Results 21 to 30 of about 44,008 (221)
Tocopherol and plastoquinone synthesis in spinach chloroplasts subfractions [PDF]
, 1980 Subfractions isolated from intact purified spinach chloroplasts are able to prenylate the aromatic moiety of -tocopherol and plastoquinone-9 precursors. The biosynthesis of -tocopherol and plastoquinone-9 is a compartmentalized process.
Bickel +21 more
core +1 more source
Molecular Therapy: Methods & Clinical Development, 2018 Choroideremia (CHM) is a rare, X-linked recessive retinal dystrophy caused by mutations in the CHM gene. CHM is ubiquitously expressed in human cells and encodes Rab escort protein 1 (REP1).
Maria I. Patrício +4 more
doaj +1 more source
Site of Prenylation Reaction in Synthesis of Phylloquinone (Vitamin K1) by Spinach Chloroplasts [PDF]
, 1981 In spinach chloroplasts, 1,4-dihydroxy-2-naphthoate is prenylated by phytyldiphosphate and subsequently methylated by S-adenosylmethionine to form phylloquinol.
Baldwin +22 more
core +1 more source
Regulation of protein prenylation
Biomedicine & Pharmacotherapy, 2023 Prenyltransferases (PTases) are known to play a role in embryonic development, normal tissue homeostasis and cancer by posttranslationally modifying proteins involved in these processes. They are being discussed as potential drug targets in an increasing number of diseases, ranging from Alzheimer's disease to malaria.
Dominik Jung, Hagen S. Bachmann
openaire +2 more sources
Frontiers in Cellular and Infection Microbiology, 2010 The Dot/Icm type IV translocated Ankyrin B (AnkB) effector of Legionella pneumophila is modified by the host prenylation machinery that anchors it into the outer leaflet of the Legionella-containing vacuole (LCV), which is essential for biological ...
Christopher T Price +3 more
doaj +1 more source
A basidomycetous hydroxynaphthalene-prenylating enzyme exhibits promiscuity toward prenyl donors
Applied Microbiology and Biotechnology, 2023 Abstract The fungal prenyltransferase ShPT from Stereum hirsutum was believed to prenylate 4-hydroxybenzyl alcohol and thereby be involved in the vibralactone biosynthesis. In this study, we demonstrate that hydroxynaphthalenes instead of benzyl alcohol or aldehyde were accepted by ShPT for regular C-prenylation in the ...
Andreas Martin +3 more
openaire +2 more sources
Multiple domain insertions and losses in the evolution of the Rab prenylation complex
BMC Evolutionary Biology, 2007 Background Rab proteins are regulators of vesicular trafficking, requiring a lipid modification for proper function, prenylation of C-terminal cysteines.
Pereira-Leal Jose B, Rasteiro Rita
doaj +1 more source
Molecules, 2022 Herein, we report the use of the Suzuki–Miyaura cross-coupling reaction for the preparation of a library of synthetic derivatives of flavonoids for biological activity assays.
Martina Hurtová +5 more
doaj +1 more source
Agonistic and antagonistic estrogens in licorice root (Glycyrrhiza glabra) [PDF]
, 2011 The roots of licorice (Glycyrrhiza glabra) are a rich source of flavonoids, in particular, prenylated flavonoids, such as the isoflavan glabridin and the isoflavene glabrene.
Bovee, T.F.H. +7 more
core +2 more sources
Beilstein Journal of Organic Chemistry, 2015 The hemisynthesis of the naturally occurring bioactive flavonoid glycoside icariin (1) has been accomplished in eleven steps with 7% overall yield from kaempferol.
Qinggang Mei +4 more
doaj +1 more source