Results 31 to 40 of about 1,660 (188)

Pharmacokinetics and pharmacodynamics of fosmidomycin monotherapy and combination therapy with clindamycin in the treatment of multidrug resistant falciparum malaria

Malaria Journal, 2007
Background The study investigated the pharmacokinetics of fosmidomycin when given alone and in combination with clindamycin in patients with acute uncomplicated falciparum malaria. Methods A total of 15 and 18 patients with acute uncomplicated Plasmodium
Chauemung Anurak, Karbwang Juntra, Ruengweerayut Ronnatrai, Na-Bangchang Kesara, Hutchinson David   +4 more
doaj   +1 more source

Pharmacokinetics of fosmidomycin, a new phosphonic acid antibiotic [PDF]

Antimicrobial Agents and Chemotherapy, 1982
The pharmacokinetics of fosmidomycin was investigated in animals and humans after parenteral and oral dosing. In dogs the serum concentration was 54.8 microgram/ml at 0.25 h after an intravenous dose of 20 mg/kg, and the half-life was 1.14 h. Peak concentration was 41.4 microgram/ml after an intramuscular dose of 20 mg/kg and 16.6 microgram/ml after an
T, Murakawa, H, Sakamoto, S, Fukada, T, Konishi, M, Nishida   +4 more
openaire   +2 more sources

Exploring the Translational Gap of a Novel Class of Escherichia coli IspE Inhibitors

ChemMedChem, Volume 18, Issue 19, October 4, 2023., 2023
Challenges in the discovery of selective IspE inhibitors with antibacterial activity and no toxicity: This work sheds light on the molecular properties for balancing enzymatic target and bacterial activities simultaneously as well as new starting points for the development of IspE inhibitors with a predicted new mode of action.
Henni‐Karoliina Ropponen, Eleonora Diamanti, Sandra Johannsen, Boris Illarionov, Rawia Hamid, Miriam Jaki, Peter Sass, Markus Fischer, Jörg Haupenthal, Anna K. H. Hirsch   +9 more
wiley   +1 more source

Optimization synthesis of phosphorous-containing natural products fosmidomycin and FR900098

, 2023
Fosmidomycin and its acetyl analogue FR900098 are two phosphorus-containing natural products with inhibitory activity against IspC enzyme in the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway of isoprenoid biosynthesis in plants and most bacteria ...
Aidong Zhang (87588), Xin Wu (10164), Chunlin Song (14557445), Jiang Duan (8506905), Hongrui Ping (14557442)   +4 more
core   +1 more source

Tackling Soil ARG‐Carrying Pathogens with Global‐Scale Metagenomics

Advanced Science, Volume 10, Issue 26, September 15, 2023., 2023
The ultimate risk of antibiotic abuse is the spread of antibiotic resistance genes (ARGs) into pathogens. This work reveals that soilborne AP diversity is driven by human activities, climatic variables, and physicochemical properties at the global scale. Specifically, agricultural land has the highest AP richness.
Binhao Wang, Jianming Xu, Yiling Wang, Erinne Stirling, Kankan Zhao, Caiyu Lu, Xiangfeng Tan, Dedong Kong, Qingyun Yan, Zhili He, Yunjie Ruan, Bin Ma   +11 more
wiley   +1 more source

SYNTHESIS AND EVALUATION OF FOSMIDOMYCIN ANALOGUES AS ANTIMALARIAL AGENTS

, 2007
This Ph.D. study constitutes part of an extensive project dealing with the design and development of new agents with antimalarial activity. The enzyme 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR), which is involved in the DOXP pathway for isoprenoid synthesis, was chosen as drug target.
Haemers, Timothy
openaire   +3 more sources

Ein neues bakterielles, von Adenosin abgeleitetes Nukleosid als Beispiel für RNA‐Modifikationsschäden

Angewandte Chemie, Volume 135, Issue 11, March 6, 2023., 2023
Durch Kombination von Tandem‐Massenspektrometrie und Isotopenmarkierung wurde 2‐Methylthio‐1,N6‐ethenoadenosin (ms2ϵA) als neue Nukleosid‐Spezies in bakterieller transfer‐RNA (tRNA) identifiziert. Das seltene Vorkommen auf tRNAs, insbesondere wenn diese in die Translation involviert sind, sowie strukturelle und metabolische Ähnlichkeiten zur bekannten ...
Larissa Bessler, Lea‐Marie Vogt, Marc Lander, Christina Dal Magro, Patrick Keller, Jonas Kühlborn, Christopher J. Kampf, Till Opatz, Mark Helm   +8 more
wiley   +1 more source

Boron-Containing Analogs of Fosmidomycin: Benzoxaborole Derivatives Exhibit Promising Activity Against Resistant Pathogens [PDF]

ACS Omega
James M. Gamrat, Christopher L. Orme, Giulia Mancini, Sarah J. Burke, Latifah M. Alhthlol, Rebecca C. Colandrea, Bryan C. Figula, Dylan T. Tomares, Jason E. Heindl, John W. Tomsho   +9 more
doaj   +2 more sources

Fosmidomycin-induced metabolic imbalance is relieved by mutations in GAPDH.

, 2022
(A) Schematic showing metabolites upstream and downstream of GAPDH function. Abundance ratios (FSM + / FSM -) are displayed for parent (par) and mutant (mut) strains.
Naomi Ghebremichael (9578319), Gavin Nicholas John (13794466), Lisa K. McLellan (10053043), Audrey Ragan Odom John (13794469), Dana M. Hodge (13794463), Andrew J. Jezewski (8934521), Ann M. Guggisberg (13794460)   +6 more
core   +1 more source

A New Bacterial Adenosine‐Derived Nucleoside as an Example of RNA Modification Damage

Angewandte Chemie International Edition, Volume 62, Issue 11, March 6, 2023., 2023
Tandem mass spectrometry combined with stable isotope labelling identified a new nucleoside species, namely 2‐methylthio‐1,N6‐ethenoadenosine (ms2ϵA), in bacterial transfer RNA (tRNA). Its rare occurrence on tRNA, especially when involved in translation, and the structural as well as metabolic relation to the known tRNA modification 2‐methylthio‐N6 ...
Larissa Bessler, Lea‐Marie Vogt, Marc Lander, Christina Dal Magro, Patrick Keller, Jonas Kühlborn, Christopher J. Kampf, Till Opatz, Mark Helm   +8 more
wiley   +1 more source