Results 11 to 20 of about 383 (148)
The isoprenoid alcohol pathway, a synthetic route for isoprenoid biosynthesis [PDF]
Proceedings of the National Academy of Sciences, 2019 Significance We have demonstrated the design, prototyping, and implementation of a non-natural route to isoprenoid biosynthesis, termed the isoprenoid alcohol (IPA) pathway. Opposed to working within the confines of native metabolic pathways, our approach of utilizing all available biochemical reactions identified a synthetic route to
James M, Clomburg +4 more
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Phosphomevalonate kinase is a cytosolic protein in humans
Journal of Lipid Research, 2004 In the past decade, a predominant peroxisomal localization has been reported for several enzymes functioning in the presqualene segment of the cholesterol/isoprenoid biosynthesis pathway.
Sietske Hogenboom +5 more
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On the Origin of Isoprenoid Biosynthesis
Molecular Biology and Evolution, 2018 Isoprenoids and their derivatives represent the largest group of organic compounds in nature and are distributed universally in the three domains of life. Isoprenoids are biosynthesized from isoprenyl diphosphate units, generated by two distinctive biosynthetic pathways: mevalonate pathway and methylerthritol 4-phosphate pathway. Archaea and eukaryotes
Hoshino, Yosuke, Gaucher, Eric A
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Cellular development associated with induced mycotoxin synthesis in the filamentous fungus Fusarium graminearum. [PDF]
PLoS ONE, 2013 Several species of the filamentous fungus Fusarium colonize plants and produce toxic small molecules that contaminate agricultural products, rendering them unsuitable for consumption. Among the most destructive of these species is F.
Jon Menke +3 more
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mSphere, 2019 Gram-negative bacteria in the order Rickettsiales have an obligate intracellular growth requirement, and some species cause human diseases such as typhus and spotted fever.
Vida Ahyong +4 more
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Scientific Reports, 2021 Methyl erythritol phosphate (MEP) is the metabolite found in the MEP pathway for isoprenoid biosynthesis, which is known to be utilized by plants, algae, and bacteria. In this study, an unprecedented observation was found in the oleaginous yeast Yarrowia
Sivamoke Dissook +5 more
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Isoprenoid biosynthesis in bacterial pathogens
Microbiology, 2012 Isoprenoid biosynthesis is essential for cell survival. Over 35 000 isoprenoid molecules have been identified to date in the three domains of life (bacteria, archaea and eukaryotes), and these molecules are involved in a wide variety of vital biological functions.
Sinéad, Heuston +3 more
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Metabolic Remodeling during Nitrogen Fixation in Zymomonas mobilis
mSystems, 2021 Zymomonas mobilis is an ethanologenic bacterium currently being developed for production of advanced biofuels. Recent studies have shown that Z. mobilis can fix dinitrogen gas (N2) as a sole nitrogen source. During N2 fixation, Z.
Julia I. Martien +7 more
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Journal of Lipid Research, 1999 Gene expression profiling is rapidly becoming a mainstay of functional genomic studies. However, there have been relatively few studies of how the data from expression profiles integrate with more classic approaches to examine gene expression. This study
Dago Dimster-Denk +10 more
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The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite
Nature Communications, 2021 Repeating fever is a hallmark of malaria. Here, a large-scale forward genetic screen in malaria-causing Plasmodium falciparum identifies genes associated with parasite tolerance to host fever, including apicoplast targeted isoprenoid biosynthesis—sharing
Min Zhang +14 more
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