Results 81 to 90 of about 1,660 (188)
Plant, Cell &Environment, Volume 47, Issue 7, Page 2334-2348, July 2024.Abstract Chloroplast function is essential for growth, development, and plant adaptation to stress. Organelle stress and plant defence responses were examined here using noxy8 (nonresponding to oxylipins 8) from a series of Arabidopsis mutants. The noxy8 mutation was located at the CLPC2 gene, encoding a chloroplast chaperone of the protease complex ...
Bran López +6 more
wiley +1 more source
The Malaria Burden: A South African Perspective
Journal of Tropical Medicine, Volume 2024, Issue 1, 2024.Malaria is a deadly disease caused by protozoan pathogens of the Plasmodium parasite. Transmission to humans occurs through the bite of an infected female Anopheles mosquito. According to the World Health Organization (WHO), an estimated 247 million cases of malaria were recorded worldwide in 2021, with approximately 619 000 malaria deaths. The initial
Marissa Balmith +3 more
wiley +1 more source
Synthesis and biological evaluation of cyclopropyl analogues of fosmidomycin as potent Plasmodium falciparum growth inhibitors [PDF]
, 2006 A series of fosmidomycin analogues featuring restricted conformational mobility has been synthesized and evaluated as inhibitors of 1-deoxy-D-xylulose 5-phosphate (DOXP) reductoisomerase and as growth inhibitors of P. falciparum.
Devreux, Vincent +5 more
core +1 more source
GAPDH mediates drug resistance and metabolism in Plasmodium falciparum malaria parasites.
PLoS Pathogens, 2022 Efforts to control the global malaria health crisis are undermined by antimalarial resistance. Identifying mechanisms of resistance will uncover the underlying biology of the Plasmodium falciparum malaria parasites that allow evasion of our most ...
Andrew J Jezewski +6 more
doaj +1 more source
Apicoplast‐Resident Processes: Exploiting the Chink in the Armour of Plasmodium falciparum Parasites
Advances in Pharmacological and Pharmaceutical Sciences, Volume 2024, Issue 1, 2024.The discovery of a relict plastid, also known as an apicoplast (apicomplexan plastid), that houses housekeeping processes and metabolic pathways critical to Plasmodium parasites’ survival has prompted increased research on identifying potent inhibitors that can impinge on apicoplast‐localised processes.
Collins Ojonugwa Mamudu +6 more
wiley +1 more source
Amino acid based prodrugs of a fosmidomycin surrogate as antimalarial and antitubercular agents
, 2019 : Fosmidomycin is a natural antibiotic with promising IspC (DXR, 1-deoxy-D-xylulose-5-phosphate reductoisomerase) inhibitory activity. This enzyme catalyzes the first committed step of the non-mevalonate isoprenoid biosynthesis pathway, which is ...
Risseeuw, Martijn +5 more
core +1 more source
Prodrugs of fosmidomycin derivatives
, 2006 Die vorliegende Dissertation beschäftigt sich mit Derivaten des Naturstoffs Fosmidomycin, insbesondere mit deren Synthese, Analytik und Bestimmung der Aktivität gegenüber dem Malaria-Erreger Plasmodium falciparum.
Schlüter, Katrin
core
Binding Modes of Reverse Fosmidomycin Analogs toward the Antimalarial Target IspC
, 2016 1-Deoxy-d-xylulose 5-phosphate reductoisomerase of Plasmodium falciparum (PfIspC, PfDxr), believed to be the rate-limiting enzyme of the nonmevalonate pathway of isoprenoid biosynthesis (MEP pathway), is a clinically validated antimalarial target.
Claudia Lienau (1648396) +13 more
core +1 more source
, 2020 Fosmidomycin inhibits IspC (1-deoxy-d-xylulose 5-phosphate reductoisomerase), the first committed enzyme in the methylerythritol phosphate (MEP) pathway of isoprenoid biosynthesis.
Leandro A. A. Avelar (8529429) +12 more
core +2 more sources
Frontiers in Microbiology, 2016 The MEP (Methyl Erythritol Phosphate) isoprenoids biosynthesis pathway is an attractive drug target to combat malaria, due to its uniqueness and indispensability for the parasite.
Gagandeep Singh Saggu +3 more
doaj +1 more source