Results 31 to 40 of about 6,069 (180)

Effect of AMH on primordial follicle populations in mouse ovaries and human pre-pubertal ovarian xenografts during doxorubicin treatment

Frontiers in Cell and Developmental Biology
IntroductionSurvival rates of the childhood cancer patients are improving, however cancer treatments such as chemotherapy may lead to infertility due to loss of the primordial follicle (PMF) reserve.
Xi Wei, Briet D. Bjarkadottir, Devi Nadjaja, Sairah Sheikh, Muhammad Fatum, Muhammad Fatum, Sheila Lane, Suzannah A. Williams   +7 more
doaj   +1 more source

Bidentate‐Ligand Molecular Bridge in NiFe‐LDH as a Dynamic Proton Relay and Electronic Modulator to Enhance the Oxygen Evolution Reaction

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
By introducing 4‐chlorobenzoic acid ligands into the interlayer of NiFe‐LDH, the carboxyl and Cl groups on either side are respectively bonded to nearby Fe atoms, yielding a stable Bridge‐Linked structure. The strong electron interaction between the ligands and metal ions suppresses metal ion leaching during the reaction process, thereby maintaining ...
Zhe Sun, Jianye Wang, Zengxuan Chen, Huashuo Zhang, Siyuan Liu, Bo Liao, Zhaojie Wang, Xiaoqing Lu   +7 more
wiley   +1 more source

Enhanced Expression of ABCB1 and Nrf2 in CD133-Positive Cancer Stem Cells Associates with Doxorubicin Resistance

Stem Cells International, 2020
The precise mechanism about drug resistance of cancer stem cells (CSCs) has not yet been completely understood. Based on the expression of CD44 and CD133, two well-recognized cell surface markers for CSC identification, we tried to separate HCT8 ...
Shinji Goto, Tsuyoshi Kawabata, Tao-Sheng Li   +2 more
doaj   +1 more source

Phytochemistry, Chemotypic Diversity and Antimicrobial Potential of Essential Oils From Native Aromatic Plants of the Americas: A Systematic Review

Flavour and Fragrance Journal, EarlyView.
This review bridges ancestral indigenous knowledge with modern pharmacology, summarizing the phytochemistry and antimicrobial properties of essential oils from seven native American species. It highlights their significant activity against bacterial, fungal and parasitic pathogens, emphasizing their potential as sustainable therapeutic and agricultural
Arley Rey Páez, Mozaniel Santana de Oliveira, João Paulo Viana Leite   +2 more
wiley   +1 more source

Dual Genotoxic and Antigenotoxic Effects of 3‐Benzoylcoumarins in Mammalian Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Coumarins are phenolic compounds widely recognized for their diverse pharmacological activities and have attracted increasing attention as potential chemopreventive agents. In the present study, four known 3‐benzoylcoumarin derivatives [(1), (2), (3), and (4)] were evaluated for their cytotoxic, mutagenic, and antigenotoxic effects in Chinese ...
Leticia Helena Parreira, Evelyn Pinheiro de Mendonça, Aléxia Polo Siqueira, Cleydson Finotti Cordeiro, Elkin José Torres Sierra, Rudy Bonfilio, Diogo Teixeira Carvalho, Pollyanna Francielli de Oliveira   +7 more
wiley   +1 more source

Lipodox® (generic doxorubicin hydrochloride liposome injection): in vivo efficacy and bioequivalence versus Caelyx® (doxorubicin hydrochloride liposome injection) in human mammary carcinoma (MX-1) xenograft and syngeneic fibrosarcoma (WEHI 164) mouse models

BMC Cancer, 2017
Background Doxorubicin (DXR) hydrochloride (HCl) liposome injection is an important part of the treatment armamentarium for a number of cancers. With growing needs for affordable and effective anticancer treatments, the development of generics is ...
Vinod Burade, Subhas Bhowmick, Kuntal Maiti, Rishit Zalawadia, Harry Ruan, Rajamannar Thennati   +5 more
doaj   +1 more source

MEPicides: α,β-Unsaturated Fosmidomycin Analogues as DXR Inhibitors against Malaria [PDF]

