Results 61 to 70 of about 1,660 (188)

Experimental Genetics of Plasmodium berghei NFU in the Apicoplast Iron-Sulfur Cluster Biogenesis Pathway. [PDF]

PLoS ONE, 2013
Eukaryotic pathogens of the phylum Apicomplexa contain a non-photosynthetic plastid, termed apicoplast. Within this organelle distinct iron-sulfur [Fe-S] cluster proteins are likely central to biosynthesis pathways, including generation of isoprenoids ...
Joana M Haussig, Kai Matuschewski, Taco W A Kooij   +2 more
doaj   +1 more source

Acyloxybenzyl and Alkoxyalkyl Prodrugs of a Fosmidomycin Surrogate as Antimalarial and Antitubercular Agents [PDF]

ACS Medicinal Chemistry Letters, 2018
Two classes of prodrugs of a fosmidomycin surrogate were synthesized and investigated for their ability to inhibit in vitro growth of P. falciparum and M. tuberculosis. To this end, a novel efficient synthesis route was developed involving a cross metathesis reaction as a key step.
Charlotte Courtens, Martijn Risseeuw, Guy Caljon, Paul Cos, Serge Van Calenbergh   +4 more
openaire   +3 more sources

Fosmidomycin biosynthesis diverges from related phosphonate natural products [PDF]

Nature Chemical Biology, 2019
Fosmidomycin and related molecules comprise a family of phosphonate natural products with potent antibacterial, antimalarial and herbicidal activities. To understand the biosynthesis of these compounds, we characterized the fosmidomycin producer, Streptomyces lavendulae, using biochemical and genetic approaches.
Elizabeth I. Parkinson, Annette Erb, Andrew C. Eliot, Kou-San Ju, William W. Metcalf   +4 more
openaire   +2 more sources

Ein neuer Malariawirkstoff hemmt die Proteinsynthese von Plasmodium falciparum

Angewandte Chemie, Volume 137, Issue 49, December 1, 2025.
Die Verbindung 31 stellt einen vielversprechenden Ansatz für die Entwicklung eines Malariawirkstoffs mit einem starken Wirkungsprofil dar (PfNF54 IC50 ± s.d. = 3,9 ± 0,4 nM). Sie hat einen neuartigen Wirkmechanismus, indem sie an zytosolische Ribosomen‐Untereinheiten bindet und dadurch die Proteinsynthese im Parasiten hemmt.
Patricia Bravo, Eleonora Diamanti, Mostafa M. Hamed, Lorenzo Bizzarri, Natalie Wiedemar, Armin Passecker, Nicolas M. B. Brancucci, Anna Albisetti, Christin Gumpp, Boris Illarionov, Markus Fischer, Matthias Witschel, Tobias Schehl, Hannes Hahne, Pascal Mäser, Matthias Rottmann, Anna K. H. Hirsch   +16 more
wiley   +1 more source

Enzyme inhibitor studies reveal complex control of methyl-D-erythritol 4-phosphate (MEP) pathway enzyme expression in Catharanthus roseus.

PLoS ONE, 2013
In Catharanthus roseus, the monoterpene moiety exerts a strong flux control for monoterpene indole alkaloid (MIA) formation. Monoterpene synthesis depends on the methyl-D-erythritol 4-phosphate (MEP) pathway. Here, we have explored the regulation of this
Mei Han, Simon C Heppel, Tao Su, Jochen Bogs, Yuangang Zu, Zhigang An, Thomas Rausch   +6 more
doaj   +1 more source

Fosmidomycin‐Clindamycin forPlasmodium falciparumInfections in African Children [PDF]

The Journal of Infectious Diseases, 2004
Fosmidomycin is a new antimalarial drug with a novel mechanism of action. Studies in Africa that have evaluated fosmidomycin as monotherapeutic agent demonstrated its excellent tolerance, but 3-times-daily treatment regimens of >or=4 days were required to achieve radical cure, prompting further research to identify and validate a suitable combination ...
Steffen, Borrmann, Ayola A, Adegnika, Pierre-Blaise, Matsiegui, Saadou, Issifou, Andreas, Schindler, Denise P, Mawili-Mboumba, Thomas, Baranek, Jochen, Wiesner, Hassan, Jomaa, Peter G, Kremsner   +9 more
openaire   +2 more sources

Eutrophication Reshapes Microbial Communities and Life‐History Strategies in the Riverine Ecosystems

Environmental Microbiology Reports, Volume 17, Issue 6, December 2025.
We use 16S rRNA amplicon and shotgun metagenomic sequencing to assess the microbiome in urban and natural riverine ecosystems. This study reveals that eutrophication reshapes microbial communities and demonstrates a tendency toward r‐strategy traits in urban river ecosystems.
Haizhou Li, Jing Fu, Xiangyu Fan, Zhiwei He, Yuekai Wang, Shanshan Yang, Jiawang Wu, Li Wu, Jin Zhou   +8 more
wiley   +1 more source

Microbe‐responsive human γδ T cells: the peculiar case of Staphylococcus aureus

Immunology &Cell Biology, Volume 103, Issue 10, Page 938-944, November-December 2025.
Human Vγ9/Vδ2 T cells display a unique responsiveness towards microbial organisms producing the metabolite HMB‐PP. However, Staphylococcus aureus does not possess HMB‐PP but can induce activation, cytokine expression and proliferation of Vγ9/Vδ2 T cells regardless. We here discuss potential pathways, ligands and biological functions in this response to
Matthias Eberl, Manuel Mata Forsberg, James E. McLaren, Eva Sverremark‐Ekström   +3 more
wiley   +1 more source

Checkerboard analysis to assess drug interaction between BAP and fosmidomycin.

, 2018
a) Representative heat plot showing a synergistic relationship between BAP (5400 μM, 1000 μg/mL) and fosmidomycin (64 μM, 12 μg/mL) in CAMHB growth medium (figure reproduced with permission, [23]).
Sara Sanders (4163479), Caren L. Freel Meyers (2026792), Paul D. Phillips (584411), Andrew T. Koppisch (584413), David Bartee (1322541), Mackenzie J. Harrison (4163482)   +5 more
core   +1 more source

Characterization of Domiphen Bromide as a New Fast-Acting Antiplasmodial Agent Inhibiting the Apicoplastidic Methyl Erythritol Phosphate Pathway

Pharmaceutics, 2022
The evolution of resistance by the malaria parasite to artemisinin, the key component of the combination therapy strategies that are at the core of current antimalarial treatments, calls for the urgent identification of new fast-acting antimalarials. The
Arnau Biosca, Miriam Ramírez, Alex Gomez-Gomez, Aritz Lafuente, Valentín Iglesias, Oscar J. Pozo, Santiago Imperial, Xavier Fernàndez-Busquets   +7 more
doaj   +1 more source