Results 41 to 50 of about 12,755 (182)

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source

Discovery of Several Novel Targets that Enhance β-Carotene Production in Saccharomyces cerevisiae

Frontiers in Microbiology, 2017
β-Carotene is the precursor of vitamin A, and also exhibits multiple pharmaceutical functions by itself. In comparison to chemical synthesis, the production of β-carotene in microbes by metabolic engineering strategy is relatively inexpensive ...
Jia Li, Jia Shen, Zhiqiang Sun, Jing Li, Changfu Li, Xiaohua Li, Xiaohua Li, Yansheng Zhang   +7 more
doaj   +1 more source

Isoprenoid alcohols utilization by malaria parasites

Frontiers in Chemistry, 2022
Plasmodium falciparum is the etiological agent of human malaria, one of the most widespread diseases in tropical and subtropical regions. Drug resistance is one of the biggest problems in controlling the disease, which leads to the need to discover new ...
Ignasi Bofill Verdaguer, Rodrigo A. C. Sussmann, Rodrigo A. C. Sussmann, Verônica Feijoli Santiago, Giuseppe Palmisano, Gabriel Cândido Moura, Juliana Tonini Mesquita, Lydia Fumiko Yamaguchi, Massuo Jorge Kato, Alejandro Miguel Katzin, Marcell Crispim   +10 more
doaj   +1 more source

Evolutionary, Functional and Mechanistic Characterisation of Microbial Terpene Synthase‐Like Genes From Springtails

Angewandte Chemie International Edition, EarlyView.
A genome analysis revealed the presence of many bacterial‐type terpene synthases in springtails. Four enzymes from Sinella curviseta were functionally characterised, resulting in the isolation of several compounds including sinellene ether, the first diterpene ether identified from a terpene synthase that represents a novel skeleton.
Min Wang, Clement Schneider, Zarley Rebholz, Stefan Schulz, Kathy Darragh, Jeroen S. Dickschat   +5 more
wiley   +1 more source

Biosynthesis of isoprenoids [PDF]

European Journal of Biochemistry, 2004
In the nonmevalonate pathway of isoprenoid biosynthesis, the conversion of 2C‐methyl‐d‐erythritol 4‐phosphate into its cyclic diphosphate proceeds via nucleotidyl intermediates and is catalyzed by the products of the ispD, ispE and ispF genes. An open reading frame of Campylobacter jejuni with similarity to the ispD and ispF genes of Escherichia coli ...
Mads, Gabrielsen, Felix, Rohdich, Wolfgang, Eisenreich, Tobias, Gräwert, Stefan, Hecht, Adelbert, Bacher, William N, Hunter   +6 more
openaire   +2 more sources

Diversity of ABBA Prenyltransferases in Marine Streptomyces sp. CNQ-509: Promiscuous Enzymes for the Biosynthesis of Mixed Terpenoid Compounds.

PLoS ONE, 2015
Terpenoids are arguably the largest and most diverse family of natural products, featuring prominently in e.g. signalling, self-defence, UV-protection and electron transfer.
Franziska Leipoldt, Philipp Zeyhle, Andreas Kulik, Jörn Kalinowski, Lutz Heide, Leonard Kaysser   +5 more
doaj   +1 more source

Evolutionary flexibility and rigidity in the bacterial methylerythritol phosphate (MEP) pathway

Frontiers in Microbiology, 2023
Terpenoids are a diverse class of compounds with wide-ranging uses including as industrial solvents, pharmaceuticals, and fragrances. Efforts to produce terpenoids sustainably by engineering microbes for fermentation are ongoing, but industrial ...
Bailey Marshall, Bailey Marshall, Kaustubh Amritkar, Michael Wolfe, Michael Wolfe, Betül Kaçar, Robert Landick, Robert Landick, Robert Landick   +8 more
doaj   +1 more source

Valorization of Textile Waste: Enzymatic Upcycling of Terephthalic Acid Toward a Sustainable PET Value Chain

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT The rapid expansion of the global textile industry, driven by the fast‐fashion paradigm, which is characterized by low‐cost, short‐lived garments made from inexpensive synthetic fibers, has intensified environmental pressures through increased waste generation, resource depletion, microplastic pollution, and greenhouse gas emissions ...
Fares Al‐Ostoot, Loredano Pollegioni, Elena Rosini   +2 more
wiley   +1 more source

Differential roles of Cassia tora 1-deoxy-D-xylulose-5-phosphate synthase and 1-deoxy-D-xylulose-5-phosphate reductoisomerase in trade-off between plant growth and drought tolerance

Frontiers in Plant Science, 2023
Due to global climate change, drought is emerging as a major threat to plant growth and agricultural productivity. Abscisic acid (ABA) has been implicated in plant drought tolerance, however, its retarding effects on plant growth cannot be ignored.
Chunyao Tian, Huige Quan, Ruiping Jiang, Qiaomu Zheng, Sipei Huang, Guodong Tan, Chaoyue Yan, Jiayu Zhou, Hai Liao   +8 more
doaj   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source