Results 41 to 50 of about 6,069 (180)

Usefulness of direct intratumoral administration of doxorubicin hydrochloride with an electro-osmosis–assisted pump

Frontiers in Drug Delivery, 2023
Patients receiving chemotherapy by intravenous (i.v.) or oral administration of anticancer drugs often experience side effects. In this study, an electro-osmotic flow (EO) pump was used for the direct administration of an anticancer drug with minimum ...
Ayu Ito, Shoko Itakura, Yuya Hasegawa, Miyu Hashimoto, Akie Okada, Mamoru Hirafuji, Hidenori Nakamura, Kenji Sugibayashi, Kenji Sugibayashi, Hiroaki Todo   +9 more
doaj   +1 more source

Cellulose Fiber‐Engineered Gradient Interfacial Channels as Ion‐Highways for High‐Loading, Long‐Life Lithium‐Ion Batteries

ENERGY &ENVIRONMENTAL MATERIALS, Volume 9, Issue 6, November 2026.
This study presents a papermaking‐inspired strategy to fabricate high‐loading battery electrodes by integrating a cellulose fiber network. This scaffold creates a gradient porous architecture, enabling ultra‐fast electrolyte infiltration and ion transport.
Wenhao Jia, Haiwei Wu, Ruihua Li, Yuting Wang, Zhixiong Zhang, Hanbin Liu, Zhijian Li, Chuanyin Xiong, Yonghao Ni, Qiang Zhang, Li Wang, Xiangming He   +11 more
wiley   +1 more source

N-Acylated sulfonamide congeners of fosmidomycin lack any inhibitory activity against DXR [PDF]

Bioorganic & Medicinal Chemistry Letters, 2015
The antibiotic fosmidomycin (3a) is an inhibitor of the non-mevalonate pathway for isoprenoid biosynthesis. Four analogues in which an acylated sulfonamide group is substituting for its phosphonate moiety have been synthesized in a fruitless effort to preserve one negative charge in order to increase the accompanying affinity for 1-deoxy-d-xylulose 5 ...
Gadakh, Bharat, Pouyez, Jenny, Wouters, Johan, Venkatesham, Akkaladevi, Cos, Paul, Van Aerschot, Arthur   +5 more
openaire   +3 more sources

Dalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF-β Signal Pathway

Mediators of Inflammation, 2016
We investigated the effect of Dalbergioidin (DAL), a well-known natural product extracted from Uraria crinita, on doxorubicin- (DXR-) induced renal fibrosis in mice.
Xianguo Ren, Yun Bo, Junting Fan, Maosheng Chen, Daliang Xu, Yang Dong, Haowei He, Xianzhi Ren, Rong Qu, Yulian Jin, Weihong Zhao, Changliang Xu   +11 more
doaj   +1 more source

Upscaling Genotyping by Amplicon Sequencing With GBAS‐GUI

Molecular Ecology Resources, Volume 26, Issue 7, October 2026.
ABSTRACT Genotyping by amplicon sequencing (GBAS) is a relatively low‐cost approach for generating genotypic data compared with established genomic methods, making it highly scalable and particularly suitable for large‐scale genetic monitoring projects.
Sebastian Sonnenberg, Thapasya Vijayan, Christina Rupprecht, Yoko Philipina Krenn, Melissa Gruber, Hannah Dorfer, Gerald Kwikiriza, Harald Meimberg, Manuel Curto   +8 more
wiley   +1 more source

DxR Clinician - Shortness of Breath Case (Out of Print) [PDF]

MedEdPORTAL, 2006
Abstract Health care professionals face the difficult task of determining the clinical reasoning skills of individual students. While observing and mentoring students during preclinical patient encounters and clinical clerkships can provide considerable insight into the clinical reasoning procedure, they do not provide any means of quantifying specific
openaire   +2 more sources

Chromosome damage induced by DNA topoisomerase II inhibitors combined with g-radiation in vitro

Genetics and Molecular Biology, 1998
Combined radiation and antineoplastic drug treatment have important applications in cancer therapy. In the present work, an evaluation was made of two known topoisomerase II inhibitors, doxorubicin (DXR) and mitoxantrone (MXN), with g-radiation.
Maria Cristina P. Araújo, Francisca da Luz Dias, Andréa O. Cecchi, Lusânia M.G. Antunes, Catarina S. Takahashi   +4 more
doaj   +1 more source

A Comparison of Doxorubicin-Resistant Colon Cancer LoVo and Leukemia HL60 Cells: Common Features, Different Underlying Mechanisms

Current Issues in Molecular Biology, 2021
Chemoresistance causes cancer relapse and metastasis, thus remaining the major obstacle to cancer therapy. While some light has been shed on the underlying mechanisms, it is clear that chemoresistance is a multifaceted problem strictly interconnected ...
Laura Locatelli, Alessandra Cazzaniga, Giorgia Fedele, Monica Zocchi, Roberta Scrimieri, Claudia Moscheni, Sara Castiglioni, Jeanette A. Maier   +7 more
doaj   +1 more source

Ovarian hormone loss modifies the nucleic acid cargo of circulating extracellular vesicles and skeletal muscle metabolism after acute exercise in rats

Experimental Physiology, Volume 111, Issue 10, Page 4578-4619, 1 October 2026.
Abstract Loss of ovarian hormones (i.e., menopause) leads to negative effects on metabolic health. While exercise offers significant benefits, it seems to be insufficient to completely reverse these changes. The mechanisms by which exercise conveys the effects throughout the body are still poorly understood.
Veera Puumalainen, Anni Maja, Tia‐Marje Korhonen, Tuuli A. Nissinen, Eero Hulkko, Janne A. Ihalainen, Maarit Lehti, Sira Karvinen   +7 more
wiley   +1 more source

Molecular Cloning and Characterization of DXS and DXR Genes in the Terpenoid Biosynthetic Pathway of Tripterygium wilfordii [PDF]

International Journal of Molecular Sciences, 2015
1-Deoxy-d-xylulose-5-phosphate synthase (DXS) and 1-deoxy-d-xylulose-5-phosphate reductoisomerase (DXR) genes are the key enzyme genes of terpenoid biosynthesis but still unknown in Tripterygium wilfordii Hook. f. Here, three full-length cDNA encoding DXS1, DXS2 and DXR were cloned from suspension cells of T. wilfordii with ORF sizes of 2154 bp (TwDXS1,
Tong, Yuru, Su, Ping, Zhao, Yujun, Zhang, Meng, Wang, Xiujuan, Liu, Yujia, Zhang, Xianan, Gao, Wei, Huang, Luqi   +8 more
openaire   +2 more sources