Results 21 to 30 of about 3,960 (214)

Genome mining reveals the unique function of UbiA-type prenyltransferase in Laetiporus sulphureus [PDF]

Natural Products and Bioprospecting
Eight UbiA-type prenyltransferases were mined in Laetiporus sulphureus by bioinformatic analysis, and phylogenetic analysis showed that they have unique functions.
Yue Wang, Qian Wang, Chunlei Wang, Pengchao Wang, Ran Wang, Jing Wu, Hirokazu Kawagishi, Chengwei Liu   +7 more
doaj   +2 more sources

Structural mechanisms of allosteric regulation in the human cis-prenyltransferase complex [PDF]

Nature Communications
Human cis-prenyltransferase (hcis-PT) synthesizes long-chain isoprenoids essential for N-linked protein glycosylation. This heteromeric complex comprises the catalytic subunit DHDDS and the regulatory Nogo-B receptor (NgBR).
Moshe Giladi, Shiri Kredi, Carlo Guardiani, Lyr Aviram, Pavla Vaňková, Yarin Gaizinger, Petr Man, Alberto Giacomello, Yoni Haitin   +8 more
doaj   +2 more sources

Genome-Wide Analysis of the Cis-Prenyltransferase (CPT) Gene Family in Taraxacum kok-saghyz Provides Insights into Its Expression Patterns in Response to Hormonal Treatments [PDF]

Plants
Taraxacum kok-saghyz (TKS) is a natural rubber (NR)-producing plant with great development prospects. Accurately understanding the molecular mechanism of natural rubber biosynthesis is of great significance.
Liyu Zhang, Huan He, Jiayin Wang, Pingping Du, Lili Wang, Guangzhi Jiang, Lele Liu, Lu Yang, Xiang Jin, Hongbin Li, Quanliang Xie   +10 more
doaj   +2 more sources

Biosynthesis of novel cannabigerolic acid derivatives by engineering the substrate specificity of aromatic prenyltransferase [PDF]

Frontiers in Bioengineering and Biotechnology
IntroductionCannabinoids possess significant therapeutic potential, but their natural chemical diversity derived from plant biosynthesis is limited. Efficient biotransformation processes are required to expand the range of accessible cannabinoids.
Hoe-Suk Lee, Jisu Park, Jisu Park, Taejung Kim, Taejung Kim, Huitae Min, Seongsu Na, Seongsu Na, Soon Young Park, Young-Tae Park, Young-Tae Park, Young Joo Yeon, Jungyeob Ham, Jungyeob Ham, Jungyeob Ham   +14 more
doaj   +2 more sources

LimF is a versatile prenyltransferase catalyzing histidine-C-geranylation on diverse nonnatural substrates [PDF]

, 2021
Prenylation plays an important role in diversifying structure and function of secondary metabolites. Although several cyanobactin prenyltransferases have been characterized, their modes of action are mainly limited to the modification of electron-rich ...
Masayuki, Satake, Dinh Thanh , Nguyen, Hiroaki, Suga, Keisuke , Hamada, Shunsuke , Kobayashi, Chikako, Okada, Yuki, Goto, Yuchen, Zhang, Kazuhiro, Ogata, Masahiro, Okada, Sumika, Inoue, Toru, Sengoku   +11 more
core   +2 more sources

Reconstitution of prenyltransferase activity on nanodiscs by components of the rubber synthesis machinery of the Para rubber tree and guayule

Scientific Reports, 2022
Natural rubber of the Para rubber tree (Hevea brasiliensis) is synthesized as a result of prenyltransferase activity. The proteins HRT1, HRT2, and HRBP have been identified as candidate components of the rubber biosynthetic machinery.
Fu Kuroiwa, Akira Nishino, Yasuko Mandal, Masataka Honzawa, Miki Suenaga-Hiromori, Kakeru Suzuki, Yukie Takani, Yukino Miyagi-Inoue, Haruhiko Yamaguchi, Satoshi Yamashita, Seiji Takahashi, Yuzuru Tozawa   +11 more
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Heterologous biosynthesis of isobavachalcone in tobacco based on in planta screening of prenyltransferases

Frontiers in Plant Science, 2022
Isobavachalcone (IBC) is a prenylated chalcone mainly distributed in some Fabaceae and Moraceae species. IBC exhibits a wide range of pharmacological properties, including anti-bacterial, anti-viral, anti-inflammatory, and anti-cancer activities. In this
Lirong Guo, Wei Zhao, Yan Wang, Yu Yang, Cuimei Wei, Jian Guo, Jianye Dai, Masami Yokota Hirai, Aike Bao, Zhigang Yang, Haijuan Chen, Yimeng Li, Yimeng Li, Yimeng Li   +13 more
doaj   +1 more source

Protein prenyltransferases [PDF]

Genome Biology, 2003
Three different protein prenyltransferases (farnesyltransferase and geranylgeranyltransferases I and II) catalyze the attachment of prenyl lipid anchors 15 or 20 carbons long to the carboxyl termini of a variety of eukaryotic proteins. Farnesyltransferase and geranylgeranyltransferase I both recognize a 'Ca1a2X' motif on their protein substrates ...
Maurer-Stroh, Sebastian, Washietl, Stefan, Eisenhaber, Frank   +2 more
openaire   +3 more sources

Artificial substrates for prenyltransferase [PDF]

Biochemical Journal, 1969
Four out of 16 new allylic pyrophosphates synthesized were found to be artificial substrates for liver prenyltransferase (EC 2.5.1.1). These were the trans-and the cis-3-ethyl-3-methylallyl, the 3,3-diethylallyl and the (mixture of cis and trans) 3-methyl-3-n-propylallyl pyrophosphates.
G, Popják, J L, Rabinowitz, J M, Baron
openaire   +2 more sources

Genome-Inspired Chemical Exploration of Marine Fungus Aspergillus fumigatus MF071

Marine Drugs, 2020
The marine-derived fungus Aspergillus fumigatus MF071, isolated from sediment collected from the Bohai Sea, China, yielded two new compounds 19S,20-epoxy-18-oxotryprostatin A (1) and 20-hydroxy-18-oxotryprostatin A (2), in addition to 28 known compounds (
Jianying Han, Miaomiao Liu, Ian D. Jenkins, Xueting Liu, Lixin Zhang, Ronald J. Quinn, Yunjiang Feng   +6 more
doaj   +1 more source