Results 21 to 30 of about 13,872 (224)

Harnessing evolution: leveraging bacterial isoprenoid pathway diversity toward improved bioengineering strategies. [PDF]

J Bacteriol
Isoprenoids play vital roles in all domains of life, from beta-carotene in bacteria to heme in humans. Two distinct metabolic pathways have evolved to synthesize the critical precursor of all mature isoprenoids: the mevalonate (MEV) and the ...
Qabar CM, Marshall BA, Landick R, Cox JS.   +3 more
europepmc   +2 more sources

Renal coenzyme A (CoA) production from VB5 fuels stem cell proliferation and tumor growth. [PDF]

Nat Commun
Coenzyme A (CoA), derived from Vitamin B5 (VB5; also called pantothenate), is essential for lipid metabolism, energy production, and cell proliferation. While the intracellular functions of CoA are well-characterized, much less is known about its tissue ...
Miao T, Liu Y, Qadiri M, Dasseux A, Asara JM, Hu Y, Sun X, Pliego-Alcántara LDC, Dibble CC, Perrimon N.   +9 more
europepmc   +3 more sources

Plastid methylerythritol phosphate pathway participates in the hypersensitive response-related cell death in Nicotiana benthamiana

Frontiers in Plant Science, 2022
Programmed cell death (PCD), a characteristic feature of hypersensitive response (HR) in plants, is an important cellular process often associated with the defense response against pathogens.
Sanghun Lee, Sanghun Lee, Sung Hee Jo, Chi Eun Hong, Jiyoung Lee, Jiyoung Lee, Byeongjin Cha, Jeong Mee Park   +7 more
doaj   +1 more source

Distinct Peculiarities of In Planta Synthesis of Isoprenoid and Aromatic Cytokinins

Biomolecules, 2020
The biosynthesis of aromatic cytokinins in planta, unlike isoprenoid cytokinins, is still unknown. To compare the final steps of biosynthesis pathways of aromatic and isoprenoid cytokinins, we synthesized a series of nucleoside derivatives of natural ...
Vladimir E. Oslovsky, Ekaterina M. Savelieva, Mikhail S. Drenichev, Georgy A. Romanov, Sergey N. Mikhailov   +4 more
doaj   +1 more source

Phosphomevalonate kinase is a cytosolic protein in humans

Journal of Lipid Research, 2004
In the past decade, a predominant peroxisomal localization has been reported for several enzymes functioning in the presqualene segment of the cholesterol/isoprenoid biosynthesis pathway.
Sietske Hogenboom, John J.M. Tuyp, Marc Espeel, Janet Koster, Ronald J.A. Wanders, Hans R. Waterham   +5 more
doaj   +1 more source

Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase [PDF]

, 2007
This research was supported by the German Academic Exchange Service (DAAD), the Wellcome Trust (TKS and WNH as Trust Senior Research fellows), the Biotechnology and Biological Science Research Council (Structural Proteomics of Rational Targets) and the ...
Tanja Sgraja, Smith, Terry K, Terry K Smith, Sgraja, Tanja, Hunter, William N., William N Hunter, Hunter, William N   +6 more
core   +1 more source

An Artificial Pathway for Isoprenoid Biosynthesis Decoupled from Native Hemiterpene Metabolism. [PDF]

ACS Synth Biol, 2019
Isoprenoids are constructed in nature using hemiterpene building blocks that are biosynthesized from lengthy enzymatic pathways with little opportunity to deploy precursor-directed biosynthesis.
Lund S, Hall R, Williams GJ.
europepmc   +2 more sources

A Metabolic Dependency for Host Isoprenoids in the Obligate Intracellular Pathogen Rickettsia parkeri Underlies a Sensitivity to the Statin Class of Host-Targeted Therapeutics

mSphere, 2019
Gram-negative bacteria in the order Rickettsiales have an obligate intracellular growth requirement, and some species cause human diseases such as typhus and spotted fever.
Vida Ahyong, Charles A. Berdan, Thomas P. Burke, Daniel K. Nomura, Matthew D. Welch   +4 more
doaj   +1 more source

Cellular development associated with induced mycotoxin synthesis in the filamentous fungus Fusarium graminearum. [PDF]

PLoS ONE, 2013
Several species of the filamentous fungus Fusarium colonize plants and produce toxic small molecules that contaminate agricultural products, rendering them unsuitable for consumption. Among the most destructive of these species is F.
Jon Menke, Jakob Weber, Karen Broz, H Corby Kistler   +3 more
doaj   +1 more source

Stable isotope and chemical inhibition analyses suggested the existence of a non-mevalonate-like pathway in the yeast Yarrowia lipolytica

Scientific Reports, 2021
Methyl erythritol phosphate (MEP) is the metabolite found in the MEP pathway for isoprenoid biosynthesis, which is known to be utilized by plants, algae, and bacteria. In this study, an unprecedented observation was found in the oleaginous yeast Yarrowia
Sivamoke Dissook, Tomohisa Kuzuyama, Yuri Nishimoto, Shigeru Kitani, Sastia Putri, Eiichiro Fukusaki   +5 more
doaj   +1 more source