Results 21 to 30 of about 12,755 (182)

Cellular development associated with induced mycotoxin synthesis in the filamentous fungus Fusarium graminearum. [PDF]

PLoS ONE, 2013
Several species of the filamentous fungus Fusarium colonize plants and produce toxic small molecules that contaminate agricultural products, rendering them unsuitable for consumption. Among the most destructive of these species is F.
Jon Menke, Jakob Weber, Karen Broz, H Corby Kistler   +3 more
doaj   +1 more source

A Metabolic Dependency for Host Isoprenoids in the Obligate Intracellular Pathogen Rickettsia parkeri Underlies a Sensitivity to the Statin Class of Host-Targeted Therapeutics

mSphere, 2019
Gram-negative bacteria in the order Rickettsiales have an obligate intracellular growth requirement, and some species cause human diseases such as typhus and spotted fever.
Vida Ahyong, Charles A. Berdan, Thomas P. Burke, Daniel K. Nomura, Matthew D. Welch   +4 more
doaj   +1 more source

Stable isotope and chemical inhibition analyses suggested the existence of a non-mevalonate-like pathway in the yeast Yarrowia lipolytica

Scientific Reports, 2021
Methyl erythritol phosphate (MEP) is the metabolite found in the MEP pathway for isoprenoid biosynthesis, which is known to be utilized by plants, algae, and bacteria. In this study, an unprecedented observation was found in the oleaginous yeast Yarrowia
Sivamoke Dissook, Tomohisa Kuzuyama, Yuri Nishimoto, Shigeru Kitani, Sastia Putri, Eiichiro Fukusaki   +5 more
doaj   +1 more source

Isoprenoid biosynthesis in bacterial pathogens

Microbiology, 2012
Isoprenoid biosynthesis is essential for cell survival. Over 35 000 isoprenoid molecules have been identified to date in the three domains of life (bacteria, archaea and eukaryotes), and these molecules are involved in a wide variety of vital biological functions.
Sinéad, Heuston, Máire, Begley, Cormac G M, Gahan, Colin, Hill   +3 more
openaire   +2 more sources

Metabolic Remodeling during Nitrogen Fixation in Zymomonas mobilis

mSystems, 2021
Zymomonas mobilis is an ethanologenic bacterium currently being developed for production of advanced biofuels. Recent studies have shown that Z. mobilis can fix dinitrogen gas (N2) as a sole nitrogen source. During N2 fixation, Z.
Julia I. Martien, Edna A. Trujillo, Tyler B. Jacobson, Mehmet Tatli, Alexander S. Hebert, David M. Stevenson, Joshua J. Coon, Daniel Amador-Noguez   +7 more
doaj   +1 more source

Comprehensive evaluation of isoprenoid biosynthesis regulation in Saccharomyces cerevisiae utilizing the Genome Reporter Matrix™

Journal of Lipid Research, 1999
Gene expression profiling is rapidly becoming a mainstay of functional genomic studies. However, there have been relatively few studies of how the data from expression profiles integrate with more classic approaches to examine gene expression. This study
Dago Dimster-Denk, Jasper Rine, John Phillips, Stewart Scherer, Paige Cundiff, Kristin DeBord, Doug Gilliland, Scott Hickman, Amy Jarvis, Lisa Tong, Matthew Ashby   +10 more
doaj   +1 more source

The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite

Nature Communications, 2021
Repeating fever is a hallmark of malaria. Here, a large-scale forward genetic screen in malaria-causing Plasmodium falciparum identifies genes associated with parasite tolerance to host fever, including apicoplast targeted isoprenoid biosynthesis—sharing
Min Zhang, Chengqi Wang, Jenna Oberstaller, Phaedra Thomas, Thomas D. Otto, Debora Casandra, Sandhya Boyapalle, Swamy R. Adapa, Shulin Xu, Katrina Button-Simons, Matthew Mayho, Julian C. Rayner, Michael T. Ferdig, Rays H. Y. Jiang, John H. Adams   +14 more
doaj   +1 more source

Broad‐Spectrum, Cell Envelope‐Active Marinocyclin Antibiotics From a Coral‐Derived Bacterium Are Effective Against Colistin‐Resistant Bacteria

Angewandte Chemie, EarlyView.
Marinocyclins, polycationic macrocyclic depsipeptides, were discovered by genome mining from the marine coral‐derived bacterium Aquimarina megaterium. The compounds have broad‐spectrum activity against gram‐positive and gram‐negative ESKAPE bacteria.
Clara Chepkirui, Sandra Silva, Jan Straetener, Chandrashekhar Padhi, Tina Keller‐Costa, Tess Lamer, Laura Reinke, Heike Brötz‐Oesterhelt, Rodrigo Costa, Jörn Piel   +9 more
wiley   +2 more sources

The suf iron-sulfur cluster synthesis pathway is required for apicoplast maintenance in malaria parasites. [PDF]

PLoS Pathogens, 2013
The apicoplast organelle of the malaria parasite Plasmodium falciparum contains metabolic pathways critical for liver-stage and blood-stage development.
Jolyn E Gisselberg, Teegan A Dellibovi-Ragheb, Krista A Matthews, Gundula Bosch, Sean T Prigge   +4 more
doaj   +1 more source

Quantifying Isoprenoids in the Ergosterol Biosynthesis by Gas Chromatography–Mass Spectrometry

Journal of Fungi, 2023
The ergosterol pathway is a promising target for the development of new antifungals since its enzymes are essential for fungal cell growth. Appropriate screening assays are therefore needed that allow the identification of potential inhibitors.
Maximilian Liebl, Ludwig Huber, Hesham Elsaman, Petra Merschak, Johannes Wagener, Fabio Gsaller, Christoph Müller   +6 more
doaj   +1 more source