Results 81 to 90 of about 1,235 (162)

Fosmidomycin, an inhibitor of isoprenoid synthesis, induces persistence in Chlamydia by inhibiting peptidoglycan assembly.

PLoS Pathogens, 2019
The antibiotic, fosmidomycin (FSM) targets the methylerythritol phosphate (MEP) pathway of isoprenoid synthesis by inhibiting the essential enzyme, 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr) and is lethal to intracellular parasites and ...
Jessica A Slade, Mary Brockett, Raghuveer Singh, George W Liechti, Anthony T Maurelli   +4 more
doaj   +1 more source

Coordinated carbon metabolite flux between the methyl erythritol phosphate (MEP) and the mevalonate (MVA) pathway regulates the withanolide biosynthesis in Withania somnifera (L.) Dunal

Discover Plants
Withanolides are bioactive triterpenoids that require isoprene units viz., isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) as precursor molecule for their biosynthesis, mediated via two independent routes, the plastidial methyl ...
Prince Choyal, Virendra Singh Rana, Maharishi Tomar, Kalidindi Usha, Bhupinder Singh   +4 more
doaj   +1 more source

Light-induced carotenogenesis enhances growth and high hydrostatic pressure tolerance in a deep-sea bacterium by reducing intracellular ROS. [PDF]

Appl Environ Microbiol
Lin J, Li X-G, Zhang W-J, Fang H-R, Zhang G-Y, Wu L-F.   +5 more
europepmc   +1 more source

β-Substitution and prodrug derivation leading to identification of fosmidomycin analogs with improved herbicidal activity. [PDF]

Pest Manag Sci
Yang Z, Zheng L, Hu Q, Bu M, Duan J, Li W, Zhang A.   +6 more
europepmc   +1 more source

Nickel-catalyzed asymmetric hydrogenation of α,β-unsaturated ester phosphonates. [PDF]

Chem Sci
Wei H, Luo Y, Han J, Hussain M, Golovanov IS, Chen J, Gridnev ID, Zhang W.   +7 more
europepmc   +1 more source

The <i>Pseudomonas aeruginosa</i> DedA protein PA4029 is an undecaprenyl phosphate flippase important for polymyxin resistance. [PDF]

mBio
Sposato D, Wang Y, Zhang X, Rossi L, De Chiara S, Di Lorenzo F, Leoni L, Rampioni G, Visca P, Bolla JR, Imperi F.   +10 more
europepmc   +1 more source

Recent advances in natural and synthetic phosphonate therapeutics. [PDF]

Curr Opin Microbiol
Cui J, Ju KS.
europepmc   +1 more source

Structure-Activity Relationships among Inhibitors of <i>Acinetobacter baumannii</i> and <i>Klebsiella pneumoniae</i> 1-Deoxy-d-xylulose 5-Phosphate Reductoisomerase (DXR/IspC) - A Promising Target for Antibiotic Development. [PDF]

ACS Infect Dis
Girma M, Dufrisne MB, Sehgal A, Dailey A, Heidel K, Bague D, Wang X, Bartholomew L, Beck R, Kirby S, Ball H, Zainab M, Lee SH, Soojhawon I, Noble SM, Dowd CS, Couch RD.   +16 more
europepmc   +1 more source

From Discovery to Manufacturing: A Quantitative Review of Phosphonates and Strategies for High-Titer Production. [PDF]

Microorganisms
Zhong X, Song B, Zhang L, Hsiang T, Ouyang L, Zhang J.   +5 more
europepmc   +1 more source

The early human interferon gamma response to Toxoplasma gondii is driven by Vγ9Vδ2 T-cell sensing of host phosphoantigens and subsequent NK-cell activation. [PDF]

PLoS Pathog
Rodriguez F, Saeij JPJ.
europepmc   +1 more source