Results 51 to 60 of about 1,660 (188)

Fosmidomycin‐Clindamycin for the Treatment ofPlasmodium falciparumMalaria [PDF]

The Journal of Infectious Diseases, 2004
It has been demonstrated that fosmidomycin has good tolerability and rapid onset of action, but late recrudescences preclude its use alone; in vitro, clindamycin has been shown to act synergistically with fosmidomycin against Plasmodium falciparum. We conducted a study in pediatric outpatients with P.
Steffen, Borrmann, Saadou, Issifou, Gilbert, Esser, Ayola A, Adegnika, Michael, Ramharter, Pierre-Blaise, Matsiegui, Sunny, Oyakhirome, Dénise P, Mawili-Mboumba, Michel A, Missinou, Jürgen F J, Kun, Hassan, Jomaa, Peter G, Kremsner   +11 more
openaire   +2 more sources

New Application of cycloSaligenyl Prodrugs Approach for the Delivery of Fosfoxacin Derivatives in Mycobacteria

Molecules, 2023
In this work, we implemented for the first time the cycloSaligenyl prodrug strategy to increase the bioavailability of fosmidomycin phosphate analogs in bacteria.
Mathilde Munier, Denis Tritsch, Didier Lièvremont, Michel Rohmer, Catherine Grosdemange-Billiard   +4 more
doaj   +1 more source

The MEP pathway in Babesia orientalis apicoplast, a potential target for anti-babesiosis drug development

Parasites & Vectors, 2018
Background The apicomplexan parasite Babesia orientalis, the causative agent of water buffalo babesiosis in China, is widespread in central and south China, resulting in a huge economic loss annually.
Lan He, Pei He, Xiaoying Luo, Muxiao Li, Long Yu, Jiaying Guo, Xueyan Zhan, Guan Zhu, Junlong Zhao   +8 more
doaj   +1 more source

Kinetic characterization and allosteric inhibition of the Yersinia pestis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). [PDF]

PLoS ONE, 2014
The methylerythritol phosphate (MEP) pathway found in many bacteria governs the synthesis of isoprenoids, which are crucial lipid precursors for vital cell components such as ubiquinone.
Amanda Haymond, Chinchu Johny, Tyrone Dowdy, Brandon Schweibenz, Karen Villarroel, Richard Young, Clark J Mantooth, Trishal Patel, Jessica Bases, Geraldine San Jose, Emily R Jackson, Cynthia S Dowd, Robin D Couch   +12 more
doaj   +1 more source

Divergent Isoprenoid Biosynthesis Pathways in Staphylococcus Species Constitute a Drug Target for Treating Infections in Companion Animals

mSphere, 2016
Staphylococcus species are a leading cause of skin and soft tissue infections in humans and animals, and the antibiotics used to treat these infections are often the same.
Ana M. Misic, Christine L. Cain, Daniel O. Morris, Shelley C. Rankin, Daniel P. Beiting   +4 more
doaj   +1 more source

Phosphonoalamides Reveal the Biosynthetic Origin of Phosphonoalanine Natural Products and a Convergent Pathway for Their Diversification

Angewandte Chemie, Volume 136, Issue 32, August 5, 2024.
The Streptomyces phosphonoalamides result from the convergence of phosphonoalanine (PnAla) biosynthesis and peptide ligation pathways. The transamination of phosphonopyruvate (PnPy) to PnAla drives unfavorable C−P bond formation despite its reversibility, establishing this early branch of phosphonate biosynthesis, while the promiscuity of the dipeptide
Jerry J. Cui, Yeying Zhang, Kou‐San Ju
wiley   +2 more sources

Fosmidomycin accumulation in E. coli.

, 2018
E. coli was treated with 110 μM (20 μg/mL) or 550 μM (100 μg/mL) fosmidomycin in CAMHB (■) or M9-glucose () medium. Intracellular fosmidomycin accumulation was monitored by LC-MS (SRM method).
Sara Sanders (4163479), Caren L. Freel Meyers (2026792), Paul D. Phillips (584411), Andrew T. Koppisch (584413), David Bartee (1322541), Mackenzie J. Harrison (4163482)   +5 more
core   +1 more source

Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase). [PDF]

PLoS ONE, 2009
Deliberate and natural outbreaks of infectious disease underscore the necessity of effective vaccines and antimicrobial/antiviral therapeutics. The prevalence of antibiotic resistant strains and the ease by which antibiotic resistant bacteria can be ...
Safdar Jawaid, Heather Seidle, Weidong Zhou, Hafsa Abdirahman, Maher Abadeer, Joseph H Hix, Monique L van Hoek, Robin D Couch   +7 more
doaj   +1 more source

A Second Target of the Antimalarial and Antibacterial Agent Fosmidomycin Revealed by Cellular Metabolic Profiling

, 2016
Antimicrobial drug resistance is an urgent problem in the control and treatment of many of the world’s most serious infections, including Plasmodium falciparum malaria, tuberculosis, and healthcare-associated infections with Gram-negative bacteria ...
Kristin M. Watts (376448), Baichen Zhang (200418), Dana Hodge (2203810), Leslie M. Hicks (200420), Audrey R. Odom (336744), David A. Hunstad (376449), Lisa M. Kemp (2203813)   +6 more
core   +1 more source

The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in Plasmodium falciparum

mBio, 2019
Members of the haloacid dehalogenase (HAD) family of metabolite phosphatases play an important role in regulating multiple pathways in Plasmodium falciparum central carbon metabolism. We show that the P.
Laure Dumont, Mark B. Richardson, Phillip van der Peet, Danushka S. Marapana, Tony Triglia, Matthew W. A. Dixon, Alan F. Cowman, Spencer J. Williams, Leann Tilley, Malcolm J. McConville, Simon A. Cobbold   +10 more
doaj   +1 more source