Results 71 to 80 of about 6,069 (180)

Synergistically Enhanced Inhibitory Effects of Pullulan Nanoparticle-Mediated Co-Delivery of Lovastatin and Doxorubicin to Triple-Negative Breast Cancer Cells

Nanoscale Research Letters, 2019
Triple-negative breast cancer (TNBC) is a subtype of breast cancer that is prone to drug resistance and difficult to treat. In this study, we grafted water-soluble pullulan with lovastatin (LV) to develop a novel amphiphilic conjugate, pullulan ...
Di Wu, Yao Chen, Shun Wen, Yi Wen, Rong Wang, Qiuting Zhang, Ge Qin, Huimei Yi, Mi Wu, Lu Lu, Xiaojun Tao, Xiyun Deng   +11 more
doaj   +1 more source

Influence of Higher Tramp Element Level on the Weldability of Automotive Steels

steel research international, Volume 97, Issue 8, Page 4316-4325, August 2026.
The use of green recycled steels is constantly expanding in the automotive industry. The increase in tramp elements resulting from the recycling of steel is problematic. Tramp elements can lead to a negative influence on the weldability. To understand the influence, the welding properties of three green steels are characterized. The potential limits of
Elias Gebhard Vogt, Patrick Veyel, Lars Gebel, Christian Meyer, Robert Thomas, Michael Thomas, Christoph Herrmann   +6 more
wiley   +1 more source

DxR Clinician - Congenital Defect Case (Out of Print)

MedEdPORTAL, 2006
Abstract Health care professionals face the difficult task of determining the clinical reasoning skills of individual students. While observing and mentoring students during preclinical patient encounters and clinical clerkships can provide considerable insight into the clinical reasoning procedure, they do not provide any means of quantifying specific
openaire   +2 more sources

The activity of Terminalia chebula Retz. extract on doxorubicin-induced renal damage in rats. [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2020
Context: Doxorubicin (DXR) is a common anticancer drug known to produce several complications. Terminalia chebula popularly known as ‘King of medicine’ is found to possess wound healing, anti-inflammatory and antioxidant properties.
Aamina Muneer, Ahmad Alhowail, Maha Aldubayan, Syed Imam Rabbani   +3 more
doaj  

Bortezomib prevents acute doxorubicin ovarian insult and follicle demise, improving the fertility window and pup birth weight in mice.

PLoS ONE, 2014
Increasing numbers of female patients survive cancer, but succumb to primary ovarian insufficiency after chemotherapy. We tested the hypothesis that Bortezomib (Bort) protects ovaries from doxorubicin (DXR) chemotherapy by treating female mice with Bort ...
Elon C Roti Roti, Ashley K Ringelstetter, Jenna Kropp, David H Abbott, Sana M Salih   +4 more
doaj   +1 more source

Novel insights into structure–function mechanism and tissue‐specific expression profiling of full‐lengthdxr gene fromCymbopogon winterianus

FEBS Open Bio, 2015
The 1‐deoxy‐d‐xylulose‐5‐phosphate reductoisomerase (DXR; EC1.1.1.267), an NADPH‐dependent reductase, plays a pivotal role in the methylerythritol 4‐phosphate pathway (MEP), in the conversion of 1‐deoxy‐d‐xylulose‐5‐phosphate (DXP) into MEP.
Kamalakshi Devi, Budheswar Dehury, Munmi Phukon, Mahendra Kumar Modi, Priyabrata Sen   +4 more
doaj   +1 more source

Reduction of doxorubicin-induced genotoxicity by Handroanthus impetiginosus in mouse bone marrow revealed by micronucleus assay

Brazilian Journal of Biology, 2017
Handroanthus impetiginosus has long been used in traditional medicine and various studies have determined the presence of bioactive chemical compounds and potential phytotherapeutics.
M. F. G. Boriollo, T. A. Silva, M. F. Rodrigues-Netto, J. J. Silva, M. B. Marques, C. T. S. Dias, J. F. Höfling, M. C. C. Resck, N. M. S. Oliveira   +8 more
doaj   +1 more source

Inhibition of DXR in the MEP pathway with lipophilic N -alkoxyaryl FR900098 analogs

RSC Medicinal Chemistry
Isoprene biosynthesis is a point of vulnerability for many pathogens. Building on prior work, we report a novel set of potent compounds that display selectivity for P. falciparum over M. tuberculosis , and act on-target intracellularly.
Darean Bague, Ruiqin Wang, Dana Hodge, Marwa O. Mikati, Jose S. Roma, Helena I. Boshoff, Allyson L. Dailey, Misgina Girma, Robin D. Couch, Audrey R. Odom John, Cynthia S. Dowd   +10 more
openaire   +2 more sources

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Forskolin attenuates doxorubicin-induced cardiotoxicity by activating SIRT1/FOXO1/PINK1/Parkin-mediated mitophagy

Scientific African
Background: Despite the advancement of cancer therapy, chemotherapy is still a standard approach in cancer treatment. Doxorubicin (DXR) is a potent chemotherapeutic drug, used for the treatment of both adult and pediatric cancers.
Yomna S. Momen, Mohamed A. Kandeil, Mohamed O. Mahmoud   +2 more
doaj   +1 more source