Results 51 to 60 of about 1,208 (158)
Acyloxybenzyl and Alkoxyalkyl Prodrugs of a Fosmidomycin Surrogate as Antimalarial and Antitubercular Agents [PDF]
ACS Medicinal Chemistry Letters, 2018 Two classes of prodrugs of a fosmidomycin surrogate were synthesized and investigated for their ability to inhibit in vitro growth of P. falciparum and M. tuberculosis. To this end, a novel efficient synthesis route was developed involving a cross metathesis reaction as a key step.
Charlotte Courtens +4 more
openaire +3 more sources
Angewandte Chemie, Volume 136, Issue 32, August 5, 2024.The Streptomyces phosphonoalamides result from the convergence of phosphonoalanine (PnAla) biosynthesis and peptide ligation pathways. The transamination of phosphonopyruvate (PnPy) to PnAla drives unfavorable C−P bond formation despite its reversibility, establishing this early branch of phosphonate biosynthesis, while the promiscuity of the dipeptide
Jerry J. Cui, Yeying Zhang, Kou‐San Ju
wiley +2 more sources
Fosmidomycin biosynthesis diverges from related phosphonate natural products [PDF]
Nature Chemical Biology, 2019 Fosmidomycin and related molecules comprise a family of phosphonate natural products with potent antibacterial, antimalarial and herbicidal activities. To understand the biosynthesis of these compounds, we characterized the fosmidomycin producer, Streptomyces lavendulae, using biochemical and genetic approaches.
Elizabeth I. Parkinson +4 more
openaire +2 more sources
PLoS ONE, 2013 In Catharanthus roseus, the monoterpene moiety exerts a strong flux control for monoterpene indole alkaloid (MIA) formation. Monoterpene synthesis depends on the methyl-D-erythritol 4-phosphate (MEP) pathway. Here, we have explored the regulation of this
Mei Han +6 more
doaj +1 more source
Ein neuer Malariawirkstoff hemmt die Proteinsynthese von Plasmodium falciparum
Angewandte Chemie, Volume 137, Issue 49, December 1, 2025.Die Verbindung 31 stellt einen vielversprechenden Ansatz für die Entwicklung eines Malariawirkstoffs mit einem starken Wirkungsprofil dar (PfNF54 IC50 ± s.d. = 3,9 ± 0,4 nM). Sie hat einen neuartigen Wirkmechanismus, indem sie an zytosolische Ribosomen‐Untereinheiten bindet und dadurch die Proteinsynthese im Parasiten hemmt.
Patricia Bravo +16 more
wiley +1 more source
Fosmidomycin‐Clindamycin forPlasmodium falciparumInfections in African Children [PDF]
The Journal of Infectious Diseases, 2004 Fosmidomycin is a new antimalarial drug with a novel mechanism of action. Studies in Africa that have evaluated fosmidomycin as monotherapeutic agent demonstrated its excellent tolerance, but 3-times-daily treatment regimens of >or=4 days were required to achieve radical cure, prompting further research to identify and validate a suitable combination ...
Steffen, Borrmann +9 more
openaire +2 more sources
Pharmaceutics, 2022 The evolution of resistance by the malaria parasite to artemisinin, the key component of the combination therapy strategies that are at the core of current antimalarial treatments, calls for the urgent identification of new fast-acting antimalarials. The
Arnau Biosca +7 more
doaj +1 more source
Eutrophication Reshapes Microbial Communities and Life‐History Strategies in the Riverine Ecosystems
Environmental Microbiology Reports, Volume 17, Issue 6, December 2025.We use 16S rRNA amplicon and shotgun metagenomic sequencing to assess the microbiome in urban and natural riverine ecosystems. This study reveals that eutrophication reshapes microbial communities and demonstrates a tendency toward r‐strategy traits in urban river ecosystems.
Haizhou Li +8 more
wiley +1 more source
Fosmidomycin uptake into Plasmodium and Babesia-infected erythrocytes is facilitated by parasite-induced new permeability pathways. [PDF]
PLoS ONE, 2011 BackgroundHighly charged compounds typically suffer from low membrane permeability and thus are generally regarded as sub-optimal drug candidates. Nonetheless, the highly charged drug fosmidomycin and its more active methyl-derivative FR900098 have ...
Stefan Baumeister +12 more
doaj +1 more source
Microbe‐responsive human γδ T cells: the peculiar case of Staphylococcus aureus
Immunology &Cell Biology, Volume 103, Issue 10, Page 938-944, November-December 2025.Human Vγ9/Vδ2 T cells display a unique responsiveness towards microbial organisms producing the metabolite HMB‐PP. However, Staphylococcus aureus does not possess HMB‐PP but can induce activation, cytokine expression and proliferation of Vγ9/Vδ2 T cells regardless. We here discuss potential pathways, ligands and biological functions in this response to
Matthias Eberl +3 more
wiley +1 more source