Antitumor Activity of Liposomal Nanoparticles Co-Encapsulating Ceramides and Doxorubicin in In Vitro Nucleolin-Expressing Neuroblastoma Models. [PDF]
CellsBackground: Neuroblastoma (NB) causes about 15% of cancer deaths in childhood. Recently, we suggested cell-surface nucleolin (NCL) as a novel target for preclinical therapy against NB.
Bensa V +9 more
europepmc +2 more sources
Anti-CD133-grafted single-walled carbon nanotubes as doxorubicin carrier. [PDF]
Biol Proced OnlineBackground Advances in nanomedicine have spurred interest in antibody-conjugated carbon nanotubes for targeted cancer therapy. CD133, a marker enriched in chemoresistant cancer stem cells, presents a strategic target for precision drug delivery.
Momeni E +4 more
europepmc +2 more sources
Daixie recipe ameliorates diet-induced MASH in mice <i>via</i> activating PI3K/AKT and Keap1/Nrf2 signaling. [PDF]
Front Endocrinol (Lausanne)BackgroundMetabolic dysfunction-associated steatohepatitis (MASH) is a highly prevalent liver disease that can progress to cirrhosis and hepatocellular carcinoma. Despite its growing clinical burden, effective therapies remain limited. Daixie recipe (DXR)
He X +18 more
europepmc +2 more sources
Doxorubicin-induced renal inflammation in rats: Protective role of Plantago major [PDF]
Avicenna Journal of Phytomedicine, 2018 Objective: The aim of the present study was to evaluate the possible protective effect of Plantago major (P. major) extract against doxorubicin (DXR)-induced renal inflammation in rats.
Nazanin Entezari Heravi +11 more
doaj +1 more source
Cortical hand bone porosity and its association with distal radius fracture in middle aged and elderly women. [PDF]
PLoS ONE, 2013 OBJECTIVE: Reduced bone mineral density (BMD), assessed by Dual Energy X-ray absorptiometry (DXA), is a well-known risk factor for fragility fracture. A large proportion of patients with fracture have only slightly reduced BMD.
Alvilde Dhainaut +3 more
doaj +1 more source
Therapeutic effect of valsartan against doxorubicin-induced renal toxicity in rats [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): Doxorubicin (DXR)-induces glomerular atrophy and fibrosis in rat kidneys. The objective of the current study was to investigate the protective effects of valsartan on DXR-induced glomerular toxicity and its mechanisms of actions in rats ...
Hai-Xia Liu, Jin Li, Qi-Xiong Li
doaj +1 more source
Dexrazoxane Diminishes Doxorubicin-Induced Acute Ovarian Damage and Preserves Ovarian Function and Fecundity in Mice. [PDF]
PLoS ONE, 2015 Advances in cancer treatment utilizing multiple chemotherapies have dramatically increased cancer survivorship. Female cancer survivors treated with doxorubicin (DXR) chemotherapy often suffer from an acute impairment of ovarian function, which can ...
Jenna Kropp +5 more
doaj +1 more source
Doxorubicin-induced vascular toxicity--targeting potential pathways may reduce procoagulant activity. [PDF]
PLoS ONE, 2013 Previous study in mice using real-time intravital imaging revealed an acute deleterious effect of doxorubicin (DXR) on the gonadal vasculature, as a prototype of an end-organ, manifested by a reduction in blood flow and disintegration of the vessel wall.
Irit Ben Aharon +8 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Background: Although doxorubicin (DXR) is one of the most used anticancer drugs, it can cause life-threatening renal damage. There has been no effective treatment for DXR-induced renal damage until now.Aim: This work aims at examining the potential ...
Ahlam M. Alhusaini +7 more
doaj +1 more source
Cancer Cell International, 2021 Background Osteosarcoma (OS) is a common type of bone malignancy that often occurs in children and adolescents. Chemoresistance is a huge barrier to cancer therapy.
Huapeng Guan +6 more
doaj +1 more source