Results 61 to 70 of about 26,580 (200)

The isoprenoid-precursor dependence of Plasmodium spp. [PDF]

, 2012
Due to the increase in resistance of Plasmodium spp. against available antimalarials, there is a need for new, effective and innovative drugs. The non-mevalonate pathway for the biosynthesis of the universal isoprenoid precursors, which is absent in ...
Meer, Jan-Ytzen van der,, Hirsch, Anna K.H.,, Hirsch, Anna K. H., van der Meer, Jan-Ytzen   +3 more
core   +1 more source

Haloarchaeal Carotenoids: Healthy Novel Compounds from Extreme Environments

Marine Drugs, 2019
Haloarchaea are halophilic microorganisms belonging to the archaea domain that inhabit salty environments (mainly soils and water) all over the world. Most of the genera included in this group can produce carotenoids at significant concentrations (even ...
Micaela Giani, Inés Garbayo, Carlos Vílchez, Rosa María Martínez-Espinosa   +3 more
doaj   +1 more source

Getting the Big Ones to Pack: Crystal Structure of Vitamin K2 With a Chaperone

Chemistry – A European Journal, EarlyView.
A method for obtaining co‐crystals of medium‐size organic molecules and ‐tetrakis(2‐fluoro‐4‐methoxyphenyl)adamantane (TFM) as chaperone was developed. This method yielded a high‐resolution x‐ray crystal structure of menaquinone MK‐4 (vitamin K2), in which layers of chaperone and vitamin guest molecules are found.
Jan Hartenfels, Greta Lília Runge‐Seither, Tim Berking, Johanna Osterbrink, Carsten Wolf, Clemens Richert   +5 more
wiley   +1 more source

Studies on isoprenoid biosynthesis in Euglena gracilis

This dissertation describes studies of isoprenoid biosynthesis in the phytoflagellate Euglena gracilis. Elucidation of a novel isoprerioid pathway, the 2-Cmethyl-D-erythritol-4-phosphate (MEP) pathway, in addition to the generally known mevalonate (MVA ...
Kim, Dojung
core   +6 more sources

Phytochemistry, Chemotypic Diversity and Antimicrobial Potential of Essential Oils From Native Aromatic Plants of the Americas: A Systematic Review

Flavour and Fragrance Journal, EarlyView.
This review bridges ancestral indigenous knowledge with modern pharmacology, summarizing the phytochemistry and antimicrobial properties of essential oils from seven native American species. It highlights their significant activity against bacterial, fungal and parasitic pathogens, emphasizing their potential as sustainable therapeutic and agricultural
Arley Rey Páez, Mozaniel Santana de Oliveira, João Paulo Viana Leite   +2 more
wiley   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Chimeric Isoprenoid Synthases and Uses Thereof [PDF]

, 2013
Provided is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous, isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing
Back, Kyoungwhan, Chappell, Joe
core  

(Appendix 2) Isoprenoid tetraether lipids in water samples of the Mediterranean Sea

, 2015
(Appendix 2) Isoprenoid tetraether lipids in water samples of the Mediterranean ...
Marta Rodrigo-Gámiz (6958991), Kim, Jung-Hyun, Middelburg, Jack J, Jung-Hyun Kim (6976445), Gianluca Marino (6976136), Rodrigo-Gámiz, Marta, Sangiorgi, Francesca, Rosalyne Buscail (6969998), Peer Helmke (6963626), Jack J Middelburg (6975785), Jaap S Sinninghe Damsté (6885257), Hopmans, Ellen C, Pross, Jörg, Rampen, Sebastiaan W, Marino, Gianluca, Helmke, Peer, Sinninghe Damsté, Jaap S, Sebastiaan W Rampen (6958994), Schouten, Stefan, Buscail, Rosalyne, Jörg Pross (6961943), Carme Huguet (8004680), Ellen C Hopmans (6975590), Francesca Sangiorgi (6085799), Huguet, Carme, Stefan Schouten (6885260)   +25 more
core   +1 more source

Geranylgeranyl-regulated transport of the prenyltransferase UBIAD1 between membranes of the ER and Golgi[S]

Journal of Lipid Research, 2016
UbiA prenyltransferase domain-containing protein-1 (UBIAD1) utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize the vitamin K2 subtype menaquinone-4.
Marc M. Schumacher, Dong-Jae Jun, Youngah Jo, Joachim Seemann, Russell A. DeBose-Boyd   +4 more
doaj   +1 more source

Gut microbiome in pediatric acute pancreatitis and Crohn's disease versus irritable bowel syndrome and healthy controls

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Pediatric acute pancreatitis (AP), Crohn's disease (CD), and irritable bowel syndrome (IBS) are associated with gut dysbiosis, but differences and similarities between conditions are unknown. We hypothesized that gut microbial ecology would differ across these disorders. Methods Stool was collected from 120 subjects (AP [n = 30], CD
Neha R. Santucci, Chinenye R. Dike, Jenny Hellmann, Nicholas J. Ollberding, Qing Duan, Philip Minar, Lee A. Denson, David B. Haslam, Daniel Castillo, Maisam Abu‐El‐Haija   +9 more
wiley   +1 more source