Results 51 to 60 of about 1,235 (162)

Phosphonoalamides Reveal the Biosynthetic Origin of Phosphonoalanine Natural Products and a Convergent Pathway for Their Diversification

Angewandte Chemie, Volume 136, Issue 32, August 5, 2024.
The Streptomyces phosphonoalamides result from the convergence of phosphonoalanine (PnAla) biosynthesis and peptide ligation pathways. The transamination of phosphonopyruvate (PnPy) to PnAla drives unfavorable C−P bond formation despite its reversibility, establishing this early branch of phosphonate biosynthesis, while the promiscuity of the dipeptide
Jerry J. Cui, Yeying Zhang, Kou‐San Ju
wiley   +2 more sources

The MEP pathway in Babesia orientalis apicoplast, a potential target for anti-babesiosis drug development

Parasites & Vectors, 2018
Background The apicomplexan parasite Babesia orientalis, the causative agent of water buffalo babesiosis in China, is widespread in central and south China, resulting in a huge economic loss annually.
Lan He, Pei He, Xiaoying Luo, Muxiao Li, Long Yu, Jiaying Guo, Xueyan Zhan, Guan Zhu, Junlong Zhao   +8 more
doaj   +1 more source

Enzyme inhibitor studies reveal complex control of methyl-D-erythritol 4-phosphate (MEP) pathway enzyme expression in Catharanthus roseus.

PLoS ONE, 2013
In Catharanthus roseus, the monoterpene moiety exerts a strong flux control for monoterpene indole alkaloid (MIA) formation. Monoterpene synthesis depends on the methyl-D-erythritol 4-phosphate (MEP) pathway. Here, we have explored the regulation of this
Mei Han, Simon C Heppel, Tao Su, Jochen Bogs, Yuangang Zu, Zhigang An, Thomas Rausch   +6 more
doaj   +1 more source

Ein neuer Malariawirkstoff hemmt die Proteinsynthese von Plasmodium falciparum

Angewandte Chemie, Volume 137, Issue 49, December 1, 2025.
Die Verbindung 31 stellt einen vielversprechenden Ansatz für die Entwicklung eines Malariawirkstoffs mit einem starken Wirkungsprofil dar (PfNF54 IC50 ± s.d. = 3,9 ± 0,4 nM). Sie hat einen neuartigen Wirkmechanismus, indem sie an zytosolische Ribosomen‐Untereinheiten bindet und dadurch die Proteinsynthese im Parasiten hemmt.
Patricia Bravo, Eleonora Diamanti, Mostafa M. Hamed, Lorenzo Bizzarri, Natalie Wiedemar, Armin Passecker, Nicolas M. B. Brancucci, Anna Albisetti, Christin Gumpp, Boris Illarionov, Markus Fischer, Matthias Witschel, Tobias Schehl, Hannes Hahne, Pascal Mäser, Matthias Rottmann, Anna K. H. Hirsch   +16 more
wiley   +1 more source

A Novel Antimalarial Agent that Inhibits Protein Synthesis in Plasmodium falciparum

Angewandte Chemie International Edition, Volume 64, Issue 49, December 1, 2025.
Compound 31 represents a promising avenue for the development as an antimalarial agent with a potent activity profile (PfNF54 IC50 ± s.d. = 3.9 ± 0.4 nM). It has a novel mode of action by binding to cytosolic ribosomal subunits, thereby inhibiting protein synthesis in the parasite.
Patricia Bravo, Eleonora Diamanti, Mostafa M. Hamed, Lorenzo Bizzarri, Natalie Wiedemar, Armin Passecker, Nicolas M. B. Brancucci, Anna Albisetti, Christin Gumpp, Boris Illarionov, Markus Fischer, Matthias Witschel, Tobias Schehl, Hannes Hahne, Pascal Mäser, Matthias Rottmann, Anna K. H. Hirsch   +16 more
wiley   +1 more source

Fosmidomycin‐Clindamycin forPlasmodium falciparumInfections in African Children [PDF]

The Journal of Infectious Diseases, 2004
Fosmidomycin is a new antimalarial drug with a novel mechanism of action. Studies in Africa that have evaluated fosmidomycin as monotherapeutic agent demonstrated its excellent tolerance, but 3-times-daily treatment regimens of >or=4 days were required to achieve radical cure, prompting further research to identify and validate a suitable combination ...
Steffen, Borrmann, Ayola A, Adegnika, Pierre-Blaise, Matsiegui, Saadou, Issifou, Andreas, Schindler, Denise P, Mawili-Mboumba, Thomas, Baranek, Jochen, Wiesner, Hassan, Jomaa, Peter G, Kremsner   +9 more
openaire   +2 more sources

Boron-Containing Analogs of Fosmidomycin: Benzoxaborole Derivatives Exhibit Promising Activity Against Resistant Pathogens [PDF]

ACS Omega
James M. Gamrat, Christopher L. Orme, Giulia Mancini, Sarah J. Burke, Latifah M. Alhthlol, Rebecca C. Colandrea, Bryan C. Figula, Dylan T. Tomares, Jason E. Heindl, John W. Tomsho   +9 more
doaj   +2 more sources

Characterization of Domiphen Bromide as a New Fast-Acting Antiplasmodial Agent Inhibiting the Apicoplastidic Methyl Erythritol Phosphate Pathway

Pharmaceutics, 2022
The evolution of resistance by the malaria parasite to artemisinin, the key component of the combination therapy strategies that are at the core of current antimalarial treatments, calls for the urgent identification of new fast-acting antimalarials. The
Arnau Biosca, Miriam Ramírez, Alex Gomez-Gomez, Aritz Lafuente, Valentín Iglesias, Oscar J. Pozo, Santiago Imperial, Xavier Fernàndez-Busquets   +7 more
doaj   +1 more source

Eutrophication Reshapes Microbial Communities and Life‐History Strategies in the Riverine Ecosystems

Environmental Microbiology Reports, Volume 17, Issue 6, December 2025.
We use 16S rRNA amplicon and shotgun metagenomic sequencing to assess the microbiome in urban and natural riverine ecosystems. This study reveals that eutrophication reshapes microbial communities and demonstrates a tendency toward r‐strategy traits in urban river ecosystems.
Haizhou Li, Jing Fu, Xiangyu Fan, Zhiwei He, Yuekai Wang, Shanshan Yang, Jiawang Wu, Li Wu, Jin Zhou   +8 more
wiley   +1 more source

Microbe‐responsive human γδ T cells: the peculiar case of Staphylococcus aureus

Immunology &Cell Biology, Volume 103, Issue 10, Page 938-944, November-December 2025.
Human Vγ9/Vδ2 T cells display a unique responsiveness towards microbial organisms producing the metabolite HMB‐PP. However, Staphylococcus aureus does not possess HMB‐PP but can induce activation, cytokine expression and proliferation of Vγ9/Vδ2 T cells regardless. We here discuss potential pathways, ligands and biological functions in this response to
Matthias Eberl, Manuel Mata Forsberg, James E. McLaren, Eva Sverremark‐Ekström   +3 more
wiley   +1 more source