Results 141 to 150 of about 1,209 (154)

Novel reverse thia-analogs of fosmidomycin: Synthesis and antiplasmodial activity

European Journal of Medicinal Chemistry, 2019
Thia analogs of fosmidomycin are potent inhibitors of the non-mevalonate isoprenoid biosynthesis enzyme 1-deoxy-d-xylulose 5-phosphate reductoisomerase (IspC, Dxr) of Plasmodium falciparum. Several new thioethers displayed antiplasmodial in vitro activity in the low nanomolar range, without apparent cytotoxic effects in HeLa cells.
Claudia, Lienau, Tobias, Gräwert, Leandro A, Alves Avelar, Boris, Illarionov, Jana, Held, Tanja C, Knaab, Beate, Lungerich, Lasse, van Geelen, Dieter, Meier, Stefanie, Geissler, Holger, Cynis, Ulrich, Riederer, Mirko, Buchholz, Rainer, Kalscheuer, Adelbert, Bacher, Benjamin, Mordmüller, Markus, Fischer, Thomas, Kurz   +17 more
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Pharmacokinetics and metabolism of fosmidomycin, a new phosphonic acid, in rats and dogs

European Journal of Drug Metabolism and Pharmacokinetics, 1982
The absorption, distribution, metabolism, and excretion of 3-(N-formylhydroxylamino) propylphosphonic acid monosodium salt (fosmidomycin), a new antibiotic, were investigated in rats and dogs after i.v. and oral dosing. After i.v. administration of 10 mg/kg of body weight, [14C]-fosmidomycin was excreted mainly in the urine (about 90% of dose within 72
T, Tsuchiya, K, Ishibashi, M, Terakawa, M, Nishiyama, N, Itoh, H, Noguchi   +5 more
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Non-Antifolate Antibiotics: Clindamycin, Doxycycline, Azithromycin and Fosmidomycin

2011
A range of antibiotics, in addition to those that target folate metabolism, have demonstrated antimalarial activity. They include those belonging to the lincosamides, tetracyclines and macrolides classes and fosmidomycin, a derivative of phosphonic acid.
Sanjeev Krishna, Henry M. Staines
openaire   +1 more source

Assessment of in vitro antimalarial interactions between dihydroartemisinin and fosmidomycin.

The Southeast Asian journal of tropical medicine and public health, 2008
Malaria remains one of the leading causes of morbidity and mortality in the tropics with an annual estimate of 500 million clinical cases and 2 million deaths. The treatment and control of malaria is becoming increasingly difficult due to Plasmodium falciparum resistance to commonly used antimalarials.
Wanna, Chaijaroenkul, Pattaya, Pruktal, Poonuch, Muhamad, Kesara, Na-Bangchang   +3 more
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Fosmidomycin, a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase in the nonmevalonate pathway for terpenoid biosynthesis

Tetrahedron Letters, 1998
Shunji Takahashi
exaly  

Fosmidomycin

2007
openaire   +1 more source

Fosmidomycin

2016
openaire   +1 more source

Fosmidomycin

2006
openaire   +1 more source

Fosmidomycin demonstrates efficacy against malaria

Inpharma Weekly, 2003
openaire   +1 more source

Fosfomycin and fosmidomycin

2010
openaire   +1 more source