Results 11 to 20 of about 2,966 (173)

Structural mechanisms of allosteric regulation in the human cis-prenyltransferase complex [PDF]

Nature Communications
Human cis-prenyltransferase (hcis-PT) synthesizes long-chain isoprenoids essential for N-linked protein glycosylation. This heteromeric complex comprises the catalytic subunit DHDDS and the regulatory Nogo-B receptor (NgBR).
Moshe Giladi, Shiri Kredi, Carlo Guardiani, Lyr Aviram, Pavla Vaňková, Yarin Gaizinger, Petr Man, Alberto Giacomello, Yoni Haitin   +8 more
doaj   +2 more sources

Structure and Mechanism of PhdC, a Prenylated-Flavin Maturase. [PDF]

Proteins
ABSTRACT Prenylated flavin mononucleotide (prFMN) is a modified flavin cofactor required by the UbiD family of (de)carboxylase enzymes. While the reduced prFMNH2 form is produced by the flavin prenyltransferase UbiX, the corresponding two‐electron oxidized prFMNiminium form is required to support UbiD catalysis. Thus, oxidative maturation of prFMNH2 is
Whittall DR, Box HG, Payne KAP, Marshall SA, Leys D.   +4 more
europepmc   +2 more sources

Prenylation of Flavanones by an Aromatic Prenyltransferase from Fusarium globosum [PDF]

Molecules
Prenylation increases the structural diversity and biological activity of flavonoids. In this study, an aromatic prenyltransferase, FgPT1, was identified from Fusarium globosum.
Dingtao Tang, Jiajie Quan, Zhengjiao Gao, Bingfeng He, Yu Hou, Peipei Fan, Meidong Pan, Jiali Yang   +7 more
doaj   +2 more sources

Reconstitution of prenyltransferase activity on nanodiscs by components of the rubber synthesis machinery of the Para rubber tree and guayule

Scientific Reports, 2022
Natural rubber of the Para rubber tree (Hevea brasiliensis) is synthesized as a result of prenyltransferase activity. The proteins HRT1, HRT2, and HRBP have been identified as candidate components of the rubber biosynthetic machinery.
Fu Kuroiwa, Akira Nishino, Yasuko Mandal, Masataka Honzawa, Miki Suenaga-Hiromori, Kakeru Suzuki, Yukie Takani, Yukino Miyagi-Inoue, Haruhiko Yamaguchi, Satoshi Yamashita, Seiji Takahashi, Yuzuru Tozawa   +11 more
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Heterologous biosynthesis of isobavachalcone in tobacco based on in planta screening of prenyltransferases

Frontiers in Plant Science, 2022
Isobavachalcone (IBC) is a prenylated chalcone mainly distributed in some Fabaceae and Moraceae species. IBC exhibits a wide range of pharmacological properties, including anti-bacterial, anti-viral, anti-inflammatory, and anti-cancer activities. In this
Lirong Guo, Wei Zhao, Yan Wang, Yu Yang, Cuimei Wei, Jian Guo, Jianye Dai, Masami Yokota Hirai, Aike Bao, Zhigang Yang, Haijuan Chen, Yimeng Li, Yimeng Li, Yimeng Li   +13 more
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Protein prenyltransferases [PDF]

Genome Biology, 2003
Three different protein prenyltransferases (farnesyltransferase and geranylgeranyltransferases I and II) catalyze the attachment of prenyl lipid anchors 15 or 20 carbons long to the carboxyl termini of a variety of eukaryotic proteins. Farnesyltransferase and geranylgeranyltransferase I both recognize a 'Ca1a2X' motif on their protein substrates ...
Maurer-Stroh, Sebastian, Washietl, Stefan, Eisenhaber, Frank   +2 more
openaire   +3 more sources

Artificial substrates for prenyltransferase [PDF]

Biochemical Journal, 1969
Four out of 16 new allylic pyrophosphates synthesized were found to be artificial substrates for liver prenyltransferase (EC 2.5.1.1). These were the trans-and the cis-3-ethyl-3-methylallyl, the 3,3-diethylallyl and the (mixture of cis and trans) 3-methyl-3-n-propylallyl pyrophosphates.
G, Popják, J L, Rabinowitz, J M, Baron
openaire   +2 more sources

Genome-Inspired Chemical Exploration of Marine Fungus Aspergillus fumigatus MF071

Marine Drugs, 2020
The marine-derived fungus Aspergillus fumigatus MF071, isolated from sediment collected from the Bohai Sea, China, yielded two new compounds 19S,20-epoxy-18-oxotryprostatin A (1) and 20-hydroxy-18-oxotryprostatin A (2), in addition to 28 known compounds (
Jianying Han, Miaomiao Liu, Ian D. Jenkins, Xueting Liu, Lixin Zhang, Ronald J. Quinn, Yunjiang Feng   +6 more
doaj   +1 more source

C7-Prenylation of Tryptophan-Containing Cyclic Dipeptides by 7-Dimethylallyl Tryptophan Synthase Significantly Increases the Anticancer and Antimicrobial Activities

Molecules, 2020
Prenylated natural products have interesting pharmacological properties and prenylation reactions play crucial roles in controlling the activities of biomolecules.
Rui Liu, Hongchi Zhang, Weiqiang Wu, Hui Li, Zhipeng An, Feng Zhou   +5 more
doaj   +1 more source

Development of Artificial Synthetic Pathway of Endophenazines in Pseudomonas chlororaphis P3

Biology, 2022
Endophenazine A is a terpenoid phenazine with phenazine-1-carboxylic acid (PCA), and dimethylallyl diphosphate (DMAPP) derived from the 2-methyl-D-erythritol-4-phosphate (MEP) pathway as the precursor, which shows good antimicrobial activity against ...
Ying Liu, Shengjie Yue, Muhammad Bilal, Malik Jan, Wei Wang, Hongbo Hu, Xuehong Zhang   +6 more
doaj   +1 more source