SYNTHESIS AND EVALUATION OF FOSMIDOMYCIN ANALOGUES AS ANTIMALARIAL AGENTS
, 2007 This Ph.D. study constitutes part of an extensive project dealing with the design and development of new agents with antimalarial activity. The enzyme 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR), which is involved in the DOXP pathway for isoprenoid synthesis, was chosen as drug target.
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Longitudinal replicated metagenomic analysis of biosolids-amended soils reveals enrichment of ARGs, virulence factors, and ESKAPE pathogens. [PDF]
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Genomic and phenotypic insight into antimicrobial resistance of <i>Pseudomonas fluorescens</i> from King George Island, Antarctica. [PDF]
Front MicrobiolSilverio MP +11 more
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MEP Pathway: First-Synthesized IspH-Directed Prodrugs with Potent Antimycobacterial Activity. [PDF]
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Understanding Drug Permeability in <i>Pseudomonas aeruginosa</i>. [PDF]
Life (Basel)Ghai I.
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1-Deoxy-d-xylulose 5-phosphate reductoisomerase as target for anti Toxoplasma gondii agents: crystal structure, biochemical characterization and biological evaluation of inhibitors. [PDF]
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Studying Target-Engagement of Anti-Infectives by Solvent-Induced Protein Precipitation and Quantitative Mass Spectrometry. [PDF]
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Mechanistic perspectives on antimalarial agents: from FDA-approved drugs to next-generation candidates. [PDF]
RSC AdvMonika, Sharma B, Awasthi SK.
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A picomolar inhibitor of the <i>Plasmodium falciparum</i> IPP pathway. [PDF]
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Integral Solvent-Induced Protein Precipitation for Target-Engagement Studies in <i>Plasmodium falciparum</i>. [PDF]
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