Results 21 to 30 of about 38,918 (216)

Nuclear Morphological Remodeling in Human Granulocytes Is Linked to Prenylation Independently from Cytoskeleton

Cells, 2020
Nuclear shape modulates cell behavior and function, while aberrant nuclear morphologies correlate with pathological phenotype severity. Nevertheless, functions of specific nuclear morphological features and underlying molecular mechanisms remain poorly ...
Sebastian Martewicz, Camilla Luni, Xi Zhu, Meihua Cui, Manli Hu, Siqi Qu, Damiano Buratto, Guang Yang, Eleonora Grespan, Nicola Elvassore   +9 more
doaj   +1 more source

Summary of prenylation and cleavage predictions.

, 2022
Summary of prenylation and cleavage predictions.
Arnav Goyal (12936633), Emily R. Hildebrandt (8554752), Walter K. Schmidt (1907722), Wayland Yeung (4475101), Brittany M. Berger (5738523), Natarajan Kannan (41300), Zhongliang Zhou (553212)   +6 more
core   +1 more source

Farnesyltransferase Enables Modular Assembly of Dual‐Functional Nanobody Conjugates for in Vivo Imaging of Inflammation

Angewandte Chemie, EarlyView.
A modular farnesyltransferase‐based chemoenzymatic platform enables fast, site‐specific labeling of nanobodies for PET imaging of inflammation. CD11b‐targeted PET agents selectively image myeloid‐driven inflammation, while CD45‐targeted PET agents provide sensitive whole‐body immune mapping.
Sneha Venkatachalapathy, Yoon Ho Lee, Ali Salehi Farid, Heydar Moravej, Sina Djafari Rouhani, Jennifer E. Rowley, Mohammad Rashidian, Mark D. Distefano   +7 more
wiley   +2 more sources

Host-mediated post-translational prenylation of novel Dot/Icm-translocated effectors of Legionella pneumophila

Frontiers in Cellular and Infection Microbiology, 2010
The Dot/Icm type IV translocated Ankyrin B (AnkB) effector of Legionella pneumophila is modified by the host prenylation machinery that anchors it into the outer leaflet of the Legionella-containing vacuole (LCV), which is essential for biological ...
Christopher T Price, Snake C Jones, Karen E Amundson, Yousef eAbu Kwaik   +3 more
doaj   +1 more source

Multiple domain insertions and losses in the evolution of the Rab prenylation complex

BMC Evolutionary Biology, 2007
Background Rab proteins are regulators of vesicular trafficking, requiring a lipid modification for proper function, prenylation of C-terminal cysteines.
Pereira-Leal Jose B, Rasteiro Rita
doaj   +1 more source

Preparation of Synthetic and Natural Derivatives of Flavonoids Using Suzuki–Miyaura Cross-Coupling Reaction

Molecules, 2022
Herein, we report the use of the Suzuki–Miyaura cross-coupling reaction for the preparation of a library of synthetic derivatives of flavonoids for biological activity assays.
Martina Hurtová, David Biedermann, Zuzana Osifová, Josef Cvačka, Kateřina Valentová, Vladimír Křen   +5 more
doaj   +1 more source

Performance of various models for prenylation prediction.

, 2022
Performance of various models for prenylation prediction.
Arnav Goyal (12936633), Emily R. Hildebrandt (8554752), Walter K. Schmidt (1907722), Wayland Yeung (4475101), Brittany M. Berger (5738523), Natarajan Kannan (41300), Zhongliang Zhou (553212)   +6 more
core   +1 more source

Synthesis of icariin from kaempferol through regioselective methylation and para-Claisen–Cope rearrangement

Beilstein Journal of Organic Chemistry, 2015
The hemisynthesis of the naturally occurring bioactive flavonoid glycoside icariin (1) has been accomplished in eleven steps with 7% overall yield from kaempferol.
Qinggang Mei, Chun Wang, Zhigang Zhao, Weicheng Yuan, Guolin Zhang   +4 more
doaj   +1 more source

Identification of the new prenyltransferase Ubi-297 from marine bacteria and elucidation of its substrate specificity

Beilstein Journal of Organic Chemistry, 2022
Aromatic prenylated metabolites have important biological roles and activities in all living organisms. Compared to their importance in all domains of life, we know relatively little about their substrate scopes and metabolic functions. Here, we describe
Jamshid Amiri Moghaddam, Huijuan Guo, Karsten Willing, Thomas Wichard, Christine Beemelmanns   +4 more
doaj   +1 more source

Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics [PDF]

, 2019
Post-translational farnesylation or geranylgeranylation at a C-terminal cysteine residue regulates the localization and function of over 100 proteins, including the Ras isoforms, and is a therapeutic target in diseases including cancer and infection ...
Thomas Lanyon-Hogg, Tate, Edward, Ventimiglia, Leandro N., Storck Saha, Elisabeth, Morales Sanfrutos, julia, Panyain, nattawasdee, Tolmachova, Tanya, Edward W. Tate, Seabra, Miguel C., Panyain, Nattawadee, Beata Wojciak-Stothard, Juan Martin-Serrano, Martin-Serrano, Juan, Morales-Sanfrutos, Julia, Ventimiglia, Leandro, Lanyon-Hogg, thomas, Julia Morales-Sanfrutos, Nattawadee Panyain, Miguel C. Seabra, Leandro N. Ventimiglia, Tate, Edward W., Wojciak-Stothard, Beata, Tanya Tolmachova, Storck, Elisabeth M., Serwa, Remigiusz A., Seabra, Miguel, Serwa, remigiusz, Remigiusz A. Serwa, Elisabeth M. Storck   +28 more
core   +1 more source