Results 31 to 40 of about 3,960 (214)

C7-Prenylation of Tryptophan-Containing Cyclic Dipeptides by 7-Dimethylallyl Tryptophan Synthase Significantly Increases the Anticancer and Antimicrobial Activities

Molecules, 2020
Prenylated natural products have interesting pharmacological properties and prenylation reactions play crucial roles in controlling the activities of biomolecules.
Rui Liu, Hongchi Zhang, Weiqiang Wu, Hui Li, Zhipeng An, Feng Zhou   +5 more
doaj   +1 more source

Development of Artificial Synthetic Pathway of Endophenazines in Pseudomonas chlororaphis P3

Biology, 2022
Endophenazine A is a terpenoid phenazine with phenazine-1-carboxylic acid (PCA), and dimethylallyl diphosphate (DMAPP) derived from the 2-methyl-D-erythritol-4-phosphate (MEP) pathway as the precursor, which shows good antimicrobial activity against ...
Ying Liu, Shengjie Yue, Muhammad Bilal, Malik Jan, Wei Wang, Hongbo Hu, Xuehong Zhang   +6 more
doaj   +1 more source

A heteromeric cis-prenyltransferase is responsible for the biosynthesis of glycosyl carrier lipids in Methanosarcina mazei [PDF]

, 2019
Cis-prenyltransferases are enzymes responsible for the biosynthesis of glycosyl carrier lipids, natural rubber, and some secondary metabolites. Certain organisms, including some archaeal species, possess multiple genes encoding cis-prenyltransferase ...
Sompiyachoke, Kitty, Emi, Koh-ichi, Hemmi, Hisashi, Okada, Miyako   +3 more
core   +1 more source

‐Prenyltransferase

, 2021
International audience: Cyanobactins comprise a widespread group of peptide metabolites produced by cyanobacteria that are often diversified by post-translational prenylation. Several enzymes have been identified in cyanobactin biosynthetic pathways that
Maho Morita, Morinaka, Brandon, I, Eric W. Schmidt, Schmidt, Eric, W, Sarkar, Snigdha, Mugilarasi Purushothaman, Muriel Gugger, Morita, Maho, Brandon I. Morinaka, Gugger, Muriel, Snigdha Sarkar, Purushothaman, Mugilarasi   +11 more
core   +1 more source

Structure, mechanism and function of prenyltransferases [PDF]

European Journal of Biochemistry, 2002
In this review, we summarize recent progress in studying three main classes of prenyltransferases: (a) isoprenyl pyrophosphate synthases (IPPSs), which catalyze chain elongation of allylic pyrophosphate substrates via consecutive condensation reactions with isopentenyl pyrophosphate (IPP) to generate linear polymers with defined chain lengths; (b ...
Po-Huang, Liang, Tzu-Ping, Ko, Andrew H-J, Wang   +2 more
openaire   +2 more sources

Case report: splicing effect of a novel heterozygous variant of the NUS1 gene in a child with epilepsy

Frontiers in Genetics, 2023
NUS1 is responsible for encoding of the Nogo-B receptor (NgBR), which is a subunit of cis-prenyltransferase. Over 25 variants in NUS1 have been reported, and these variants have been found to be associated with various phenotypes, such as congenital ...
Yan Hu, Mingwei Huang, Jialun Wen, Jian Gao, Weiwei Long, Yansheng Shen, Qi Zeng, Yan Chen, Tian Zhang, Jianxiang Liao, Qiuli Liu, Nannan Li, Sufang Lin   +12 more
doaj   +1 more source

Transient Prenyltransferase–Cyclase Association in Fusicoccadiene Synthase, an Assembly-Line Terpene Synthase

, 2022
Fusicoccadiene synthase from the fungus Phomopsis amygdali (PaFS) is an assembly-line terpene synthase that catalyzes the first two steps in the biosynthesis of Fusiccocin A, a diterpene glycoside.
Jacque L. Faylo (13954626), Kushol Gupta (1435129), Kenji Murakami (1903816), Trevor van Eeuwen (13954629), David W. Christianson (1294293)   +4 more
core   +1 more source

Crystal Structure of Geranylgeranyl Pyrophosphate Synthase (CrtE) Involved in Cyanobacterial Terpenoid Biosynthesis

Frontiers in Plant Science, 2020
Cyanobacteria are photosynthetic prokaryotes that perform oxygenic photosynthesis. Due to their ability to use the photon energy of sunlight to fix carbon dioxide into biomass, cyanobacteria are promising hosts for the sustainable production of ...
Yuchi Feng, R. Marc L. Morgan, Paul D. Fraser, Klaus Hellgardt, Peter J. Nixon   +4 more
doaj   +1 more source

Type 1 polyisoprenoid diphosphate phosphatase modulates geranylgeranyl-mediated control of HMG CoA reductase and UBIAD1

eLife, 2021
UbiA prenyltransferase domain-containing protein-1 (UBIAD1) utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize the vitamin K2 subtype menaquinone-4. The prenyltransferase has emerged as a key regulator of sterol-accelerated, endoplasmic reticulum
Rania Elsabrouty, Youngah Jo, Seonghwan Hwang, Dong-Jae Jun, Russell A DeBose-Boyd   +4 more
doaj   +1 more source

Characterization of an Isoflavonoid-Specific Prenyltransferase from Lupinus albus [PDF]

, 2012
Article on the characterization of an isoflavonoid-specific prenyltransferase from Lupinus ...
Huhman, David, Shen, Guoan, Snyder, John, Sumner, Lloyd W., Dixon, R. A., Lei, Zhentian   +5 more
core   +1 more source