Results 21 to 30 of about 18,433 (200)
Characterization of a Cis-Prenyltransferase from Lilium longiflorum Anther
Molecules, 2019 A group of prenyltransferases catalyze chain elongation of farnesyl diphosphate (FPP) to designated lengths via consecutive condensation reactions with specific numbers of isopentenyl diphosphate (IPP).
Jyun-Yu Yao +4 more
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Journal of Lipid Research, 2006 More than 100 proteins necessary for eukaryotic cell growth, differentiation, and morphology require posttranslational modification by the covalent attachment of an isoprenoid lipid (prenylation).
Kimberly T. Lane, Lorena S. Beese
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Inhibitory Effects of Fosmidomycin Against Babesia microti in vitro
Frontiers in Cell and Developmental Biology, 2020 Babesia microti, the main pathogen causing human babesiosis, has been reported to exhibit resistance to the traditional treatment of azithromycin + atovaquone and clindamycin + quinine, suggesting the necessity of developing new drugs.
Sen Wang +24 more
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eLife, 2020 UbiA prenyltransferase domain-containing protein-1 (UBIAD1) synthesizes the vitamin K subtype menaquinone-4 (MK-4). Previous studies in cultured cells (Schumacher et al., 2015) revealed that UBIAD1 also inhibits endoplasmic reticulum (ER)-associated ...
Youngah Jo +9 more
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The isoprenoid alcohol pathway, a synthetic route for isoprenoid biosynthesis [PDF]
Proceedings of the National Academy of Sciences, 2019 Significance We have demonstrated the design, prototyping, and implementation of a non-natural route to isoprenoid biosynthesis, termed the isoprenoid alcohol (IPA) pathway. Opposed to working within the confines of native metabolic pathways, our approach of utilizing all available biochemical reactions identified a synthetic route to
James M, Clomburg +4 more
openaire +2 more sources
Phosphomevalonate kinase is a cytosolic protein in humans
Journal of Lipid Research, 2004 In the past decade, a predominant peroxisomal localization has been reported for several enzymes functioning in the presqualene segment of the cholesterol/isoprenoid biosynthesis pathway.
Sietske Hogenboom +5 more
doaj +1 more source
Diversifying Isoprenoid Platforms via Atypical Carbon Substrates and Non-model Microorganisms
Frontiers in Microbiology, 2021 Isoprenoid compounds are biologically ubiquitous, and their characteristic modularity has afforded products ranging from pharmaceuticals to biofuels. Isoprenoid production has been largely successful in Escherichia coli and Saccharomyces cerevisiae with ...
David N. Carruthers +3 more
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Tocopherol biosynthesis in Leishmania (L.) amazonensis promastigotes
FEBS Open Bio, 2019 Leishmaniasis is a neglected disease caused by a trypanosomatid protozoan of the genus Leishmania. Most drugs used to treat leishmaniasis are highly toxic, and the emergence of drug‐resistant strains has been observed.
José Mário F. Balanco +5 more
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Advanced Science, EarlyView.A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker +11 more
wiley +1 more source
Downregulation of Squalene Synthase Broadly Impacts Isoprenoid Biosynthesis in Guayule
Metabolites, 2022 Production of natural rubber by Parthenium argentaum (guayule) requires increased yield for economic sustainability. An RNAi gene silencing strategy was used to engineer isoprenoid biosynthesis by downregulation of squalene synthase (SQS), such that the ...
Dante Placido +8 more
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