Results 51 to 60 of about 5,889 (160)
Structural studies onMycobacterium tuberculosisDXR in complex with the antibiotic FR-900098
Acta Crystallographica Section D Biological Crystallography, 2012 A number of pathogens, including the causative agents of tuberculosis and malaria, synthesize the essential isoprenoid precursor isopentenyl diphosphate via the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway rather than the classical mevalonate pathway that is found in humans. As part of a structure-based drug-discovery program against tuberculosis,
Björkelid, Christofer +4 more
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Journal of Interactive Media in Education, 1998 : Clinical reasoning is essentially a problem-solving process, in which medical students must learn to gather and interpret data, generate hypotheses and make decisions.
Deborah A. Bryce +3 more
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Scientific Reports, 2022 Up to now, there is only limited information available on a possible relationship between clinical characteristics and the mineralization of metacarpal bones and finger joint space distance (JSD) in patients with psoriatic arthritis (PsA).
Alexander Pfeil +10 more
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Genetics and Molecular Biology, 2007 In this study two different crosses involving the wing cell markers mwh and flr³ (standard (ST) cross and high bioactivation (HB) cross, the latter being characterized by a high constitutive level of cytochrome P450 which leads to an increased ...
Edson José Fragiorge +2 more
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PLoS ONE, 2012 The therapeutic effect of doxorubicin (DXR) in the treatment of soft tissue sarcomas (STS) is limited by its toxicity and the development of multidrug resistance (MDR), the latter mainly induced by high expression of efflux pumps (e.g., P-glycoprotein [P-
Victor Hugo Villar +8 more
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DxR Clinician - Congenital Defect Case (Out of Print)
MedEdPORTAL, 2006 Abstract Health care professionals face the difficult task of determining the clinical reasoning skills of individual students. While observing and mentoring students during preclinical patient encounters and clinical clerkships can provide considerable insight into the clinical reasoning procedure, they do not provide any means of quantifying specific
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Nanoscale Research Letters, 2019 Triple-negative breast cancer (TNBC) is a subtype of breast cancer that is prone to drug resistance and difficult to treat. In this study, we grafted water-soluble pullulan with lovastatin (LV) to develop a novel amphiphilic conjugate, pullulan ...
Di Wu +11 more
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The activity of Terminalia chebula Retz. extract on doxorubicin-induced renal damage in rats. [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2020 Context: Doxorubicin (DXR) is a common anticancer drug known to produce several complications. Terminalia chebula popularly known as ‘King of medicine’ is found to possess wound healing, anti-inflammatory and antioxidant properties.
Aamina Muneer +3 more
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PLoS ONE, 2014 Increasing numbers of female patients survive cancer, but succumb to primary ovarian insufficiency after chemotherapy. We tested the hypothesis that Bortezomib (Bort) protects ovaries from doxorubicin (DXR) chemotherapy by treating female mice with Bort ...
Elon C Roti Roti +4 more
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FEBS Open Bio, 2015 The 1‐deoxy‐d‐xylulose‐5‐phosphate reductoisomerase (DXR; EC1.1.1.267), an NADPH‐dependent reductase, plays a pivotal role in the methylerythritol 4‐phosphate pathway (MEP), in the conversion of 1‐deoxy‐d‐xylulose‐5‐phosphate (DXP) into MEP.
Kamalakshi Devi +4 more
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