Results 21 to 30 of about 383 (148)
Angewandte Chemie, EarlyView.Fluorescence‐based visualization and targeted mass–spectrometric enrichment of membrane‐embedded isoprenoids in Bacillus subtilis via cell‐permeant, alkynylated DMAPP analogs. ABSTRACT Isoprenoids are a chemically and functionally diverse class of metabolites that underlie essential bacterial physiology including respiration and cell envelope ...
Zackary N. Hulsey +7 more
wiley +2 more sources
The suf iron-sulfur cluster synthesis pathway is required for apicoplast maintenance in malaria parasites. [PDF]
PLoS Pathogens, 2013 The apicoplast organelle of the malaria parasite Plasmodium falciparum contains metabolic pathways critical for liver-stage and blood-stage development.
Jolyn E Gisselberg +4 more
doaj +1 more source
Quantifying Isoprenoids in the Ergosterol Biosynthesis by Gas Chromatography–Mass Spectrometry
Journal of Fungi, 2023 The ergosterol pathway is a promising target for the development of new antifungals since its enzymes are essential for fungal cell growth. Appropriate screening assays are therefore needed that allow the identification of potential inhibitors.
Maximilian Liebl +6 more
doaj +1 more source
Combination of Entner-Doudoroff pathway with MEP increases isoprene production in engineered Escherichia coli. [PDF]
PLoS ONE, 2013 Embden-Meyerhof pathway (EMP) in tandem with 2-C-methyl-D-erythritol 4-phosphate pathway (MEP) is commonly used for isoprenoid biosynthesis in E. coli. However, this combination has limitations as EMP generates an imbalanced distribution of pyruvate and ...
Huaiwei Liu +7 more
doaj +1 more source
Methylerythritol Phosphate Pathway of Isoprenoid Biosynthesis [PDF]
Annual Review of Biochemistry, 2013 Isoprenoids are a class of natural products with more than 55,000 members. All isoprenoids are constructed from two precursors, isopentenyl diphosphate and its isomer dimethylallyl diphosphate. Two of the most important discoveries in isoprenoid biosynthetic studies in recent years are the elucidation of a second isoprenoid biosynthetic pathway [the ...
Lishan, Zhao +4 more
openaire +2 more sources
CHIMIA, 2009 Isoprenoids (or terpenoids) are a large and structurally diverse class of biomolecules that are essential for the survival of all forms of life.
Christopher J. Thibodeaux, Hung-wen Liu
doaj +1 more source
Biosynthesis of Isoprenoid Precursors in Arabidopsis
, 2012 Isoprenoids are the most functionally and structurally diverse group of plant metabolites reported to date. Many of them participate in essential processes, like respiration (ubiquinone), photosynthesis (carotenoids, chlorophylls, plastoquinone), and regulation of growth and development (cytokinins, brassinosteroids, gibberellins, abscisic acid ...
Rodríguez Concepción, Manuel +3 more
openaire +2 more sources
Combining genotype improvement and statistical media optimization for isoprenoid production in E. coli. [PDF]
PLoS ONE, 2013 Isoprenoids are a large and diverse class of compounds that includes many high value natural products and are thus in great demand. To meet the increasing demand for isoprenoid compounds, metabolic engineering of microbes has been used to produce ...
Congqiang Zhang +5 more
doaj +1 more source
Current Plant Biology, 2021 Carotenoids are long conjugated isoprenoid molecules with over 1117 identified structures, belongs to the class of hydrocarbons, involved in a range of biological processes in plants and humans.
Prashant Swapnil +5 more
doaj +1 more source
MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis
Scientific Reports, 2017 The emergence of Plasmodium falciparum resistant to frontline therapeutics has prompted efforts to identify and validate agents with novel mechanisms of action. MEPicides represent a new class of antimalarials that inhibit enzymes of the methylerythritol
Rachel L. Edwards +10 more
doaj +1 more source