Results 121 to 130 of about 1,209 (154)

A kalihinol analog disrupts apicoplast function and vesicular trafficking in <i>P. falciparum</i> malaria. [PDF]

Science
Chahine Z, Abel S, Hollin T, Barnes GL, Chung JH, Daub ME, Renard I, Choi JY, Vydyam P, Pal A, Alba-Argomaniz M, Banks CAS, Kirkwood J, Saraf A, Camino I, Castaneda P, Cuevas MC, De Mercado-Arnanz J, Fernandez-Alvaro E, Garcia-Perez A, Ibarz N, Viera-Morilla S, Prudhomme J, Joyner CJ, Bei AK, Florens L, Ben Mamoun C, Vanderwal CD, Le Roch KG.   +28 more
europepmc   +1 more source

Safeguarding artemisinin: integrating bioproduction innovation and resistance management for malaria eradication. [PDF]

Malar J
Farmanpour Kalalagh K, Rezaei A, Hazrati S, Nicola S, Moradi S, Davarpanah Dizaj S, Tariverdizadeh N, Beyraghdar Kashkooli A.   +7 more
europepmc   +1 more source

Fast-Acting Chalcogen-Phosphoranes Inhibit Sensitive and Resistant <i>Plasmodium falciparum</i> Strains. [PDF]

ACS Omega
Moura IMR, Barbosa CS, Mendes GR, Aguiar ACC, Cruz FC, Menezes PH, Guido RVC.   +6 more
europepmc   +1 more source

Chemical modulation of chloroplast de- and redifferentiation reveals a role for the SAL1-PAP retrograde pathway in facilitating plastid transitions. [PDF]

Proc Natl Acad Sci U S A
Perez-Colao P, Cruces J, Perez-Rodriguez S, Koprivova A, Kopriva S, Skirycz A, Lozano-Juste J, Rodriguez-Concepcion M.   +7 more
europepmc   +1 more source

Promiscuity of an Alcohol-Dependent Hemiterpene Pathway for the In Vivo Production of a Non-Natural Alkylated Tryptophan Derivative. [PDF]

ACS Synth Biol
Gayen AK, Pitts Hall RS, Lund S, Williams GJ.   +3 more
europepmc   +1 more source

Acyloxymethyl and alkoxycarbonyloxymethyl prodrugs of a fosmidomycin surrogate as antimalarial and antibacterial agents

European Journal of Medicinal Chemistry, 2023
Fosmidomycin is a natural antibiotic with potent IspC (DXR, 1-deoxy-d-xylulose-5-phosphate reductoisomerase) inhibitory activity. This enzyme catalyzes the first committed step of the non-mevalonate isoprenoid biosynthesis pathway, which is essential in most bacteria, including A. baumanii and M.
Serge Van Calenbergh, Guy Caljon, Tom Coenye   +2 more
exaly   +5 more sources

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Fosmidomycin as an Antimalarial Drug: A Meta-Analysis of Clinical Trials

Future Microbiology, 2015
With first indications of resistance against artemisinin compounds, the development of novel alternative antimalarials remains an urgent need. One candidate is fosmidomycin (Fos), a phosphonic acid derivative. This PRISMA guideline-adhering and PROSPERO-registered systematic review and meta-analysis provides an overview of the state-of-the-art of the ...
Benjamin Mordmüller, Martin Grobusch, Peter Gottfried Kremsner   +2 more
exaly   +4 more sources

Fosmidomycin for the treatment of malaria

Parasitology Research, 2003
In malaria parasites, isoprenoids are synthesised by the mevalonate independent 1-deoxy- D-xylulose 5-phosphate (DOXP) pathway. Fosmidomycin, a natural antibiotic originally developed for the treatment of bacterial infections, represents an inhibitor of DOXP reductoisomerase, an essential enzyme of this pathway.
Jochen, Wiesner, Steffen, Borrmann, Hassan, Jomaa   +2 more
openaire   +2 more sources

Prodrugs of Reverse Fosmidomycin Analogues

Journal of Medicinal Chemistry, 2015
Fosmidomycin inhibits IspC (Dxr, 1-deoxy-d-xylulose 5-phosphate reductoisomerase), a key enzyme in nonmevalonate isoprenoid biosynthesis that is essential in Plasmodium falciparum. The drug has been used successfully to treat malaria patients in clinical studies, thus validating IspC as an antimalarial target.
Brücher, Karin, Gräwert, Tobias, Konzuch, Sarah, Held, Jana, Lienau, Claudia, Behrendt, Christoph, Illarionov, Boris, Maes, Louis, Bacher, Adelbert, Wittlin, Sergio, Mordmüller, Benjamin, Fischer, Markus, Kurz, Thomas   +12 more
openaire   +4 more sources

Carboxylic Acid Analogues of Fosmidomycin

Zeitschrift für Naturforschung B, 2003
N-Alkylation of N-Boc-O-benzylhydroxylamine (1) with benzyl 4-bromobutyrate (2) in DMF gave N,O-bisprotected benzyl 4-hydroxyamino-butyrate (3), which was converted into 4-benzyloxyamino-butyric acid benzyl ester (4) with TFA in methylene chloride.
Thomas Kurz, Detlef Geffken, Claudia Wackendorff   +2 more
openaire   +1 more source