation or geranylgeranylation at a C-terminal cysteine residue regulates the localization and function of over 100 proteins, including the Ras isoforms, and is a therapeutic target in diseases including cancer and infection ...
Thomas Lanyon-Hogg +28 more
core +1 more source