Journal of Medicinal Chemistry, 2018
Severe malaria due to Plasmodium falciparum remains a significant global health threat. DXR, the second enzyme in the MEP pathway, plays an important role to synthesize building blocks for isoprenoids. This enzyme is a promising drug target for malaria due to its essentiality as well as its absence in humans.
Xu Wang, Rachel L. Edwards, Haley Ball, Claire Johnson, Amanda Haymond, Misgina Girma, Michelle Manikkam, Robert C. Brothers, Kyle T. McKay, Stacy D. Arnett, Damon M. Osbourn, Sophie Alvarez, Helena I. Boshoff, Marvin J. Meyers, Robin D. Couch, Audrey R. Odom John, Cynthia S. Dowd   +16 more
openaire   +2 more sources

Protective effects of Bombyx mori, quercetin and benazepril against doxorubicin induced cardiotoxicity and nephrotoxicity

Journal of Saudi Chemical Society, 2016
The present study was conducted with the aim of evaluating the protective effects of Bombyx mori, quercetin and benazepril on doxorubicin (DXR) induced cardiotoxicity and nephrotoxicity in rats. B.
Abdul S. Nazmi, Shibli J. Ahmad, Krishna K. Pillai, Mohammad Akhtar, Aftab Ahmad, Abul K. Najmi   +5 more
doaj   +1 more source

Chinese Guideline on Risk Management of Osteoporosis in the General Public

Orthopaedic Surgery, EarlyView.
Summary of the background, key recommendations, and expected impact of the public guideline for osteoporosis risk management. ABSTRACT Background Osteoporosis is a common chronic skeletal disorder characterized by decreased bone mass and microarchitectural deterioration, resulting in increased fragility and fracture risk. With rapid population aging in
Shiyong Zhang, Jinqiu Yuan, Zhuojing Luo, Jiacan Su, Weibo Xia, Kehu Yang, Fuxin Wei, Osteoporosis Group, Chinese Association of Orthopaedic Surgeons, Youth Osteoporosis Group, Chinese Orthopaedic Association, Chinese Medical Association, Health Communication Branch, Chinese Preventive Medicine Association, Spine and Joint Health Branch, Guangdong Health Care Association, Chinese Health Risk Management Collaboration–Osteoporosis Group (CHRIMAC‐OP), Zhuojing Luo, Jiacan Su, Weibo Xia, Kehu Yang, Fuxin Wei, Jinqiu Yuan, Xiao Chen, Bo Gao, Yang Guo, Xiaofeng Gong, Junjie Huang, Yafang Huang, Tianyong Hou, Da He, Bin Liu, Yajun Liu, Fangping Li, Ying Li, Wei Li, Jiang Li, Zhihao Li, Xiahong Lin, Houqing Long, Jianwen Mo, Wenfei Ni, Yuanjun Teng, Liang Wang, Xiaobin Wang, Hongli Wang, Nan Wu, Hongfei Xiang, Bin Yan, Dejin Yang, Min Yang, Wei Ye, Hongping Yu, Ziji Zhang, Shiyong Zhang, Xinyu Chen, Ningning Chen, Qiangsheng He, Linmin Hu, Wenjing Li, Zijun Li, Qiji Li, Chengkai Lin, Qingfeng Luo, Tianyi Liu, Ningning Mi, Mina Ma, Jun Shen, Peng She, Huidong Tian, Siqing Wu, Junming Wan, Yongsheng Wang, Bin Xia, Peng Xie, Jinyu Zhao, Fei Zhang, Penghui Zhang, Danni Wang, Lei Cheng, Zhongshi Li, Xinyu Liu, Jing Wang, Shengping Yang, Binsheng Yu   +84 more
wiley   +1 more source

Genoprotective Effects of Thai Royal Jelly against Doxorubicin in Human Lymphocytes

Natural Product Communications, 2018
Genoprotective effects of royal jelly (RJ) treatments against doxorubicin (DXR), a potent genotoxic chemotherapeutic compound in human lymphocytes were investigated using the sister chromatid exchange (SCE) assay, and their molecular mechanisms were ...
Wantha Jenkhetkan, Sumon Thitiorul, Chalerm Jansom, Treetip Ratanavalachai   +3 more
doaj   +1 more source