Results 1 to 10 of about 11,839 (145)
On the Origin of Isoprenoid Biosynthesis. [PDF]
Mol Biol Evol, 2018 Isoprenoids and their derivatives represent the largest group of organic compounds in nature and are distributed universally in the three domains of life. Isoprenoids are biosynthesized from isoprenyl diphosphate units, generated by two distinctive biosynthetic pathways: mevalonate pathway and methylerthritol 4-phosphate pathway. Archaea and eukaryotes
Hoshino Y, Gaucher EA.
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The isoprenoid alcohol pathway, a synthetic route for isoprenoid biosynthesis. [PDF]
Proc Natl Acad Sci U S A, 2019 Significance We have demonstrated the design, prototyping, and implementation of a non-natural route to isoprenoid biosynthesis, termed the isoprenoid alcohol (IPA) pathway. Opposed to working within the confines of native metabolic pathways, our approach of utilizing all available biochemical reactions identified a synthetic route to ...
Clomburg JM +4 more
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Targeting the isoprenoid pathway in choleste biosynthesis: An approach to identify isoprenoid biosynthesis inhibitors. [PDF]
Arch Pharm (Weinheim)Abstract The development of novel cholesterol biosynthesis inhibitors is a task of major concern due to the diverse roles of cholesterol and its precursors in physiological processes. Therefore, appropriate screening assays are required, which can be used to identify and quantify specific inhibitors targeting the desired enzyme. Here,
Liebl M, Olander F, Müller C.
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Isoprenoid biosynthesis in Plasmodium falciparum. [PDF]
Eukaryot Cell, 2014 ABSTRACT Malaria kills nearly 1 million people each year, and the protozoan parasite Plasmodium falciparum has become increasingly resistant to current therapies. Isoprenoid synthesis via the methylerythritol phosphate (MEP) pathway represents an attractive target for the development of new antimalarials ...
Guggisberg AM, Amthor RE, Odom AR.
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Methylerythritol phosphate pathway of isoprenoid biosynthesis. [PDF]
Annu Rev Biochem, 2013 Isoprenoids are a class of natural products with more than 55,000 members. All isoprenoids are constructed from two precursors, isopentenyl diphosphate and its isomer dimethylallyl diphosphate. Two of the most important discoveries in isoprenoid biosynthetic studies in recent years are the elucidation of a second isoprenoid biosynthetic pathway [the ...
Zhao L, Chang WC, Xiao Y, Liu HW, Liu P.
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Isoprenoid biosynthesis regulation in poplars by methylerythritol phosphate and mevalonic acid pathways [PDF]
Frontiers in Plant Science, 2022 Ali Movahedi +2 more
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Shortcut for isoprenoid biosynthesis [PDF]
Nature Catalysis, 2019 Jan-Stefan Voller, Voller Jan-Stefan
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Role of Peroxisomes in Isoprenoid Biosynthesis [PDF]
Journal of Histochemistry & Cytochemistry, 1999 Our group and others have recently demonstrated that peroxisomes contain a number of enzymes involved in cholesterol biosynthesis that previously were considered to be cytosolic or located in the endoplasmic reticulum (ER). Peroxisomes have been shown to contain HMG-CoA reductase, mevalonate kinase, phosphomevalonate kinase, phosphomevalonate ...
N, Aboushadi +3 more
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Isoprenoid biosynthesis in bacterial pathogens
Microbiology, 2012 Isoprenoid biosynthesis is essential for cell survival. Over 35 000 isoprenoid molecules have been identified to date in the three domains of life (bacteria, archaea and eukaryotes), and these molecules are involved in a wide variety of vital biological functions.
Sinéad, Heuston +3 more
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Biosynthesis of Isoprenoid Precursors in Arabidopsis
, 2012 Isoprenoids are the most functionally and structurally diverse group of plant metabolites reported to date. Many of them participate in essential processes, like respiration (ubiquinone), photosynthesis (carotenoids, chlorophylls, plastoquinone), and regulation of growth and development (cytokinins, brassinosteroids, gibberellins, abscisic acid ...
Rodríguez Concepción, Manuel +3 more
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