Results 91 to 100 of about 1,660 (188)

Improved Efficacy of Fosmidomycin against Plasmodium and Mycobacterium Species by Combination with the Cell-Penetrating Peptide Octaarginine

, 2013
Cellular drug delivery can improve efficacy and render intracellular pathogens susceptible to compounds that cannot permeate cells. The transport of physiologically active compounds across membranes into target cells can be facilitated by cell ...
Sparr, Christof, Seebach, Dieter, Gengenbacher, M., Purkayastha, N., Amulic, Borko, Sparr, C., Matuschewski, K., Kolesinska, Beata, Matuschewski, Kai, Kamena, F., Kamena, Faustin, Seebach, D., Purkayastha, Nirupam, Amulic, B., Kolesinska, B., Gengenbacher, Martin   +15 more
core   +1 more source

Fosmidomycin transport through the phosphate‐specific porins OprO and OprP of Pseudomonas aeruginosa

, 2021
The Gram‐negative bacterium Pseudomonas aeruginosa is an opportunistic pathogen, responsible for many hospital‐acquired infections. The bacterium is quite resistant toward many antibiotics, in particular because of the fine‐tuned permeability of its ...
Benz, Roland, Claudio Piselli, Roland Benz, Piselli, Claudio   +3 more
core   +1 more source

NGS Transcriptomes and Enzyme Inhibitors Unravel Complexity of Picrosides Biosynthesis in Picrorhiza kurroa Royle ex. Benth.

PLoS ONE, 2015
Picrorhiza kurroa is an important medicinal herb valued for iridoid glycosides, Picroside-I (P-I) and Picroside-II (P-II), which have several pharmacological activities.
Kirti Shitiz, Neha Sharma, Tarun Pal, Hemant Sood, Rajinder S Chauhan   +4 more
doaj   +1 more source

Fosmidomycin Decreases Membrane Hopanoids and Potentiates the Effects of Colistin on Burkholderia multivorans Clinical Isolates [PDF]

, 2014
Burkholderia cepacia complex (Bcc) pulmonary infections in people living with cystic fibrosis (CF) are difficult to treat because of the extreme intrinsic resistance of most isolates to a broad range of antimicrobials.
Malott, Rebecca J., Dalleska, Nathan F., Newman, Dianne K., Zlosnik, James E. A., Wu, Chia-Hung, Lee, Tracy D., Speert, David P., Hird, Trevor J.   +7 more
core  

Metabolic and transcriptional analyses in response to potent inhibitors establish MEP pathway as major route for camptothecin biosynthesis in Nothapodytes nimmoniana (Graham) Mabb

BMC Plant Biology, 2019
Background Nothapodytes nimmoniana, a plant of pivotal medicinal significance is a source of potent anticancer monoterpene indole alkaloid (MIA) camptothecin (CPT). This compound owes its potency due to topoisomerase-I inhibitory activity.
Gulzar A. Rather, Arti Sharma, Syed Mudassir Jeelani, Prashant Misra, Veenu Kaul, Surrinder K. Lattoo   +5 more
doaj   +1 more source

Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii [PDF]

, 2011
Apicomplexa are important pathogens that include the causative agents of malaria, toxoplasmosis, and cryptosporidiosis. Apicomplexan parasites contain a relict chloroplast, the apicoplast.
Moreno, SNJ, Yongcheng Song, Goodman, CD, Christopher D. Goodman, Carrie F. Brooks, Sandeep Sundriyal, Strurm, A, Brooks, CF, McFadden, GI, Sundriyal, S, Angelika Strurm, Silvia N.J. Moreno, Striepen, B, Boris Striepen, Anglin, JL, Sethu C. Nair, Song, Y, Geoffrey I. McFadden, Justin L. Anglin, Nair, SC   +19 more
core   +1 more source

Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum.

PLoS Biology, 2011
Plasmodium spp parasites harbor an unusual plastid organelle called the apicoplast. Due to its prokaryotic origin and essential function, the apicoplast is a key target for development of new anti-malarials. Over 500 proteins are predicted to localize to
Ellen Yeh, Joseph L DeRisi
doaj   +1 more source

A Journey from the Pool of Chiral Synthetic Building Blocks to Cell-Penetrating Peptides, to a Novel Type of Enzyme – and back

CHIMIA, 2013
The roles of polyhydroxy-butyrates/alkanoates (PHB/PHA) in biology, for the preparation of chiral building blocks, and as a source of inspiration for the discovery of ?- and ?-peptides are discussed.
Dieter Seebach
doaj   +1 more source

Dxr is essential in and fosmidomycin resistance is due to a lack of uptake-2

, 2011
Ted to (A) 1 mg/ml of fosmidomycin for 30 min; (B) 20 μg/ml of fosmidomycin for 60 min. Cell-free extracts (CFE) or culture supernatants (SN) were prepared and serial dilutions were applied to paper disks as described in the methods.
Tanya Parish (26264), Amanda C Brown (92772)   +1 more
core   +1 more source

The effect of MEP pathway and other inhibitors on the intracellular localization of a plasma membrane-targeted, isoprenylable GFP reporter protein in tobacco BY-2 cells [v2; ref status: indexed, http://f1000r.es/2af]

F1000Research, 2013
We have established an in vivo visualization system for the geranylgeranylation of proteins in a stably transformed tobacco BY-2 cell line, based on the expression of a dexamethasone-inducible GFP fused to the carboxy-terminal basic domain of the rice ...
Michael Hartmann, Andrea Hemmerlin, Elisabet Gas-Pascual, Esther Gerber, Denis Tritsch, Michel Rohmer, Thomas J Bach   +6 more
doaj   +1 more source