Results 41 to 50 of about 26,580 (200)

The lytB gene of Escherichia coli is essential and specifies a product needed for isoprenoid biosynthesis [PDF]

, 2001
LytB and GcpE, because they are codistributed with other pathway enzymes, have been predicted to catalyze unknown steps in the nonmevalonate pathway for isoprenoid biosynthesis.
McLennan, Neil, Coulson, Andrew, McAteer, Sean, Masters, Millicent/Mrs Donachie   +3 more
core  

Chimeric Isoprenoid Synthases and Uses Thereof [PDF]

, 1998
Disclosed is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing
Back, Kyoungwhan, Chappell, Joseph
core   +1 more source

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

Advanced Science, EarlyView.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen, Bao Chen, Wenhui Zhang, Guifang Sun, Yao Zhao, Jianpeng Zhang, Baofu Xu   +6 more
wiley   +1 more source

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source

Sustainable Production of Microbial Isoprenoid Derived Advanced Biojet Fuels Using Different Generation Feedstocks: A Review

Frontiers in Bioengineering and Biotechnology, 2020
As the fastest mode of transport, the aircraft is a major driver for globalization and economic growth. The development of alternative advanced liquid fuels is critical to sustainable development within the sector.
Laura Ellen Walls, Laura Ellen Walls, Leonardo Rios-Solis, Leonardo Rios-Solis   +3 more
doaj   +1 more source

Isoprenoid biosynthesis regulation in poplars by methylerythritol phosphate and mevalonic acid pathways

Frontiers in Plant Science, 2022
It is critical to develop plant isoprenoid production when dealing with human-demanded industries such as flavoring, aroma, pigment, pharmaceuticals, and biomass used for biofuels.
Ali Movahedi, Hui Wei, Boas Pucker, Mostafa Ghaderi-Zefrehei, Fatemeh Rasouli, Fatemeh Rasouli, Ali Kiani-Pouya, Ali Kiani-Pouya, Tingbo Jiang, Qiang Zhuge, Liming Yang, Xiaohong Zhou   +11 more
doaj   +1 more source

Beyond Conventional: A Review of Phytochemical‐Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management

Advanced Science, EarlyView.
This review systematically bridges chronic wound pathology with natural phytochemical hydrogel therapeutics. A pathology‐to‐phytochemical mechanistic mapping framework is established, linking specific wound hallmarks to targeted phytochemical interventions.
Yitao Zhou, Xing Liu, Cuiyi Wang, Xiaoxuan Zhao, Pengrun Zhang, Jingjing Gu, Qiuhua Sun, Malcolm Xing, Yeqin Yang   +8 more
wiley   +1 more source

A redundant isoprenoid biosynthetic pathway supports Staphylococcus aureus metabolic versatility

mBio
Isoprenoids are ubiquitous molecules that serve as fundamental building blocks for life. In bacteria, isoprenoids are precursors for carotenoid pigments, respiratory cofactors, and essential sugar carrier lipids, such as lipid II.
Troy A. Burtchett, Elizabeth N. Ottosen, Tomotaka Jitsukawa, Momoko Kaneko, Miu Yasui, Jessica A. Lysne, Paige J. Kies, Jessica A. Bailey, Sean M. Thomas, Shingo Fujisaki, Neal D. Hammer   +10 more
doaj   +1 more source

Discovery of new targets for antimalarial chemotherapy

Parasite, 2008
The understanding of the biology and the biochemistry of malaria parasites has considerably increased over the past two decades with the discovery of many potential targets for new antimalarial drugs.
Grellier P., Depoix D., Schrével J., Florent I.   +3 more
doaj   +1 more source

Role of phosphate limitation and pyruvate decarboxylase in rewiring of the metabolic network for increasing flux towards isoprenoid pathway in a TATA binding protein mutant of Saccharomyces cerevisiae

Microbial Cell Factories, 2018
Background Production of isoprenoids, a large and diverse class of commercially important chemicals, can be achieved through engineering metabolism in microorganisms. Several attempts have been made to reroute metabolic flux towards isoprenoid pathway in
Manisha Wadhwa, Sumana Srinivasan, Anand K. Bachhawat, K. V. Venkatesh   +3 more
doaj   +1 more source