Results 11 to 20 of about 12,755 (182)

On the Origin of Isoprenoid Biosynthesis. [PDF]

Mol Biol Evol, 2018
Isoprenoids and their derivatives represent the largest group of organic compounds in nature and are distributed universally in the three domains of life. Isoprenoids are biosynthesized from isoprenyl diphosphate units, generated by two distinctive biosynthetic pathways: mevalonate pathway and methylerthritol 4-phosphate pathway. Archaea and eukaryotes
Hoshino Y, Gaucher EA.
europepmc   +3 more sources

The isoprenoid alcohol pathway, a synthetic route for isoprenoid biosynthesis. [PDF]

Proc Natl Acad Sci U S A, 2019
Significance We have demonstrated the design, prototyping, and implementation of a non-natural route to isoprenoid biosynthesis, termed the isoprenoid alcohol (IPA) pathway. Opposed to working within the confines of native metabolic pathways, our approach of utilizing all available biochemical reactions identified a synthetic route to
Clomburg JM, Qian S, Tan Z, Cheong S, Gonzalez R.   +4 more
europepmc   +4 more sources

Isoprenoid biosynthesis in Plasmodium falciparum. [PDF]

Eukaryot Cell, 2014
ABSTRACT Malaria kills nearly 1 million people each year, and the protozoan parasite Plasmodium falciparum has become increasingly resistant to current therapies. Isoprenoid synthesis via the methylerythritol phosphate (MEP) pathway represents an attractive target for the development of new antimalarials ...
Guggisberg AM, Amthor RE, Odom AR.
europepmc   +5 more sources

Targeting the isoprenoid pathway in choleste biosynthesis: An approach to identify isoprenoid biosynthesis inhibitors. [PDF]

Arch Pharm (Weinheim)
Abstract The development of novel cholesterol biosynthesis inhibitors is a task of major concern due to the diverse roles of cholesterol and its precursors in physiological processes. Therefore, appropriate screening assays are required, which can be used to identify and quantify specific inhibitors targeting the desired enzyme. Here,
Liebl M, Olander F, Müller C.
europepmc   +4 more sources

Microbial (E)-4-hydroxy-3-methylbut-2-enyl pyrophosphate reductase (IspH) and its biotechnological potential: A mini review

Frontiers in Bioengineering and Biotechnology, 2022
(E)-4-hydroxy-3-methylbut-2-enyl pyrophosphate (HMBPP) reductase (IspH) is a [4Fe-4S] cluster-containing enzyme, involved in isoprenoid biosynthesis as the final enzyme of the methylerythritol phosphate (MEP) pathway found in many bacteria and malaria ...
Shiyong Huang, Shiyong Huang, Yanfen Xue, Yanhe Ma, Cheng Zhou   +4 more
doaj   +1 more source

Role of Peroxisomes in Isoprenoid Biosynthesis [PDF]

Journal of Histochemistry & Cytochemistry, 1999
Our group and others have recently demonstrated that peroxisomes contain a number of enzymes involved in cholesterol biosynthesis that previously were considered to be cytosolic or located in the endoplasmic reticulum (ER). Peroxisomes have been shown to contain HMG-CoA reductase, mevalonate kinase, phosphomevalonate kinase, phosphomevalonate ...
N, Aboushadi, W H, Engfelt, V G, Paton, S K, Krisans   +3 more
openaire   +2 more sources

Growth-uncoupled isoprenoid synthesis in Rhodobacter sphaeroides

Biotechnology for Biofuels, 2020
Background Microbial cell factories are usually engineered and employed for cultivations that combine product synthesis with growth. Such a strategy inevitably invests part of the substrate pool towards the generation of biomass and cellular maintenance.
Enrico Orsi, Ioannis Mougiakos, Wilbert Post, Jules Beekwilder, Marco Dompè, Gerrit Eggink, John van der Oost, Servé W. M. Kengen, Ruud A. Weusthuis   +8 more
doaj   +1 more source

Distinct Peculiarities of In Planta Synthesis of Isoprenoid and Aromatic Cytokinins

Biomolecules, 2020
The biosynthesis of aromatic cytokinins in planta, unlike isoprenoid cytokinins, is still unknown. To compare the final steps of biosynthesis pathways of aromatic and isoprenoid cytokinins, we synthesized a series of nucleoside derivatives of natural ...
Vladimir E. Oslovsky, Ekaterina M. Savelieva, Mikhail S. Drenichev, Georgy A. Romanov, Sergey N. Mikhailov   +4 more
doaj   +1 more source

Plastid methylerythritol phosphate pathway participates in the hypersensitive response-related cell death in Nicotiana benthamiana

Frontiers in Plant Science, 2022
Programmed cell death (PCD), a characteristic feature of hypersensitive response (HR) in plants, is an important cellular process often associated with the defense response against pathogens.
Sanghun Lee, Sanghun Lee, Sung Hee Jo, Chi Eun Hong, Jiyoung Lee, Jiyoung Lee, Byeongjin Cha, Jeong Mee Park   +7 more
doaj   +1 more source

Phosphomevalonate kinase is a cytosolic protein in humans

Journal of Lipid Research, 2004
In the past decade, a predominant peroxisomal localization has been reported for several enzymes functioning in the presqualene segment of the cholesterol/isoprenoid biosynthesis pathway.
Sietske Hogenboom, John J.M. Tuyp, Marc Espeel, Janet Koster, Ronald J.A. Wanders, Hans R. Waterham   +5 more
doaj   +1 more source