Results 71 to 80 of about 7,254 (221)

Analysis of the activity of oncocalyxone A (Auxemma oncocalyx) and doxorubicin on the in vitro development of porcine oocytes

Revista de la Sociedad Científica del Paraguay, 2019
Most anticancer drugs like doxorubicin (DXR) have low specificity that results in undesirable effects especially when it comes to collateral effects on reproduction. Plants are excellent sources when searching for new drugs.
Johanna Leiva Revilla, Carolina Maside, Luis Vieira, Jesús Cadenas, Ana Clara Ferreira Acioly, Victor Macedo Paes, Francisco Leo Agiar, Juliana Jales de Hollanda Celestino, Benner Geraldo Alves, Otilia Deusdenia Loiola Pessoa, Ricardo Toniolli, Ana Paula Rodrigues, José Ricardo de Figueiredo   +12 more
doaj   +1 more source

Hsa_circ_0004674 promotes osteosarcoma doxorubicin resistance by regulating the miR-342-3p/FBN1 axis

Journal of Orthopaedic Surgery and Research, 2021
Background The occurrence of chemoresistance is a common problem in tumor treatment. Circular RNA (circRNA) has been confirmed to be related to tumor chemoresistance.
Yumei Bai, Yanghua Li, Juan Bai, Yumei Zhang   +3 more
doaj   +1 more source

Targeting Dxr/IspC to develop drugs against malaria and tuberculosis

The FASEB Journal, 2019
The methylerythritol phosphate pathway (the MEP pathway) of isoprenoid biosynthesis is essential for the survival of many pathogenic organisms, including Plasmodium falciparum and Mycobacterium tuberculosis , causative agents of malaria and tuberculosis,
Misgina Belachew Girma, Haley Ball, Cynthia Dowd, Robin Couch   +3 more
openaire   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, Volume 13, Issue 35, 24 June 2026.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Dexra pretreatment prevents DXR-induced decrease in mice survivorship through 8 months of life.

, 2015
Plot represents the percentage of animals that survived as a function of days post-treatment through 8 months of age. At experiment initiation across all trials: n = 16 Ctl (vehicle control), 16 DXR, 21 Dexra1:DXR1 (1:1 mg ratio), 16 Dexra10:DXR1 (10:1 ...
Elon C. Roti Roti (148117), David H. Abbott (141598), Hasan Khatib (186938), Jenna Kropp (435547), Sana M. Salih (148129), Ashley Ringelstetter (823425)   +5 more
core   +1 more source

Structural studies onMycobacterium tuberculosisDXR in complex with the antibiotic FR-900098

Acta Crystallographica Section D Biological Crystallography, 2012
A number of pathogens, including the causative agents of tuberculosis and malaria, synthesize the essential isoprenoid precursor isopentenyl diphosphate via the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway rather than the classical mevalonate pathway that is found in humans. As part of a structure-based drug-discovery program against tuberculosis,
Björkelid, Christofer, Bergfors, Terese, Unge, Torsten, Mowbray, Sherry L., Jones, T. Alwyn   +4 more
openaire   +4 more sources

Light‑Driven Propulsion of Graphene Aerogels in Microgravity

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Ultralight graphene aerogels convert laser light into thrust. Parabolic‐flight experiments directly compare their motion in microgravity and at 1 g, revealing order‐of‐magnitude enhancements in distance, velocity, and transient thrust when weight and friction are removed (∼50 times enhancement).
Omnia Khattab, Rami Elkaffas, Basel Altawil, Omar Alsuwaidi, Afnan Almubashir, Claire Perfetti, Shanavas Shajahan, Marco Braibanti, Sean Swei, Carlo Saverio Iorio, Yarjan Abdul Samad   +10 more
wiley   +1 more source

DXR induces both single- and double-strand DNA breaks in oocytes; old oocytes are more susceptible to DXR-induced apoptosis; and, some strains of mice are more prone to DXR-induced apoptosis than others.

, 2013
DNA damage was assessed in oocytes of B6C3F1 mice incubated in the presence of DXR (200 nM) for 24 h. DXR induced both single (A) and double-strand DNA breaks (B).
Loro L. Kujjo (354585), Shigeyuki Yokoyama (19189), Ricardo J. G. Pereira (354587), Wataru Kagawa (367112), Tiina Laine (367111), Gloria I. Perez (354590), Hitoshi Kurumizaka (207278)   +6 more
core   +1 more source

Evolutionary diversification and characterization of the eubacterial gene family encoding DXR type II, an alternative isoprenoid biosynthetic enzyme [PDF]

, 2013
Background Isoprenoids constitute a vast family of natural compounds performing diverse and essential functions in all domains of life. In most eubacteria, isoprenoids are synthesized through the methylerythritol 4-phosphate (MEP) pathway. The production
Albert, Víctor A., Albert, VA, Carretero Paulet, Lorenzo, Rodriguez-Concepción, M, Victor A Albert, Félix J Sangari, Rodriguez-Concepcion, Manuel, Jordi Pérez-Gil, Pérez-Gil, Jordi, Sangari, Félix J., Manuel Rodríguez-Concepción, Sangari, J., Carretero-Paulet, Lorenzo, Lorenzo Carretero-Paulet, Rodríguez Concepción, Manuel, Agnieszka Lipska, Lipska, Agnieszka, Perez-Gil, J.   +17 more
core   +1 more source

Economic Evaluation of a Novel Treatment of Attention-Deficit/Hyperactivity Disorder in US Motor Vehicle Drivers

Journal of Health Economics and Outcomes Research
# Background Attention-deficit/hyperactivity disorder (ADHD) affects approximately 4.4% of US adults. ADHD is associated with high-risk driving behavior and costly motor vehicle accidents. DYANAVEL XR (DXR) (Tris Pharma, Inc.) is a once-daily fast-acting
Jacie T. Cooper, John E. Schneider, Jim Potenziano, David S. Fam   +3 more
doaj   +1 more source