Results 41 to 50 of about 18,433 (200)

A Comprehensive Study of Bidirectional Interactions Between the Human Microbiome and Blood Malignancies and Hematologic Conditions: Focus on Novel Therapeutic Strategies

Journal of Clinical Laboratory Analysis, EarlyView.
Microbiota‐targeted therapeutic strategies in hematological disorders. aHSCT: Transplanted immune cells from the donor may attack the recipient's tissues, especially when damage to the intestinal epithelium disrupts the gut microbiota, contributing to GVHD. Maintaining a balanced gut microbiota that supports immune regulation helps reduce GVHD risk and
Alireza Molajafari, Hadi Sedigh Ebrahim‐Saraie, Majid Taati Moghadam, Meysam Hasannejad‐Bibalan   +3 more
wiley   +1 more source

Recent Advances in the Development of Mammalian Geranylgeranyl Diphosphate Synthase Inhibitors

Molecules, 2017
The enzyme geranylgeranyl diphosphate synthase (GGDPS) catalyzes the synthesis of the 20-carbon isoprenoid geranylgeranyl diphosphate (GGPP). GGPP is the isoprenoid donor for protein geranylgeranylation reactions catalyzed by the enzymes geranylgeranyl ...
Staci L. Haney, Veronica S. Wills, David F. Wiemer, Sarah A. Holstein   +3 more
doaj   +1 more source

A genetic and pharmacological analysis of isoprenoid pathway by LC-MS/MS in fission yeast. [PDF]

PLoS ONE, 2012
Currently, statins are the only drugs acting on the mammalian isoprenoid pathway. The mammalian genes in this pathway are not easily amenable to genetic manipulation.
Tomonori Takami, Yue Fang, Xin Zhou, Wurentuya Jaiseng, Yan Ma, Takayoshi Kuno   +5 more
doaj   +1 more source

Gut microbiome in pediatric acute pancreatitis and Crohn's disease versus irritable bowel syndrome and healthy controls

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Pediatric acute pancreatitis (AP), Crohn's disease (CD), and irritable bowel syndrome (IBS) are associated with gut dysbiosis, but differences and similarities between conditions are unknown. We hypothesized that gut microbial ecology would differ across these disorders. Methods Stool was collected from 120 subjects (AP [n = 30], CD
Neha R. Santucci, Chinenye R. Dike, Jenny Hellmann, Nicholas J. Ollberding, Qing Duan, Philip Minar, Lee A. Denson, David B. Haslam, Daniel Castillo, Maisam Abu‐El‐Haija   +9 more
wiley   +1 more source

Adaptation of hydroxymethylbutenyl diphosphate reductase enables volatile isoprenoid production

eLife, 2020
Volatile isoprenoids produced by plants are emitted in vast quantities into the atmosphere, with substantial effects on global carbon cycling. Yet, the molecular mechanisms regulating the balance between volatile and non-volatile isoprenoid production ...
Mareike Bongers, Jordi Perez-Gil, Mark P Hodson, Lars Schrübbers, Tune Wulff, Morten OA Sommer, Lars K Nielsen, Claudia E Vickers   +7 more
doaj   +1 more source

Combining genotype improvement and statistical media optimization for isoprenoid production in E. coli. [PDF]

PLoS ONE, 2013
Isoprenoids are a large and diverse class of compounds that includes many high value natural products and are thus in great demand. To meet the increasing demand for isoprenoid compounds, metabolic engineering of microbes has been used to produce ...
Congqiang Zhang, Xixian Chen, Ruiyang Zou, Kang Zhou, Gregory Stephanopoulos, Heng-Phon Too   +5 more
doaj   +1 more source

Late Holocene environmental history of Dojran, Macedonia: Investigating the interplay of imperial dynamics and climatic change

Journal of Quaternary Science, EarlyView.
ABSTRACT This study presents a high‐resolution, multi‐proxy reconstruction of environmental and land‐use change from Lake Dojran over historical times (last 2500 years), combining pollen, biomarkers, radiocarbon dating, Ottoman taxation records and other historical data.
Alessia Masi, Lucrezia Masci, Georgios C. Liakopoulos, Monica Bini, Alexander Francke, Ilaria Isola, Carlo Ricotta, Laura Sadori, Alexander Sarantis, Sławomir Sprawski, Jakub Sypiański, Irene Tunno, Cristiano Vignola, Bernd Wagner, Giovanni Zanchetta, Adam Izdebski   +15 more
wiley   +1 more source

Haloarchaeal Carotenoids: Healthy Novel Compounds from Extreme Environments

Marine Drugs, 2019
Haloarchaea are halophilic microorganisms belonging to the archaea domain that inhabit salty environments (mainly soils and water) all over the world. Most of the genera included in this group can produce carotenoids at significant concentrations (even ...
Micaela Giani, Inés Garbayo, Carlos Vílchez, Rosa María Martínez-Espinosa   +3 more
doaj   +1 more source

Growth-uncoupled isoprenoid synthesis in Rhodobacter sphaeroides

Biotechnology for Biofuels, 2020
Background Microbial cell factories are usually engineered and employed for cultivations that combine product synthesis with growth. Such a strategy inevitably invests part of the substrate pool towards the generation of biomass and cellular maintenance.
Enrico Orsi, Ioannis Mougiakos, Wilbert Post, Jules Beekwilder, Marco Dompè, Gerrit Eggink, John van der Oost, Servé W. M. Kengen, Ruud A. Weusthuis   +8 more
doaj   +1 more source

Separation of trichothecene mycotoxins in a matrix of hemp (Cannabis sativa L.) seed, and quantification of deoxynivalenol in hemp grain infected with Fusarium graminearum

JSFA reports, EarlyView.
Abstract Background Fusarium graminearum, one of the causal agents of ear rot in maize and head blight of cereal grains, also infects hemp (Cannabis sativa L. containing a maximum of 0.3% tetrahydrocannabinol or THC). This fungal pathogen produces trichothecene mycotoxins when it infects maize and cereal grains, but little is known about its production
Isabelle A. Kagan, Magdalena Ricciardi, Henry S. Smith, Rachel R. Schendel, Robert Pearce, Nicole Gauthier   +5 more
wiley   +1 more source