Results 11 to 20 of about 5,893 (179)
Dexrazoxane Diminishes Doxorubicin-Induced Acute Ovarian Damage and Preserves Ovarian Function and Fecundity in Mice. [PDF]
PLoS ONE, 2015 Advances in cancer treatment utilizing multiple chemotherapies have dramatically increased cancer survivorship. Female cancer survivors treated with doxorubicin (DXR) chemotherapy often suffer from an acute impairment of ovarian function, which can ...
Jenna Kropp +5 more
doaj +1 more source
Doxorubicin-induced vascular toxicity--targeting potential pathways may reduce procoagulant activity. [PDF]
PLoS ONE, 2013 Previous study in mice using real-time intravital imaging revealed an acute deleterious effect of doxorubicin (DXR) on the gonadal vasculature, as a prototype of an end-organ, manifested by a reduction in blood flow and disintegration of the vessel wall.
Irit Ben Aharon +8 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Background: Although doxorubicin (DXR) is one of the most used anticancer drugs, it can cause life-threatening renal damage. There has been no effective treatment for DXR-induced renal damage until now.Aim: This work aims at examining the potential ...
Ahlam M. Alhusaini +7 more
doaj +1 more source
Cancer Cell International, 2021 Background Osteosarcoma (OS) is a common type of bone malignancy that often occurs in children and adolescents. Chemoresistance is a huge barrier to cancer therapy.
Huapeng Guan +6 more
doaj +1 more source
Doxorubicin increases permeability of murine small intestinal epithelium and cultured T84 monolayers
Scientific Reports, 2020 Enteric bacteria and/or their products are necessary for doxorubicin (DXR)-induced small intestine mucosal damage. While DXR does not induce gross loss of epithelium, others have shown elevated serum endotoxin after DXR administration.
Paul Cray +3 more
doaj +1 more source
Research in Pharmaceutical Sciences, 2021 Background and purpose: The clinical use of the chemotherapeutic drug, doxorubicin (DXR), is significantly limited by its extensive multi-organ toxicity.
Rasha Ezzat Mostafa +2 more
doaj +1 more source
Projected lung areas using dynamic X-ray (DXR) [PDF]
European Journal of Radiology Open, 2020 Dynamic X-ray (DXR) provides images of multiple phases of breath with less radiation exposure than CT. The exact images at end-inspiratory or end-expiratory phases can be chosen accurately.To investigate the correlation of the projected lung area (PLA) by dynamic chest X-ray with pulmonary functions.One hundred sixty-two healthy volunteers who received
Takuya Hino +13 more
openaire +3 more sources
Inhibitory Activity of Proanthocyanidins Against 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase
Natural Product Communications, 2021 1-Deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is a key enzyme in the methylerythritol phosphate pathway for terpenoid biosynthesis. Furthermore, it is an ideal target for the screening of novel antibiotics because it is present in causative ...
Xian Hui +6 more
doaj +1 more source
Bio-Responsive Carriers for Controlled Delivery of Doxorubicin to Cancer Cells
Pharmaceutics, 2022 The cellular internalization of drug carriers occurs via different endocytic pathways that ultimately involve the endosomes and the lysosomes, organelles where the pH value drops to 6.0 and 5.0, respectively.
Gheorghe Fundueanu +7 more
doaj +1 more source
Comparison of innovative and non-invasive methods in estimating the fat content in pork trimmings
Czech Journal of Food Sciences, 2017 The purpose of research was to determine a possibility of application of computer vision systems (CVS) for estimation of fat content in pork trimmings in comparison with methods based on DXR (dual energy X-ray) and NIR (near-infrared reflectance ...
Krzysztof Dasiewicz +2 more
doaj +1 more source