Results 71 to 80 of about 23,928 (250)

Genomic Content in Avian Haemosporidian Parasites Suggests Co‐Regulation of Apicoplast and Mitochondrial Nucleoids

Integrative Zoology, EarlyView.
Apicoplast genomic content and mitochondrial genomic content were found to be strongly correlated (rho = 0.93) for infections going from low to high. Apicoplast and mitochondrial genomic content were deemed as more predictive factors of parasitemia for different infection intensities.
Gaia Porporato, Peter Pibaque, Alanis Cruz Flores, Simone Cescutti, Nayden Chakarov   +4 more
wiley   +1 more source

Geranylgeranyl-regulated transport of the prenyltransferase UBIAD1 between membranes of the ER and Golgi[S]

Journal of Lipid Research, 2016
UbiA prenyltransferase domain-containing protein-1 (UBIAD1) utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize the vitamin K2 subtype menaquinone-4.
Marc M. Schumacher, Dong-Jae Jun, Youngah Jo, Joachim Seemann, Russell A. DeBose-Boyd   +4 more
doaj   +1 more source

Metabolic engineering of Isoprenoid biosynthesis

, 2013
International audienceIsoprenoids constitute one of the largest families of natural compounds. They play essential functions in plant growth and development and furnish compounds of high interest for humans.
Boureau, Lisa, Gallusci, Philippe, Mortain-Bertrand, Anne, Bert, Linda, Linda S. Bert, Anne Pribat, Anne Mortain-Bertrand, Pribat, Anne, Teyssier, Emeline, Philippe Gallusci, ROLIN, Dominique, Dominique Rolin, Emeline Teyssier, Rolin, Dominique, D., Lisa Boureau   +14 more
core   +1 more source

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report

Allergy, EarlyView.
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter, Ioana Agache, Beatriz Cabanillas, Roberto Berni Canani, Pasquale Comberiati, Holger Garn, Cristina Gomez‐Casado, Karin Hufnagl, Ekaterina Khaleva, Gregorio P. Milani, Daniel Munblit, Nikolaos Douladiris, Liam O'Mahony, Frank Redegeld, Carmen Riggioni, Peter K. Smith, Betty van Esch, Emilia Vassilopoulou, Carina Venter, Diego G. Peroni   +19 more
wiley   +1 more source

The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in Plasmodium falciparum

mBio, 2019
Members of the haloacid dehalogenase (HAD) family of metabolite phosphatases play an important role in regulating multiple pathways in Plasmodium falciparum central carbon metabolism. We show that the P.
Laure Dumont, Mark B. Richardson, Phillip van der Peet, Danushka S. Marapana, Tony Triglia, Matthew W. A. Dixon, Alan F. Cowman, Spencer J. Williams, Leann Tilley, Malcolm J. McConville, Simon A. Cobbold   +10 more
doaj   +1 more source

The lytB gene of Escherichia coli is essential and specifies a product needed for isoprenoid biosynthesis

, 2001
LytB and GcpE, because they are codistributed with other pathway enzymes, have been predicted to catalyze unknown steps in the nonmevalonate pathway for isoprenoid biosynthesis.
McLennan, Neil, Coulson, Andrew, McAteer, Sean, Masters, Millicent/Mrs Donachie   +3 more
core  

Synthesis of isoprenoid chain-contained chemical probes for an investigation of molecular interactions by using quartz crystal microbalance

, 2013
Five probes including four that contained isoprenoid chain were synthesized. These probes were assembled onto the gold-coated quartz crystal chips for analysis of their interactions with four yeast proteins by using the quartz crystal microbalance ...
赵宗保, Zhao, Zongbao Kent, Hou, Shuhua, Zhang, Yixin, Liu, Wujun   +4 more
core   +1 more source

Investigating the Dietary, Economic, and Social Practices of a Neolithic Funnel Beaker Community in Wanna, Germany, Through Raw Material and Organic Residue Analyses of Pottery

Archaeometry, EarlyView.
ABSTRACT This study details the analysis of an assemblage of Funnel Beaker pottery from Wanna in Northern Germany investigated using petrographic, geochemical, and organic residue analyses. The analyses revealed specialized production of pottery vessels for funerary contexts, but that domestic and funerary pottery were used intensively to process ...
I. L. Wiltshire, K. Struckmeyer, A. Behrens, M. Mennenga, M. Roffet‐Salque   +4 more
wiley   +1 more source

Targeting the isoprenoid pathway in choleste biosynthesis: An approach to identify isoprenoid biosynthesis inhibitors [PDF]

The development of novel cholesterol biosynthesis inhibitors is a task of major concern due to the diverse roles of cholesterol and its precursors in physiological processes.
Müller, Christoph, Olander, Florian, Liebl, Maximilian   +2 more
core   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source