Synthesis and Antiplasmodial Activity of Novel Fosmidomycin Derivatives and Conjugates with Artemisinin and Aminochloroquinoline [PDF]
Molecules, 2020 Malaria, despite many efforts, remains among the most problematic infectious diseases worldwide, mainly due to the development of drug resistance by Plasmodium falciparum.
Despina Palla +6 more
doaj +4 more sources
Methyl-Jasmonate Functions as a Molecular Switch Promoting Cross-Talk between Pathways for the Biosynthesis of Isoprenoid Backbones Used to Modify Proteins in Plants [PDF]
PlantsIn plants, the plastidial mevalonate (MVA)-independent pathway is required for the modification with geranylgeranyl groups of CaaL-motif proteins, which are substrates of protein geranylgeranyltransferase type-I (PGGT-I).
Quentin Chevalier +8 more
doaj +2 more sources
Beyond the MEP Pathway: A novel kinase required for prenol utilization by malaria parasites. [PDF]
PLoS PathogensA proposed treatment for malaria is a combination of fosmidomycin and clindamycin. Both compounds inhibit the methylerythritol 4-phosphate (MEP) pathway, the parasitic source of farnesyl and geranylgeranyl pyrophosphate (FPP and GGPP, respectively). Both
Marcell Crispim +10 more
doaj +2 more sources
Resistance of the Burkholderia cepacia complex to fosmidomycin and fosmidomycin derivatives [PDF]
International Journal of Antimicrobial Agents, 2011 The Burkholderia cepacia complex (BCC) is a group of 17 closely related opportunistic pathogens that are able to infect the respiratory tract of cystic fibrosis patients. BCC bacteria are intrinsically resistant to many antibiotics and are therefore difficult to eradicate.
Anne-Sophie, Messiaen +7 more
openaire +2 more sources
Preparation of gem-difluorinated retrohydroxamic-fosmidomycin [PDF]
ARKIVOC, 2015 From several decades, some organophosphorus compounds specifically designed to alter biological systems were introduced on market as agr ochemicals (ie glyphosate and glufosinate as herbicides). Nevertheless, it becomes necessary to find new compounds in order to counter plant resistances already observed with glyphosate. Fosmi domicyn and its N-acetyl
Jean-Noël Volle +7 more
doaj +2 more sources
Fosmidomycin, a Novel Chemotherapeutic Agent for Malaria [PDF]
Antimicrobial Agents and Chemotherapy, 2003 ABSTRACT In previous studies, fosmidomycin has been shown to possess activity against Plasmodium falciparum in vitro and in the mouse model. It has a novel mode of action through inhibition of 1-deoxy- d -xylulose 5-phosphate reductoisomerase, an enzyme of the nonmevalonate pathway ...
Bertrand, Lell +9 more
openaire +2 more sources
Pharmacokinetics of fosmidomycin, a new phosphonic acid antibiotic [PDF]
Antimicrobial Agents and Chemotherapy, 1982 The pharmacokinetics of fosmidomycin was investigated in animals and humans after parenteral and oral dosing. In dogs the serum concentration was 54.8 microgram/ml at 0.25 h after an intravenous dose of 20 mg/kg, and the half-life was 1.14 h. Peak concentration was 41.4 microgram/ml after an intramuscular dose of 20 mg/kg and 16.6 microgram/ml after an
T, Murakawa +4 more
openaire +2 more sources
Isoprene Increases Thermotolerance of Fosmidomycin-Fed Leaves [PDF]
Plant Physiology, 2001 Abstract Isoprene is synthesized and emitted in large amounts by a number of plant species, especially oak (Quercus sp.) and aspen (Populussp.) trees. It has been suggested that isoprene improves thermotolerance by helping photosynthesis cope with high temperature.
Sharkey, Thomas D. +2 more
openaire +3 more sources
Exploring the Translational Gap of a Novel Class of Escherichia coli IspE Inhibitors
ChemMedChem, Volume 18, Issue 19, October 4, 2023., 2023 Challenges in the discovery of selective IspE inhibitors with antibacterial activity and no toxicity: This work sheds light on the molecular properties for balancing enzymatic target and bacterial activities simultaneously as well as new starting points for the development of IspE inhibitors with a predicted new mode of action.
Henni‐Karoliina Ropponen +9 more
wiley +1 more source
Tackling Soil ARG‐Carrying Pathogens with Global‐Scale Metagenomics
Advanced Science, Volume 10, Issue 26, September 15, 2023., 2023 The ultimate risk of antibiotic abuse is the spread of antibiotic resistance genes (ARGs) into pathogens. This work reveals that soilborne AP diversity is driven by human activities, climatic variables, and physicochemical properties at the global scale. Specifically, agricultural land has the highest AP richness.
Binhao Wang +11 more
wiley +1 more source