Results 31 to 40 of about 383 (148)

Effects of aluminum (Al) stress on the isoprenoid metabolism of two Citrus species differing in Al-tolerance

Ecotoxicology and Environmental Safety
Isoprenoid metabolism and its derivatives took part in photosynthesis, growth regulation, signal transduction, and plant defense to biotic and abiotic stresses.
Lin-Tong Yang, Yan-Yu Wang, Xiao-Ying Chen, Qiu-Xiang Fu, Yi-Min Ren, Xi-Wen Lin, Xin Ye, Li-Song Chen   +7 more
doaj   +1 more source

Multi‐tissue Metabolic GWAS and Drought‐Responsive Multi‐omics Reveal the Genetic Basis of the Quinoa Metabolome

Advanced Science, EarlyView.
A multi‐omics framework combining multitissue genome‐wide association studies, metabolomics, transcriptomics, proteomics, and functional validation uncovers the genetic basis of specialized metabolism in quinoa. The study identifies hundreds of metabolite‐associated loci, prioritizes candidate genes for saponin, betalain, and flavonoid biosynthesis ...
Julia von Steimker, Elodie L. Rey, Clara Stanschewski, Regina Wendenburg, Annabella Klemmer, Markéta Macho, Venkatesh P. Thirumalaikumar, Noha O. Saber, Aleksandra Skirycz, Alisdair R. Fernie, Mark Tester, Saleh Alseekh   +11 more
wiley   +1 more source

Exploring Drug Targets in Isoprenoid Biosynthetic Pathway for Plasmodium falciparum

Biochemistry Research International, 2014
Emergence of rapid drug resistance to existing antimalarial drugs in Plasmodium falciparum has created the need for prediction of novel targets as well as leads derived from original molecules with improved activity against a validated drug target.
Tabish Qidwai, Farrukh Jamal, Mohd Y. Khan, Bechan Sharma   +3 more
doaj   +1 more source

Overexpression of a pseudo-etiolated-in-light-like protein in Taraxacum koksaghyz leads to a pale green phenotype and enables transcriptome-based network analysis of photomorphogenesis and isoprenoid biosynthesis

Frontiers in Plant Science, 2023
IntroductionPlant growth and greening in response to light require the synthesis of photosynthetic pigments such as chlorophylls and carotenoids, which are derived from isoprenoid precursors.
Silva Melissa Wolters, Vincent Alexander Benninghaus, Kai-Uwe Roelfs, Nicole van Deenen, Richard M. Twyman, Dirk Prüfer, Dirk Prüfer, Christian Schulze Gronover   +7 more
doaj   +1 more source

Discovery of Several Novel Targets that Enhance β-Carotene Production in Saccharomyces cerevisiae

Frontiers in Microbiology, 2017
β-Carotene is the precursor of vitamin A, and also exhibits multiple pharmaceutical functions by itself. In comparison to chemical synthesis, the production of β-carotene in microbes by metabolic engineering strategy is relatively inexpensive ...
Jia Li, Jia Shen, Zhiqiang Sun, Jing Li, Changfu Li, Xiaohua Li, Xiaohua Li, Yansheng Zhang   +7 more
doaj   +1 more source

Isoprenoid alcohols utilization by malaria parasites

Frontiers in Chemistry, 2022
Plasmodium falciparum is the etiological agent of human malaria, one of the most widespread diseases in tropical and subtropical regions. Drug resistance is one of the biggest problems in controlling the disease, which leads to the need to discover new ...
Ignasi Bofill Verdaguer, Rodrigo A. C. Sussmann, Rodrigo A. C. Sussmann, Verônica Feijoli Santiago, Giuseppe Palmisano, Gabriel Cândido Moura, Juliana Tonini Mesquita, Lydia Fumiko Yamaguchi, Massuo Jorge Kato, Alejandro Miguel Katzin, Marcell Crispim   +10 more
doaj   +1 more source

Biosynthesis of isoprenoids [PDF]

European Journal of Biochemistry, 2004
In the nonmevalonate pathway of isoprenoid biosynthesis, the conversion of 2C‐methyl‐d‐erythritol 4‐phosphate into its cyclic diphosphate proceeds via nucleotidyl intermediates and is catalyzed by the products of the ispD, ispE and ispF genes. An open reading frame of Campylobacter jejuni with similarity to the ispD and ispF genes of Escherichia coli ...
Mads, Gabrielsen, Felix, Rohdich, Wolfgang, Eisenreich, Tobias, Gräwert, Stefan, Hecht, Adelbert, Bacher, William N, Hunter   +6 more
openaire   +2 more sources

Evolutionary, Functional and Mechanistic Characterisation of Microbial Terpene Synthase‐Like Genes From Springtails

Angewandte Chemie International Edition, EarlyView.
A genome analysis revealed the presence of many bacterial‐type terpene synthases in springtails. Four enzymes from Sinella curviseta were functionally characterised, resulting in the isolation of several compounds including sinellene ether, the first diterpene ether identified from a terpene synthase that represents a novel skeleton.
Min Wang, Clement Schneider, Zarley Rebholz, Stefan Schulz, Kathy Darragh, Jeroen S. Dickschat   +5 more
wiley   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Diversity of ABBA Prenyltransferases in Marine Streptomyces sp. CNQ-509: Promiscuous Enzymes for the Biosynthesis of Mixed Terpenoid Compounds.

PLoS ONE, 2015
Terpenoids are arguably the largest and most diverse family of natural products, featuring prominently in e.g. signalling, self-defence, UV-protection and electron transfer.
Franziska Leipoldt, Philipp Zeyhle, Andreas Kulik, Jörn Kalinowski, Lutz Heide, Leonard Kaysser   +5 more
doaj   +1 more source