Results 21 to 30 of about 6,069 (180)

Doxorubicin Embedded into Nanofibrillated Bacterial Cellulose (NFBC) Produces a Promising Therapeutic Outcome for Peritoneally Metastatic Gastric Cancer in Mice Models via Intraperitoneal Direct Injection

Nanomaterials, 2021
Natural materials such as bacterial cellulose are gaining interest for their use as drug-delivery vehicles. Herein, the utility of nanofibrillated bacterial cellulose (NFBC), which is produced by culturing a cellulose-producing bacterium ...
Hidenori Ando, Takashi Mochizuki, Amr S. Abu Lila, Shunsuke Akagi, Kenji Tajima, Kenji Fujita, Taro Shimizu, Yu Ishima, Tokuo Matsushima, Takatomo Kusano, Tatsuhiro Ishida   +10 more
doaj   +1 more source

Improving Bone Mineral Density Screening by Using Digital X‐Radiogrammetry Combined With Mammography

JBMR Plus, 2022
Fracture risk evaluation of postmenopausal women is suboptimal, but most women undergo screening mammography. Digital X‐radiogrammetry (DXR) determines bone mineral density (BMD) at the metacarpal shaft and can be performed on mammography equipment. This
Amshuman Rao, Elisabeth Elder, Jacqueline R. Center, Thach Tran, Nicholas Pocock, Grahame J. Elder   +5 more
doaj   +1 more source

DXR Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues

Journal of Medicinal Chemistry, 2013
The antimalarial compound fosmidomycin targets DXR, the enzyme that catalyzes the first committed step in the MEP pathway, producing the essential isoprenoid precursors, isopentenyl diphosphate and dimethylallyl diphosphate. The MEP pathway is used by a number of pathogens, including Mycobacterium tuberculosis and apicomplexan parasites, and differs ...
Jansson, Anna, Więckowska, Anna, Björkelid, Christofer, Yahiaoui, Samir, Sooriyaarachchi, Sanjeewani, Lindh, Martin, Bergfors, Terese, Dharavath, Shyamraj, Desroses, Matthieu, Suresh, Surisetti, Andaloussi, Mounir, Nikhil, Rautela, Sreevalli, Sharma, Srinivasa, Bachally R., Larhed, Mats, Jones, T. Alwyn, Karlén, Anders, Mowbray, Sherry L.   +17 more
openaire   +4 more sources

Decrease of the DXR-induced genotoxicity and nongenotoxic effects of Theobroma cacao revealed by micronucleus assay [PDF]

Brazilian Journal of Biology
This study evaluated the genotoxicity of lyophilized glycolic extract of Theobroma cacao Linné seeds (TCL), using the micronucleus assay in bone marrow of mice. The interaction between TCL and doxorubicin (DXR) was also analyzed. Experimental groups were
M. F. G. Boriollo, V. E. Alves, T. A. Silva, J. J. Silva, G. B. S. Barros, C. T. S. Dias, J. F. Höfling, N. M. S. Oliveira   +7 more
doaj   +2 more sources

Epithelial Regeneration After Doxorubicin Arises Primarily From Early Progeny of Active Intestinal Stem CellsSummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims: aISCs (aISCs) are sensitive to acute insults including chemotherapy and irradiation. Regeneration after aISC depletion has primarily been explored in irradiation (IR).
Breanna J. Sheahan, Ally N. Freeman, Theresa M. Keeley, Linda C. Samuelson, Jatin Roper, Stephanie Hasapis, Chang-Lung Lee, Christopher M. Dekaney   +7 more
doaj   +1 more source

Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake [PDF]

BMC Microbiology, 2008
Fosmidomycin is a phosphonic antibiotic which inhibits 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Dxr), the first committed step of the non-mevalonate pathway of isoprenoid biosynthesis. In Mycobacterium tuberculosis Dxr is encoded by Rv2870c, and although the antibiotic has been shown to inhibit the recombinant enzyme 1, mycobacteria are ...
Parish Tanya, Brown Amanda C
openaire   +3 more sources

A Chinese Compound Prescription Ding Xin Recipe Combined with Amiodarone for Treating Premature Ventricular Complexes: A Randomized, Double-Blind, Multicenter, Placebo-Controlled Trial

Digital Chinese Medicine, 2018
: Objective To evaluate the efficacy and safety of Ding Xin Recipe (DXR) combined with amiodarone in patients with PVCs.Methods A total of 360 patients with PVCs across 7 centers in China were randomly assigned in a 1:1:1 ratio to receive up to 8 weeks ...
Feng-Hua Zhou, Yu-Hua Jia, Sui-Lin Ye, Lin-Jie Lou, Ping Yang, Jie Li, Yue-Jun Zhang, Rong-Jiang Qian   +7 more
doaj   +1 more source

Bone mineral density by digital X-ray radiogrammetry is strongly decreased and associated with joint destruction in long-standing Rheumatoid Arthritis: a cross-sectional study

BMC Musculoskeletal Disorders, 2011
Background The aims were to explore bone mineral density (BMD) by digital X-ray radiogrammetry (DXR) in postmenopausal women with long-lasting rheumatoid arthritis (RA) in relation to dual x-ray absorptiometry (DXA)-BMD, joint destruction by conventional
Forsblad-d'Elia Helena, Carlsten Hans
doaj   +1 more source

The role of exogenous epidermal growth factor on Ki-67 proliferation marker expression in the submandibular salivary gland of albino rats receiving doxorubicin [version 1; peer review: 2 approved, 1 approved with reservations]

F1000Research, 2020
Background: This study was conducted to evaluate the role of exogenous epidermal growth factor (EGF) injection on the Ki-67 immuno-expression in submandibular salivary gland tissue of rats receiving doxorubicin (DXR). Methods: A total of 21 two-month-old
Mohamed Mansy, Malak Soliman, Rabab Mubarak, Mohamed Shamel   +3 more
doaj   +1 more source

Early detection of doxorubicin myocardial injury by ultrasonic tissue characterization in an experimental animal model

Cardiovascular Ultrasound, 2012
In the clinical setting, the early detection of myocardial injury induced by doxorubicin (DXR) is still considered a challenge. To assess whether ultrasonic tissue characterization (UTC) can identify early DXR-related myocardial lesions and their ...
Romano Minna Moreira, Pazin-Filho Antônio, O’Connel João, Simões Marcus, Schmidt André, Campos Érica C, Rossi Marcos, Maciel Benedito   +7 more
doaj   +1 more source