Results 21 to 30 of about 3,663 (218)

Study of Terpenoid Synthesis and Prenyltransferase in Roots of Rehmannia glutinosa Based on iTRAQ Quantitative Proteomics

Frontiers in Plant Science, 2021
Rehmannia glutinosa has important medicinal value; terpenoid is one of the main active components in R. glutinosa. In this study, iTRAQ technique was used to analyze the relative abundance of proteins in roots of R. glutinosa, and 6,752 reliable proteins
Peilei Chen, Xiaoyan Wei, Qianting Qi, Wenjing Jia, Mingwei Zhao, Huina Wang, Yanqing Zhou, Hongying Duan   +7 more
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The discovery of a key prenyltransferase gene assisted by a chromosome-level Epimedium pubescens genome

Frontiers in Plant Science, 2022
Epimedium pubescens is a species of the family Berberidaceae in the basal eudicot lineage, and a main plant source for the traditional Chinese medicine “Herba Epimedii”. The current study achieved a chromosome-level genome assembly of E.
Guoan Shen, Yanjiao Luo, Yanjiao Luo, Yu Yao, Guoqing Meng, Guoqing Meng, Yixin Zhang, Yuanyue Wang, Chaoqun Xu, Xiang Liu, Xiang Liu, Cheng Zhang, Cheng Zhang, Gang Ding, Yongzhen Pang, Hui Zhang, Baolin Guo   +16 more
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Artificial substrates for prenyltransferase [PDF]

Biochemical Journal, 1969
Four out of 16 new allylic pyrophosphates synthesized were found to be artificial substrates for liver prenyltransferase (EC 2.5.1.1). These were the trans-and the cis-3-ethyl-3-methylallyl, the 3,3-diethylallyl and the (mixture of cis and trans) 3-methyl-3-n-propylallyl pyrophosphates.
G, Popják, J L, Rabinowitz, J M, Baron
openaire   +2 more sources

Genome-Inspired Chemical Exploration of Marine Fungus Aspergillus fumigatus MF071

Marine Drugs, 2020
The marine-derived fungus Aspergillus fumigatus MF071, isolated from sediment collected from the Bohai Sea, China, yielded two new compounds 19S,20-epoxy-18-oxotryprostatin A (1) and 20-hydroxy-18-oxotryprostatin A (2), in addition to 28 known compounds (
Jianying Han, Miaomiao Liu, Ian D. Jenkins, Xueting Liu, Lixin Zhang, Ronald J. Quinn, Yunjiang Feng   +6 more
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Development of Artificial Synthetic Pathway of Endophenazines in Pseudomonas chlororaphis P3

Biology, 2022
Endophenazine A is a terpenoid phenazine with phenazine-1-carboxylic acid (PCA), and dimethylallyl diphosphate (DMAPP) derived from the 2-methyl-D-erythritol-4-phosphate (MEP) pathway as the precursor, which shows good antimicrobial activity against ...
Ying Liu, Shengjie Yue, Muhammad Bilal, Malik Jan, Wei Wang, Hongbo Hu, Xuehong Zhang   +6 more
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C7-Prenylation of Tryptophan-Containing Cyclic Dipeptides by 7-Dimethylallyl Tryptophan Synthase Significantly Increases the Anticancer and Antimicrobial Activities

Molecules, 2020
Prenylated natural products have interesting pharmacological properties and prenylation reactions play crucial roles in controlling the activities of biomolecules.
Rui Liu, Hongchi Zhang, Weiqiang Wu, Hui Li, Zhipeng An, Feng Zhou   +5 more
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LaPT2 Gene Encodes a Flavonoid Prenyltransferase in White Lupin

Frontiers in Plant Science, 2021
Legume plants are rich in prenylated flavonoid compounds, which play an important role in plant defense and human health. In the present study, we identified a prenyltransferase (PT) gene, named LaPT2, in white lupin (Lupinus albus), which shows a high ...
Jinyue Liu, Jinyue Liu, Jinyue Liu, Yaying Xia, Yaying Xia, Yaying Xia, Wenbo Jiang, Guoan Shen, Yongzhen Pang   +8 more
doaj   +1 more source

Structure, mechanism and function of prenyltransferases [PDF]

European Journal of Biochemistry, 2002
In this review, we summarize recent progress in studying three main classes of prenyltransferases: (a) isoprenyl pyrophosphate synthases (IPPSs), which catalyze chain elongation of allylic pyrophosphate substrates via consecutive condensation reactions with isopentenyl pyrophosphate (IPP) to generate linear polymers with defined chain lengths; (b ...
Po-Huang, Liang, Tzu-Ping, Ko, Andrew H-J, Wang   +2 more
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LimF is a versatile prenyltransferase catalyzing histidine-C-geranylation on diverse nonnatural substrates

, 2021
Prenylation plays an important role in diversifying structure and function of secondary metabolites. Although several cyanobactin prenyltransferases have been characterized, their modes of action are mainly limited to the modification of electron-rich ...
Masayuki, Satake, Dinh Thanh , Nguyen, Hiroaki, Suga, Keisuke , Hamada, Shunsuke , Kobayashi, Chikako, Okada, Yuki, Goto, Yuchen, Zhang, Kazuhiro, Ogata, Masahiro, Okada, Sumika, Inoue, Toru, Sengoku   +11 more
core   +1 more source

Case report: splicing effect of a novel heterozygous variant of the NUS1 gene in a child with epilepsy

Frontiers in Genetics, 2023
NUS1 is responsible for encoding of the Nogo-B receptor (NgBR), which is a subunit of cis-prenyltransferase. Over 25 variants in NUS1 have been reported, and these variants have been found to be associated with various phenotypes, such as congenital ...
Yan Hu, Mingwei Huang, Jialun Wen, Jian Gao, Weiwei Long, Yansheng Shen, Qi Zeng, Yan Chen, Tian Zhang, Jianxiang Liao, Qiuli Liu, Nannan Li, Sufang Lin   +12 more
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