Isoprenoid biosynthesis regulation in poplars by methylerythritol phosphate and mevalonic acid pathways [PDF]
Frontiers in Plant Science, 2022 It is critical to develop plant isoprenoid production when dealing with human-demanded industries such as flavoring, aroma, pigment, pharmaceuticals, and biomass used for biofuels.
Ali Movahedi, Boas Pucker, Qiang Zhuge
exaly +4 more sources
Downregulation of Squalene Synthase Broadly Impacts Isoprenoid Biosynthesis in Guayule [PDF]
Metabolites, 2022 Production of natural rubber by Parthenium argentaum (guayule) requires increased yield for economic sustainability. An RNAi gene silencing strategy was used to engineer isoprenoid biosynthesis by downregulation of squalene synthase (SQS), such that the ...
Dante Placido +8 more
doaj +2 more sources
Progress and prospects in metabolic engineering approaches for isoprenoid biosynthesis in microalgae [PDF]
Biotechnology for Biofuels and BioproductsIsoprenoids constitute a large and various number of bio-compounds, with many profitable applications in pharmaceutical, nutraceutical, and industrial fields.
Sonia Mohamadnia +3 more
doaj +2 more sources
Overexpression of a pseudo-etiolated-in-light-like protein in Taraxacum koksaghyz leads to a pale green phenotype and enables transcriptome-based network analysis of photomorphogenesis and isoprenoid biosynthesis [PDF]
Frontiers in Plant Science, 2023 IntroductionPlant growth and greening in response to light require the synthesis of photosynthetic pigments such as chlorophylls and carotenoids, which are derived from isoprenoid precursors.
Silva Melissa Wolters +7 more
doaj +2 more sources
MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis [PDF]
Scientific Reports, 2017 The emergence of Plasmodium falciparum resistant to frontline therapeutics has prompted efforts to identify and validate agents with novel mechanisms of action. MEPicides represent a new class of antimalarials that inhibit enzymes of the methylerythritol
Rachel L. Edwards +10 more
doaj +2 more sources
Exploring the Isoprenoid Biosynthesis Pathway’s Role in Oncogenic Viruses [PDF]
VirusesOncogenic viruses, which are causative for some cancers, are typically acquired in youth and suppressed until older age. These malignancies account for over 10% of the cancer burden and often reprogram cellular metabolic pathways to promote their own ...
Louise N. Blaha +4 more
doaj +2 more sources
Harnessing evolution: leveraging bacterial isoprenoid pathway diversity toward improved bioengineering strategies [PDF]
Journal of BacteriologyIsoprenoids play vital roles in all domains of life, from beta-carotene in bacteria to heme in humans. Two distinct metabolic pathways have evolved to synthesize the critical precursor of all mature isoprenoids: the mevalonate (MEV) and the ...
Christine M. Qabar +3 more
doaj +2 more sources
The Mevalonate Pathway: Innovations, Applications, and Challenges in Biotechnology with Emphasis on Fungal Biology [PDF]
Journal of FungiThe mevalonate (MVA) pathway is a central metabolic route responsible for the biosynthesis of isoprenoids with broad biological and biotechnological relevance.
Aisel Valle Garay +16 more
doaj +2 more sources
Renal coenzyme A (CoA) production from VB5 fuels stem cell proliferation and tumor growth [PDF]
Nature CommunicationsCoenzyme A (CoA), derived from Vitamin B5 (VB5; also called pantothenate), is essential for lipid metabolism, energy production, and cell proliferation. While the intracellular functions of CoA are well-characterized, much less is known about its tissue ...
Ting Miao +9 more
doaj +2 more sources
Diversifying Isoprenoid Platforms via Atypical Carbon Substrates and Non-model Microorganisms
Frontiers in Microbiology, 2021 Isoprenoid compounds are biologically ubiquitous, and their characteristic modularity has afforded products ranging from pharmaceuticals to biofuels. Isoprenoid production has been largely successful in Escherichia coli and Saccharomyces cerevisiae with ...
David N. Carruthers +3 more
doaj +1 more source