Results 21 to 30 of about 26,580 (200)

Phytochrome-dependent temperature perception modulates isoprenoid metabolism [PDF]

, 2020
Changes in environmental temperature influence many aspects of plant metabolism; however, the underlying regulatory mechanisms remain poorly understood.
Bermudez Salazar, Luisa, De Haro, L. A., Haslam, Richard P., Conte, M., Bianchetti, R., Freschi, Luciano, Fernie, A. R., de Haro, L., Bianchetti, Ricardo, Fernie, Alisdair R., Conte, Mariana, Rossi, M., Haslam, R., Bianchetti, R. E., Bermudez, L, Michaelson, L., Fernie, A., Freschi, L., Michaelson, L. V., Bermudez, L., Haslam, R. P., Michaelson, Louise, Bermúdez, Luisa, De Luca, B., Demarco, D., de Haro, Luis Alejandro, Michaelson, Louise V., De Luca, Belen, Rossi, Magdalena, Bianchetti, Ricardo E., de Luca, Maria Belén, Carrari, F., Demarco, Diego, Carrari, Fernando, Rosado, Daniele, Carrari, Fernando Oscar, Rosado, D.   +36 more
core   +1 more source

Identification and quantification of dolichol and dolichoic acid in neuromelanin from substantia nigra of the human brains⃞

Journal of Lipid Research, 2007
Neuromelanin (NM) isolated from the substantia nigra of the human brain is found to contain a series of dolichoic acids (dol-CA) containing 14–20 isoprene units. This is the first observation of dol-CA in a natural system.
Weslyn C. Ward, Ziqiang Guan, Fabio A. Zucca, Ruggero G. Fariello, Reza Kordestani, Luigi Zecca, Christian R.H. Raetz, John D. Simon   +7 more
doaj   +1 more source

Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase [PDF]

, 2007
This research was supported by the German Academic Exchange Service (DAAD), the Wellcome Trust (TKS and WNH as Trust Senior Research fellows), the Biotechnology and Biological Science Research Council (Structural Proteomics of Rational Targets) and the ...
Tanja Sgraja, Smith, Terry K, Terry K Smith, Sgraja, Tanja, Hunter, William N., William N Hunter, Hunter, William N   +6 more
core   +1 more source

Environmental and genetic factors associated with solanesol accumulation in potato leaves

Frontiers in Plant Science, 2016
Solanesol is a high value 45-carbon, unsaturated, all-trans-nonaprenol isoprenoid. Recently solanesol has received particular attention because of its utility, both in its own right and as a precursor in the production of numerous compounds used in the ...
Raymond Campbell, Sabine Freitag, Glenn Bryan, Derek Stewart, Mark Andrew Taylor   +4 more
doaj   +1 more source

The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase

eLife, 2015
Schnyder corneal dystrophy (SCD) is an autosomal dominant disorder in humans characterized by abnormal accumulation of cholesterol in the cornea.
Marc M Schumacher, Rania Elsabrouty, Joachim Seemann, Youngah Jo, Russell A DeBose-Boyd   +4 more
doaj   +1 more source

Characterization of a Cis-Prenyltransferase from Lilium longiflorum Anther

Molecules, 2019
A group of prenyltransferases catalyze chain elongation of farnesyl diphosphate (FPP) to designated lengths via consecutive condensation reactions with specific numbers of isopentenyl diphosphate (IPP).
Jyun-Yu Yao, Kuo-Hsun Teng, Ming-Che Liu, Co-Shine Wang, Po-Huang Liang   +4 more
doaj   +1 more source

Farnesyltransferase Enables Modular Assembly of Dual‐Functional Nanobody Conjugates for in Vivo Imaging of Inflammation

Angewandte Chemie, EarlyView.
A modular farnesyltransferase‐based chemoenzymatic platform enables fast, site‐specific labeling of nanobodies for PET imaging of inflammation. CD11b‐targeted PET agents selectively image myeloid‐driven inflammation, while CD45‐targeted PET agents provide sensitive whole‐body immune mapping.
Sneha Venkatachalapathy, Yoon Ho Lee, Ali Salehi Farid, Heydar Moravej, Sina Djafari Rouhani, Jennifer E. Rowley, Mohammad Rashidian, Mark D. Distefano   +7 more
wiley   +2 more sources

Thematic review series: Lipid Posttranslational Modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I

Journal of Lipid Research, 2006
More than 100 proteins necessary for eukaryotic cell growth, differentiation, and morphology require posttranslational modification by the covalent attachment of an isoprenoid lipid (prenylation).
Kimberly T. Lane, Lorena S. Beese
doaj   +1 more source

Broad‐Spectrum, Cell Envelope‐Active Marinocyclin Antibiotics From a Coral‐Derived Bacterium Are Effective Against Colistin‐Resistant Bacteria

Angewandte Chemie, EarlyView.
Marinocyclins, polycationic macrocyclic depsipeptides, were discovered by genome mining from the marine coral‐derived bacterium Aquimarina megaterium. The compounds have broad‐spectrum activity against gram‐positive and gram‐negative ESKAPE bacteria.
Clara Chepkirui, Sandra Silva, Jan Straetener, Chandrashekhar Padhi, Tina Keller‐Costa, Tess Lamer, Laura Reinke, Heike Brötz‐Oesterhelt, Rodrigo Costa, Jörn Piel   +9 more
wiley   +2 more sources

Inhibitory Effects of Fosmidomycin Against Babesia microti in vitro

Frontiers in Cell and Developmental Biology, 2020
Babesia microti, the main pathogen causing human babesiosis, has been reported to exhibit resistance to the traditional treatment of azithromycin + atovaquone and clindamycin + quinine, suggesting the necessity of developing new drugs.
Sen Wang, Sen Wang, Muxiao Li, Muxiao Li, Xiaoying Luo, Xiaoying Luo, Long Yu, Long Yu, Zheng Nie, Zheng Nie, Qin Liu, Qin Liu, Xiaomeng An, Xiaomeng An, Yangsiqi Ao, Yangsiqi Ao, Qin Liu, Jiaxu Chen, Yu Tian, Junlong Zhao, Junlong Zhao, Junlong Zhao, Lan He, Lan He, Lan He   +24 more
doaj   +1 more source