Results 31 to 40 of about 2,966 (173)
Angewandte Chemie, EarlyView.Fluorescence‐based visualization and targeted mass–spectrometric enrichment of membrane‐embedded isoprenoids in Bacillus subtilis via cell‐permeant, alkynylated DMAPP analogs. ABSTRACT Isoprenoids are a chemically and functionally diverse class of metabolites that underlie essential bacterial physiology including respiration and cell envelope ...
Zackary N. Hulsey +7 more
wiley +2 more sources
Evolutionary Developments in Plant Specialized Metabolism, Exemplified by Two Transferase Families
Frontiers in Plant Science, 2019 Plant specialized metabolism emerged from the land colonization by ancient plants, becoming diversified along with plant evolution. To date, more than 1 million metabolites have been predicted to exist in the plant kingdom, and their metabolic processes ...
Hiroaki Kusano +5 more
doaj +1 more source
Structure of a membrane-embedded prenyltransferase homologous to UBIAD1. [PDF]
PLoS Biology, 2014 Membrane-embedded prenyltransferases from the UbiA family catalyze the Mg2+-dependent transfer of a hydrophobic polyprenyl chain onto a variety of acceptor molecules and are involved in the synthesis of molecules that mediate electron transport ...
Hua Huang +5 more
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Enzymatic studies on aromatic prenyltransferases [PDF]
Journal of Natural Medicines, 2020 AbstractAromatic prenyltransferases (PTases), including ABBA-type and dimethylallyl tryptophan synthase (DMATS)-type enzymes from bacteria and fungi, play important role for diversification of the natural products and improvement of the biological activities.
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Microbial soluble aromatic prenyltransferases for engineered biosynthesis
Synthetic and Systems Biotechnology, 2021 Prenyltransferase (PTase) enzymes play crucial roles in natural product biosynthesis by transferring isoprene unit(s) to target substrates, thereby generating prenylated compounds.
He-Ping Chen, Ikuro Abe
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Structure, catalysis, and inhibition mechanism of prenyltransferase [PDF]
IUBMB Life, 2020 AbstractIsoprenoids, also known as terpenes or terpenoids, represent a large family of natural products composed of five‐carbon isopentenyl diphosphate or its isomer dimethylallyl diphosphate as the building blocks. Isoprenoids are structurally and functionally diverse and include dolichols, steroid hormones, carotenoids, retinoids, aromatic ...
Hsin‐Yang Chang +2 more
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eLife, 2016 Natural rubber (NR) is stored in latex as rubber particles (RPs), rubber molecules surrounded by a lipid monolayer. Rubber transferase (RTase), the enzyme responsible for NR biosynthesis, is believed to be a member of the cis-prenyltransferase (cPT ...
Satoshi Yamashita +12 more
doaj +1 more source
The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase
eLife, 2015 Schnyder corneal dystrophy (SCD) is an autosomal dominant disorder in humans characterized by abnormal accumulation of cholesterol in the cornea.
Marc M Schumacher +4 more
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Beilstein Journal of Organic Chemistry, 2022 Aromatic prenylated metabolites have important biological roles and activities in all living organisms. Compared to their importance in all domains of life, we know relatively little about their substrate scopes and metabolic functions. Here, we describe
Jamshid Amiri Moghaddam +4 more
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Cloning and Characterization of Protein Prenyltransferase Alpha Subunit in Rice
Rice Science, 2021 Protein prenylation plays a crucial role in plant development and stress response. We report the function of prenyltransferase α-subunit in rice. Protein-protein interactions showed that the farnesyl- transferase (OsPFT)/geranylgeranyltransferase-I ...
Wang Tao +4 more
doaj +1 more source