Results 21 to 30 of about 23,928 (250)
eLife, 2019 Autosomal-dominant Schnyder corneal dystrophy (SCD) is characterized by corneal opacification owing to overaccumulation of cholesterol. SCD is caused by mutations in UBIAD1, which utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize vitamin K2 ...
Youngah Jo +10 more
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Carotenoids from Haloarchaea and Their Potential in Biotechnology
Marine Drugs, 2015 The production of pigments by halophilic archaea has been analysed during the last half a century. The main reasons that sustains this research are: (i) many haloarchaeal species possess high carotenoids production availability; (ii) downstream processes
Montserrat Rodrigo-Baños +4 more
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Journal of Lipid Research, 2007 Neuromelanin (NM) isolated from the substantia nigra of the human brain is found to contain a series of dolichoic acids (dol-CA) containing 14–20 isoprene units. This is the first observation of dol-CA in a natural system.
Weslyn C. Ward +7 more
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The isoprenoid alcohol pathway, a synthetic route for isoprenoid biosynthesis [PDF]
Proceedings of the National Academy of Sciences, 2019 Significance We have demonstrated the design, prototyping, and implementation of a non-natural route to isoprenoid biosynthesis, termed the isoprenoid alcohol (IPA) pathway. Opposed to working within the confines of native metabolic pathways, our approach of utilizing all available biochemical reactions identified a synthetic route to ...
James M, Clomburg +4 more
openaire +2 more sources
Environmental and genetic factors associated with solanesol accumulation in potato leaves
Frontiers in Plant Science, 2016 Solanesol is a high value 45-carbon, unsaturated, all-trans-nonaprenol isoprenoid. Recently solanesol has received particular attention because of its utility, both in its own right and as a precursor in the production of numerous compounds used in the ...
Raymond Campbell +4 more
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Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase [PDF]
, 2007 This research was supported by the German Academic Exchange Service (DAAD), the Wellcome Trust (TKS and WNH as Trust Senior Research fellows), the Biotechnology and Biological Science Research Council (Structural Proteomics of Rational Targets) and the ...
Tanja Sgraja +6 more
core +1 more source
The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase
eLife, 2015 Schnyder corneal dystrophy (SCD) is an autosomal dominant disorder in humans characterized by abnormal accumulation of cholesterol in the cornea.
Marc M Schumacher +4 more
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Characterization of a Cis-Prenyltransferase from Lilium longiflorum Anther
Molecules, 2019 A group of prenyltransferases catalyze chain elongation of farnesyl diphosphate (FPP) to designated lengths via consecutive condensation reactions with specific numbers of isopentenyl diphosphate (IPP).
Jyun-Yu Yao +4 more
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Journal of Lipid Research, 2006 More than 100 proteins necessary for eukaryotic cell growth, differentiation, and morphology require posttranslational modification by the covalent attachment of an isoprenoid lipid (prenylation).
Kimberly T. Lane, Lorena S. Beese
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Inhibitory Effects of Fosmidomycin Against Babesia microti in vitro
Frontiers in Cell and Developmental Biology, 2020 Babesia microti, the main pathogen causing human babesiosis, has been reported to exhibit resistance to the traditional treatment of azithromycin + atovaquone and clindamycin + quinine, suggesting the necessity of developing new drugs.
Sen Wang +24 more
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