Results 71 to 80 of about 1,208 (158)

Apicoplast‐Resident Processes: Exploiting the Chink in the Armour of Plasmodium falciparum Parasites

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2024, Issue 1, 2024.
The discovery of a relict plastid, also known as an apicoplast (apicomplexan plastid), that houses housekeeping processes and metabolic pathways critical to Plasmodium parasites’ survival has prompted increased research on identifying potent inhibitors that can impinge on apicoplast‐localised processes.
Collins Ojonugwa Mamudu, Mercy Eyitomi Tebamifor, Mary Ohunene Sule, Titilope Modupe Dokunmu, Olubanke Olujoke Ogunlana, Franklyn Nonso Iheagwam, Parasuraman Pavadai   +6 more
wiley   +1 more source

Effect of fosmidomycin on metabolic and transcript profiles of the methylerythritol phosphate pathway in Plasmodium falciparum

Memorias do Instituto Oswaldo Cruz, 2007
In Plasmodium falciparum, the formation of isopentenyl diphosphate and dimethylallyl diphosphate, central intermediates in the biosynthesis of isoprenoids, occurs via the methylerythritol phosphate (MEP) pathway.
María B Cassera, Emilio F Merino, Valnice J Peres, Emilia A Kimura, Gerhard Wunderlich, Alejandro M Katzin   +5 more
doaj  

New insight in isoprenoids biosynthesis process and future prospects for drug designing in Plasmodium

Frontiers in Microbiology, 2016
The MEP (Methyl Erythritol Phosphate) isoprenoids biosynthesis pathway is an attractive drug target to combat malaria, due to its uniqueness and indispensability for the parasite.
Gagandeep Singh Saggu, Zarna Rajeshkumar Pala, Shilpi Garg, Vishal Saxena   +3 more
doaj   +1 more source

NGS Transcriptomes and Enzyme Inhibitors Unravel Complexity of Picrosides Biosynthesis in Picrorhiza kurroa Royle ex. Benth.

PLoS ONE, 2015
Picrorhiza kurroa is an important medicinal herb valued for iridoid glycosides, Picroside-I (P-I) and Picroside-II (P-II), which have several pharmacological activities.
Kirti Shitiz, Neha Sharma, Tarun Pal, Hemant Sood, Rajinder S Chauhan   +4 more
doaj   +1 more source

Metabolic and transcriptional analyses in response to potent inhibitors establish MEP pathway as major route for camptothecin biosynthesis in Nothapodytes nimmoniana (Graham) Mabb

BMC Plant Biology, 2019
Background Nothapodytes nimmoniana, a plant of pivotal medicinal significance is a source of potent anticancer monoterpene indole alkaloid (MIA) camptothecin (CPT). This compound owes its potency due to topoisomerase-I inhibitory activity.
Gulzar A. Rather, Arti Sharma, Syed Mudassir Jeelani, Prashant Misra, Veenu Kaul, Surrinder K. Lattoo   +5 more
doaj   +1 more source

Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum.

PLoS Biology, 2011
Plasmodium spp parasites harbor an unusual plastid organelle called the apicoplast. Due to its prokaryotic origin and essential function, the apicoplast is a key target for development of new anti-malarials. Over 500 proteins are predicted to localize to
Ellen Yeh, Joseph L DeRisi
doaj   +1 more source

A Journey from the Pool of Chiral Synthetic Building Blocks to Cell-Penetrating Peptides, to a Novel Type of Enzyme – and back

CHIMIA, 2013
The roles of polyhydroxy-butyrates/alkanoates (PHB/PHA) in biology, for the preparation of chiral building blocks, and as a source of inspiration for the discovery of ?- and ?-peptides are discussed.
Dieter Seebach
doaj   +1 more source

The effect of MEP pathway and other inhibitors on the intracellular localization of a plasma membrane-targeted, isoprenylable GFP reporter protein in tobacco BY-2 cells [v2; ref status: indexed, http://f1000r.es/2af]

F1000Research, 2013
We have established an in vivo visualization system for the geranylgeranylation of proteins in a stably transformed tobacco BY-2 cell line, based on the expression of a dexamethasone-inducible GFP fused to the carboxy-terminal basic domain of the rice ...
Michael Hartmann, Andrea Hemmerlin, Elisabet Gas-Pascual, Esther Gerber, Denis Tritsch, Michel Rohmer, Thomas J Bach   +6 more
doaj   +1 more source

The effect of MEP pathway and other inhibitors on the intracellular localization of a plasma membrane-targeted, isoprenylable GFP reporter protein in tobacco BY-2 cells [v1; ref status: indexed, http://f1000r.es/yx]

F1000Research, 2013
We have established an in vivo visualization system for the geranylgeranylation of proteins in a stably transformed tobacco BY-2 cell line, based on the expression of a dexamethasone-inducible GFP fused to the carboxy-terminal basic domain of the rice ...
Michael Hartmann, Andrea Hemmerlin, Elisabet Gas-Pascual, Esther Gerber, Denis Tritsch, Michel Rohmer, Thomas J Bach   +6 more
doaj   +1 more source

Fosmidomycin, an inhibitor of isoprenoid synthesis, induces persistence in Chlamydia by inhibiting peptidoglycan assembly.

PLoS Pathogens, 2019
The antibiotic, fosmidomycin (FSM) targets the methylerythritol phosphate (MEP) pathway of isoprenoid synthesis by inhibiting the essential enzyme, 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr) and is lethal to intracellular parasites and ...
Jessica A Slade, Mary Brockett, Raghuveer Singh, George W Liechti, Anthony T Maurelli   +4 more
doaj   +1 more source