Results 151 to 160 of about 1,660 (188)
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Lancet, The, 2002
Safe and effective antimalarial drugs with new methods of action are urgently needed. Fosmidomycin inhibits the synthesis of isoprenoid by Plasmodium falciparum, and suppresses the growth of multidrug-resistant strains in vitro. Our aim was to assess the efficacy and tolerability of fosmidomycin in adults with malaria in Gabon. We administered the drug
Michel A Missinou +2 more
exaly +3 more sources
Safe and effective antimalarial drugs with new methods of action are urgently needed. Fosmidomycin inhibits the synthesis of isoprenoid by Plasmodium falciparum, and suppresses the growth of multidrug-resistant strains in vitro. Our aim was to assess the efficacy and tolerability of fosmidomycin in adults with malaria in Gabon. We administered the drug
Michel A Missinou +2 more
exaly +3 more sources
Synthesis of antimalarial compounds fosmidomycin and FR900098 through N- or P-alkylation reactions
Tetrahedron, 2013 Two straightforward and convenient routes for the synthesis of the antimalarial agents FR900098 and fosmidomycin are described. In the key steps N- or P-alkylation reactions are used.
Surisetti Suresh, Mats Larhed
exaly +2 more sources
Arylmethyl substituted derivatives of Fosmidomycin: Synthesis and antimalarial activity
European Journal of Medicinal Chemistry, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Rolf D Walter, Bärbel Bergmann
exaly +3 more sources
Fosmidomycin for the treatment of malaria
Parasitology Research, 2003In malaria parasites, isoprenoids are synthesised by the mevalonate independent 1-deoxy- D-xylulose 5-phosphate (DOXP) pathway. Fosmidomycin, a natural antibiotic originally developed for the treatment of bacterial infections, represents an inhibitor of DOXP reductoisomerase, an essential enzyme of this pathway.
Jochen, Wiesner +2 more
openaire +2 more sources
Synthesis of N-Substituted phosphoramidic acid esters as “reverse” fosmidomycin analogues
Tetrahedron, 2019 An efficient synthetic pathway to a series of novel “reverse” fosmidomycin analogues has been developed, commencing from substituted benzylamines. In these analogues, the fosmidomycin hydroxamate moiety is reversed and the tetrahedral methylene carbon ...
Heinrich C Hoppe +2 more
exaly +3 more sources
Fosmidomycin as an Antimalarial Drug: A Meta-Analysis of Clinical Trials
Future Microbiology, 2015With first indications of resistance against artemisinin compounds, the development of novel alternative antimalarials remains an urgent need. One candidate is fosmidomycin (Fos), a phosphonic acid derivative. This PRISMA guideline-adhering and PROSPERO-registered systematic review and meta-analysis provides an overview of the state-of-the-art of the ...
Bertrand Lell +2 more
exaly +4 more sources
Carboxylic Acid Analogues of Fosmidomycin
Zeitschrift für Naturforschung B, 2003N-Alkylation of N-Boc-O-benzylhydroxylamine (1) with benzyl 4-bromobutyrate (2) in DMF gave N,O-bisprotected benzyl 4-hydroxyamino-butyrate (3), which was converted into 4-benzyloxyamino-butyric acid benzyl ester (4) with TFA in methylene chloride.
Thomas Kurz +2 more
openaire +1 more source
Hydroxyurea Analogues of Fosmidomycin
Zeitschrift für Naturforschung B, 2003Abstract Benzyloxyureas (4) have been prepared by reactions of diethyl 3-benzyloxyamino-propyl-phosphonate (3) with isocyanates, potassium cyanate or 1,1’-carbonyldiimidazole / methylamine. Conversion of phosphonic esters 4 into phosphonic acids 6 by means of bromotrimethylsilane and catalytic hydrogenation of 4, 6 afforded the target ...
Thomas Kurz +2 more
openaire +1 more source
Comparison of the response ofEscherichia coli to fosfomycin and fosmidomycin
European Journal of Clinical Microbiology, 1987The responses of Escherichia coli to fosfomycin and fosmidomycin were investigated by continuous turbidimetric monitoring of cultures exposed to the drugs and by microscopy. The activity of both agents was potentiated by glucose-6-phosphate, suggesting that they share the inducible hexose phosphate transport system in Escherichia coli, but several ...
Y, Kanimoto, D, Greenwood
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Conformationally Restrained Aromatic Analogues of Fosmidomycin and FR900098
Archiv der Pharmazie, 2007AbstractThe synthesis and in‐vitro antimalarial activity of conformationally restrained bis(pivaloyloxymethyl) ester analogues of the natural product fosmidomycin is presented. In contrast to α‐aryl‐substituted analogues, conformationally restrained aromatic analogues exhibit only moderate in‐vitro antimalarial activity against the chloroquine ...
Thomas, Kurz +5 more
openaire +2 more sources