Results 81 to 90 of about 5,908 (179)

Inhibition of DXR in the MEP pathway with lipophilic N -alkoxyaryl FR900098 analogs

RSC Medicinal Chemistry
Isoprene biosynthesis is a point of vulnerability for many pathogens. Building on prior work, we report a novel set of potent compounds that display selectivity for P. falciparum over M. tuberculosis , and act on-target intracellularly.
Darean Bague, Ruiqin Wang, Dana Hodge, Marwa O. Mikati, Jose S. Roma, Helena I. Boshoff, Allyson L. Dailey, Misgina Girma, Robin D. Couch, Audrey R. Odom John, Cynthia S. Dowd   +10 more
openaire   +2 more sources

Forskolin attenuates doxorubicin-induced cardiotoxicity by activating SIRT1/FOXO1/PINK1/Parkin-mediated mitophagy

Scientific African
Background: Despite the advancement of cancer therapy, chemotherapy is still a standard approach in cancer treatment. Doxorubicin (DXR) is a potent chemotherapeutic drug, used for the treatment of both adult and pediatric cancers.
Yomna S. Momen, Mohamed A. Kandeil, Mohamed O. Mahmoud   +2 more
doaj   +1 more source

Ray-Guided Volumetric Water Caustics in Single Scattering Media with DXR [PDF]

, 2019
This chapter presents a hybrid algorithm that uses ray tracing and rasterization to render surface and volumetric caustics in single scattering participating media. The algorithm makes use of ray tracing based on DirectX Raytracing (DXR) to generate data that drives hardware tessellation to adaptively refine triangular beam volumes that are rendered to
openaire   +1 more source

DxR Case Study

Communications of the Association for Information Systems, 2000
Carol Saunders, Blake Ives
openaire   +2 more sources

Effect of corticosteroids on phlebitis induced by intravenous infusion of antineoplastic agents in rabbits

International Journal of Medical Sciences, 2009
Purpose: Phlebitis caused by intravenous infusion of antineoplastic agents is one of the critical problems when anticancer therapy is prolonged. We have already reported that both rapid infusion and dilution of the injection solution were effective ...
Emiko Kohno, Saori Murase, Kenji Matsuyama, Noboru Okamura
doaj  

The Diverse Binding Modes Explain the Nanomolar Levels of Inhibitory Activities Against 1-Deoxy-d-Xylulose 5-Phosphate Reductoisomerase from Plasmodium falciparum Exhibited by Reverse Hydroxamate Analogs of Fosmidomycin with Varying N-Substituents

Molecules
It is established that reverse hydroxamate analogs of fosmidomycin inhibit the growth of Plasmodium falciparum by inhibiting 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR), the second enzyme of the non-mevalonate pathway, which is absent in humans.
Sana Takada, Mona A. Abdullaziz, Stefan Höfmann, Talea Knak, Shin-ichiro Ozawa, Yasumitsu Sakamoto, Thomas Kurz, Nobutada Tanaka   +7 more
doaj   +1 more source

Synthesis of prodrugs of DXR bisubstrate inhibitors

, 2020
Catherine Grosdemange-Billiard, Aurore Dreaneau, Didier Lièvremont, Meghan Ricciardi   +3 more
openaire   +2 more sources

Effect of organic tomato ( Lycopersicon esculentum ) extract on the genotoxicity of doxorubicin in the Drosophila wing spot test

Genetics and Molecular Biology, 2009
The consumption of organic tomatoes (ORTs) reduces the risk of harmful effects to humans and the environment caused by exposure to toxic agrochemicals. In this study, we used the somatic mutation and recombination test (SMART) of wing spots in Drosophila
Elaine S. Dutra, Cristina D. Dias, Bethânia C. de Araújo, Antônio J. S. Castro, Júlio C. Nepomuceno   +4 more
doaj  

[Estimation of bone mass of hemodialysis patients by digital radiologic radiogrammetry (DXR)].

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2003
Bone mass (BMD) may be evaluated by digital X-ray radiogrammetry (DXR) which it is estimated from multiple cortical measures carried out on five regions of interest over a simple hand-forearm X-ray film. We included 168 HD patients (108 men and 60 women; 63 +/- 14 and 66 +/- 12 years old respectively--p < 0.05-) coming from seven HD units in Asturias ...
L, Reyes, M, Rodríguez García, C, Gómez Alonso, J, Megido, P, Ruiz de Alegría, A, Fonseca, M, Gorostidi, E, Gago, R, Forascepi, J, Guerediaga, J B, Cannata Andía   +10 more
openaire   +1 more source

[Inhibitory effect of 5F11-DXR immunoconjugate on human lung cancer cells].

Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2012
To evaluate the inhibition effect of immunoconjugate of doxorubicin(DXR) with a monoclonal antibody, 5F11 on human lung cancer cells and its reversal effect on resistant lung cancer cells to chemotherapeutic drug.DXR was attached to 5F11 using dilute glutaraldehyde crossing.The antitumor activity of immunoconjugate, 5F11-DXR, against the sensitive ...
J, Tang, B, Lai, Y, Zhu, H, Wang, X, Zhan, Y, Wang   +5 more
openaire   +1 more source