Results 81 to 90 of about 3,663 (218)

Mitochondrial damage and cholesterol storage in human hepatocellular carcinoma cells with silencing of UBIAD1 gene expression

Molecular Genetics and Metabolism Reports, 2014
Heterozygous mutations in the UBIAD1 gene cause Schnyder corneal dystrophy characterized by abnormal cholesterol and phospholipid deposits in the cornea.
Carlos R. Morales, Lubov S. Grigoryeva, Xuefang Pan, Luigi Bruno, Gilles Hickson, Michael H. Ngo, Christopher R. McMaster, Mark E. Samuels, Alexey V. Pshezhetsky   +8 more
doaj   +1 more source

Catalytic Potential of Cannabis Prenyltransferase to Expand Cannabinoid Scaffold Diversity

, 2023
Biologically active cannabinoids are derived from cannabigerolic acid (CBGA), which is biosynthesized by aromatic prenyltransferase CsPT4. We exploit the catalytic versatility of CsPT4 to synthesize various CBGA analogues, including a geranylated ...
Ryosuke Tanaya (17456819), Yuan-E Lee (11873209), Hironobu Takahashi (145499), Suresh Awale (2020432), Futoshi Taura (5403), Takeshi Kodama (1470661), Takuya Ito (57473), Tetsuro Shinada (1267575), Hiroyuki Morita (505542), Yoko Yasuno (8702841)   +9 more
core   +1 more source

Structural and functional insights into TBC1D17 highlight the importance of the previously uncharacterized Rab‐binding domain

Protein Science, Volume 35, Issue 5, May 2026.
Abstract TBC (Tre2/Bub2/Cdc16) domain‐containing proteins constitute the widespread family of GTPase‐activating proteins (GAPs). They interact with the Rab superfamily of small GTPases, stimulate GTP hydrolysis, and regulate vesicle trafficking. TBC1D17, involved in Shiga toxin trafficking, autophagy and glucose metabolism regulation, constitutes an ...
Dominika Nielipińska, Marta Orlikowska, Maciej Nielipiński, Bartosz Sekuła, Katarzyna M. Błażewska, Edyta Gendaszewska‐Darmach, Agnieszka J. Pietrzyk‐Brzezińska   +6 more
wiley   +1 more source

Protein Prenyltransferases and Their Inhibitors: Structural and Functional Characterization

International Journal of Molecular Sciences, 2022
Protein prenylation is a post-translational modification controlling the localization, activity, and protein–protein interactions of small GTPases, including the Ras superfamily. This covalent attachment of either a farnesyl (15 carbon) or a geranylgeranyl (20 carbon) isoprenoid group is catalyzed by four prenyltransferases, namely farnesyltransferase (
Aleksandra Marchwicka, Daria Kamińska, Mohsen Monirialamdari, Katarzyna M. Błażewska, Edyta Gendaszewska-Darmach   +4 more
openaire   +2 more sources

Measurement of the α-Secondary Kinetic Isotope Effect for a Prenyltransferase by MALDI Mass Spectrometry

, 2016
Measurement of the α-Secondary Kinetic Isotope Effect for a Prenyltransferase by MALDI Mass ...
Valerie A. Weller (3004026), Mark D. Distefano (559344)   +1 more
core   +1 more source

Indole C6 Functionalization of Tryprostatin B Using Prenyltransferase CdpNPT

, 2020
Tryprostatin A and B are prenylated, tryptophan-containing, diketopiperazine natural products, displaying cytotoxic activity through different mechanisms of action.
Anthony W. Burgett, Shanteri Singh, Sara M. Brown, Eric D. Gardner, Matthew C. Finneran, Dustin A. Dimas   +5 more
core   +1 more source

Mechanism of Dimethylallyltryptophan Synthase: Evidence for a Dimethylallyl Cation Intermediate in an Aromatic Prenyltransferase Reaction

, 2016
Mechanism of Dimethylallyltryptophan Synthase: Evidence for a Dimethylallyl Cation Intermediate in an Aromatic Prenyltransferase ...
Martin E. Tanner (1443997), Louis Y. P. Luk (1303959)   +1 more
core   +1 more source

cDNA cloning of a prenyltransferase from the medicinal plant Hypericum perforatum [PDF]

, 2009
Das Johanniskraut (Hypericum perforatum L.) ist eine alte Heilpflanze, deren Extrakte in der antidepressiven Therapie zum Einsatz kommen. Der Hauptinhaltsstoff ist das polyprenylierte bizyklische Acylphloroglucinol-Derivat Hyperforin.
Kühle, Susanne
core   +1 more source

A Novel Dual‐Target Compound Designed With Potent Herbicidal and Fungicidal Activity Inspired by Conserved Phytoene Synthase Domains

Plant Biotechnology Journal, Volume 24, Issue 5, Page 2903-2913, May 2026.
ABSTRACT The development of dual‐target inhibitors represents a cost‐effective strategy for integrated pest management. Here, we report the first dual‐target inhibitors designed against the evolutionarily conserved domain of phytoene synthase (PSY), a key enzyme in carotenoid biosynthesis.
Di Zhang, Liang Li, Chunxue Wang, Nuo Zhou, Zhilei Yu, Tianyi Shen, Baifan Wang, Qiang Bian, Dejun Ma, Yucheng Gu, Han Xu, Zhen Xi   +11 more
wiley   +1 more source

Chromosome‐Scale Haplotype Genome Assemblies for the Australian Mango ‘Kensington Pride’ and a Wild Relative, Mangifera laurina, Provide Insights Into Anthracnose‐Resistance and Volatile Compound Biosynthesis Genes

Plant Biotechnology Journal, Volume 24, Issue 5, Page 3172-3188, May 2026.
ABSTRACT Mango (Mangifera indica) is one of the most popular fruits cultivated in tropical and subtropical regions of the world. The availability of reference genomes helps to identify the genetic basis of important traits. Here, we report assembled high‐quality chromosome‐level genomes for the Australian mango cultivar ‘Kensington Pride’ and M ...
Upendra Kumari Wijesundara, Agnelo Furtado, Ardashir Kharabian Masouleh, Natalie L. Dillon, Heather E. Smyth, Robert J. Henry   +5 more
wiley   +1 more source