Results 141 to 150 of about 1,660 (188)

Perturbation-specific transcriptional mapping for unbiased target elucidation of antibiotics. [PDF]

Proc Natl Acad Sci U S A
Romano KP, Bagnall J, Warrier T, Sullivan J, Ferrara K, Orzechowski M, Nguyen PH, Raines K, Livny J, Shoresh N, Hung DT.   +10 more
europepmc   +1 more source

Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH). [PDF]

Proc Natl Acad Sci U S A
Sundararaman SA, Miller JJ, Daley EC, O'Brien KA, Kasak P, Daniels AM, Edwards RL, Heidel KM, Bague DA, Wilson MA, Koelper AJ, Kourtoglou EC, White AD, August SA, Apple GA, Rouamba RW, Durand AJ, Esteb JJ, Muller FL, Johnson RJ, Hoops GC, Dowd CS, Odom John AR.   +22 more
europepmc   +1 more source

Inhibition of DXR in the MEP pathway with lipophilic <i>N</i>-alkoxyaryl FR900098 analogs. [PDF]

RSC Med Chem
Bague D, Wang R, Hodge D, Mikati MO, Roma JS, Boshoff HI, Dailey AL, Girma M, Couch RD, Odom John AR, Dowd CS.   +10 more
europepmc   +1 more source

A kalihinol analog disrupts apicoplast function and vesicular trafficking in <i>P. falciparum</i> malaria. [PDF]

Science
Chahine Z, Abel S, Hollin T, Barnes GL, Chung JH, Daub ME, Renard I, Choi JY, Vydyam P, Pal A, Alba-Argomaniz M, Banks CAS, Kirkwood J, Saraf A, Camino I, Castaneda P, Cuevas MC, De Mercado-Arnanz J, Fernandez-Alvaro E, Garcia-Perez A, Ibarz N, Viera-Morilla S, Prudhomme J, Joyner CJ, Bei AK, Florens L, Ben Mamoun C, Vanderwal CD, Le Roch KG.   +28 more
europepmc   +1 more source

Safeguarding artemisinin: integrating bioproduction innovation and resistance management for malaria eradication. [PDF]

Malar J
Farmanpour Kalalagh K, Rezaei A, Hazrati S, Nicola S, Moradi S, Davarpanah Dizaj S, Tariverdizadeh N, Beyraghdar Kashkooli A.   +7 more
europepmc   +1 more source

Chemical modulation of chloroplast de- and redifferentiation reveals a role for the SAL1-PAP retrograde pathway in facilitating plastid transitions. [PDF]

Proc Natl Acad Sci U S A
Perez-Colao P, Cruces J, Perez-Rodriguez S, Koprivova A, Kopriva S, Skirycz A, Lozano-Juste J, Rodriguez-Concepcion M.   +7 more
europepmc   +1 more source

Fast-Acting Chalcogen-Phosphoranes Inhibit Sensitive and Resistant <i>Plasmodium falciparum</i> Strains. [PDF]

ACS Omega
Moura IMR, Barbosa CS, Mendes GR, Aguiar ACC, Cruz FC, Menezes PH, Guido RVC.   +6 more
europepmc   +1 more source

Promiscuity of an Alcohol-Dependent Hemiterpene Pathway for the In Vivo Production of a Non-Natural Alkylated Tryptophan Derivative. [PDF]

ACS Synth Biol
Gayen AK, Pitts Hall RS, Lund S, Williams GJ.   +3 more
europepmc   +1 more source

Resistance of the Burkholderia cepacia complex to fosmidomycin and fosmidomycin derivatives [PDF]

International Journal of Antimicrobial Agents, 2011
The Burkholderia cepacia complex (BCC) is a group of 17 closely related opportunistic pathogens that are able to infect the respiratory tract of cystic fibrosis patients. BCC bacteria are intrinsically resistant to many antibiotics and are therefore difficult to eradicate.
Regina Ortmann, Martin Schlitzer, Serge Van Calenbergh   +2 more
exaly   +4 more sources

Acyloxymethyl and alkoxycarbonyloxymethyl prodrugs of a fosmidomycin surrogate as antimalarial and antibacterial agents

European Journal of Medicinal Chemistry, 2023
Fosmidomycin is a natural antibiotic with potent IspC (DXR, 1-deoxy-d-xylulose-5-phosphate reductoisomerase) inhibitory activity. This enzyme catalyzes the first committed step of the non-mevalonate isoprenoid biosynthesis pathway, which is essential in most bacteria, including A. baumanii and M.
Paul Cos, Guy Caljon, Tom Coenye
exaly   +7 more sources