Results 41 to 50 of about 5,893 (179)

MEPicides: α,β-Unsaturated Fosmidomycin Analogues as DXR Inhibitors against Malaria [PDF]

Journal of Medicinal Chemistry, 2018
Severe malaria due to Plasmodium falciparum remains a significant global health threat. DXR, the second enzyme in the MEP pathway, plays an important role to synthesize building blocks for isoprenoids. This enzyme is a promising drug target for malaria due to its essentiality as well as its absence in humans.
Xu Wang, Rachel L. Edwards, Haley Ball, Claire Johnson, Amanda Haymond, Misgina Girma, Michelle Manikkam, Robert C. Brothers, Kyle T. McKay, Stacy D. Arnett, Damon M. Osbourn, Sophie Alvarez, Helena I. Boshoff, Marvin J. Meyers, Robin D. Couch, Audrey R. Odom John, Cynthia S. Dowd   +16 more
openaire   +2 more sources

Genoprotective Effects of Thai Royal Jelly against Doxorubicin in Human Lymphocytes

Natural Product Communications, 2018
Genoprotective effects of royal jelly (RJ) treatments against doxorubicin (DXR), a potent genotoxic chemotherapeutic compound in human lymphocytes were investigated using the sister chromatid exchange (SCE) assay, and their molecular mechanisms were ...
Wantha Jenkhetkan, Sumon Thitiorul, Chalerm Jansom, Treetip Ratanavalachai   +3 more
doaj   +1 more source

Usefulness of direct intratumoral administration of doxorubicin hydrochloride with an electro-osmosis–assisted pump

Frontiers in Drug Delivery, 2023
Patients receiving chemotherapy by intravenous (i.v.) or oral administration of anticancer drugs often experience side effects. In this study, an electro-osmotic flow (EO) pump was used for the direct administration of an anticancer drug with minimum ...
Ayu Ito, Shoko Itakura, Yuya Hasegawa, Miyu Hashimoto, Akie Okada, Mamoru Hirafuji, Hidenori Nakamura, Kenji Sugibayashi, Kenji Sugibayashi, Hiroaki Todo   +9 more
doaj   +1 more source

Integrated Metabolomic and Transcriptomic Analysis Revealed the Capsanthin Biosynthesis and Sequestration in Processing Type Red Pepper (Capsicum annuum var. conoides)

eFood, Volume 7, Issue 4, August 2026.
This study establishes that fruit color divergence in Yanjiao pepper cultivars arises from hierarchical regulation of carotenoid metabolism, driven by yellow‐blue chromaticity variation and cultivar‐specific metabolic strategies. These findings provide a mechanistic framework for breeding peppers with enhanced color stability and nutraceutical value ...
Qi Chen, Ming Wang, Minjie Duan, Youjin Hao, Jian Ming, Honghai Li   +5 more
wiley   +1 more source

DxR Clinician - Shortness of Breath Case (Out of Print) [PDF]

MedEdPORTAL, 2006
Abstract Health care professionals face the difficult task of determining the clinical reasoning skills of individual students. While observing and mentoring students during preclinical patient encounters and clinical clerkships can provide considerable insight into the clinical reasoning procedure, they do not provide any means of quantifying specific
openaire   +2 more sources

Dalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF-β Signal Pathway

Mediators of Inflammation, 2016
We investigated the effect of Dalbergioidin (DAL), a well-known natural product extracted from Uraria crinita, on doxorubicin- (DXR-) induced renal fibrosis in mice.
Xianguo Ren, Yun Bo, Junting Fan, Maosheng Chen, Daliang Xu, Yang Dong, Haowei He, Xianzhi Ren, Rong Qu, Yulian Jin, Weihong Zhao, Changliang Xu   +11 more
doaj   +1 more source

A Comparison of Doxorubicin-Resistant Colon Cancer LoVo and Leukemia HL60 Cells: Common Features, Different Underlying Mechanisms

Current Issues in Molecular Biology, 2021
Chemoresistance causes cancer relapse and metastasis, thus remaining the major obstacle to cancer therapy. While some light has been shed on the underlying mechanisms, it is clear that chemoresistance is a multifaceted problem strictly interconnected ...
Laura Locatelli, Alessandra Cazzaniga, Giorgia Fedele, Monica Zocchi, Roberta Scrimieri, Claudia Moscheni, Sara Castiglioni, Jeanette A. Maier   +7 more
doaj   +1 more source

Thickness‐Dependent Plasma Activation in Binder‐Free Multilayer Ni–Co–O Anodes for Alkaline Oxygen Evolution

Advanced Energy and Sustainability Research, Volume 7, Issue 7, July 2026.
Depth‐limited nitrogen plasma activation in binder‐free multilayer Ni–Co–O anodes enables thickness‐dependent surface modification. Plasma treatment induces enrichment of Co at the surface, increases nanoscale roughness and pore density, improves wettability, and strengthens interfacial cohesion.
Mohit Chatwani, Christian Marcks, Christina Meinert, Ioannis Spanos, Adarsh Jain, Viktor Mackert, Ahammed Suhail Odungat, Timo Wagner, Lars Grebener, Abhishek Shaji, Hao Yun, Mena‐Alexander Kräenbring, Nicolas Wöhrl, Anna K. Mechler, Vineetha Vinayakumar, Doris Segets   +15 more
wiley   +1 more source

Multi-Hit Ray Tracing in DXR [PDF]

, 2019
Multi-hit ray traversal is a class of ray traversal algorithm that finds one or more, and possibly all, primitives intersected by a ray, ordered by point of intersection. Multi-hit traversal generalizes traditional first-hit ray traversal and is useful in computer graphics and physics-based simulation.
openaire   +1 more source

Molecular Cloning and Characterization of DXS and DXR Genes in the Terpenoid Biosynthetic Pathway of Tripterygium wilfordii [PDF]

International Journal of Molecular Sciences, 2015
1-Deoxy-d-xylulose-5-phosphate synthase (DXS) and 1-deoxy-d-xylulose-5-phosphate reductoisomerase (DXR) genes are the key enzyme genes of terpenoid biosynthesis but still unknown in Tripterygium wilfordii Hook. f. Here, three full-length cDNA encoding DXS1, DXS2 and DXR were cloned from suspension cells of T. wilfordii with ORF sizes of 2154 bp (TwDXS1,
Tong, Yuru, Su, Ping, Zhao, Yujun, Zhang, Meng, Wang, Xiujuan, Liu, Yujia, Zhang, Xianan, Gao, Wei, Huang, Luqi   +8 more
openaire   +2 more sources