Results 111 to 120 of about 1,235 (162)

Identification of Natural-Product Inhibitors of the 2<i>C</i>‑Methyl‑d‑erythritol 4‑Phosphate Pathway. [PDF]

ACS Med Chem Lett
Diamanti E, Alhayek A, Lacour A, Shahrour MW, Willocx D, Illarionov B, Fischer M, Stadler M, Reiling N, Herrmann J, Müller R, Hirsch AKH.   +11 more
europepmc   +1 more source

Apicoplast-derived isoprenoids are essential for biosynthesis of GPI protein anchors, and consequently for egress and invasion in Plasmodium falciparum. [PDF]

PLoS Pathog
Bulloch MS, Huynh LK, Kennedy K, Ralton JE, McConville MJ, Ralph SA.   +5 more
europepmc   +1 more source

Identifying antimalarials that disrupt malaria parasite transmission when fed to the mosquito. [PDF]

Int J Parasitol
Farrell SN, Cozijnsen A, Mollard V, Kancharla P, Dodean RA, Kelly JX, McFadden GI, Goodman CD.   +7 more
europepmc   +1 more source

Perturbation-specific transcriptional mapping for unbiased target elucidation of antibiotics. [PDF]

Proc Natl Acad Sci U S A
Romano KP, Bagnall J, Warrier T, Sullivan J, Ferrara K, Orzechowski M, Nguyen PH, Raines K, Livny J, Shoresh N, Hung DT.   +10 more
europepmc   +1 more source

Commonly prescribed medicines antagonise anti-MRSA antibiotics and select for resistance. [PDF]

Microbiology (Reading)
Sohail Z, Claireaux HA, Edwards AM, Douglas EJA.   +3 more
europepmc   +1 more source

Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH). [PDF]

Proc Natl Acad Sci U S A
Sundararaman SA, Miller JJ, Daley EC, O'Brien KA, Kasak P, Daniels AM, Edwards RL, Heidel KM, Bague DA, Wilson MA, Koelper AJ, Kourtoglou EC, White AD, August SA, Apple GA, Rouamba RW, Durand AJ, Esteb JJ, Muller FL, Johnson RJ, Hoops GC, Dowd CS, Odom John AR.   +22 more
europepmc   +1 more source

Inhibition of DXR in the MEP pathway with lipophilic <i>N</i>-alkoxyaryl FR900098 analogs. [PDF]

RSC Med Chem
Bague D, Wang R, Hodge D, Mikati MO, Roma JS, Boshoff HI, Dailey AL, Girma M, Couch RD, Odom John AR, Dowd CS.   +10 more
europepmc   +1 more source

A kalihinol analog disrupts apicoplast function and vesicular trafficking in <i>P. falciparum</i> malaria. [PDF]

Science
Chahine Z, Abel S, Hollin T, Barnes GL, Chung JH, Daub ME, Renard I, Choi JY, Vydyam P, Pal A, Alba-Argomaniz M, Banks CAS, Kirkwood J, Saraf A, Camino I, Castaneda P, Cuevas MC, De Mercado-Arnanz J, Fernandez-Alvaro E, Garcia-Perez A, Ibarz N, Viera-Morilla S, Prudhomme J, Joyner CJ, Bei AK, Florens L, Ben Mamoun C, Vanderwal CD, Le Roch KG.   +28 more
europepmc   +1 more source

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Fosmidomycin for malaria

Lancet, The, 2002
Safe and effective antimalarial drugs with new methods of action are urgently needed. Fosmidomycin inhibits the synthesis of isoprenoid by Plasmodium falciparum, and suppresses the growth of multidrug-resistant strains in vitro. Our aim was to assess the efficacy and tolerability of fosmidomycin in adults with malaria in Gabon. We administered the drug
Steffen Borrmann, Ayola A. Adegnika, Saadou Issifou   +2 more
exaly   +3 more sources