Results 21 to 30 of about 1,208 (158)

Fosmidomycin, a Novel Chemotherapeutic Agent for Malaria [PDF]

Antimicrobial Agents and Chemotherapy, 2003
ABSTRACT In previous studies, fosmidomycin has been shown to possess activity against Plasmodium falciparum in vitro and in the mouse model. It has a novel mode of action through inhibition of 1-deoxy- d -xylulose 5-phosphate reductoisomerase, an enzyme of the nonmevalonate pathway ...
Bertrand, Lell, Ronnatrai, Ruangweerayut, Jochen, Wiesner, Michel Anoumou, Missinou, Andreas, Schindler, Thomas, Baranek, Martin, Hintz, David, Hutchinson, Hassan, Jomaa, Peter Gottfried, Kremsner   +9 more
openaire   +2 more sources

Pharmacokinetics and pharmacodynamics of fosmidomycin monotherapy and combination therapy with clindamycin in the treatment of multidrug resistant falciparum malaria

Malaria Journal, 2007
Background The study investigated the pharmacokinetics of fosmidomycin when given alone and in combination with clindamycin in patients with acute uncomplicated falciparum malaria. Methods A total of 15 and 18 patients with acute uncomplicated Plasmodium
Chauemung Anurak, Karbwang Juntra, Ruengweerayut Ronnatrai, Na-Bangchang Kesara, Hutchinson David   +4 more
doaj   +1 more source

Pharmacokinetics of fosmidomycin, a new phosphonic acid antibiotic [PDF]

Antimicrobial Agents and Chemotherapy, 1982
The pharmacokinetics of fosmidomycin was investigated in animals and humans after parenteral and oral dosing. In dogs the serum concentration was 54.8 microgram/ml at 0.25 h after an intravenous dose of 20 mg/kg, and the half-life was 1.14 h. Peak concentration was 41.4 microgram/ml after an intramuscular dose of 20 mg/kg and 16.6 microgram/ml after an
T, Murakawa, H, Sakamoto, S, Fukada, T, Konishi, M, Nishida   +4 more
openaire   +2 more sources

Isoprene Increases Thermotolerance of Fosmidomycin-Fed Leaves [PDF]

Plant Physiology, 2001
Abstract Isoprene is synthesized and emitted in large amounts by a number of plant species, especially oak (Quercus sp.) and aspen (Populussp.) trees. It has been suggested that isoprene improves thermotolerance by helping photosynthesis cope with high temperature.
Sharkey, Thomas D., Chen, Xiuyen, Yeh, Sansun   +2 more
openaire   +3 more sources

Exploring the Translational Gap of a Novel Class of Escherichia coli IspE Inhibitors

ChemMedChem, Volume 18, Issue 19, October 4, 2023., 2023
Challenges in the discovery of selective IspE inhibitors with antibacterial activity and no toxicity: This work sheds light on the molecular properties for balancing enzymatic target and bacterial activities simultaneously as well as new starting points for the development of IspE inhibitors with a predicted new mode of action.
Henni‐Karoliina Ropponen, Eleonora Diamanti, Sandra Johannsen, Boris Illarionov, Rawia Hamid, Miriam Jaki, Peter Sass, Markus Fischer, Jörg Haupenthal, Anna K. H. Hirsch   +9 more
wiley   +1 more source

α,α-Difluorophosphonohydroxamic Acid Derivatives among the Best Antibacterial Fosmidomycin Analogues

Molecules, 2021
Three α,α-difluorophosphonate derivatives of fosmidomycin were synthesized from diethyl 1,1-difluorobut-3-enylphosphonate and were evaluated on Escherichia coli.
Aurore Dreneau, Fanny S. Krebs, Mathilde Munier, Chheng Ngov, Denis Tritsch, Didier Lièvremont, Michel Rohmer, Catherine Grosdemange-Billiard   +7 more
doaj   +1 more source

Boron-Containing Analogs of Fosmidomycin: Benzoxaborole Derivatives Exhibit Promising Activity Against Resistant Pathogens [PDF]

ACS Omega
James M. Gamrat, Christopher L. Orme, Giulia Mancini, Sarah J. Burke, Latifah M. Alhthlol, Rebecca C. Colandrea, Bryan C. Figula, Dylan T. Tomares, Jason E. Heindl, John W. Tomsho   +9 more
doaj   +2 more sources

Tackling Soil ARG‐Carrying Pathogens with Global‐Scale Metagenomics

Advanced Science, Volume 10, Issue 26, September 15, 2023., 2023
The ultimate risk of antibiotic abuse is the spread of antibiotic resistance genes (ARGs) into pathogens. This work reveals that soilborne AP diversity is driven by human activities, climatic variables, and physicochemical properties at the global scale. Specifically, agricultural land has the highest AP richness.
Binhao Wang, Jianming Xu, Yiling Wang, Erinne Stirling, Kankan Zhao, Caiyu Lu, Xiangfeng Tan, Dedong Kong, Qingyun Yan, Zhili He, Yunjie Ruan, Bin Ma   +11 more
wiley   +1 more source

Resistance of Francisella novicida to Fosmidomycin Associated with Mutations in the Glycerol-3-Phosphate Transporter

Frontiers in Microbiology, 2012
The methylerythritol phosphate (MEP) pathway is essential in most prokaryotes and some lower eukaryotes but absent from human cells, and is a validated target for antimicrobial drug development.
Ryan S Mackie, Ryan S Mackie, Elizabeth S McKenney, Monique L van Hoek, Monique L van Hoek   +4 more
doaj   +1 more source

Predicting Drug Resistance Using Deep Mutational Scanning

Molecules, 2020
Drug resistance is a major healthcare challenge, resulting in a continuous need to develop new inhibitors. The development of these inhibitors requires an understanding of the mechanisms of resistance for a critical mass of occurrences.
Gur Pines, Reilly G. Fankhauser, Carrie A. Eckert   +2 more
doaj   +1 more source