Results 11 to 20 of about 13,872 (224)

Downregulation of Squalene Synthase Broadly Impacts Isoprenoid Biosynthesis in Guayule. [PDF]

Metabolites, 2022
Production of natural rubber by Parthenium argentaum (guayule) requires increased yield for economic sustainability. An RNAi gene silencing strategy was used to engineer isoprenoid biosynthesis by downregulation of squalene synthase (SQS), such that the ...
Placido D, Dong N, Amer B, Dong C, Ponciano G, Kahlon T, Whalen M, Baidoo EEK, McMahan C.   +8 more
europepmc   +4 more sources

MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis. [PDF]

Sci Rep, 2017
The emergence of Plasmodium falciparum resistant to frontline therapeutics has prompted efforts to identify and validate agents with novel mechanisms of action. MEPicides represent a new class of antimalarials that inhibit enzymes of the methylerythritol
Edwards RL, Brothers RC, Wang X, Maron MI, Ziniel PD, Tsang PS, Kraft TE, Hruz PW, Williamson KC, Dowd CS, John ARO.   +10 more
europepmc   +3 more sources

Growth-uncoupled isoprenoid synthesis in Rhodobacter sphaeroides.

Biotechnology for Biofuels, 2020
Microbial cell factories are usually engineered and employed for cultivations that combine product synthesis with growth. Such a strategy inevitably invests part of the substrate pool towards the generation of biomass and cellular maintenance.
Beekwilder, Jules, Post, Wilbert, Kengen, Servé W M, Eggink, Gerrit, Kengen, Servé W.M., Dompè, Marco, van der Oost, John, Weusthuis, Ruud A, Orsi, Enrico, Mougiakos, Ioannis, Weusthuis, Ruud A.   +10 more
core   +2 more sources

Archaeal isoprenoid biosynthesis [PDF]

, 2018
Many high value natural products - including artemisinin, squalene, and farnesene – are isoprenoids. Efforts to commercially produce isoprenoids are often complicated by low concentrations of isoprenoid precursors and the toxicity of isoprenoids in common production platforms (i.e. bacteria and yeasts).
Liman, Lie Stefanus Geraldy, author, Santangelo, Thomas, advisor, Laybourn, Paul, committee member, Peebles, Christie, committee member   +3 more
openaire   +2 more sources

Isoprenoid biosynthesis in the diatom Haslea ostrearia [PDF]

New Phytologist, 2018
Summary Diatoms are eukaryotic, unicellular algae that are responsible for c. 20% of the Earth's primary production. Their dominance and success in contemporary oceans have prompted investigations on their distinctive metabolism and physiology. One metabolic pathway that remains largely unexplored in diatoms is isoprenoid biosynthesis, which is ...
Anastasia Athanasakoglou, Emilia Grypioti, Sofia Michailidou, Codruta Ignea, Antonios M. Makris, Kriton Kalantidis, Guillaume Massé, Anagnostis Argiriou, Frederic Verret, Sotirios C. Kampranis   +9 more
openaire   +5 more sources

Metabolic plasticity for isoprenoid biosynthesis in bacteria

Biochemical Journal, 2013
Isoprenoids are a large family of compounds synthesized by all free-living organisms. In most bacteria, the common precursors of all isoprenoids are produced by the MEP (methylerythritol 4-phosphate) pathway. The MEP pathway is absent from archaea, fungi and animals (including humans), which synthesize their isoprenoid precursors using the completely ...
Pérez-Gil, Jordi, Rodriguez-Concepcion, Manuel   +1 more
openaire   +4 more sources

Progress and prospects in metabolic engineering approaches for isoprenoid biosynthesis in microalgae. [PDF]

Biotechnol Biofuels Bioprod
Isoprenoids constitute a large and various number of bio-compounds, with many profitable applications in pharmaceutical, nutraceutical, and industrial fields.
Mohamadnia S, Valverde-Pérez B, Tavakoli O, Angelidaki I.   +3 more
europepmc   +2 more sources

Overexpression of a pseudo-etiolated-in-light-like protein in Taraxacum koksaghyz leads to a pale green phenotype and enables transcriptome-based network analysis of photomorphogenesis and isoprenoid biosynthesis. [PDF]

Front Plant Sci, 2023
IntroductionPlant growth and greening in response to light require the synthesis of photosynthetic pigments such as chlorophylls and carotenoids, which are derived from isoprenoid precursors.
Wolters SM, Benninghaus VA, Roelfs KU, van Deenen N, Twyman RM, Prüfer D, Schulze Gronover C.   +6 more
europepmc   +2 more sources

Diversifying Isoprenoid Platforms via Atypical Carbon Substrates and Non-model Microorganisms

Frontiers in Microbiology, 2021
Isoprenoid compounds are biologically ubiquitous, and their characteristic modularity has afforded products ranging from pharmaceuticals to biofuels. Isoprenoid production has been largely successful in Escherichia coli and Saccharomyces cerevisiae with ...
David N. Carruthers, David N. Carruthers, Taek Soon Lee, Taek Soon Lee   +3 more
doaj   +1 more source

Microbial (E)-4-hydroxy-3-methylbut-2-enyl pyrophosphate reductase (IspH) and its biotechnological potential: A mini review

Frontiers in Bioengineering and Biotechnology, 2022
(E)-4-hydroxy-3-methylbut-2-enyl pyrophosphate (HMBPP) reductase (IspH) is a [4Fe-4S] cluster-containing enzyme, involved in isoprenoid biosynthesis as the final enzyme of the methylerythritol phosphate (MEP) pathway found in many bacteria and malaria ...
Shiyong Huang, Shiyong Huang, Yanfen Xue, Yanhe Ma, Cheng Zhou   +4 more
doaj   +1 more source