Results 21 to 30 of about 7,254 (221)
Inhibitory Activity of Proanthocyanidins Against 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase
Natural Product Communications, 2021 1-Deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is a key enzyme in the methylerythritol phosphate pathway for terpenoid biosynthesis. Furthermore, it is an ideal target for the screening of novel antibiotics because it is present in causative ...
Xian Hui +6 more
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Bio-Responsive Carriers for Controlled Delivery of Doxorubicin to Cancer Cells
Pharmaceutics, 2022 The cellular internalization of drug carriers occurs via different endocytic pathways that ultimately involve the endosomes and the lysosomes, organelles where the pH value drops to 6.0 and 5.0, respectively.
Gheorghe Fundueanu +7 more
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Comparison of innovative and non-invasive methods in estimating the fat content in pork trimmings
Czech Journal of Food Sciences, 2017 The purpose of research was to determine a possibility of application of computer vision systems (CVS) for estimation of fat content in pork trimmings in comparison with methods based on DXR (dual energy X-ray) and NIR (near-infrared reflectance ...
Krzysztof Dasiewicz +2 more
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Cancer Management and Research, 2021 Jianjun Yuan,* Yan Liu,* Quan Zhang, Zhishuai Ren, Guang Li, Rong Tian Department of Spine Surgery, Tianjin Union Medical Center, Tianjin, 300121, People’s Republic of China*These authors contributed equally to this workCorrespondence: Rong ...
Yuan J +5 more
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Nanomaterials, 2021 Natural materials such as bacterial cellulose are gaining interest for their use as drug-delivery vehicles. Herein, the utility of nanofibrillated bacterial cellulose (NFBC), which is produced by culturing a cellulose-producing bacterium ...
Hidenori Ando +10 more
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DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues
Journal of Medicinal Chemistry, 2013 The antimalarial compound fosmidomycin targets DXR, the enzyme that catalyzes the first committed step in the MEP pathway, producing the essential isoprenoid precursors, isopentenyl diphosphate and dimethylallyl diphosphate. The MEP pathway is used by a number of pathogens, including Mycobacterium tuberculosis and apicomplexan parasites, and differs ...
Jansson, Anna +17 more
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Improving Bone Mineral Density Screening by Using Digital X‐Radiogrammetry Combined With Mammography
JBMR Plus, 2022 Fracture risk evaluation of postmenopausal women is suboptimal, but most women undergo screening mammography. Digital X‐radiogrammetry (DXR) determines bone mineral density (BMD) at the metacarpal shaft and can be performed on mammography equipment. This
Amshuman Rao +5 more
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Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake [PDF]
BMC Microbiology, 2008 Fosmidomycin is a phosphonic antibiotic which inhibits 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr), the first committed step of the non-mevalonate pathway of isoprenoid biosynthesis. In Mycobacterium tuberculosis Dxr is encoded by Rv2870c, and although the antibiotic has been shown to inhibit the recombinant enzyme 1, mycobacteria are ...
Parish Tanya, Brown Amanda C
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Cellular and Molecular Gastroenterology and Hepatology, 2021 Background & Aims: aISCs (aISCs) are sensitive to acute insults including chemotherapy and irradiation. Regeneration after aISC depletion has primarily been explored in irradiation (IR).
Breanna J. Sheahan +7 more
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, 2021 DirectX Raytracing (DXR) performance guides have mainly focused on accelerating ray tracing on the graphics processing unit (GPU). This chapter will focus on avoiding stalls and bottlenecks caused by DXR on the central processing unit (CPU) side.
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