Results 101 to 110 of about 1,660 (188)

Effects of fosmidomycin on plant photosynthesis as measured by gas exchange and chlorophyll fluorescence

, 2010
In higher plants, many isoprenoids are synthesised via the chloroplastic 1-deoxy-d-xylulose 5-phosphate/2-C-methyl-d-erythritol 4-phosphate (MEP) pathway.
Mullineaux, Philip M., Mullineaux, Philip M, Vickers, Claudia, Vickers, Claudia E, Possell, Malcolm, Hewitt, C. Nicholas, Hewitt, C Nicholas, Vickers, Claudia E., Hewitt, C. N., Ryan, Annette   +9 more
core   +1 more source

The effect of MEP pathway and other inhibitors on the intracellular localization of a plasma membrane-targeted, isoprenylable GFP reporter protein in tobacco BY-2 cells [v1; ref status: indexed, http://f1000r.es/yx]

F1000Research, 2013
We have established an in vivo visualization system for the geranylgeranylation of proteins in a stably transformed tobacco BY-2 cell line, based on the expression of a dexamethasone-inducible GFP fused to the carboxy-terminal basic domain of the rice ...
Michael Hartmann, Andrea Hemmerlin, Elisabet Gas-Pascual, Esther Gerber, Denis Tritsch, Michel Rohmer, Thomas J Bach   +6 more
doaj   +1 more source

Whole genome sequencing to evaluate the resistance landscape following antimalarial treatment failure with fosmidomycin-clindamycin

, 2016
Novel antimalarial therapies are needed in the face of emerging resistance to artemisinin combination therapies. A previous study found a high cure rate in Mozambican children with uncomplicated ...
Bassat Orellana, Quique, Moraleda Redecilla, Cinta, Mayor Aparicio, Alfredo Gabriel, Guggisberg, Ann M., Sundararaman, Sesh A., Kremsner, Peter G., Hahn, Beatrice H., Lanaspa, Miguel, González, Raquel, Hutchinson, David, Cisteró, Pau, Odom, Audrey R.   +11 more
core   +1 more source

Fosmidomycin, an inhibitor of isoprenoid synthesis, induces persistence in Chlamydia by inhibiting peptidoglycan assembly.

PLoS Pathogens, 2019
The antibiotic, fosmidomycin (FSM) targets the methylerythritol phosphate (MEP) pathway of isoprenoid synthesis by inhibiting the essential enzyme, 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr) and is lethal to intracellular parasites and ...
Jessica A Slade, Mary Brockett, Raghuveer Singh, George W Liechti, Anthony T Maurelli   +4 more
doaj   +1 more source

The effects of fosmidomycin inhibition of dxr on DXP metabolism.

, 2012
Twenty five microgram per milliliter fosmidomycin was used to inhibit MEC biosynthesis at 4 h after induction, and the metabolites of BL21 Gold (DE3) harboring pET-SIDF and pAC-LYC were analyzed before and 2 h after inhibition; Presented data were ...
Kang Zhou (122652), Ruiyang Zou (122656), Heng-Phon Too (122667), Gregory Stephanopoulos (122663)   +3 more
core   +1 more source

Isolation of Genomic Deoxyxylulose Phosphate Reductoisomerase (DXR) Mutations Conferring Resistance to Fosmidomycin

, 2018
Sequence to activity mapping technologies are rapidly developing, enabling the isolation of mutations that confer novel phenotypes. Here we used the CRISPR EnAbled Trackable genome Engineering (CREATE) technology to investigate the inhibition of the ...
Ryan T. Gill, Gur Pines, Marcelo C. Bassalo, Alaksh Choudhury, Eun Joong Oh, Andrew D. Garst   +5 more
core   +1 more source

Coordinated carbon metabolite flux between the methyl erythritol phosphate (MEP) and the mevalonate (MVA) pathway regulates the withanolide biosynthesis in Withania somnifera (L.) Dunal

Discover Plants
Withanolides are bioactive triterpenoids that require isoprene units viz., isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) as precursor molecule for their biosynthesis, mediated via two independent routes, the plastidial methyl ...
Prince Choyal, Virendra Singh Rana, Maharishi Tomar, Kalidindi Usha, Bhupinder Singh   +4 more
doaj   +1 more source

N-acylated sulfonamide congeners of fosmidomycin lack any inhibitory activity against DXR

, 2015
: The antibiotic fosmidomycin (3a) is an inhibitor of the non-mevalonate pathway for isoprenoid biosynthesis. Four analogues in which an acylated sulfonamide group is substituting for its phosphonate moiety have been synthesized in a fruitless effort to ...
Pouyez, Jenny, Wouters, Johan, Gadakh, Bharat, Cos, Paul, Van Aerschot, Arthur, Venkatesham, Akkaladevi   +5 more
core  

The design, synthesis and antiplasmodial activity of a series of halogenated fosmidomycin analogues and hybrid drugs

, 2012
Malaria continues to be a devastating disease and a major cause of death in sub-Saharan Africa. With resistance against most of the available antimalarial drugs, there is a need for ongoing research and development of antimalarial agents.
Afolayan, Anthonia Folake
core  

NOA1: A Tool for Understanding Nitric Oxide Accumulation and Fosmidomycin Resistance in Arabidopsis

, 2012
Chloroplasts generate important cellular signals and synthesize diverse products. The chloroplast-localized protein, Nitric Oxide Associated-1 (NOA1), is implicated in nitric oxide (NO) accumulation and linked to the methylerythritol phosphate (MEP ...
Van Ree, Kalie
core