Results 71 to 80 of about 1,660 (188)
Environmental Microbiology Reports, Volume 17, Issue 5, October 2025.A comprehensive genomic and phenotypic analysis of Limosilactobacillus fermentum CRL2085 revealed key probiotic and nutritional traits supporting its safe application in cattle feed. The strain harbors genes for stress tolerance, adhesion, exopolysaccharide production, and B‐vitamin biosynthesis, and efficiently metabolizes plant‐derived carbohydrates,
Cecilia M. Aristimuño Ficoseco +9 more
wiley +1 more source
Divergent Strategy for the Synthesis of α-Aryl-Substituted Fosmidomycin Analogues
, 2016 Fosmidomycin is the first representative of a new class of antimalarial drugs acting through inhibition of 1-deoxy-d-xylulose 5-phosphate (DOXP) reductoisomerase (DXR), an essential enzyme in the non-mevalonate pathway for the synthesis of isoprenoids ...
Jef Rozenski (57476) +5 more
core +1 more source
Fosmidomycin uptake into Plasmodium and Babesia-infected erythrocytes is facilitated by parasite-induced new permeability pathways. [PDF]
PLoS ONE, 2011 BackgroundHighly charged compounds typically suffer from low membrane permeability and thus are generally regarded as sub-optimal drug candidates. Nonetheless, the highly charged drug fosmidomycin and its more active methyl-derivative FR900098 have ...
Stefan Baumeister +12 more
doaj +1 more source
Plastids in a Pinch: Coordinating Stress and Developmental Responses Through Retrograde Signalling
Plant, Cell &Environment, Volume 48, Issue 9, Page 6897-6911, September 2025.ABSTRACT Plastids are crucial for fuelling and regulating plant growth and development. Photosynthesising chloroplasts provide energy for growth, while other plastids play additional key roles in various aspects of plant physiology. For function and development, plastids greatly depend on nucleus‐encoded proteins, and they can modulate the synthesis of
Elizabeth van Veen +2 more
wiley +1 more source
mBio, 2018 In the malaria parasite Plasmodium falciparum, synthesis of isoprenoids from glycolytic intermediates is essential for survival. The antimalarial fosmidomycin (FSM) inhibits isoprenoid synthesis. In P.
Ann M. Guggisberg +6 more
doaj +1 more source
In Vitro and In Vivo Synergy of Fosmidomycin, a Novel Antimalarial Drug, with Clindamycin [PDF]
Antimicrobial Agents and Chemotherapy, 2002 ABSTRACT Fosmidomycin acts through inhibition of 1-deoxy- d -xylulose 5-phosphate (DOXP) reductoisomerase, a key enzyme of the nonmevalonate pathway of isoprenoid biosynthesis. It possesses potent antimalarial activity in vitro and in murine malaria.
Jochen, Wiesner +4 more
openaire +2 more sources
Environmental Microbiology Reports, Volume 16, Issue 6, December 2024.Housefly body‐surface samples were collected from five distinct sites associated with human activities and subjected to metagenomic sequencing analysis. The results revealed that the composition of species and ARGs on the housefly body surface reflected the characteristics of their respective environments.
Yuhan Yang, Ping Xu, Wei He, Fei Tao
wiley +1 more source
Environmental Microbiology Reports, Volume 16, Issue 6, December 2024.Minimal research has been conducted on the phyllosphere resistome in relatively pristine environments. This study reports an increase in the abundance of phyllosphere resistomes along an elevational gradient in a national natural reserve, with implications for the spread of antibiotic resistance genes (ARGs). Abstract Antibiotic resistance genes (ARGs)
Yihui Ding +6 more
wiley +1 more source
DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues
, 2016 The antimalarial compound fosmidomycin targets DXR, the enzyme that catalyzes the first committed step in the MEP pathway, producing the essential isoprenoid precursors, isopentenyl diphosphate and dimethylallyl diphosphate.
Sharma Sreevalli (1926910) +17 more
core +1 more source
iMeta, Volume 3, Issue 4, August 2024.In this study, we constructed the first relatively comprehensive duck gut microbial gene catalog and metagenome‐assembled genomes using 375 duck gastrointestinal tract metagenomic samples from four different duck breeds across five intestinal segments under two distinct rearing conditions. Furthermore, the present study expands the understanding of the
Lingyan Ma +9 more
wiley +1 more source